DK380279A - Fremgangsmaade til fremstilling af benzimidazolcarbamater - Google Patents
Fremgangsmaade til fremstilling af benzimidazolcarbamaterInfo
- Publication number
- DK380279A DK380279A DK380279A DK380279A DK380279A DK 380279 A DK380279 A DK 380279A DK 380279 A DK380279 A DK 380279A DK 380279 A DK380279 A DK 380279A DK 380279 A DK380279 A DK 380279A
- Authority
- DK
- Denmark
- Prior art keywords
- halogenated lower
- compounds
- procedure
- benzimidazole carbamates
- disclosed
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
- C07C17/263—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
- C07C17/2635—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions involving a phosphorus compound, e.g. Wittig synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
- C07C205/11—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
- C07D235/32—Benzimidazole-2-carbamic acids, unsubstituted or substituted; Esters thereof; Thio-analogues thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Paper (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/941,997 US4174400A (en) | 1978-09-13 | 1978-09-13 | Anthelmintic benzimidazoles |
Publications (1)
Publication Number | Publication Date |
---|---|
DK380279A true DK380279A (da) | 1980-03-14 |
Family
ID=25477431
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK380279A DK380279A (da) | 1978-09-13 | 1979-09-12 | Fremgangsmaade til fremstilling af benzimidazolcarbamater |
Country Status (8)
Country | Link |
---|---|
US (1) | US4174400A (da) |
EP (1) | EP0009361B1 (da) |
JP (1) | JPS5540681A (da) |
AT (1) | ATE7598T1 (da) |
AU (1) | AU534087B2 (da) |
DE (1) | DE2967005D1 (da) |
DK (1) | DK380279A (da) |
ZA (1) | ZA794850B (da) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2845537A1 (de) * | 1978-10-19 | 1980-04-30 | Bayer Ag | Benzimidazolylcarbamidsaeureester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
JPS58174607A (ja) * | 1982-04-02 | 1983-10-13 | トスカ紳士服株式会社 | 縫成品の製造法 |
IL78703A (en) * | 1985-05-10 | 1993-02-21 | Benzon Alfred | Method of producing extracellular enzymes, the enzymes produced thereby and compositions containing them; a hybrid plasmid and a dna fragment comprising dna encoding the enzymes; a microorganism harbouring the plasmid; and a method for removing nucleic acids from biological materials |
US5922913A (en) * | 1998-11-06 | 1999-07-13 | Srm Chemical, Ltd., Co. | Process for nitrating aromatic amines |
SI1341769T1 (sl) | 2000-12-15 | 2008-02-29 | Vertex Pharma | Inhibitorji bakterijske giraze in njihove uporabe |
US8193352B2 (en) * | 2003-01-31 | 2012-06-05 | Vertex Pharmaceuticals Incorporated | Gyrase inhibitors and uses thereof |
US8404852B2 (en) | 2003-01-31 | 2013-03-26 | Vertex Pharmaceuticals Incorporated | Gyrase inhibitors and uses thereof |
AR042956A1 (es) * | 2003-01-31 | 2005-07-13 | Vertex Pharma | Inhibidores de girasa y usos de los mismos |
US7618974B2 (en) * | 2003-01-31 | 2009-11-17 | Vertex Pharmaceuticals Incorporated | Gyrase inhibitors and uses thereof |
US7582641B2 (en) * | 2003-01-31 | 2009-09-01 | Vertex Pharmaceuticals Incorporated | Gyrase inhibitors and uses thereof |
US7569591B2 (en) * | 2003-01-31 | 2009-08-04 | Vertex Pharmaceuticals Incorporated | Gyrase inhibitors and uses thereof |
