ZA807513B - N-admantane-substituted tetra-peptide amides - Google Patents

N-admantane-substituted tetra-peptide amides

Info

Publication number
ZA807513B
ZA807513B ZA00807513A ZA807513A ZA807513B ZA 807513 B ZA807513 B ZA 807513B ZA 00807513 A ZA00807513 A ZA 00807513A ZA 807513 A ZA807513 A ZA 807513A ZA 807513 B ZA807513 B ZA 807513B
Authority
ZA
South Africa
Prior art keywords
admantane
peptide amides
substituted tetra
tetra
substituted
Prior art date
Application number
ZA00807513A
Other languages
English (en)
Inventor
R Mazur
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of ZA807513B publication Critical patent/ZA807513B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA00807513A 1979-12-03 1980-12-02 N-admantane-substituted tetra-peptide amides ZA807513B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/099,765 US4273704A (en) 1979-12-03 1979-12-03 N-Adamantane-substituted tetrapeptide amides

Publications (1)

Publication Number Publication Date
ZA807513B true ZA807513B (en) 1982-07-28

Family

ID=22276513

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA00807513A ZA807513B (en) 1979-12-03 1980-12-02 N-admantane-substituted tetra-peptide amides

Country Status (16)

Country Link
US (1) US4273704A ( )
JP (1) JPS5692847A ( )
AU (1) AU6499080A ( )
BE (1) BE886472A ( )
CA (1) CA1151642A ( )
DE (1) DE3044793A1 ( )
DK (1) DK513480A ( )
ES (2) ES8205753A1 ( )
FR (1) FR2476073A1 ( )
GB (1) GB2066262B ( )
IT (1) IT1127930B ( )
NL (1) NL8006586A ( )
NO (1) NO803640L ( )
PT (1) PT72141B ( )
SE (1) SE8008428L ( )
ZA (1) ZA807513B ( )

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4404135A (en) * 1981-07-20 1983-09-13 G. D. Searle & Co. Enkephalin derivatives
US4407746A (en) * 1981-12-14 1983-10-04 G. D. Searle & Co. Cyclohexyl and phenyl substituted enkephalins
CS231221B1 (en) * 1982-06-29 1984-10-15 Martin Flegel L-alanyl-d-isoglutamine adamantylamide
US4629784A (en) * 1983-08-16 1986-12-16 The University Of Georgia Research Foundation, Inc. Synthesis of cyclopropane amino acids
DE3485587D1 (de) * 1983-08-16 1992-04-23 Univ Georgia Res Found Herstellung von aminocyclopropancarbonsaeuren und von peptiden.
US4510085A (en) * 1984-04-12 1985-04-09 G.D. Searle & Co. Antihypertensive tetrapeptide amides
US4514332A (en) * 1984-04-16 1985-04-30 G. D. Searle & Co. Tetrapeptide adamantyl amides
FR2572399B1 (fr) * 1984-10-31 1987-01-16 Panmedica Sa Nouveaux derives de l'adamantanamine, leurs procedes de preparation et medicaments les contenant
US4822775A (en) * 1986-02-14 1989-04-18 G. D. Searle & Co. Phenyl substituted dipeptide amides
US4880829A (en) * 1985-08-14 1989-11-14 G. D. Searle And Company Substituted dipeptide amides #3
US4758675A (en) * 1986-07-14 1988-07-19 G. D. Searle & Co. 3-thiophene-substituted tyrosyl dipeptide amides
US5652335A (en) * 1990-02-28 1997-07-29 Teikoku Seiyaku Kabushiki Kaisha Physiologically active substance well capable of permeating biomembrane
CA2076849A1 (en) * 1990-02-28 1991-08-29 Kouki Kitagawa Physiologically active substance well capable of permeating biomembrane
EP1574495A1 (en) 1997-01-14 2005-09-14 Daicel Chemical Industries, Ltd. Adamantane derivatives
US7795468B2 (en) * 2001-01-19 2010-09-14 Chevron U.S.A. Inc. Functionalized higher diamondoids
US7880001B2 (en) * 2004-04-29 2011-02-01 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme
US8415354B2 (en) 2004-04-29 2013-04-09 Abbott Laboratories Methods of use of inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
US20050245534A1 (en) * 2004-04-29 2005-11-03 Link James T Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme
US20050261302A1 (en) * 2004-04-29 2005-11-24 Hoff Ethan D Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their therapeutic application
US20100222316A1 (en) 2004-04-29 2010-09-02 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
US20080275112A1 (en) * 2004-07-23 2008-11-06 Schreiner Peter R Invention Concerning Aminoadamantane Compounds
CA2585735A1 (en) * 2004-11-02 2006-05-11 Pfizer Inc. Novel compounds of substituted and unsubstituted adamantyl amides
US20090192198A1 (en) 2005-01-05 2009-07-30 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
US8198331B2 (en) * 2005-01-05 2012-06-12 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
NZ555966A (en) * 2005-01-05 2011-03-31 Abbott Lab Adamantyl derivatives as inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
HRP20050242B1 (en) * 2005-03-15 2010-09-30 Institut Ruđer Bošković Synthetic peptides containing unnatural adamantane related amino acids for use as antitumour drugs
JP5736098B2 (ja) 2007-08-21 2015-06-17 アッヴィ・インコーポレイテッド 中枢神経系障害を治療するための医薬組成物
EP2399926A1 (en) * 2010-06-22 2011-12-28 Justus-Liebig-Universität Giessen Peptides incorporating 3-aminoadamantane carboxylic acids enhance synaptic plasticity and act as neurogenic agents
CN112552374B (zh) * 2019-09-10 2024-06-04 西藏海思科制药有限公司 一种肽酰胺类化合物及其中间体的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2732451A1 (de) * 1976-07-27 1978-02-02 Reckitt & Colmann Prod Ltd Peptidverbindungen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneipraeparate

