ZA833246B - A process for preparing nicotinonitriles and nicotinamides and intermediates used therein - Google Patents

A process for preparing nicotinonitriles and nicotinamides and intermediates used therein

Info

Publication number
ZA833246B
ZA833246B ZA833246A ZA833246A ZA833246B ZA 833246 B ZA833246 B ZA 833246B ZA 833246 A ZA833246 A ZA 833246A ZA 833246 A ZA833246 A ZA 833246A ZA 833246 B ZA833246 B ZA 833246B
Authority
ZA
South Africa
Prior art keywords
nicotinonitriles
nicotinamides
preparing
intermediates used
intermediates
Prior art date
Application number
ZA833246A
Other languages
English (en)
Inventor
Karl Olaf Gelotte
Baldev Singh
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Publication of ZA833246B publication Critical patent/ZA833246B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA833246A 1982-05-24 1983-05-06 A process for preparing nicotinonitriles and nicotinamides and intermediates used therein ZA833246B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/381,062 US4413127A (en) 1982-05-24 1982-05-24 Preparation of 1,2-dihydro-6-(lower alkyl)-2-oxo-5-(pyridinyl)nicotinonitriles

Publications (1)

Publication Number Publication Date
ZA833246B true ZA833246B (en) 1984-01-25

Family

ID=23503512

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA833246A ZA833246B (en) 1982-05-24 1983-05-06 A process for preparing nicotinonitriles and nicotinamides and intermediates used therein

Country Status (7)

Country Link
US (1) US4413127A (xx)
JP (1) JPS5925374A (xx)
CA (1) CA1183138A (xx)
ES (1) ES540882A0 (xx)
MX (1) MX5918A (xx)
PH (1) PH19017A (xx)
ZA (1) ZA833246B (xx)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4469871A (en) * 1982-05-24 1984-09-04 Sterling Drug Inc. Process for preparing 2-(lower-alkoxy)-1-(pyridinyl) ethenyl lower-alkyl ketones
EP0200024B1 (de) 1985-04-30 1992-07-01 ARZNEIMITTELWERK DRESDEN GmbH 3-Cyan-pyridine, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
US4681944A (en) * 1985-06-11 1987-07-21 Ippolito Robert M Process for preparing certain 1-lower alkanoyl or benzoyl-4-(lower alkanoyl or benzoyl-methylidene)-1,4-dihydropyridines or acid addition salts thereof
US5204463A (en) * 1989-08-10 1993-04-20 Glaxo Inc. Substituted methoxyphenyl-4,5 dihydro-3(2H)-pridazinones having cardiotonic and beta blocking activities
US5153209A (en) * 1989-09-22 1992-10-06 Glaxo Inc. Pyridone nitriles useful in treating cardiovascular disease
US5051431A (en) * 1989-09-22 1991-09-24 Glaxo Inc. Pyridone nitriles useful in treating cardiovascular disease
US5100892A (en) * 1990-11-13 1992-03-31 Glaxo Inc. Dihydropyridine vasodilator agents
US6118002A (en) * 1999-03-02 2000-09-12 Wyckoff Chemical Company, Inc. Purification of 1,2-dihydro-6-alkyl-2-oxo-5-(pyridinyl)-nicotinonitriles
CN103804288A (zh) * 2012-11-12 2014-05-21 四川新斯顿制药有限责任公司 一种米力农的合成方法
CN103965101B (zh) * 2014-05-21 2016-07-06 合肥久诺医药科技有限公司 一种米力农的制备方法
AU2016218976B2 (en) 2015-02-13 2021-04-01 Cumberland Pharmaceuticals, Inc. Milrinone composition and method for administering same
CN104744357A (zh) * 2015-03-30 2015-07-01 浙江中维药业有限公司 米力农的重结晶提纯方法
CN111377858B (zh) * 2018-12-30 2023-04-07 鲁南制药集团股份有限公司 一种米力农的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2824121A (en) * 1954-11-04 1958-02-18 Kay Fries Chemicals Inc Process for preparation of oxy alkylidene compounds
US4223149A (en) * 1979-07-26 1980-09-16 Sterling Drug Inc. Process for producing 3-cyano-5-(pyridinyl)-2(1H)-pyridinones
US4313951A (en) * 1979-11-26 1982-02-02 Sterling Drug Inc. 3-Substituted-6-(lower-alkyl)-5-(pyridinyl)-2(1H)-pyridinones, their cardiotonic use and intermediates therefor
NZ196573A (en) * 1980-03-28 1984-03-16 Sterling Drug Inc 6-pyrid-(3 or 4)-yl-(1h or 3h)-imidazo (4,5-b)pyridines

Also Published As

Publication number Publication date
JPS5925374A (ja) 1984-02-09
US4413127A (en) 1983-11-01
JPH0127064B2 (xx) 1989-05-26
PH19017A (en) 1985-12-03
ES8601896A1 (es) 1985-11-16
CA1183138A (en) 1985-02-26
MX5918A (es) 1993-09-01
ES540882A0 (es) 1985-11-16

Similar Documents

Publication Publication Date Title
PT77062B (en) Process for preparing n-methyl 11-aza-10-deoxo-10-dihydroerythromycin a and intermediates therefor
ZA83161B (en) Process and apparatus for the manufacture of a toothrack
GB2042520B (en) 2-penem compounds and a method for preparing them
GB2159430B (en) A sludge-handling apparatus
EG16473A (en) Process for preparing n-formyl and n-hydroxy-methyl-3-phenoxy-1-azetidinecarboxamides
DE3162325D1 (en) Paper-sizing agents and a process for their preparation
GB2123850B (en) A fermentation apparatus
ZA833246B (en) A process for preparing nicotinonitriles and nicotinamides and intermediates used therein
DE3360926D1 (en) Hydroquinone ethers and a process for preparing them
DE3369988D1 (en) Fluoroepoxides and a process for production thereof
IL70545A (en) Process for preparing 5-vinyl-2-pyrrolidinone and novel intermediate therefor
EP0088408A3 (en) Process for preparing 2-keto-l-gulonic acid and a mutant
GB2156197B (en) A fish-beheading apparatus
PT73026A (en) Process for preparing carbapenams and carbapen-2-ems
PH21245A (en) Process for preparing nicotinonitriles and nicotinamides and intermediates used therein
EP0158489A3 (en) Handling apparatus & method
DE3361286D1 (en) 2,2-dimethyl-3-aryl-cyclobutanones, a process for their preparation and new 2,2-dimethyl-3-aryl-4-halo-cyclobutanones
DE3367091D1 (en) A process for preparing nicotinonitriles and intermediates used therein
DE3071273D1 (en) Disoxidant and process for preparing same
PT72510A (en) Novel piperidinoquinazolines and a process for the preparation thereof
DE3169906D1 (en) 17-beta-ethynylsteroids and process for preparing same
ZA848969B (en) Chemical intermediates and a process for their preparation
ZA818050B (en) New phenoxybenzaldehydes and a process for their preparation
PT77702A (en) Process for preparing a new spirodecane
PH20297A (en) A-58365 factors a and b and method of use thereof