ZA794850B - Halogenated loweralkenyl benzimidazoles - Google Patents
Halogenated loweralkenyl benzimidazolesInfo
- Publication number
- ZA794850B ZA794850B ZA00794850A ZA794850A ZA794850B ZA 794850 B ZA794850 B ZA 794850B ZA 00794850 A ZA00794850 A ZA 00794850A ZA 794850 A ZA794850 A ZA 794850A ZA 794850 B ZA794850 B ZA 794850B
- Authority
- ZA
- South Africa
- Prior art keywords
- halogenated lower
- halogenated
- compounds
- loweralkenyl
- benzimidazoles
- Prior art date
Links
- 150000001556 benzimidazoles Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 230000000507 anthelmentic effect Effects 0.000 abstract 1
- 239000000921 anthelmintic agent Substances 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 230000000843 anti-fungal effect Effects 0.000 abstract 1
- 239000003429 antifungal agent Substances 0.000 abstract 1
- 229940121375 antifungal agent Drugs 0.000 abstract 1
- 239000003899 bactericide agent Substances 0.000 abstract 1
- 125000003785 benzimidazolyl group Chemical class N1=C(NC2=C1C=CC=C2)* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000005645 nematicide Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
- C07C17/263—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
- C07C17/2635—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions involving a phosphorus compound, e.g. Wittig synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
- C07C205/11—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
- C07D235/32—Benzimidazole-2-carbamic acids, unsubstituted or substituted; Esters thereof; Thio-analogues thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Paper (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/941,997 US4174400A (en) | 1978-09-13 | 1978-09-13 | Anthelmintic benzimidazoles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA794850B true ZA794850B (en) | 1981-04-29 |
Family
ID=25477431
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA00794850A ZA794850B (en) | 1978-09-13 | 1979-09-12 | Halogenated loweralkenyl benzimidazoles |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4174400A (de) |
| EP (1) | EP0009361B1 (de) |
| JP (1) | JPS5540681A (de) |
| AT (1) | ATE7598T1 (de) |
| AU (1) | AU534087B2 (de) |
| DE (1) | DE2967005D1 (de) |
| DK (1) | DK380279A (de) |
| ZA (1) | ZA794850B (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2845537A1 (de) * | 1978-10-19 | 1980-04-30 | Bayer Ag | Benzimidazolylcarbamidsaeureester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| JPS58174607A (ja) * | 1982-04-02 | 1983-10-13 | トスカ紳士服株式会社 | 縫成品の製造法 |
| IL78703A (en) * | 1985-05-10 | 1993-02-21 | Benzon Alfred | Method of producing extracellular enzymes, the enzymes produced thereby and compositions containing them; a hybrid plasmid and a dna fragment comprising dna encoding the enzymes; a microorganism harbouring the plasmid; and a method for removing nucleic acids from biological materials |
| US5922913A (en) * | 1998-11-06 | 1999-07-13 | Srm Chemical, Ltd., Co. | Process for nitrating aromatic amines |
| SI1341769T1 (sl) | 2000-12-15 | 2008-02-29 | Vertex Pharma | Inhibitorji bakterijske giraze in njihove uporabe |
| US7569591B2 (en) * | 2003-01-31 | 2009-08-04 | Vertex Pharmaceuticals Incorporated | Gyrase inhibitors and uses thereof |