Also Published As

Publication number Publication date
JPS5692847A (en) 1981-07-27
IT8050294A0 (it) 1980-12-02
NL8006586A (nl) 1981-07-01
ES508060A0 (es) 1982-10-01
AU6499080A (en) 1981-06-11
NO803640L (no) 1981-06-04
FR2476073A1 (fr) 1981-08-21
ES8300087A1 (es) 1982-10-01
GB2066262A (en) 1981-07-08
ES497353A0 (es) 1982-06-16
ES8205753A1 (es) 1982-06-16
CA1151642A (en) 1983-08-09
US4273704A (en) 1981-06-16
IT1127930B (it) 1986-05-28
BE886472A (fr) 1981-06-03
DK513480A (da) 1981-07-09
PT72141B (en) 1981-10-28
GB2066262B (en) 1983-05-11
PT72141A (en) 1981-01-01
SE8008428L (sv) 1981-06-04
DE3044793A1 (de) 1981-06-19

Similar Documents

Publication Publication Date Title
ZA807513B (en) N-admantane-substituted tetra-peptide amides
GB2054586B (en) Antihypertensive amides
NZ193353A (en) Herbicidal -azolyloxyalkanoic acid amides
CS345184A2 (en) Zpusob pripravy n heterocyklyl 4 piperidinaminu
CS270884A2 (en) Zpusob konstrukce replikovatelneho prostredku pro klonovani
CS510880A2 (en) Zarizeni pro injekcni strikacky
GB2042051B (en) Releasable fastening
JPS55118483A (en) 55alkyll22*44cyanophenyl**1*33dioxanes
DE3067021D1 (en) Improved gamma-sorbitol polymorph and uses thereof
JPS5636485A (en) 2*33dihydroo2*6*77trisubstitutedd55 acylbenzofuran
GB8304996D0 (en) Pyrrolacetic amides
JPS5695198A (en) Ee55*22halogenovinyl**2**deoxycytidines
JPS5645478A (en) 5**aminoalkyll4**44dialkylpsoralen
JPS5645480A (en) 4**substitutedd4*5**88trialkylpsoralen
GB2058782B (en) Polyprenylcarboxylic acid amides
CS683380A2 (en) Zarizeni pro miseni plynu
JPS5697276A (en) Alphaaaryll1hh1*2*44triazolee11ethanols
CS660880A2 (en) Zpusob vyroby 2 substituovanych 4 substituovanych kyselin 5 thiazolkarboxylovych
JPS5699475A (en) 11*88quinolyl**22pyrrolidinone
CS570580A2 (en) Zarizeni pro kontinualni chemicke zpracovani kapalin
GB8319141D0 (en) 2 6 6-trimethyl-cyclo-hex-3-en-1-one
CS60780A2 (en) Zpusob vyroby 4 amino 2 piperidinochinazolinovych derivatu
CS688580A2 (en) Cerpadlo pro vstrikovani tekuteho paliva
CS332480A2 (en) Spradaci komora pro bezvretenovy dopradaci stroj
CS619580A2 (en) Pridrzne zarizeni pro nohu