ZA843615B - 2-alkylthio-1-aminoalkyl-2-pyrroline-3-carbonitriles,processes for their preparation,as well as their use in the prophylaxis and therapy of thrombotic states - Google Patents
2-alkylthio-1-aminoalkyl-2-pyrroline-3-carbonitriles,processes for their preparation,as well as their use in the prophylaxis and therapy of thrombotic statesInfo
- Publication number
- ZA843615B ZA843615B ZA843615A ZA843615A ZA843615B ZA 843615 B ZA843615 B ZA 843615B ZA 843615 A ZA843615 A ZA 843615A ZA 843615 A ZA843615 A ZA 843615A ZA 843615 B ZA843615 B ZA 843615B
- Authority
- ZA
- South Africa
- Prior art keywords
- carbonitriles
- pyrroline
- aminoalkyl
- prophylaxis
- alkylthio
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000011321 prophylaxis Methods 0.000 title abstract 2
- 238000002560 therapeutic procedure Methods 0.000 title abstract 2
- 230000001732 thrombotic effect Effects 0.000 title abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 239000003705 antithrombocytic agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/38—2-Pyrrolones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrrole Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19833317653 DE3317653A1 (de) | 1983-05-14 | 1983-05-14 | 2-alkylthio-1-aminoalkyl-2-pyrrolin-3-carbonitrile, verfahren zu deren herstellung sowie deren verwendung bei der prophylaxe und therapie thrombotischer zustaende |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA843615B true ZA843615B (en) | 1984-12-24 |
Family
ID=6199021
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA843615A ZA843615B (en) | 1983-05-14 | 1984-05-14 | 2-alkylthio-1-aminoalkyl-2-pyrroline-3-carbonitriles,processes for their preparation,as well as their use in the prophylaxis and therapy of thrombotic states |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4499089A (enExample) |
| EP (1) | EP0125684B1 (enExample) |
| JP (1) | JPS59212469A (enExample) |
| AT (1) | ATE28189T1 (enExample) |
| AU (1) | AU2798884A (enExample) |
| CS (1) | CS244815B2 (enExample) |
| DD (1) | DD222305A5 (enExample) |
| DE (2) | DE3317653A1 (enExample) |
| DK (1) | DK239084A (enExample) |
| ES (3) | ES532438A0 (enExample) |
| GR (1) | GR82094B (enExample) |
| HU (1) | HUT34158A (enExample) |
| SU (1) | SU1251800A3 (enExample) |
| YU (1) | YU83284A (enExample) |
| ZA (1) | ZA843615B (enExample) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL176372B (nl) * | 1952-02-26 | Salvat Editores | Werkwijze voor het bereiden van drukinkt alsmede werkwijze voor het bereiden van een preparaat om aan drukinkt te worden toegevoegd. | |
| FI59246C (fi) * | 1974-06-24 | 1981-07-10 | Otsuka Pharma Co Ltd | Foerfarande foer framstaellning av benscykloamidderivat anvaendbara vid trombos- och emboliterapin |
| NZ182264A (en) * | 1975-10-25 | 1979-01-11 | Beecham Group Ltd | 2-carboxyalkyl-1-hydroxyalkyl-pyrrolidin-3,5-dione or-piperidin-3,6-dione derivatives prarmaceutical compostions |
| US4329347A (en) * | 1978-02-17 | 1982-05-11 | Boehringer Ingelheim Gmbh | Cardiotonic and antithrombotic sulfur-containing derivatives of carbostyril |
| DK75779A (da) * | 1978-03-13 | 1979-09-14 | Du Pont | 4,5-diaryl-2- (substitueret thio) pyrroler og sulfoxider og sulfoner deraf samt fremgangsmaader til deres fremstilling og anvendelse |
| DE3212591A1 (de) * | 1982-04-03 | 1983-10-13 | Gödecke AG, 1000 Berlin | 2-pyrrolin-3-carbonitril-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel |
-
1983
- 1983-05-14 DE DE19833317653 patent/DE3317653A1/de not_active Ceased
-
1984
- 1984-05-04 CS CS843308A patent/CS244815B2/cs unknown
- 1984-05-10 GR GR74677A patent/GR82094B/el unknown
- 1984-05-10 US US06/608,828 patent/US4499089A/en not_active Expired - Fee Related
- 1984-05-11 HU HU841851A patent/HUT34158A/hu unknown
- 1984-05-11 DD DD84262957A patent/DD222305A5/de unknown
- 1984-05-11 JP JP59093126A patent/JPS59212469A/ja active Pending
- 1984-05-11 YU YU00832/84A patent/YU83284A/xx unknown
- 1984-05-11 SU SU843737938A patent/SU1251800A3/ru active
- 1984-05-11 ES ES532438A patent/ES532438A0/es active Granted
- 1984-05-11 ES ES532445A patent/ES532445A0/es active Granted
- 1984-05-11 ES ES532446A patent/ES8502421A1/es not_active Expired
- 1984-05-14 AU AU27988/84A patent/AU2798884A/en not_active Abandoned
- 1984-05-14 EP EP84105457A patent/EP0125684B1/de not_active Expired
- 1984-05-14 DK DK239084A patent/DK239084A/da not_active Application Discontinuation
- 1984-05-14 ZA ZA843615A patent/ZA843615B/xx unknown
- 1984-05-14 DE DE8484105457T patent/DE3464601D1/de not_active Expired
- 1984-05-14 AT AT84105457T patent/ATE28189T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE3464601D1 (en) | 1987-08-13 |
| ES532446A0 (es) | 1985-01-01 |
| ES8502867A1 (es) | 1985-02-01 |
| EP0125684B1 (de) | 1987-07-08 |
| CS244815B2 (en) | 1986-08-14 |
| ES532438A0 (es) | 1985-02-01 |
| DD222305A5 (de) | 1985-05-15 |
| ES8502868A1 (es) | 1985-02-01 |
| DK239084A (da) | 1984-11-15 |
| HUT34158A (en) | 1985-02-28 |
| ES532445A0 (es) | 1985-02-01 |
| SU1251800A3 (ru) | 1986-08-15 |
| ATE28189T1 (de) | 1987-07-15 |
| DK239084D0 (da) | 1984-05-14 |
| EP0125684A1 (de) | 1984-11-21 |
| ES8502421A1 (es) | 1985-01-01 |
| AU2798884A (en) | 1984-11-15 |
| GR82094B (enExample) | 1984-12-13 |
| JPS59212469A (ja) | 1984-12-01 |
| YU83284A (en) | 1986-10-31 |
| DE3317653A1 (de) | 1984-11-15 |
| CS330884A2 (en) | 1985-09-17 |
| US4499089A (en) | 1985-02-12 |
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