| AR042956A1 (es) * | 2003-01-31 | 2005-07-13 | Vertex Pharma | Inhibidores de girasa y usos de los mismos |
| US7618974B2 (en) * | 2003-01-31 | 2009-11-17 | Vertex Pharmaceuticals Incorporated | Gyrase inhibitors and uses thereof |
| US8193352B2 (en) * | 2003-01-31 | 2012-06-05 | Vertex Pharmaceuticals Incorporated | Gyrase inhibitors and uses thereof |
| US7582641B2 (en) * | 2003-01-31 | 2009-09-01 | Vertex Pharmaceuticals Incorporated | Gyrase inhibitors and uses thereof |
| US8404852B2 (en) | 2003-01-31 | 2013-03-26 | Vertex Pharmaceuticals Incorporated | Gyrase inhibitors and uses thereof |
| US20060004090A1 (en) * | 2004-07-01 | 2006-01-05 | Roberts William J | Forskolin compositions and methods for administration |
| EP2643304A2 (de) * | 2010-11-24 | 2013-10-02 | Sequent Scientific Ltd. | Verfahren zur herstellung von albendazol |
| ES2705923T3 (es) | 2011-01-14 | 2019-03-27 | Spero Trinem Inc | Formas sólidas de inhibidor de girasa (R)-1-etil-3-[6-fluoro-5-[2-(1-hidroxi-1-metil-etil)pirimidin-5-il]-7-(tetrahidrofuran-2-il)-1H-bencimidazol-2-il]urea |
| EP2663556B1 (de) | 2011-01-14 | 2014-10-15 | Vertex Pharmaceuticals Incorporated | Verfahren zur herstellung von gyrase- und topoisomerase-iv-hemmern |
| EP2663558A1 (de) | 2011-01-14 | 2013-11-20 | Vertex Pharmaceuticals Incorporated | Feste formen von gyrasehemmer-(r)-1-ethyl-3-[5-[2-{1-hydroxy-1-methyl-ethyl-}pyrimidin-5-yl-]7-(tetrahydrofuran-2-yl-)-1h-benzimidazol-2-yl-]harnstoff |
| SG191946A1 (en) | 2011-01-14 | 2013-08-30 | Vertex Pharma | Pyrimidine gyrase and topoisomerase iv inhibitors |
| CN103702994B (zh) | 2011-06-20 | 2016-03-23 | 沃泰克斯药物股份有限公司 | 旋转酶和拓扑异构酶抑制剂的磷酸酯 |
| US9572809B2 (en) | 2012-07-18 | 2017-02-21 | Spero Trinem, Inc. | Combination therapy to treat Mycobacterium diseases |
| WO2014015105A1 (en) | 2012-07-18 | 2014-01-23 | Vertex Pharmaceuticals Incorporated | Solid forms of (r)-2-(5-(2-(3-ethylureido)-6-fluoro-7-(tetrahydrofuran-2-yl)-1h-benzo[d]imidazol-5-yl)pyrimidin-2-yl)propan-2-yl dihydrogen phosphate and salts thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE666795A (de) * | 1964-08-04 | 1966-01-13 | ||
| US3929824A (en) * | 1972-12-29 | 1975-12-30 | Syntex Inc | 5(6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity |
| US3929821A (en) * | 1972-12-29 | 1975-12-30 | Syntex Inc | 5 (6)-Benzene ring substituted benzimidazole-2-carbamate derivatives |
| DE2332398A1 (de) * | 1973-06-26 | 1975-01-23 | Hoechst Ag | 2-carbalkoxy-amino-benzimidazol-5(6)phenylaether, ihre herstellung und verwendung in mitteln gegen helminthen |
| US3929823A (en) * | 1973-11-21 | 1975-12-30 | Syntex Inc | 5(6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity |
| US3993768A (en) * | 1974-11-25 | 1976-11-23 | Syntex (U.S.A.) Inc. | 5(6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity |
| IT1076022B (it) * | 1977-04-20 | 1985-04-22 | Montedison Spa | Benzimidazolcarbammati antielmintici |
-
1978
- 1978-09-13 US US05/941,997 patent/US4174400A/en not_active Expired - Lifetime
-
1979
- 1979-09-05 AU AU50607/79A patent/AU534087B2/en not_active Ceased
- 1979-09-10 AT AT79301858T patent/ATE7598T1/de active
- 1979-09-10 DE DE7979301858T patent/DE2967005D1/de not_active Expired
