ZA829463B - Process for manufacturing low molecular weight heparins by depolymerization of normal heparin - Google Patents

Process for manufacturing low molecular weight heparins by depolymerization of normal heparin

Info

Publication number
ZA829463B
ZA829463B ZA829463A ZA829463A ZA829463B ZA 829463 B ZA829463 B ZA 829463B ZA 829463 A ZA829463 A ZA 829463A ZA 829463 A ZA829463 A ZA 829463A ZA 829463 B ZA829463 B ZA 829463B
Authority
ZA
South Africa
Prior art keywords
depolymerization
molecular weight
low molecular
weight heparins
manufacturing low
Prior art date
Application number
ZA829463A
Other languages
English (en)
Inventor
Milton R Smith
Eduardo Amaya
Fernando Fussi
Original Assignee
Hepar Ind Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hepar Ind Inc filed Critical Hepar Ind Inc
Publication of ZA829463B publication Critical patent/ZA829463B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Materials Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
ZA829463A 1982-07-19 1982-12-23 Process for manufacturing low molecular weight heparins by depolymerization of normal heparin ZA829463B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39921782A 1982-07-19 1982-07-19

Publications (1)

Publication Number Publication Date
ZA829463B true ZA829463B (en) 1983-10-26

Family

ID=23578637

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA829463A ZA829463B (en) 1982-07-19 1982-12-23 Process for manufacturing low molecular weight heparins by depolymerization of normal heparin

Country Status (10)

Country Link
EP (1) EP0101141A3 (es)
JP (1) JPS5920302A (es)
AR (1) AR231644A1 (es)
AU (1) AU1033183A (es)
CA (1) CA1195322A (es)
DK (1) DK172798B1 (es)
ES (1) ES8402319A1 (es)
NZ (1) NZ202996A (es)
PT (1) PT76111A (es)
ZA (1) ZA829463B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1214609B (it) * 1985-05-17 1990-01-18 Opocrin Spa Esosaminoglicani solfati depolimerizzati ad attivita'antitrombotica, fibrinolitica, antinfiammatoria, loro procedimento di preparazione e composizioni farmaceutiche che li contengono.
DE3751275T2 (de) * 1986-08-20 1995-09-07 Univ Miami Alkylesters of Heparin mit niedrigem Molecular Gewicht.
US4745106A (en) * 1986-08-20 1988-05-17 Griffin Charles C Heparin derivatives having improved anti-Xa specificity
US4942156A (en) * 1986-08-20 1990-07-17 Hepar Industries, Inc. Low molecular weight heparin derivatives having improved anti-Xa specificity
US5744457A (en) * 1995-03-31 1998-04-28 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5763427A (en) * 1995-03-31 1998-06-09 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US6001820A (en) * 1995-03-31 1999-12-14 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5767269A (en) * 1996-10-01 1998-06-16 Hamilton Civic Hospitals Research Development Inc. Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
FR2763848B1 (fr) * 1997-05-28 2000-01-28 Rhone Poulenc Rorer Sa Utilisation des heparines de bas poids moleculaire pour la prevention et le traitement du trauma du systeme nerveux central
MXPA02000142A (es) * 1999-06-30 2003-07-21 Hamilton Civic Hospitals Res Composiciones de heparina que inhiben los factores de coagulacion asociados con el coagulo.
JP2002293804A (ja) * 2001-03-28 2002-10-09 Itoham Foods Inc 低分子量ヘパリンの製造法
WO2022015794A1 (en) 2020-07-14 2022-01-20 Optimvia, Llc Methods for synthesizing non-anticoagulant heparan sulfate
WO2021007429A1 (en) 2019-07-09 2021-01-14 Optimvia Llc Methods for synthesizing anticoagulant polysaccharides

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3179566A (en) * 1963-05-16 1965-04-20 Canada Packers Ltd Purification of heparin
US3482014A (en) * 1966-06-29 1969-12-02 Canada Packers Ltd Orally active heparin and method for making and using same
CA1136620A (en) * 1979-01-08 1982-11-30 Ulf P.F. Lindahl Heparin fragments having selective anticoagulation activity
JPS56120704A (en) * 1980-01-28 1981-09-22 Hepar Ind Inc Method of obtaining low molecular weight heparin having heightened pharmacologic property* product manufactured thereby and its use
US4281108A (en) * 1980-01-28 1981-07-28 Hepar Industries, Inc. Process for obtaining low molecular weight heparins endowed with elevated pharmacological properties, and product so obtained

Also Published As

Publication number Publication date
DK172798B1 (da) 1999-07-19
ES519015A0 (es) 1984-02-01
CA1195322A (en) 1985-10-15
PT76111A (en) 1983-02-01
EP0101141A2 (en) 1984-02-22
EP0101141A3 (en) 1985-05-22
AR231644A1 (es) 1985-01-31
JPH0442401B2 (es) 1992-07-13
AU1033183A (en) 1984-01-26
ES8402319A1 (es) 1984-02-01
DK325583D0 (da) 1983-07-14
JPS5920302A (ja) 1984-02-02
NZ202996A (en) 1985-10-11
DK325583A (da) 1984-01-20

Similar Documents

Publication Publication Date Title
GB8303740D0 (en) Production of low molecular weight polymers
DE3375790D1 (en) Polymer molecular weight reduction process
ZA83357B (en) Process for the production of high molecular weight polyester
GB2068011B (en) Process for obtaining low molecular weight heparins endowed with elevated pharmacological properties and product so obtained
YU73681A (en) Process for obtaining mucopolysaccharides of anticoagulant properties
GB2094829B (en) Process for the dehydration of a low molecular weight alcohol
PT76111A (en) Process for manufacturing low molecular weight heparins by depolymerization of normal heparin
DE3366185D1 (en) Process for preparing high molecular weight compounds
FR2503714B1 (fr) Procede d'obtention de mucopolysaccharides biologiquement actifs, de purete elevee, par depolymerisation de l'heparine
EP0056293A3 (en) Process for extruding a modified high molecular weight poly(ethylene terephthalate) resin
DE3270927D1 (en) Process for producing ethylene polymers
DE3277304D1 (en) Process for isolating polymer
DE3362204D1 (en) Process for the production of p-vinyl phenol polymer
EP0048391A3 (en) Process for the production of polymers that contain polyphenylene ether groups
DE3163056D1 (en) Process for the production of polymers with at least one terminal primary hydroxyl group
DE3374935D1 (en) Process for the depolymerization and sulfation of polysaccharides
DE3473280D1 (en) A process for the preparation of high molecular weight polymeric antidegradants
EP0115944A3 (en) Production of high molecular weight polybenzimidazoles
DE3367403D1 (en) Single stage production of improved high molecular weight polybenzimidazole
JPS54148890A (en) Method of making chitosan of low molecular weight
GB8302088D0 (en) Specific depolymerization of polysaccharide
DE3469745D1 (en) Process for the production of high molecular weight organoaluminum polymers
JPS53133292A (en) Process for producing salt of hydroxycarboxylated polymer with reduced molecular weight
GB2080317B (en) Process for the production of polyquinazolone-based polymers
GB2012790B (en) Process for the recovery of heparin