ES8607225A1 - Procedimiento para la obtencion de 6-cetoprostaglandinas conteniendo azufre - Google Patents
Procedimiento para la obtencion de 6-cetoprostaglandinas conteniendo azufreInfo
- Publication number
- ES8607225A1 ES8607225A1 ES539648A ES539648A ES8607225A1 ES 8607225 A1 ES8607225 A1 ES 8607225A1 ES 539648 A ES539648 A ES 539648A ES 539648 A ES539648 A ES 539648A ES 8607225 A1 ES8607225 A1 ES 8607225A1
- Authority
- ES
- Spain
- Prior art keywords
- atoms
- alkyl
- substituted
- bond
- effects
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 title abstract 2
- 229910052717 sulfur Inorganic materials 0.000 title abstract 2
- 239000011593 sulfur Substances 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 22
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- -1 R1 is H Chemical group 0.000 abstract 3
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 229910052794 bromium Inorganic materials 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004849 alkoxymethyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000004419 alkynylene group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 230000008602 contraction Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 230000002107 myocardial effect Effects 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 125000004665 trialkylsilyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0033—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing sulfur
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pyridine Compounds (AREA)
- Pyrane Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE 6-CETOPROSTAGLANDINAS CONTENIENDO AZUFRE. CONSISTE EN: HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UNO DE FORMULA (III), C30J A 0JC, EN ALCOHOLES O ETERES, COMO DISOLVENTES, Y EN PRESENCIA DE UN CATALIZADOR BASICO, COMO HIDROXIDOS DE METAL ALCALINO O ALCALINO-TERREO, ALCOHOLATOS DE METAL ALCALINO Y OTROS, EN ATMOSFERA DE NITROGENO, PARA OBTENER UN COMPUESTO DE FORMULA (I) Y SUS SALES FISIOLOGICAMENTE COMPATIBLES. SIENDO: D, ALQUILENO DE C 1 A 3, Y OTROS; M, H, O EQUIVALENTE DE UN CATION; R1, H, ALQUILO DE C 1 A 4 Y OTROS; R2, ALQUILO DE C 1 A 7, Y OTROS; R3 Y R4, H, ALQUILO DE C 1 A 7, Y OTROS; R5, H, O ALQUILO DE C 1 A 3; M, POSICION B; N, POSICION A. SE UTILIZAN EN FARMACOLOGIA COMO HIPOPRESORES SANGUINEOS Y COMO INHIBIDORES DE LA AGREGACION DE TROMBOCITOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19843401542 DE3401542A1 (de) | 1984-01-18 | 1984-01-18 | Schwefelhaltige 6-ketoprostaglandine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES539648A0 ES539648A0 (es) | 1986-05-16 |
| ES8607225A1 true ES8607225A1 (es) | 1986-05-16 |
Family
ID=6225229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES539648A Expired ES8607225A1 (es) | 1984-01-18 | 1985-01-17 | Procedimiento para la obtencion de 6-cetoprostaglandinas conteniendo azufre |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4680288A (es) |
| EP (1) | EP0150461B1 (es) |
| JP (1) | JPS60161967A (es) |
| AT (1) | ATE33248T1 (es) |
| AU (1) | AU570532B2 (es) |
| CA (1) | CA1251788A (es) |
| DE (2) | DE3401542A1 (es) |
| ES (1) | ES8607225A1 (es) |
| HU (1) | HU192661B (es) |
| IE (1) | IE850109L (es) |
| ZA (1) | ZA85397B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3569728D1 (en) * | 1984-03-05 | 1989-06-01 | Teijin Ltd | 7-thiaprostaglandin e 1?'s and process for their preparation |
| DE3533576A1 (de) * | 1985-09-20 | 1987-03-26 | Merck Patent Gmbh | Cyclopentanderivate |
| DE3620442A1 (de) * | 1986-06-18 | 1987-12-23 | Merck Patent Gmbh | Ketolactone |
| CA2027814C (en) * | 1989-10-20 | 1996-07-30 | Ryuji Ueno | Treatment of hepatobiliary disease with 15-keto-prostaglandin compounds |
| US5254588A (en) * | 1989-11-22 | 1993-10-19 | Kabushikikaisha Ueno Seiyaku Oyo Kenkyujo | Treatment of pulmonary dysfunction with 15-ketoprostaglandin compounds |
| US5256696A (en) * | 1989-11-22 | 1993-10-26 | Kabushikikaisha Ueno Seiyaku Oyo Kenkyujo | Treatment of cardiac dysfunction with 15-ketoprostaglandin compounds |
| GB9011588D0 (en) * | 1990-05-24 | 1990-07-11 | Wellcome Found | Prostaglandin analogues for use in medicine |
| AU2003224244A1 (en) * | 2002-03-27 | 2003-10-13 | Rosanto Pharmaceuticals Ltd | Improvements in pharmaceutical compositions |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH612933A5 (es) * | 1972-11-17 | 1979-08-31 | Merck Patent Gmbh | |
| DE2422924A1 (de) * | 1974-05-11 | 1975-11-27 | Merck Patent Gmbh | Thiaprostaglandine |
