ES540882A0 - Un procedimiento para preparar 1,2-dihidro-6-(alquilo infe- rior)-2-oxo-5-(piridinil)nicotinonitrilos - Google Patents
Un procedimiento para preparar 1,2-dihidro-6-(alquilo infe- rior)-2-oxo-5-(piridinil)nicotinonitrilosInfo
- Publication number
- ES540882A0 ES540882A0 ES540882A ES540882A ES540882A0 ES 540882 A0 ES540882 A0 ES 540882A0 ES 540882 A ES540882 A ES 540882A ES 540882 A ES540882 A ES 540882A ES 540882 A0 ES540882 A0 ES 540882A0
- Authority
- ES
- Spain
- Prior art keywords
- nicotinonitrils
- piridinyl
- dihydro
- oxo
- preparing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/381,062 US4413127A (en) | 1982-05-24 | 1982-05-24 | Preparation of 1,2-dihydro-6-(lower alkyl)-2-oxo-5-(pyridinyl)nicotinonitriles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8601896A1 ES8601896A1 (es) | 1985-11-16 |
| ES540882A0 true ES540882A0 (es) | 1985-11-16 |
Family
ID=23503512
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES540882A Granted ES540882A0 (es) | 1982-05-24 | 1985-03-01 | Un procedimiento para preparar 1,2-dihidro-6-(alquilo infe- rior)-2-oxo-5-(piridinil)nicotinonitrilos |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4413127A (es) |
| JP (1) | JPS5925374A (es) |
| CA (1) | CA1183138A (es) |
| ES (1) | ES540882A0 (es) |
| MX (1) | MX5918A (es) |
| PH (1) | PH19017A (es) |
| ZA (1) | ZA833246B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4469871A (en) * | 1982-05-24 | 1984-09-04 | Sterling Drug Inc. | Process for preparing 2-(lower-alkoxy)-1-(pyridinyl) ethenyl lower-alkyl ketones |
| EP0200024B1 (de) | 1985-04-30 | 1992-07-01 | ARZNEIMITTELWERK DRESDEN GmbH | 3-Cyan-pyridine, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung |
| US4681944A (en) * | 1985-06-11 | 1987-07-21 | Ippolito Robert M | Process for preparing certain 1-lower alkanoyl or benzoyl-4-(lower alkanoyl or benzoyl-methylidene)-1,4-dihydropyridines or acid addition salts thereof |
| US5204463A (en) * | 1989-08-10 | 1993-04-20 | Glaxo Inc. | Substituted methoxyphenyl-4,5 dihydro-3(2H)-pridazinones having cardiotonic and beta blocking activities |
| US5153209A (en) * | 1989-09-22 | 1992-10-06 | Glaxo Inc. | Pyridone nitriles useful in treating cardiovascular disease |
| US5051431A (en) * | 1989-09-22 | 1991-09-24 | Glaxo Inc. | Pyridone nitriles useful in treating cardiovascular disease |
| US5100892A (en) * | 1990-11-13 | 1992-03-31 | Glaxo Inc. | Dihydropyridine vasodilator agents |
| US6118002A (en) * | 1999-03-02 | 2000-09-12 | Wyckoff Chemical Company, Inc. | Purification of 1,2-dihydro-6-alkyl-2-oxo-5-(pyridinyl)-nicotinonitriles |
| CN103804288A (zh) * | 2012-11-12 | 2014-05-21 | 四川新斯顿制药有限责任公司 | 一种米力农的合成方法 |
| CN103965101B (zh) * | 2014-05-21 | 2016-07-06 | 合肥久诺医药科技有限公司 | 一种米力农的制备方法 |
| AU2016218976B2 (en) | 2015-02-13 | 2021-04-01 | Cumberland Pharmaceuticals, Inc. | Milrinone composition and method for administering same |
| CN104744357A (zh) * | 2015-03-30 | 2015-07-01 | 浙江中维药业有限公司 | 米力农的重结晶提纯方法 |
| CN111377858B (zh) * | 2018-12-30 | 2023-04-07 | 鲁南制药集团股份有限公司 | 一种米力农的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2824121A (en) * | 1954-11-04 | 1958-02-18 | Kay Fries Chemicals Inc | Process for preparation of oxy alkylidene compounds |
| US4223149A (en) * | 1979-07-26 | 1980-09-16 | Sterling Drug Inc. | Process for producing 3-cyano-5-(pyridinyl)-2(1H)-pyridinones |
| US4313951A (en) * | 1979-11-26 | 1982-02-02 | Sterling Drug Inc. | 3-Substituted-6-(lower-alkyl)-5-(pyridinyl)-2(1H)-pyridinones, their cardiotonic use and intermediates therefor |
| NZ196573A (en) * | 1980-03-28 | 1984-03-16 | Sterling Drug Inc | 6-pyrid-(3 or 4)-yl-(1h or 3h)-imidazo (4,5-b)pyridines |
-
1982
- 1982-05-24 US US06/381,062 patent/US4413127A/en not_active Expired - Lifetime
-
1983
- 1983-05-06 ZA ZA833246A patent/ZA833246B/xx unknown
- 1983-05-13 CA CA000428114A patent/CA1183138A/en not_active Expired
- 1983-05-19 PH PH28936A patent/PH19017A/en unknown
- 1983-05-19 JP JP58088338A patent/JPS5925374A/ja active Granted
-
1985
- 1985-03-01 ES ES540882A patent/ES540882A0/es active Granted
-
1987
- 1987-04-06 MX MX591887A patent/MX5918A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5925374A (ja) | 1984-02-09 |
| US4413127A (en) | 1983-11-01 |
| JPH0127064B2 (es) | 1989-05-26 |
| PH19017A (en) | 1985-12-03 |
| ES8601896A1 (es) | 1985-11-16 |
| ZA833246B (en) | 1984-01-25 |
| CA1183138A (en) | 1985-02-26 |
| MX5918A (es) | 1993-09-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC2A | Transfer of patent |
Owner name: STERLING WINTHROP INC. |
|
| PC1A | Transfer granted | ||
| FD1A | Patent lapsed |
Effective date: 20050713 |