ES8605773A1 - Procedimiento para la obtencion de derivados de diaminoaci- dos - Google Patents
Procedimiento para la obtencion de derivados de diaminoaci- dosInfo
- Publication number
- ES8605773A1 ES8605773A1 ES543258A ES543258A ES8605773A1 ES 8605773 A1 ES8605773 A1 ES 8605773A1 ES 543258 A ES543258 A ES 543258A ES 543258 A ES543258 A ES 543258A ES 8605773 A1 ES8605773 A1 ES 8605773A1
- Authority
- ES
- Spain
- Prior art keywords
- cnh2n
- leu
- atoms
- cmh2m
- phe
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/86—Renin inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE DIAMINOACIDOS. CONSISTE EN LIBERAR LOS DERIVADOS DE DIAMINOACIDOS DE UNO DE SUS DERIVADOS FUNCIONALES MEDIANTE TRATAMIENTO CON UN AGENTE SOLVOLIZANTE O HIDROGENOLIZANTE; O AMINIZAR UN DERIVADO DE AMINOCETOACIDO DE FORMULA (II) EN FORMA REDUCTIVA PARA OBTENER DERIVADOS DE DIAMINOACIDOS DE FORMULA (I) DONDE X ES H, R2-O-CNH2N-CO-, R2-CNH2N-O-CO Y OTROS; Z ES DESDE 0 HASTA 4 RESTOS DE AMINOACIDO ENLAZADOS ENTRE SI EN FORMA DE PEPTIDO, SELECCIONADOS DEL GRUPO ABU, ADA, ARG, DAB Y OTROS; R1 ES H, A, CICLOALQUILO CON C 3 A 7, AR O CPH2P-W; E SIGNIFICA AUSENTE, ALA, GLY Y OTROS; G SIGNIFICA AUSENTE, HIS, PHE, TRP, TYR O -NH-CH(CH2R1)-CH(NH2)-CH2-CO; E Y SIGNIFICA -O-CMH2M-R3, -NH-CMH2M-R3 Y OTROS. SE EMPLEAN EN MEDICINA HUMANA Y VETERINARIA, ESPECIALMENTE PARA LA PROFILAXIS Y PARA EL TRATAMIENTO DE ENFERMEDADES CARDIACAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19843418491 DE3418491A1 (de) | 1984-05-18 | 1984-05-18 | Diaminosaeurederivate |
Publications (2)
Publication Number | Publication Date |
---|---|
ES543258A0 ES543258A0 (es) | 1986-01-01 |
ES8605773A1 true ES8605773A1 (es) | 1986-01-01 |
Family
ID=6236210
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES543258A Expired ES8605773A1 (es) | 1984-05-18 | 1985-05-17 | Procedimiento para la obtencion de derivados de diaminoaci- dos |
Country Status (10)
Country | Link |
---|---|
US (1) | US4666888A (es) |
EP (1) | EP0161588B1 (es) |
JP (1) | JPS6117546A (es) |
AT (1) | ATE55612T1 (es) |
AU (1) | AU587186B2 (es) |
CA (1) | CA1268597A (es) |
DE (2) | DE3418491A1 (es) |
ES (1) | ES8605773A1 (es) |
HU (1) | HU200478B (es) |
ZA (1) | ZA853762B (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI850948L (fi) * | 1984-03-12 | 1985-09-13 | Pfizer | Renin inhibitorer som innehaoller statin eller dess derivat. |
US4746649A (en) * | 1984-05-18 | 1988-05-24 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Diamino acid derivatives |
DE3438545A1 (de) * | 1984-10-20 | 1986-04-24 | Merck Patent Gmbh, 6100 Darmstadt | Peptide |
EP0181110A3 (en) * | 1984-10-22 | 1988-05-11 | Kissei Pharmaceutical Co. Ltd. | Histidine derivatives as renin inhibitors |
EP0190891A3 (en) * | 1985-01-31 | 1988-04-20 | Kissei Pharmaceutical Co. Ltd. | Novel amino acid derivatives |
PT82077B (fr) * | 1985-02-26 | 1987-09-25 | Sanofi Sa | Procede pour l'obtention des derives aminoalcools peptidiques inhibiteurs de la renine et des proteases acides |
FR2585708B1 (fr) * | 1985-07-31 | 1989-07-07 | Sanofi Sa | Derives aminoalcools peptidiques inhibiteurs de la resine et des proteases acides, leur procede de preparation et leur application en therapeutique |
DE3512128A1 (de) * | 1985-04-03 | 1986-10-09 | Merck Patent Gmbh, 6100 Darmstadt | Peptide |
IT1186733B (it) * | 1985-06-05 | 1987-12-16 | Eniricerche Spa | Composti tripeptidici ad azione ipotensiva |
EP0206807A3 (en) * | 1985-06-28 | 1988-01-20 | Kissei Pharmaceutical Co. Ltd. | Novel amino acid derivatives |
