ZA786739B - Hydantoin derivatives and salts thereof,their syntheses,and intermediates,and pharmaceutical formulations - Google Patents

Hydantoin derivatives and salts thereof,their syntheses,and intermediates,and pharmaceutical formulations

Info

Publication number
ZA786739B
ZA786739B ZA786739A ZA786739A ZA786739B ZA 786739 B ZA786739 B ZA 786739B ZA 786739 A ZA786739 A ZA 786739A ZA 786739 A ZA786739 A ZA 786739A ZA 786739 B ZA786739 B ZA 786739B
Authority
ZA
South Africa
Prior art keywords
syntheses
intermediates
salts
pharmaceutical formulations
hydantoin derivatives
Prior art date
Application number
ZA786739A
Other languages
English (en)
Inventor
N Whittaker
A Caldwell
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of ZA786739B publication Critical patent/ZA786739B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA786739A 1977-12-01 1978-11-30 Hydantoin derivatives and salts thereof,their syntheses,and intermediates,and pharmaceutical formulations ZA786739B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5009377 1977-12-01

Publications (1)

Publication Number Publication Date
ZA786739B true ZA786739B (en) 1980-07-30

Family

ID=10454631

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA786739A ZA786739B (en) 1977-12-01 1978-11-30 Hydantoin derivatives and salts thereof,their syntheses,and intermediates,and pharmaceutical formulations

Country Status (6)

Country Link
EP (1) EP0002259B1 (xx)
JP (1) JPS5492962A (xx)
AU (1) AU531493B2 (xx)
DE (1) DE2862445D1 (xx)
DK (1) DK543178A (xx)
ZA (1) ZA786739B (xx)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL59065A0 (en) * 1979-01-18 1980-05-30 Beecham Group Ltd Hydantoin derivatives,their preparation pharmaceutical compositons containing them
EP0023083A1 (en) * 1979-06-27 1981-01-28 Beecham Group Plc Oxodiazole derivatives, processes for their production and pharmaceutical composition containing them
US5137904A (en) * 1989-05-30 1992-08-11 G. D. Searle & Co. Thiohydantoin inhibitors of collagen-induced and ADP-induced platelet aggregation
JPH04297461A (ja) * 1991-03-27 1992-10-21 Otsuka Pharmaceut Factory Inc ２−チオヒダントイン誘導体
US5593993A (en) * 1991-08-02 1997-01-14 Medivir Ab Method for inhibition of HIV related viruses
IL102548A (en) * 1991-08-02 1998-08-16 Medivir Ab Use of painting derivatives in the preparation of drugs for VIH inhibition and treatment of SDIA and new compounds
FR2845385B1 (fr) * 2002-10-04 2004-12-31 Fournier Lab Sa Composes derives de la 2-thiohydantoine et leur utilisation en therapeutique
FR2845383B1 (fr) * 2002-10-04 2004-12-31 Fournier Lab Sa Composes derives de la 2-thiohydantoine et leur utilisation en therapeutique
US20060025589A1 (en) * 2002-10-01 2006-02-02 Jean Binet 2-Thiohydantoine derivative compounds and use thereof for the treatment of diabetes
FR2845384B1 (fr) * 2002-10-04 2004-12-31 Fournier Lab Sa Composes derives de la 2-thiohydantoine et leur utilisation en therapeutique
DE602004031881D1 (de) 2003-12-19 2011-04-28 Univ California Verfahren und materialien zur beurteilung von prostatakrebstherapien
WO2005099693A2 (en) 2004-02-24 2005-10-27 The Regents Of The University Of California Methods and materials for assessing prostate cancer therapies and compounds
US7709517B2 (en) 2005-05-13 2010-05-04 The Regents Of The University Of California Diarylhydantoin compounds
DK2656842T3 (en) 2006-03-27 2016-11-07 Univ California Androgen receptor MODULATOR FOR THE TREATMENT OF PROSTATE CANCER AND androgen receptor-ASSOCIATED DISEASES
SG10201408699TA (en) 2006-03-29 2015-02-27 Univ California Diarylthiohydantoin compounds
UY31432A1 (es) 2007-10-26 2009-05-29 Compuestos de diarilhidantoina
MX355915B (es) 2010-02-16 2018-05-04 Aragon Pharmaceuticals Inc Moduladores del receptor de androgenos y usos de los mismos.
EA202190820A1 (ru) 2012-09-26 2021-10-29 Арагон Фармасьютикалз, Инк. Антиандрогены для лечения неметастатического кастрационно-резистентного рака простаты
JOP20200097A1 (ar) 2013-01-15 2017-06-16 Aragon Pharmaceuticals Inc معدل مستقبل أندروجين واستخداماته
TWI726969B (zh) 2016-01-11 2021-05-11 比利時商健生藥品公司 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物
WO2019078920A1 (en) 2017-10-16 2019-04-25 Aragon Pharmaceuticals, Inc. ANTI-ANDROGENS FOR THE TREATMENT OF NON-METASTATIC RESISTANT PROSTATE CANCER

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB817745A (en) * 1956-12-14 1959-08-06 Ici Ltd 2-thiohydantoins
DE2138225A1 (de) * 1971-07-30 1973-02-08 Diamalt Ag Hydantoinderivate
DE2539730A1 (de) * 1975-09-06 1977-03-17 Bayer Ag Mit carbonsaeureestergruppen modifizierte hydantoine
AU515174B2 (en) * 1976-06-03 1981-03-19 Wellcome Foundation Limited, The Hydantoin derivatives
CA1176261A (en) * 1976-06-03 1984-10-16 Albert G. Caldwell Hydantoin derivatives
GB1598662A (en) * 1976-12-18 1981-09-23 Beecham Group Ltd 10,12-diazoprostaglandins
IL53559A0 (en) * 1976-12-18 1978-03-10 Beecham Group Ltd Novel prostaglandin analogues their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
EP0002259A2 (en) 1979-06-13
JPS5492962A (en) 1979-07-23
EP0002259B1 (en) 1984-10-03
DE2862445D1 (en) 1984-11-08
EP0002259A3 (en) 1979-06-27
DK543178A (da) 1979-06-02
AU4208778A (en) 1979-06-07
AU531493B2 (en) 1983-08-25

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