ZA853762B - Diamino acid derivatives - Google Patents

Diamino acid derivatives

Info

Publication number
ZA853762B
ZA853762B ZA853762A ZA853762A ZA853762B ZA 853762 B ZA853762 B ZA 853762B ZA 853762 A ZA853762 A ZA 853762A ZA 853762 A ZA853762 A ZA 853762A ZA 853762 B ZA853762 B ZA 853762B
Authority
ZA
South Africa
Prior art keywords
cnh2n
leu
atoms
cmh2m
phe
Prior art date
Application number
ZA853762A
Other languages
English (en)
Inventor
Peter Raddatz
Claus Schmitges
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of ZA853762B publication Critical patent/ZA853762B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/86—Renin inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA853762A 1984-05-18 1985-05-17 Diamino acid derivatives ZA853762B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843418491 DE3418491A1 (de) 1984-05-18 1984-05-18 Diaminosaeurederivate

Publications (1)

Publication Number Publication Date
ZA853762B true ZA853762B (en) 1986-01-29

Family

ID=6236210

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA853762A ZA853762B (en) 1984-05-18 1985-05-17 Diamino acid derivatives

Country Status (10)

Country Link
US (1) US4666888A (xx)
EP (1) EP0161588B1 (xx)
JP (1) JPS6117546A (xx)
AT (1) ATE55612T1 (xx)
AU (1) AU587186B2 (xx)
CA (1) CA1268597A (xx)
DE (2) DE3418491A1 (xx)
ES (1) ES543258A0 (xx)
HU (1) HU200478B (xx)
ZA (1) ZA853762B (xx)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1254699A (en) * 1984-03-12 1989-05-23 Jasjit S. Bindra Renin inhibitors containing statine or derivatives thereof
US4746649A (en) * 1984-05-18 1988-05-24 Merck Patent Gesellschaft Mit Beschraenkter Haftung Diamino acid derivatives
DE3438545A1 (de) * 1984-10-20 1986-04-24 Merck Patent Gmbh, 6100 Darmstadt Peptide
EP0181110A3 (en) * 1984-10-22 1988-05-11 Kissei Pharmaceutical Co. Ltd. Histidine derivatives as renin inhibitors
EP0190891A3 (en) * 1985-01-31 1988-04-20 Kissei Pharmaceutical Co. Ltd. Novel amino acid derivatives
PT82077B (fr) * 1985-02-26 1987-09-25 Sanofi Sa Procede pour l'obtention des derives aminoalcools peptidiques inhibiteurs de la renine et des proteases acides
FR2585708B1 (fr) * 1985-07-31 1989-07-07 Sanofi Sa Derives aminoalcools peptidiques inhibiteurs de la resine et des proteases acides, leur procede de preparation et leur application en therapeutique
DE3512128A1 (de) * 1985-04-03 1986-10-09 Merck Patent Gmbh, 6100 Darmstadt Peptide
IT1186733B (it) * 1985-06-05 1987-12-16 Eniricerche Spa Composti tripeptidici ad azione ipotensiva
EP0206807A3 (en) * 1985-06-28 1988-01-20 Kissei Pharmaceutical Co. Ltd. Novel amino acid derivatives
US4853463A (en) * 1985-09-04 1989-08-01 Kissei Pharmaceutical Co., Ltd. Amino acid derivatives
DE3538749A1 (de) * 1985-10-31 1987-05-07 Merck Patent Gmbh Peptide
DE3540495A1 (de) * 1985-11-15 1987-05-21 Merck Patent Gmbh Aminosaeurederivate
ATE116994T1 (de) * 1986-06-10 1995-01-15 Merck Patent Gmbh Reninhemmende aminosäurederivate.
JPS6322081A (ja) * 1986-07-11 1988-01-29 Kissei Pharmaceut Co Ltd 新規なアミノ酸誘導体
MY103189A (en) * 1986-10-31 1993-05-29 Pfizer Nor-statine and nor-cyclostatine polypeptides
DE3717631A1 (de) * 1987-05-26 1988-12-15 Merck Patent Gmbh Aminosaeurederivate
WO1989001488A1 (en) * 1987-08-07 1989-02-23 The Upjohn Company Renin inhibiting peptides with nonpeptide linkages
WO1990005531A1 (en) * 1988-11-21 1990-05-31 Abbott Laboratories Method for treating vascular diseases
DK0547151T3 (da) * 1990-08-29 2003-03-17 Humanetics Corp Behandlingsmåde til fremme af vægttab under anvendelse af et substitueret delta-5-androsten
MX2011008084A (es) 2009-01-30 2011-10-03 Nestec Sa Cartucho de bomba de infusion con mecanismo de válvula de anti-flujo.
PE20140880A1 (es) * 2011-02-08 2014-08-06 Merck Patent Gmbh Derivados de aminostatina para el tratamiento de artrosis
JP6430936B2 (ja) 2012-07-24 2018-11-28 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ 関節症の処置のためのヒドロキシスタチン誘導体
CN110835639B (zh) * 2018-08-16 2021-08-10 苏州同力生物医药有限公司 一种制备(s)-1,2,3,4-四氢异喹啉-1-甲酸及其衍生物的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1258748A (en) * 1981-10-08 1989-08-22 Daniel F. Veber Renin inhibitory peptides
CA1245217A (en) * 1981-12-10 1988-11-22 Joshua S. Boger Renin inhibitory peptides having phe su13 xx deletion
JPS60500415A (ja) * 1983-02-07 1985-03-28 アクチェボラゲット・ヘッスレ 酵素抑制剤
AU573735B2 (en) * 1983-02-07 1988-06-23 Aktiebolaget Hassle Peptide analogue enzyme inhibitors
CA1254699A (en) * 1984-03-12 1989-05-23 Jasjit S. Bindra Renin inhibitors containing statine or derivatives thereof
US4661473A (en) * 1984-03-27 1987-04-28 Merck & Co., Inc. Renin inhibitors containing peptide isosteres

Also Published As

Publication number Publication date
JPS6117546A (ja) 1986-01-25
HU200478B (en) 1990-06-28
EP0161588A2 (de) 1985-11-21
US4666888A (en) 1987-05-19
AU587186B2 (en) 1989-08-10
DE3579188D1 (de) 1990-09-20
HUT40072A (en) 1986-11-28
EP0161588B1 (de) 1990-08-16
ATE55612T1 (de) 1990-09-15
ES8605773A1 (es) 1986-01-01
AU4228585A (en) 1985-11-21
DE3418491A1 (de) 1985-11-21
CA1268597A (en) 1990-05-01
ES543258A0 (es) 1986-01-01
EP0161588A3 (en) 1987-06-16

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