ZA824883B - 6-(4-(w-(1-imidazolyl)-alkyl)-phenyl)-3-oxo-2,3,4,5-tetrahydro-pyridazines and acid addition salts thereof, and a process for the preparation of these compounds, and pharmaceutical products containing them - Google Patents

6-(4-(w-(1-imidazolyl)-alkyl)-phenyl)-3-oxo-2,3,4,5-tetrahydro-pyridazines and acid addition salts thereof, and a process for the preparation of these compounds, and pharmaceutical products containing them

Info

Publication number
ZA824883B
ZA824883B ZA824883A ZA824883A ZA824883B ZA 824883 B ZA824883 B ZA 824883B ZA 824883 A ZA824883 A ZA 824883A ZA 824883 A ZA824883 A ZA 824883A ZA 824883 B ZA824883 B ZA 824883B
Authority
ZA
South Africa
Prior art keywords
pyridazines
imidazolyl
tetrahydro
oxo
phenyl
Prior art date
Application number
ZA824883A
Other languages
English (en)
Inventor
H Lautenschlaeger
G Hilboll
H Friehe
J Loehr
Original Assignee
Nattermann A & Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nattermann A & Cie filed Critical Nattermann A & Cie
Publication of ZA824883B publication Critical patent/ZA824883B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA824883A 1981-07-31 1982-07-08 6-(4-(w-(1-imidazolyl)-alkyl)-phenyl)-3-oxo-2,3,4,5-tetrahydro-pyridazines and acid addition salts thereof, and a process for the preparation of these compounds, and pharmaceutical products containing them ZA824883B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813130251 DE3130251A1 (de) 1981-07-31 1981-07-31 6-(4-((omega)-(1-imidazolyl)-alkyl)-phenyl)-3-oxo -2,3,4,5-tetrahydro-pyridazine und deren saeureadditionssalze, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate

Publications (1)

Publication Number Publication Date
ZA824883B true ZA824883B (en) 1983-04-27

Family

ID=6138199

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA824883A ZA824883B (en) 1981-07-31 1982-07-08 6-(4-(w-(1-imidazolyl)-alkyl)-phenyl)-3-oxo-2,3,4,5-tetrahydro-pyridazines and acid addition salts thereof, and a process for the preparation of these compounds, and pharmaceutical products containing them

Country Status (9)

Country Link
US (1) US4507298A (en, 2012)
EP (1) EP0071060B1 (en, 2012)
JP (1) JPS5826883A (en, 2012)
AT (1) ATE22079T1 (en, 2012)
DE (1) DE3130251A1 (en, 2012)
DK (1) DK343582A (en, 2012)
GR (1) GR76192B (en, 2012)
IE (1) IE53398B1 (en, 2012)
ZA (1) ZA824883B (en, 2012)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4353905A (en) * 1981-09-17 1982-10-12 Warner-Lambert Company Substituted 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones and 6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones
HU190412B (en) * 1981-09-17 1986-09-29 Warner-Lambert Co,Us Process for producing substituted 4,5-dihiydro-6-bracket-substituted-bracket closed-phenyl-3-bracket-2h-bracket closed-pyridazinones and 6-bracket-substituted-bracket closed-phenyl-3-bracket-2h-bracket closed-pyridazinones
DE3212304A1 (de) * 1982-04-02 1983-10-06 Nattermann A & Cie Imidazolylphenyl-tetrahydropyridazine, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
US4734415A (en) * 1982-08-13 1988-03-29 Warner-Lambert Company Substituted 4,5-dihydro-6-(substituted)-phenyl-3(2H)-pyridazinones and 6-(substituted) phenyl-3(2H)-pyridazinones
DE3310197A1 (de) * 1983-03-21 1984-09-27 A. Nattermann & Cie GmbH, 5000 Köln Substituierte 3-mercapto-pyridazine und deren 3-alkylthioderivate sowie verfahren zu ihrer herstellung
DE3321012A1 (de) * 1983-06-10 1984-12-13 A. Nattermann & Cie GmbH, 5000 Köln Substituierte 4,5-dihydro-6-(thien-2-yl)-3(2h)-pyridazinone und 6-(thien-2-yl)-3(2h)-pyridazinone sowie verfahren zu ihrer herstellung
US4599332A (en) * 1983-12-07 1986-07-08 Warner-Lambert Company 4,5-dihydro-6-[2-[4-(1H-imidazol-1-yl)phenyl]-ethenyl]-3(2H)-pyridazinones and related compounds
DE3401911A1 (de) * 1984-01-20 1985-08-01 A. Nattermann & Cie GmbH, 5000 Köln Substituierte 4,5-dihydro-6-vinyl-3(2h)-pyridazinone und 6-vinyl-3(2h)-pyridazinone sowie verfahren zu ihrer herstellung
JPS61158969A (ja) * 1984-12-24 1986-07-18 ワーナー‐ランバート・コンパニー ４，５‐ジヒドロ‐４，４‐ジアルキル‐６‐（置換）フエニル‐３（２ｈ）‐ピリダジノン類
US4826835A (en) * 1985-10-23 1989-05-02 Rorer Pharmaceutical Corporation Pyridyl-pyridazinone and pyridyl-pyrazolinone compounds and their use in the treatment of congestive heart failure
US4783463A (en) * 1985-10-23 1988-11-08 Rorer Pharmaceutical Corporation Pyridyl-pyridazinone and pyridyl-pyrazolinone compounds and their use in the treatment of congestive heart failure
US5210092A (en) * 1990-09-25 1993-05-11 Fujisawa Pharmaceutical Co., Ltd. Angiotensin ii antagonizing heterocyclic derivatives
JP2018513199A (ja) * 2015-04-24 2018-05-24 メッドシャイン ディスカバリー インコーポレイテッド イミダゾール系化合物
WO2018072702A1 (zh) * 2016-10-20 2018-04-26 南京明德新药研发股份有限公司 一种咪唑类化合物的晶型、盐型及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2013793C2 (de) * 1970-03-23 1983-02-03 Bayer Ag, 5090 Leverkusen N-Methyl-imidazol-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
GB1383906A (en) * 1971-02-22 1974-02-12 Bdh Pharmaceuticals Ltd Pyridazinones
BE790106A (fr) * 1971-10-14 1973-04-13 Basf Ag Dihydropyridazones, leur preparation et leurs utilisations therapeutiques
HU175471B (hu) * 1977-06-13 1980-08-28 Gyogyszerkutato Intezet Sposob poluchenija novykh proizvodnykh 3-skobka-1-pirazolil-skobka zakryta-piridazina
US4353905A (en) * 1981-09-17 1982-10-12 Warner-Lambert Company Substituted 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones and 6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones

Also Published As

Publication number Publication date
DK343582A (da) 1983-02-01
EP0071060B1 (de) 1986-09-10
DE3130251A1 (de) 1983-02-17
JPH0372068B2 (en, 2012) 1991-11-15
DE3130251C2 (en, 2012) 1989-06-08
ATE22079T1 (de) 1986-09-15
JPS5826883A (ja) 1983-02-17
US4507298A (en) 1985-03-26
GR76192B (en, 2012) 1984-08-03
EP0071060A2 (de) 1983-02-09
IE53398B1 (en) 1988-11-09
EP0071060A3 (en) 1984-03-21
IE821632L (en) 1983-01-31

Similar Documents

Publication Publication Date Title
ZA824883B (en) 6-(4-(w-(1-imidazolyl)-alkyl)-phenyl)-3-oxo-2,3,4,5-tetrahydro-pyridazines and acid addition salts thereof, and a process for the preparation of these compounds, and pharmaceutical products containing them
ZA834648B (en) Triphenylimidazolyloxyalkanoic acids and their derivatives,processes for their preparation and pharmaceutical products containing these compounds
PT77616A (en) Process for preparing imidazolylalkylthien-2-yl-tetrahydropyri-dazines and of pharmaceutical compositions containing the same
ATE37882T1 (de) Cephalosporinverbindungen, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische praeparate.
EP0422485A3 (en) Quinolone carboxylic acid derivatives, process for their preparation and their use
DE3662041D1 (en) New carboxylic acid derivatives, their manufacturing process, use and medicines containing these compounds
ZA824882B (en) 6-(5-(w-(1-imidazolyl)-alkyl)-thien-2-yl)-3-oxo-2,3,4,5-tetra-hydro-pyridazines and acid addition salts thereof, a process for the preparation of these compounds, and pharmaceutical products containing them
JPS57145862A (en) Quinolinecarboxylic acid derivative
AU559519B2 (en) 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3- carboxylic acids
AU8961182A (en) 3-(1,2,4-triazol-1-yl)-propyl phosphonates
EP0214592A3 (en) Pyrrolobenzimidazoles, pyrrolobenzoxazoles and pyrrolobenzothiazoles, process for their preparation and medicaments containing these products
EP0281943A3 (en) Substituted pyridine-2,4-carboxylic acid derivatives, process for their preparation, their use as well as medicaments based on these compounds
DE3160595D1 (en) Polyprenyl carboxylic acid derivatives, process for the preparation of the same, and pharmaceutical compositions
ATE8618T1 (de) Derivate von biphenyl-alkyl-carboxylaten, deren herstellungsverfahren und deren verwendung als arzneimittel.
ATE9330T1 (de) Phenethanolamin-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
PT71486A (en) Process for the resolution of d,1 2-(6-methoxy-2-naphthyl)propionic acid
PH17831A (en) Process for the manufacture of 5-mercapto 1,2,3-triazole
GR76040B (en, 2012)
IL87198A0 (en) Leukotriene antagonists,a process for the preparation thereof and pharmaceutical compositions containing them
ZA828491B (en) Alkylcycloalkyl imidazolylmethyl ketones and a process for their preparation
ES8206510A1 (es) Procedimiento para la preparacion del compuesto 3-metil-3- (o-metoxi-fenoxi)-benzo-2,4-dioxaciclohexanona
JPS54128599A (en) Pyrrolobenzazepin derivative
JPS57209235A (en) Tetrahydronaphthalene derivative and its preparation
HRP930085A2 (en) PROCESS FOR THE PREPARATION OF BF2-KETONIC COMPOUND PYRIDOL (1,2,3-de)(1,4) BENZOXAZYNE-6-CARBOXYLIC ACID
JPS5714567A (en) Manufacture of pivaloylacetic acid 2-chloro-5-(4-(2,4-di-tert-amyl)- phenoxybutylamido)-anilide