ZA838826B - Sulfonate prodrugs of corticosteroids - Google Patents
Sulfonate prodrugs of corticosteroidsInfo
- Publication number
- ZA838826B ZA838826B ZA838826A ZA838826A ZA838826B ZA 838826 B ZA838826 B ZA 838826B ZA 838826 A ZA838826 A ZA 838826A ZA 838826 A ZA838826 A ZA 838826A ZA 838826 B ZA838826 B ZA 838826B
- Authority
- ZA
- South Africa
- Prior art keywords
- corticosteroids
- sulfonate prodrugs
- prodrugs
- sulfonate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/459,742 US4472392A (en) | 1983-01-21 | 1983-01-21 | Sulfonate containing ester prodrugs of corticosteroids |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA838826B true ZA838826B (en) | 1984-07-25 |
Family
ID=23825979
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA838826A ZA838826B (en) | 1983-01-21 | 1983-11-25 | Sulfonate prodrugs of corticosteroids |
Country Status (8)
Country | Link |
---|---|
US (1) | US4472392A (fr) |
EP (1) | EP0120557B1 (fr) |
JP (1) | JPS59137500A (fr) |
CA (1) | CA1199908A (fr) |
DE (1) | DE3478605D1 (fr) |
HK (1) | HK43993A (fr) |
MX (1) | MX9203197A (fr) |
ZA (1) | ZA838826B (fr) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1310009C (fr) * | 1984-03-28 | 1992-11-10 | John Mark Braughler | Promedicaments de type esters steroidiques |
US4588718A (en) * | 1984-03-28 | 1986-05-13 | The Upjohn Company | Carboxy containing ester prodrugs of corticosteroids |
US5446177A (en) * | 1984-12-28 | 1995-08-29 | Alcon Laboratories, Inc. | Anti-inflammatory compounds for ophthalmic use |
US4686214A (en) * | 1985-10-30 | 1987-08-11 | Alcon Laboratories, Inc. | Anti-inflammatory compounds for ophthalmic use |
JP2549724B2 (ja) * | 1987-07-16 | 1996-10-30 | ジ・アップジョン・カンパニー | アルカンー1,nージカルボン酸モノー(2ースルファトエチル)アミド類のアミン塩類 |
BR9307746A (pt) * | 1993-01-08 | 1995-11-14 | Astra Ab | Derivados de esteróides especificos para otratamento de cólon e ileo |
US5420120A (en) * | 1993-12-17 | 1995-05-30 | Alcon Laboratories, Inc. | Anti-inflammatory glucocorticoid compounds for topical ophthalmic use |
WO2004017904A2 (fr) * | 2002-08-23 | 2004-03-04 | The Mclean Hospital Corporation | Conjugues de corticosteroides et utilisations de ceux-ci |
CA2537185A1 (fr) * | 2003-08-29 | 2005-03-10 | Ranbaxy Laboratories Limited | Inhibiteurs de la phosphodiesterase de type iv |
US20070259874A1 (en) * | 2003-11-26 | 2007-11-08 | Palle Venkata P | Phosphodiesterase Inhibitors |
WO2007031838A1 (fr) | 2005-09-16 | 2007-03-22 | Ranbaxy Laboratories Limited | Pyrazolo[3,4-b]pyridines substituees en tant qu'inhibiteurs de la phosphodiesterase |
RU2008119323A (ru) | 2005-10-19 | 2009-11-27 | Рэнбакси Лабораториз Лимитед (In) | Фармацевтические композиции мускаринового рецептора |
JP2009512677A (ja) * | 2005-10-19 | 2009-03-26 | ランバクシー ラボラトリーズ リミテッド | ホスホジエステラーゼタイプiv阻害剤の組成物 |
EP2066661A2 (fr) * | 2006-09-22 | 2009-06-10 | Ranbaxy Laboratories Limited | Inhibiteurs de phosphodiesterase |
EA200900472A1 (ru) * | 2006-09-22 | 2009-10-30 | Ранбакси Лабораторис Лимитед | Ингибиторы фосфодиэстеразы iv типа |
CN103787927B (zh) * | 2006-10-12 | 2017-03-01 | Bhi有限合资公司 | 递送3‑氨基‑1‑丙磺酸的方法、化合物、组合物和载体 |