US20060004090A1 (en) * | 2004-07-01 | 2006-01-05 | Roberts William J | Forskolin compositions and methods for administration |
EP2643304A2 (en) * | 2010-11-24 | 2013-10-02 | Sequent Scientific Ltd. | A process for preparation of albendazole |
AU2012205416B2 (en) | 2011-01-14 | 2017-02-02 | Spero Therapeutics, Inc. | Solid forms of gyrase inhibitor (R)-1-ethyl-3-(5-(2-{1-hydroxy-1-methyl-ethyl}pyrimidin-5-yl)-7-(tetrahydrofuran-2-yl}-1H-benzimidazol-2-yl)urea |
EP2663556B1 (en) | 2011-01-14 | 2014-10-15 | Vertex Pharmaceuticals Incorporated | Process of making gyrase and topoisomerase iv inhibitors |
TWI535714B (zh) | 2011-01-14 | 2016-06-01 | 維泰克斯製藥公司 | 旋轉酶抑制劑(r)-1-乙基-3-[6-氟-5-[2-(1-羥基-1-甲基-乙基)嘧啶-5-基]-7-(四氫呋喃-2-基)-1h-苯并咪唑-2-基]脲之固體形式 |
EP2663557B1 (en) | 2011-01-14 | 2015-05-27 | Vertex Pharmaceuticals Incorporated | Pyrimidine gyrase and topoisomerase iv inhibitors |
CN103702994B (zh) | 2011-06-20 | 2016-03-23 | 沃泰克斯药物股份有限公司 | 旋转酶和拓扑异构酶抑制剂的磷酸酯 |
WO2014014845A1 (en) | 2012-07-18 | 2014-01-23 | Vertex Pharmaceuticals Incorporated | Combination therapy comprising|1 -ethyl-3-[5-[2-{1 -hydroxy-1 -methyl-ethyl}pyrimidin-5-yl]-7-(tetra hydrofuran-2-|yl}-1 h-benzimidazol-2-yl]urea and derivatives thereof to treat mycobacterium|diseases |
TWI595002B (zh) | 2012-07-18 | 2017-08-11 | 思沛羅三南公司 | (R)-2-(5-(2-(3-乙基脲基)-6-氟-7-(四氫呋喃-2-基)-1H-苯并[d]咪唑-5-基)嘧啶-2-基)丙烷-2-基磷酸二氫鹽之固體形式及其鹽 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE666795A (da) * | 1964-08-04 | 1966-01-13 | ||
US3929821A (en) * | 1972-12-29 | 1975-12-30 | Syntex Inc | 5 (6)-Benzene ring substituted benzimidazole-2-carbamate derivatives |
US3929824A (en) * | 1972-12-29 | 1975-12-30 | Syntex Inc | 5(6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity |
DE2332398A1 (de) * | 1973-06-26 | 1975-01-23 | Hoechst Ag | 2-carbalkoxy-amino-benzimidazol-5(6)phenylaether, ihre herstellung und verwendung in mitteln gegen helminthen |
US3929823A (en) * | 1973-11-21 | 1975-12-30 | Syntex Inc | 5(6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity |
US3993768A (en) * | 1974-11-25 | 1976-11-23 | Syntex (U.S.A.) Inc. | 5(6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity |
IT1076022B (it) * | 1977-04-20 | 1985-04-22 | Montedison Spa | Benzimidazolcarbammati antielmintici |
-
1978
- 1978-09-13 US US05/941,997 patent/US4174400A/en not_active Expired - Lifetime
-
1979
- 1979-09-05 AU AU50607/79A patent/AU534087B2/en not_active Ceased
- 1979-09-10 DE DE7979301858T patent/DE2967005D1/de not_active Expired
- 1979-09-10 EP EP79301858A patent/EP0009361B1/en not_active Expired
- 1979-09-10 AT AT79301858T patent/ATE7598T1/de active
- 1979-09-12 ZA ZA00794850A patent/ZA794850B/xx unknown
- 1979-09-12 DK DK380279A patent/DK380279A/da not_active Application Discontinuation
- 1979-09-13 JP JP11678579A patent/JPS5540681A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US4174400A (en) | 1979-11-13 |
AU534087B2 (en) | 1984-01-05 |
AU5060779A (en) | 1980-03-20 |
DE2967005D1 (en) | 1984-06-28 |
ZA794850B (en) | 1981-04-29 |
ATE7598T1 (de) | 1984-06-15 |
EP0009361A1 (en) | 1980-04-02 |
JPS5540681A (en) | 1980-03-22 |
EP0009361B1 (en) | 1984-05-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ATS | Application withdrawn |