ZA794472B - Pyridazinone-substituted benzimidazoles,processes for their preparation,and pharmaceutical compositions thereof - Google Patents

Pyridazinone-substituted benzimidazoles,processes for their preparation,and pharmaceutical compositions thereof

Info

Publication number
ZA794472B
ZA794472B ZA00794472A ZA794472A ZA794472B ZA 794472 B ZA794472 B ZA 794472B ZA 00794472 A ZA00794472 A ZA 00794472A ZA 794472 A ZA794472 A ZA 794472A ZA 794472 B ZA794472 B ZA 794472B
Authority
ZA
South Africa
Prior art keywords
pyridazinone
processes
preparation
pharmaceutical compositions
substituted benzimidazoles
Prior art date
Application number
ZA00794472A
Other languages
English (en)
Inventor
W Eberlein
V Austel
W Haarmann
J Heider
W Diederen
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of ZA794472B publication Critical patent/ZA794472B/xx

Links

Classifications

    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F8/00—Arrangements for software engineering
    • G06F8/30—Creation or generation of source code
    • G06F8/31—Programming languages or programming paradigms
    • G06F8/313—Logic programming, e.g. PROLOG programming language
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Software Systems (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Theoretical Computer Science (AREA)
  • Computing Systems (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • General Physics & Mathematics (AREA)
  • Vascular Medicine (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA00794472A 1978-08-25 1979-08-24 Pyridazinone-substituted benzimidazoles,processes for their preparation,and pharmaceutical compositions thereof ZA794472B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19782837161 DE2837161A1 (de) 1978-08-25 1978-08-25 Neue benzimidazole und deren verwendung

Publications (1)

Publication Number Publication Date
ZA794472B true ZA794472B (en) 1981-04-29

Family

ID=6047905

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA00794472A ZA794472B (en) 1978-08-25 1979-08-24 Pyridazinone-substituted benzimidazoles,processes for their preparation,and pharmaceutical compositions thereof

Country Status (3)

Country Link
JP (1) JPS5533479A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE2837161A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA794472B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3505609A1 (de) * 1985-02-19 1986-08-21 Merck Patent Gmbh, 6100 Darmstadt Benzimidazolyl-pyridazinone
DE3804490A1 (de) * 1988-02-12 1989-08-24 Heumann Pharma Gmbh & Co Substituierte 6-phenyldihydro-3(2h)-pyridazinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3805635A1 (de) * 1988-02-24 1989-09-07 Thomae Gmbh Dr K Verwendung von benzimidazolen zur herstellung eines arzneimittels mit antiischaemischen wirkungen am herzen und dessen kombinationen mit ss-blockern oder bradycardica
DE3814057A1 (de) * 1988-04-26 1989-11-09 Heumann Pharma Gmbh & Co 6-oxo-pyridazinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3913597A1 (de) * 1989-04-25 1990-11-08 Heumann Pharma Gmbh & Co Diazinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE4001622A1 (de) * 1990-01-20 1991-07-25 Thomae Gmbh Dr K Orale arzneimittelformen von pimobendan
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
JP4714921B2 (ja) * 2005-02-14 2011-07-06 トーアエイヨー株式会社 ピモベンダンの製造法及びその中間体
JP5175730B2 (ja) * 2005-08-15 2013-04-03 アイアールエム・リミテッド・ライアビリティ・カンパニー Ｔｐｏ模倣剤としての化合物および組成物
CN101355876B (zh) 2005-11-09 2012-09-05 康宾纳特克斯公司 一种适用于眼部给药的组合物
CN103601792B (zh) 2007-06-04 2016-06-29 协同医药品公司 有效用于胃肠功能紊乱、炎症、癌症和其他疾病治疗的鸟苷酸环化酶激动剂
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CA2726917C (en) 2008-06-04 2018-06-26 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP2321341B1 (en) 2008-07-16 2017-02-22 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN108676076A (zh) 2011-03-01 2018-10-19 辛纳吉制药公司 制备鸟苷酸环化酶c激动剂的方法
EP2804603A1 (en) 2012-01-10 2014-11-26 President and Fellows of Harvard College Beta-cell replication promoting compounds and methods of their use
HK1218629A1 (zh) 2013-02-25 2017-03-03 Bausch Health Ireland Limited 用於结肠清洁的鸟苷酸环化酶受体激动剂
US9486494B2 (en) 2013-03-15 2016-11-08 Synergy Pharmaceuticals, Inc. Compositions useful for the treatment of gastrointestinal disorders
CA2905438A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
SI3004138T1 (sl) 2013-06-05 2024-07-31 Bausch Health Ireland Limited Ultra čisti agonisti gvanilat ciklaze C, postopek za njihovo pripravo in uporabo
MX375926B (es) 2013-08-09 2025-03-07 Ardelyx Inc Compuestos y metodos para inhibir el transporte de fosfato.
EP3972599A1 (en) 2019-05-21 2022-03-30 Ardelyx, Inc. Combination for lowering serum phosphate in a patient

