DK380279A - Fremgangsmaade til fremstilling af benzimidazolcarbamater - Google Patents

Fremgangsmaade til fremstilling af benzimidazolcarbamater

Info

Publication number
DK380279A
DK380279A DK380279A DK380279A DK380279A DK 380279 A DK380279 A DK 380279A DK 380279 A DK380279 A DK 380279A DK 380279 A DK380279 A DK 380279A DK 380279 A DK380279 A DK 380279A
Authority
DK
Denmark
Prior art keywords
halogenated lower
compounds
procedure
benzimidazole carbamates
disclosed
Prior art date
Application number
DK380279A
Other languages
English (en)
Inventor
H Mrozik
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of DK380279A publication Critical patent/DK380279A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • C07C17/263—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
    • C07C17/2635—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions involving a phosphorus compound, e.g. Wittig synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
    • C07C205/11—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • C07D235/32—Benzimidazole-2-carbamic acids, unsubstituted or substituted; Esters thereof; Thio-analogues thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Paper (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK380279A 1978-09-13 1979-09-12 Fremgangsmaade til fremstilling af benzimidazolcarbamater DK380279A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/941,997 US4174400A (en) 1978-09-13 1978-09-13 Anthelmintic benzimidazoles

Publications (1)

Publication Number Publication Date
DK380279A true DK380279A (da) 1980-03-14

Family

ID=25477431

Family Applications (1)

Application Number Title Priority Date Filing Date
DK380279A DK380279A (da) 1978-09-13 1979-09-12 Fremgangsmaade til fremstilling af benzimidazolcarbamater

Country Status (8)

Country Link
US (1) US4174400A (da)
EP (1) EP0009361B1 (da)
JP (1) JPS5540681A (da)
AT (1) ATE7598T1 (da)
AU (1) AU534087B2 (da)
DE (1) DE2967005D1 (da)
DK (1) DK380279A (da)
ZA (1) ZA794850B (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2845537A1 (de) * 1978-10-19 1980-04-30 Bayer Ag Benzimidazolylcarbamidsaeureester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
JPS58174607A (ja) * 1982-04-02 1983-10-13 トスカ紳士服株式会社 縫成品の製造法
IL78703A (en) * 1985-05-10 1993-02-21 Benzon Alfred Method of producing extracellular enzymes, the enzymes produced thereby and compositions containing them; a hybrid plasmid and a dna fragment comprising dna encoding the enzymes; a microorganism harbouring the plasmid; and a method for removing nucleic acids from biological materials
US5922913A (en) * 1998-11-06 1999-07-13 Srm Chemical, Ltd., Co. Process for nitrating aromatic amines
SI1341769T1 (sl) * 2000-12-15 2008-02-29 Vertex Pharma Inhibitorji bakterijske giraze in njihove uporabe
US8404852B2 (en) 2003-01-31 2013-03-26 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
AR042956A1 (es) * 2003-01-31 2005-07-13 Vertex Pharma Inhibidores de girasa y usos de los mismos
US7569591B2 (en) * 2003-01-31 2009-08-04 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US7618974B2 (en) * 2003-01-31 2009-11-17 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US8193352B2 (en) * 2003-01-31 2012-06-05 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US7582641B2 (en) * 2003-01-31 2009-09-01 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US20060004090A1 (en) * 2004-07-01 2006-01-05 Roberts William J Forskolin compositions and methods for administration
WO2012070069A2 (en) * 2010-11-24 2012-05-31 Sequent Scientific Limited A process for preparation of albendazole
EP2663557B1 (en) 2011-01-14 2015-05-27 Vertex Pharmaceuticals Incorporated Pyrimidine gyrase and topoisomerase iv inhibitors
ES2526902T3 (es) 2011-01-14 2015-01-16 Vertex Pharmaceuticals Incorporated Procesos de producción de inhibidores de la girasa y topoisomerasa IV
BR112013017985B1 (pt) 2011-01-14 2021-06-29 Spero Therapeutics Inc. Formas sólidas de inibidor de girase (r)-1-etil-3-[6-flúor-5-[2-(1-hidróxi-1-metil-etil)pirimidin- 5-il]-7-(tetra-hidrofuran-2-il)-1h-benzimidazol-2-il]ureia, seu sal de ácido clorídrico, método de preparação das mesmas e composição farmacêutica que os compreende
CA2824401A1 (en) 2011-01-14 2012-07-19 Vertex Pharmaceuticals Incorporated Solid forms of gyrase inhibitor (r)-1-ethyl-3-[5-[2-(1-hydroxy-1-methyl-ethyl)pyrimidin-5-yl]-7-(tetrahydrofuran-2-yl)-1h-benzimidazol-2-yl]urea
TWI554515B (zh) 2011-06-20 2016-10-21 維泰克斯製藥公司 旋轉酶（ｇｙｒａｓｅ）及拓樸異構酶抑制劑之磷酸酯
WO2014015105A1 (en) 2012-07-18 2014-01-23 Vertex Pharmaceuticals Incorporated Solid forms of (r)-2-(5-(2-(3-ethylureido)-6-fluoro-7-(tetrahydrofuran-2-yl)-1h-benzo[d]imidazol-5-yl)pyrimidin-2-yl)propan-2-yl dihydrogen phosphate and salts thereof
WO2014014845A1 (en) 2012-07-18 2014-01-23 Vertex Pharmaceuticals Incorporated Combination therapy comprising|1 -ethyl-3-[5-[2-{1 -hydroxy-1 -methyl-ethyl}pyrimidin-5-yl]-7-(tetra hydrofuran-2-|yl}-1 h-benzimidazol-2-yl]urea and derivatives thereof to treat mycobacterium|diseases

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE666795A (da) * 1964-08-04 1966-01-13
US3929821A (en) * 1972-12-29 1975-12-30 Syntex Inc 5 (6)-Benzene ring substituted benzimidazole-2-carbamate derivatives
US3929824A (en) * 1972-12-29 1975-12-30 Syntex Inc 5(6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity
DE2332398A1 (de) * 1973-06-26 1975-01-23 Hoechst Ag 2-carbalkoxy-amino-benzimidazol-5(6)phenylaether, ihre herstellung und verwendung in mitteln gegen helminthen
US3929823A (en) * 1973-11-21 1975-12-30 Syntex Inc 5(6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity
US3993768A (en) * 1974-11-25 1976-11-23 Syntex (U.S.A.) Inc. 5(6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity
IT1076022B (it) * 1977-04-20 1985-04-22 Montedison Spa Benzimidazolcarbammati antielmintici

Also Published As

Publication number Publication date
EP0009361B1 (en) 1984-05-23
AU534087B2 (en) 1984-01-05
ZA794850B (en) 1981-04-29
DE2967005D1 (en) 1984-06-28
ATE7598T1 (de) 1984-06-15
AU5060779A (en) 1980-03-20
JPS5540681A (en) 1980-03-22
EP0009361A1 (en) 1980-04-02
US4174400A (en) 1979-11-13

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Legal Events

Date Code Title Description
ATS Application withdrawn