ZA825876B - Novel cyclophoshamide derivatives process for their preparation and their use - Google Patents

Novel cyclophoshamide derivatives process for their preparation and their use

Info

Publication number
ZA825876B
ZA825876B ZA825876A ZA825876A ZA825876B ZA 825876 B ZA825876 B ZA 825876B ZA 825876 A ZA825876 A ZA 825876A ZA 825876 A ZA825876 A ZA 825876A ZA 825876 B ZA825876 B ZA 825876B
Authority
ZA
South Africa
Prior art keywords
cyclophoshamide
novel
preparation
derivatives process
derivatives
Prior art date
Application number
ZA825876A
Other languages
English (en)
Inventor
Hansjoerg Eibl
Cenek Kolar
Friedrich Robert Seiler
Hans-Harald Sedlacek
Original Assignee
Max Planck Gesellschaft
Behringwerke Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft, Behringwerke Ag filed Critical Max Planck Gesellschaft
Publication of ZA825876B publication Critical patent/ZA825876B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
    • C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
    • C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
    • C07F9/65846—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA825876A 1981-08-14 1982-08-13 Novel cyclophoshamide derivatives process for their preparation and their use ZA825876B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813132221 DE3132221A1 (de) 1981-08-14 1981-08-14 Neue cyclophosphamid-derivate, verfahren zu ihrer herstellung und ihre verwendung

Publications (1)

Publication Number Publication Date
ZA825876B true ZA825876B (en) 1983-06-29

Family

ID=6139355

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA825876A ZA825876B (en) 1981-08-14 1982-08-13 Novel cyclophoshamide derivatives process for their preparation and their use

Country Status (8)

Country Link
EP (1) EP0072531A1 (da)
JP (1) JPS5841892A (da)
AU (1) AU8717082A (da)
DE (1) DE3132221A1 (da)
DK (1) DK364782A (da)
ES (1) ES514852A0 (da)
PT (1) PT75416B (da)
ZA (1) ZA825876B (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3225227A1 (de) * 1982-07-06 1984-01-12 Max Planck Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Derivate des n.n-bis-(2-chlor-aethyl)-phosphorsaeureamids
ZA851062B (en) * 1984-03-01 1985-11-27 Asta Werke Ag Chem Fab Salts of oxazaphosphorine derivatives and process for their production
FR2684102B1 (fr) * 1991-11-21 1994-03-11 Etat Francais Delegue Armement Procede de preparation de polyazidoalcools ainsi que de polyaminoalcools et polyazidothiols derives de ceux-ci.
NZ513728A (en) * 1999-03-05 2001-09-28 Metabasis Therapeutics Inc Novel phosphorus-containing prodrugs
EP1634886A3 (en) * 1999-03-05 2006-03-29 Metabasis Therapeutics, Inc. Novel phosphorus-containing prodrug
US7205404B1 (en) 1999-03-05 2007-04-17 Metabasis Therapeutics, Inc. Phosphorus-containing prodrugs
US6506739B1 (en) 2001-05-01 2003-01-14 Telik, Inc. Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents
FR2968662B1 (fr) * 2010-12-10 2013-11-22 Roussy Inst Gustave Nouveaux derives d'oxazaphosphorines pre-activees, utilisation et methode de preparation
US10449210B2 (en) 2014-02-13 2019-10-22 Ligand Pharmaceuticals Inc. Prodrug compounds and their uses
EP3164136A4 (en) 2014-07-02 2018-04-04 Ligand Pharmaceuticals, Inc. Prodrug compounds and uses therof
RU2020126177A (ru) 2018-01-09 2022-02-10 Лиганд Фармасьютикалз, Инк. Ацетальные соединения и их терапевтическое применение

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL99649C (da) * 1956-12-20
JPS5230519B2 (da) * 1972-04-05 1977-08-09
PL100390B1 (pl) * 1975-10-06 1978-09-30 Sposob wytwarzania 2-tlenku-2-/bis/2-chloroetylo/-amino/-1-/okso-3-aza-2-fosfacykloheksanu/cyklofosfamidu/o czynnosci optycznej

Also Published As

Publication number Publication date
ES8400752A1 (es) 1983-11-01
AU8717082A (en) 1983-02-17
ES514852A0 (es) 1983-11-01
PT75416B (de) 1985-05-31
DK364782A (da) 1983-02-15
EP0072531A1 (de) 1983-02-23
DE3132221A1 (de) 1983-05-19
PT75416A (de) 1982-09-01
JPS5841892A (ja) 1983-03-11

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