Also Published As

Publication number Publication date
JPS6324996B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1988-05-23
JPS5533479A (en) 1980-03-08
DE2837161A1 (de) 1980-03-06

Similar Documents

Publication Publication Date Title
DE2962051D1 (en) Benzimidazoles, their preparation and pharmaceutical compositions containing them
DE2965062D1 (en) Imidazole derivatives, their preparation and pharmaceutical compositions
CY1250A (en) N-heterocyclyl-4-piperdinamines,methods for their preparation and pharmaceutical compositions comprising them
PH21386A (en) Platinum-diamine complexes, their pharmaceutical compositions and process for the preparation thereof
ZA794472B (en) Pyridazinone-substituted benzimidazoles,processes for their preparation,and pharmaceutical compositions thereof
IL57708A0 (en) Aminopropoxyindole derivatives,their preparation and pharmaceutical compositions containing them
DE2960954D1 (en) 1-aryloxy-3-nitratoalkylamino-2-propanols, process for their preparation and pharmaceutical compositions
ZA783829B (en) 1-acyl-2-cyanoaziridines,processes for their preparation and pharmaceutical compositions thereof
DE2964209D1 (en) Spiro-furanohydantoin derivatives, process for their preparation and pharmaceutical compositions containing them
IL57599A0 (en) Indolealkylamines,pharmaceutical formulations containing these and processes for their preparation
DE2965287D1 (en) Bis-imidazoles, their preparation and pharmaceutical compositions containing them
IL57297A0 (en) 4-amino-2-piperidinoquinazoline derivatives,their preparation and pharmaceutical compositions containing them
ZA793131B (en) Indolealkylamines,pharmaceutical formulations containing these,and processes for their preparation
IL57891A0 (en) Alkylthiophenoxyalkylamines,their preparation and pharmaceutical compositions containing them
ZA793682B (en) New piperidylbenzimidazolinone derivatives,processes for their preparation and pharmaceutical compositions containing them
IL58620A (en) Aryltrifluoroethanol derivatives,their preparation and pharmaceutical compositions containing them
IL56816A0 (en) N-phenylaniline derivatives,their preparation and pharmaceutical compositions containing them
IL56686A0 (en) Acylaminoalkyl-syanoguanidines,their preparation and pharmaceutical compositions containing them
DE2960503D1 (en) Novel androstadienes, processes for their preparation and pharmaceutical compositions containing them
DE3060079D1 (en) Spiro-quinolylhydantoins, process for their preparation and pharmaceutical compositions thereof
IL57219A (en) 10-methoxy-daunorubicin,10-methoxy-doxorubicin,their derivatives,preparation thereof,and pharmaceutical compositions comprising them
IL56890A0 (en) 2-amino-carbazole derivatives,their preparation and pharmaceutical compositions containing them
IL56913A (en) Sprio-steroid-oxazolidinone derivatives,their preparation and pharmaceutical compositions containing them
IL57754A0 (en) Benzopyranotriazoles,their preparation and pharmaceutical compositions containing them
DE2963868D1 (en) Carbostyrile derivatives, their preparation and pharmaceutical compositions containing them