| DE2550004C2 (de) * | 1975-11-07 | 1984-04-26 | Merck Patent Gmbh, 6100 Darmstadt | Thiaprostaglandine sowie Verfahren zu ihrer Herstellung |
| DE2644972C2 (de) * | 1976-10-06 | 1986-06-19 | Merck Patent Gmbh, 6100 Darmstadt | Thiaprostansäurederivate, deren Herstellung und diese Verbindungen enthaltende Mittel |
| US4205178A (en) * | 1976-12-30 | 1980-05-27 | The Upjohn Company | 6-Keto prostaglandin E-type compounds |
| JPS6022710B2 (ja) * | 1977-09-16 | 1985-06-03 | 小野薬品工業株式会社 | プロスタグランジン類似化合物 |
| DE2913856A1 (de) * | 1979-04-06 | 1980-10-23 | Hoechst Ag | Neue prostaglandinderivate in der 6-keto-pge tief 1 -reihe |
| DE2946116A1 (de) * | 1979-11-15 | 1981-05-27 | Hoechst Ag, 6000 Frankfurt | Neue prostaglandinderivate in der 6-keto-pga(pfeil abwaerts)1 -reihe(pfeil abwaerts) |
-
1984
- 1984-01-18 DE DE19843401542 patent/DE3401542A1/de not_active Withdrawn
- 1984-12-20 EP EP84116000A patent/EP0150461B1/de not_active Expired
- 1984-12-20 DE DE8484116000T patent/DE3470159D1/de not_active Expired
- 1984-12-20 AT AT84116000T patent/ATE33248T1/de not_active IP Right Cessation
-
1985
- 1985-01-16 CA CA000472165A patent/CA1251788A/en not_active Expired
- 1985-01-17 AU AU37766/85A patent/AU570532B2/en not_active Ceased
- 1985-01-17 IE IE850109A patent/IE850109L/xx unknown
- 1985-01-17 HU HU85200A patent/HU192661B/hu not_active IP Right Cessation
- 1985-01-17 ES ES539648A patent/ES8607225A1/es not_active Expired
- 1985-01-17 ZA ZA85397A patent/ZA85397B/xx unknown
- 1985-01-18 JP JP60006057A patent/JPS60161967A/ja active Pending
- 1985-01-18 US US06/692,490 patent/US4680288A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE3401542A1 (de) | 1985-08-01 |
| EP0150461A2 (de) | 1985-08-07 |
| CA1251788A (en) | 1989-03-28 |
| US4680288A (en) | 1987-07-14 |
| HU192661B (en) | 1987-06-29 |
| HUT39156A (en) | 1986-08-28 |
| IE850109L (en) | 1985-07-18 |
| AU570532B2 (en) | 1988-03-17 |
| ATE33248T1 (de) | 1988-04-15 |
| EP0150461A3 (en) | 1985-08-21 |
| DE3470159D1 (en) | 1988-05-05 |
| ES539648A0 (es) | 1986-05-16 |
| ZA85397B (en) | 1985-09-25 |
| JPS60161967A (ja) | 1985-08-23 |
| EP0150461B1 (de) | 1988-03-30 |
| AU3776685A (en) | 1985-07-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI864614A (fi) | Nya difosfonsyraderivat, foerfaranden foer framstaellning av dessa samt laekemedel innehaollande dessa foereningar. | |
| BE898778A (fr) | Vinylcephalosporines substituees | |
| IT1152261B (it) | Macchina per l'assemblaggio automatico di parti componenti | |
| ES8607225A1 (es) | Procedimiento para la obtencion de 6-cetoprostaglandinas conteniendo azufre | |
| KR860004986A (ko) | 중합성 티오에스테르 상승제 조성물 | |
| AU564667B2 (en) | 5 (or 3- amino-6-)substituted phenyl)-2, 3 or (2,5)- dihydro-3 (or5)-imoni-2 alkyl 1, 2, 4 triazine | |
| MY101482A (en) | Organophosphorus compound, process for its preparation and insecticidal, miticidal or nematicidal composition containing it | |
| DK44888A (da) | Natriumsalt af 5-chlor-3-(2-thenoyl)-2-oxindol-1-carboxamid | |
| IT8521501A0 (it) | Procedimento di preparazione di un composto dell'acido 7-amminocefalosporanico. | |
| PT93485A (pt) | Processo de preparacao de derivados de 1h,3h-pirrolo{1,2-c}tiazol-7-carboxamida e de composicoes farmaceuticas que os contem | |
| ATE20747T1 (de) | Schwefelhaltige indolderivate. | |
| ES8601151A1 (es) | Procedimiento para la obtencion de derivados de fenilsulfonil-isotiourea sustituidos de efecto herbicida | |
| ZA858041B (en) | Pyridinderivatives | |
| FR2552083B1 (fr) | Derives de (alkynyloxy-3 hydroxy-2-propyl)-4 piperazinyl-1 n-phenyl acetamide, leur preparation et leur application en therapeutique | |
| ES8504822A1 (es) | Procedimiento para la preparacion de un nuevo derivado del pirrolo ortocondensado | |
| FI850969A0 (fi) | Monosilylerade aminofenyletylaminderivat, foerfarande foer deras framstaellning och deras anvaendning vid befraemjandet av tillvaext. | |
| IT8621580A1 (it) | Indurimento mediante irradiazione di composti polimerizzabili cationicamente | |
| IT8323139A0 (it) | Caviglia per l'assemblaggio di parti di mobili. | |
| DK436284A (da) | Salte af antimalariaphenanthrenmethanolforbindelser | |
| ATE56005T1 (de) | Pyridinderivate. | |
| IT1153160B (it) | Sali dell'ascido 5-(4clorobenzoil)-1,4 dimetil-2-pirrolacetico | |
| ES2052824T3 (es) | Procedimiento para la produccion de halosilanos. | |
| PH24449A (en) | Substituted 2-furanyl or 5-oxo-2-furanyl methoxy phosphoryl alkyl cyclimmonium salts | |
| SE8300994D0 (sv) | Borlegeringstillsats jemte sett for kontinuerlig gjutning av borstal | |
| RO91133A2 (ro) | Compozitie de ingrasamint tip suspensie |