US4853463A (en) * | 1985-09-04 | 1989-08-01 | Kissei Pharmaceutical Co., Ltd. | Amino acid derivatives |
DE3538749A1 (de) * | 1985-10-31 | 1987-05-07 | Merck Patent Gmbh | Peptide |
DE3540495A1 (de) * | 1985-11-15 | 1987-05-21 | Merck Patent Gmbh | Aminosaeurederivate |
EP0249096B1 (de) * | 1986-06-10 | 1995-01-11 | Merck Patent Gmbh | Reninhemmende Aminosäurederivate. |
JPS6322081A (ja) * | 1986-07-11 | 1988-01-29 | Kissei Pharmaceut Co Ltd | 新規なアミノ酸誘導体 |
MY103189A (en) * | 1986-10-31 | 1993-05-29 | Pfizer | Nor-statine and nor-cyclostatine polypeptides |
DE3717631A1 (de) * | 1987-05-26 | 1988-12-15 | Merck Patent Gmbh | Aminosaeurederivate |
EP0364493A1 (en) * | 1987-08-07 | 1990-04-25 | The Upjohn Company | Renin inhibiting peptides with nonpeptide linkages |
WO1990005531A1 (en) * | 1988-11-21 | 1990-05-31 | Abbott Laboratories | Method for treating vascular diseases |
DE69133158T2 (de) * | 1990-08-29 | 2003-07-17 | Humanetics Corp | Behandlungsverfahren zur förderung des gewichtsverlustes unter verwendung eines substituierten delta-5-androstens |
BRPI1007944A2 (pt) | 2009-01-30 | 2016-02-23 | Nestec Sa | "cassete de bomba de infusão com mecanismo de vávula antifluxo livre" |
ES2649964T3 (es) | 2011-02-08 | 2018-01-16 | Merck Patent Gmbh | Derivados de aminoestatina para el tratamiento de la artrosis |
CN104507957B (zh) | 2012-07-24 | 2018-12-25 | 默克专利股份有限公司 | 用于治疗关节病的羟基他汀衍生物 |
CN110835639B (zh) * | 2018-08-16 | 2021-08-10 | 苏州同力生物医药有限公司 | 一种制备(s)-1,2,3,4-四氢异喹啉-1-甲酸及其衍生物的方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1258748A (en) * | 1981-10-08 | 1989-08-22 | Daniel F. Veber | Renin inhibitory peptides |
CA1245217A (en) * | 1981-12-10 | 1988-11-22 | Joshua S. Boger | Renin inhibitory peptides having phe su13 xx deletion |
JPS60500415A (ja) * | 1983-02-07 | 1985-03-28 | アクチェボラゲット・ヘッスレ | 酵素抑制剤 |
AU573735B2 (en) * | 1983-02-07 | 1988-06-23 | Aktiebolaget Hassle | Peptide analogue enzyme inhibitors |
FI850948L (fi) * | 1984-03-12 | 1985-09-13 | Pfizer | Renin inhibitorer som innehaoller statin eller dess derivat. |
US4661473A (en) * | 1984-03-27 | 1987-04-28 | Merck & Co., Inc. | Renin inhibitors containing peptide isosteres |
-
1984
- 1984-05-18 DE DE19843418491 patent/DE3418491A1/de not_active Withdrawn
-
1985
- 1985-05-03 EP EP85105391A patent/EP0161588B1/de not_active Expired - Lifetime
- 1985-05-03 AT AT85105391T patent/ATE55612T1/de not_active IP Right Cessation
- 1985-05-03 DE DE8585105391T patent/DE3579188D1/de not_active Expired - Fee Related
- 1985-05-10 AU AU42285/85A patent/AU587186B2/en not_active Ceased
- 1985-05-16 CA CA000481660A patent/CA1268597A/en not_active Expired - Fee Related
- 1985-05-17 HU HU851867A patent/HU200478B/hu not_active IP Right Cessation
- 1985-05-17 ZA ZA853762A patent/ZA853762B/xx unknown
- 1985-05-17 ES ES543258A patent/ES8605773A1/es not_active Expired
- 1985-05-17 JP JP60104118A patent/JPS6117546A/ja active Pending
- 1985-05-17 US US06/735,247 patent/US4666888A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0161588A3 (en) | 1987-06-16 |
AU587186B2 (en) | 1989-08-10 |
CA1268597A (en) | 1990-05-01 |
ZA853762B (en) | 1986-01-29 |
EP0161588B1 (de) | 1990-08-16 |
US4666888A (en) | 1987-05-19 |
DE3579188D1 (de) | 1990-09-20 |
EP0161588A2 (de) | 1985-11-21 |
HUT40072A (en) | 1986-11-28 |
AU4228585A (en) | 1985-11-21 |
ATE55612T1 (de) | 1990-09-15 |
JPS6117546A (ja) | 1986-01-25 |
HU200478B (en) | 1990-06-28 |
DE3418491A1 (de) | 1985-11-21 |
ES543258A0 (es) | 1986-01-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970303 |