ZA845829B - 1,6-naphthyridinone derivatives,a process for the preparation thereof and their application for controlling vascular diseases - Google Patents

1,6-naphthyridinone derivatives,a process for the preparation thereof and their application for controlling vascular diseases

Info

Publication number
ZA845829B
ZA845829B ZA845829A ZA845829A ZA845829B ZA 845829 B ZA845829 B ZA 845829B ZA 845829 A ZA845829 A ZA 845829A ZA 845829 A ZA845829 A ZA 845829A ZA 845829 B ZA845829 B ZA 845829B
Authority
ZA
South Africa
Prior art keywords
general formula
group
alkyl
see diagramm
groups
Prior art date
Application number
ZA845829A
Other languages
English (en)
Inventor
Gerhard Satzinger
Johannes Hartenstein
Karl Mannhardt
Juergen Kleinschroth
Manfred Herrmann
Edgar Fritschi
Horst-Dietmar Tauschel
Bernd Wagner
Guenter Wolf
Original Assignee
Goedecke Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Goedecke Ag filed Critical Goedecke Ag
Publication of ZA845829B publication Critical patent/ZA845829B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
ZA845829A 1983-07-30 1984-07-27 1,6-naphthyridinone derivatives,a process for the preparation thereof and their application for controlling vascular diseases ZA845829B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19833327650 DE3327650A1 (de) 1983-07-30 1983-07-30 1,6-naphthyridinon-derivate, verfahren zu deren herstellung und deren verwendung bei der bekaempfung von gefaesserkrankungen

Publications (1)

Publication Number Publication Date
ZA845829B true ZA845829B (en) 1985-03-27

Family

ID=6205414

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA845829A ZA845829B (en) 1983-07-30 1984-07-27 1,6-naphthyridinone derivatives,a process for the preparation thereof and their application for controlling vascular diseases

Country Status (12)

Country Link
EP (1) EP0133530B1 (ru)
JP (1) JPS6054385A (ru)
AT (1) ATE41423T1 (ru)
AU (1) AU3129984A (ru)
DD (1) DD223151A5 (ru)
DE (2) DE3327650A1 (ru)
DK (1) DK369384A (ru)
ES (1) ES8504800A1 (ru)
FI (1) FI843005A (ru)
GR (1) GR82225B (ru)
HU (1) HUT34485A (ru)
ZA (1) ZA845829B (ru)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4698341A (en) * 1983-07-30 1987-10-06 Godecke Aktiengesellschaft Use of 1,6-naphthyridinone derivatives in treating pulmonary thrombosis
DE3502831A1 (de) * 1985-01-29 1986-07-31 Gödecke AG, 1000 Berlin 1,6-naphthyridinon-derivate, verfahren zu deren herstellung und deren verwendung
US4532247A (en) * 1983-08-08 1985-07-30 Sterling Drug Inc. 5-(Hydroxyalkyl or alkanoyloxymethyl)-1,6-naphthyridin-2(1H)-one and cardiotonic use thereof
DE3602655A1 (de) * 1985-01-29 1987-07-30 Goedecke Ag 1,6-naphthyridin-derivate, verfahren zu deren herstellung und deren verwendung
IL75987A (en) * 1984-08-25 1991-07-18 Goedecke Ag Tri-and tetrasubstituted-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them
DE3431303A1 (de) * 1984-08-25 1986-02-27 Goedecke Ag 1,6-naphthyridin-derivate, verfahren zu deren herstellung und deren verwendung
IT1201454B (it) * 1985-08-19 1989-02-02 Boehringer Biochemia Srl 1,4-diidropiridine-2-sostituite
DE3605742A1 (de) * 1986-02-22 1987-08-27 Goedecke Ag Pyrrolo(3,4-b)pyridine, verfahren zu deren herstellung und deren verwendung
IT1229118B (it) * 1988-07-29 1991-07-22 Simes Composti attivi sul sistema cardiovascolare che presentano sia la struttura dei beta-bloccanti sia una porzione calcio-antagonista
JPH0734202A (ja) * 1993-07-23 1995-02-03 Toshiba Corp 蒸気タービン用ロータ
US6499946B1 (en) 1999-10-21 2002-12-31 Kabushiki Kaisha Toshiba Steam turbine rotor and manufacturing method thereof
WO2002010164A2 (en) * 2000-08-02 2002-02-07 Abbott Laboratories Dihydronaphthyridine- and dihydropyrrolopyridine-derivated compounds as potassium channel openers
JP4509664B2 (ja) 2003-07-30 2010-07-21 株式会社東芝 蒸気タービン発電設備
DE102006026585A1 (de) 2006-06-07 2007-12-13 Bayer Healthcare Aktiengesellschaft Substituierte 4-Aryl-1,4-dihydro-1,6-naphthyridine und ihre Verwendung
DE102006026583A1 (de) 2006-06-07 2007-12-13 Bayer Healthcare Aktiengesellschaft Aryl-substituierte hetero-bicyclische Verbindungen und ihre Verwendung
DE102007009494A1 (de) 2007-02-27 2008-08-28 Bayer Healthcare Ag Substituierte 4-Aryl-1, 4-dihydro-1,6-naphthyridinamide und ihre Verwendung

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5553291A (en) * 1978-10-17 1980-04-18 Nippon Kayaku Co Ltd Naphthylidine derivative and its preparation
HU183174B (en) * 1980-06-26 1984-04-28 Chinoin Gyogyszer Es Vegyeszet Process for producing 1,6-naphtirine derivatives
US4304914A (en) * 1980-07-07 1981-12-08 Usv Pharmaceutical Corporation Naphthyridone derivatives
EP0059291B1 (en) * 1981-02-27 1985-03-27 American Home Products Corporation Antihypertensive agents

Also Published As

Publication number Publication date
DK369384A (da) 1985-01-31
FI843005A0 (fi) 1984-07-27
DK369384D0 (da) 1984-07-27
EP0133530A2 (de) 1985-02-27
ES534685A0 (es) 1985-05-01
DD223151A5 (de) 1985-06-05
ATE41423T1 (de) 1989-04-15
AU3129984A (en) 1985-01-31
FI843005A (fi) 1985-01-31
EP0133530B1 (de) 1989-03-15
HUT34485A (en) 1985-03-28
JPS6054385A (ja) 1985-03-28
DE3477195D1 (en) 1989-04-20
ES8504800A1 (es) 1985-05-01
DE3327650A1 (de) 1985-02-14
JPS6346077B2 (ru) 1988-09-13
GR82225B (ru) 1984-12-13
EP0133530A3 (en) 1987-12-23

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