- 1979-09-10 EP EP79301858A patent/EP0009361B1/de not_active Expired
- 1979-09-12 DK DK380279A patent/DK380279A/da not_active Application Discontinuation
- 1979-09-12 ZA ZA00794850A patent/ZA794850B/xx unknown
- 1979-09-13 JP JP11678579A patent/JPS5540681A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP0009361A1 (de) | 1980-04-02 |
| US4174400A (en) | 1979-11-13 |
| JPS5540681A (en) | 1980-03-22 |
| ATE7598T1 (de) | 1984-06-15 |
| DK380279A (da) | 1980-03-14 |
| EP0009361B1 (de) | 1984-05-23 |
| DE2967005D1 (en) | 1984-06-28 |
| AU534087B2 (en) | 1984-01-05 |
| AU5060779A (en) | 1980-03-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA794850B (en) | Halogenated loweralkenyl benzimidazoles | |
| ES8507541A1 (es) | Un procedimiento para la preparacion de 1h-imidazolez y 1h-1,2,4-triazoles. | |
| BR9910621A (pt) | Novos compostos de imidazol 2-alquil substituìdos | |
| DE69011318D1 (de) | Diazinderivate als Angiotensin II Rezeptor Antagonisten. | |
| DE69430128D1 (en) | Cyclodepsipeptide | |
| TR200101978T2 (tr) | 3,3-Biarilpiperidin ve 2,2-biarilmorfolin türevleri. | |
| AR002761A1 (es) | Un compuesto derivado del triazol, su uso, una composicion farmaceutica que lo contiene, un metodo de tratamiento o prevencion de una infeccion fungica enun paciente humano mediante dicho compuesto o composicion, y procedimiento y compuestos intermedios para prepararlo. | |
| SE8404065D0 (sv) | Novel biologically active compounds | |
| PE20050950A1 (es) | Derivados de triazol sustituidos como antagonistas de oxitocina | |
| IL78139A0 (en) | Herbicidal and insecticidal compositions containing pyrazole derivatives,certain such novel compounds and their preparation | |
| EP0251014A3 (en) | 2-trifluoromethyl benzimidazoles | |
| EG16476A (en) | Substituted benzoyl-(thio)ureas,process for their preparation and their use as pest combating agents | |
| DE69112070D1 (de) | Anthelmintische und coccidizide 3-carbamoyl-4-hydroxycumarine, ihre verwendung und zusammensetzungen. | |
| TR200001235T2 (tr) | Pestisit olarak triflorometil bifenilil-dihalofenil azolinler | |
| DK269785D0 (da) | 4(5-)substituerede imidazoler og fremgangsmaade til fremstilling heraf | |
| ES450694A1 (es) | Procedimiento para la preparacion de derivados de urea con efecto herbicida. | |
| FI822706L (fi) | Foerfarande foer framstaellning av farmakologiskt aktiva heteroaryloxipropanolaminer | |
| HUT42284A (en) | Insecticide and acaricide compositions containing substituted furazane derivatives as active agents and process for producing these compounds | |
| FR2364910A1 (fr) | Nouvelles thiazolidines, leur preparation et leur application comme agent de lutte contre les parasites | |
| ATE85331T1 (de) | Azolverbindungen. | |
| ZA817670B (en) | 2-(n-aryl,n-1,2,3-thiadiazolylcarbonyl)-aminobutyrolactones,their preparation,fungicidal agents containing these compounds,and their use as fungicides | |
| ES8400443A1 (es) | Mejoras introducidas en un procedimiento para la preparacion de hidroximidatos y tiolhidroximidatos heterobiciclicos y derivados ester carbamato de lso mismos. | |
| SU1154907A1 (ru) | Дигидрохлорид 3-(2-диэтиламиноэтилтио)-5-(2-морфолиноэтил)-1,2,4-триазино(5,6-в)индола, обладающий стресспротективной активностью |