EP1958947A1 (fr) | 2007-02-15 | 2008-08-20 | Ranbaxy Laboratories Limited | Inhibiteurs de la phosphodiestérase de type 4 |
CA2680625C (fr) | 2007-03-14 | 2016-02-23 | Ranbaxy Laboratories Limited | Derives de pyrazolo(3,4-b)pyridine comme inhibiteurs de phosphodiesterase |
EP2124943A1 (fr) * | 2007-03-14 | 2009-12-02 | Ranbaxy Laboratories Limited | Dérivés de pyrazolo[3,4-b]pyridine comme inhibiteurs de phosphodiestérases |
BRPI0908229A8 (pt) * | 2008-02-25 | 2017-10-10 | Eyegate Pharma S A S | Uso de um corticosteróide, derivado de corticosteróide, pró-fármaco ou sal deste, kit e dispositivo para dispensar iontoforeticamente um corticosteróide, derivado de corticosteróide, pró-fármaco ou sal deste no olho de um paciente para tratar um distúrbio ocular mediado por inflamação no referido paciente, e, formulação apropriada para dispensação iontoforética ocular de um corticosteróide, derivado de corticosteróide, pró-fármaco ou sal deste no olho de um paciente |
EP2111861A1 (fr) | 2008-04-21 | 2009-10-28 | Ranbaxy Laboratories Limited | Compositions d'inhibiteurs de type IV de la phosphodiestérase |
CN116514829A (zh) * | 2020-08-21 | 2023-08-01 | 诺茗(北京)生物医药有限公司 | 一种水溶性抗肿瘤前药及其药物组合物和用途 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3089881A (en) * | 1957-10-29 | 1963-05-14 | Schering Corp | Sulfocarboxylic acid esters of hydroxylated steroids |
US2986559A (en) * | 1959-01-07 | 1961-05-30 | Schering Corp | Novel therapeutic salts and processes for their manufacture |
US3171846A (en) * | 1962-07-10 | 1965-03-02 | Erba Carlo Spa | Prednisolone-21-double esters |
NL124139C (fr) * | 1964-11-04 | |||
FR6590M (fr) * | 1967-10-31 | 1968-12-30 | ||
US3609712A (en) * | 1969-01-15 | 1971-09-28 | Ibm | Insulated gate field effect transistor memory array |
US4221787A (en) * | 1978-03-28 | 1980-09-09 | Interx Research Corporation | Esteramide prodrugs of anti-inflammatory corticosteroids |
SU818489A3 (ru) * | 1978-10-04 | 1981-03-30 | Шеринг Аг (Фирма) | Способ получени кортикоид -21- СульфОпРОпиОНАТОВ или иХ СОлЕй |
DE2848423A1 (de) * | 1978-11-08 | 1980-05-29 | Merck Patent Gmbh | Hydrocortisonester, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung |
-
1983
- 1983-01-21 US US06/459,742 patent/US4472392A/en not_active Expired - Lifetime
- 1983-11-22 CA CA000441640A patent/CA1199908A/fr not_active Expired
- 1983-11-25 ZA ZA838826A patent/ZA838826B/xx unknown
-
1984
- 1984-01-19 EP EP84300332A patent/EP0120557B1/fr not_active Expired
- 1984-01-19 DE DE8484300332T patent/DE3478605D1/de not_active Expired
- 1984-01-21 JP JP59009363A patent/JPS59137500A/ja active Granted
-
1992
- 1992-06-26 MX MX9203197A patent/MX9203197A/es unknown
-
1993
- 1993-05-06 HK HK439/93A patent/HK43993A/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
HK43993A (en) | 1993-05-14 |
MX9203197A (es) | 1992-09-01 |
DE3478605D1 (en) | 1989-07-13 |
US4472392A (en) | 1984-09-18 |
JPH0226639B2 (fr) | 1990-06-12 |
EP0120557A2 (fr) | 1984-10-03 |
EP0120557B1 (fr) | 1989-06-07 |
JPS59137500A (ja) | 1984-08-07 |
EP0120557A3 (en) | 1985-02-06 |
CA1199908A (fr) | 1986-01-28 |
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