ZA731501B - New 2,6-diamino-dihydropyridines,their production,and their medicinal use - Google Patents

New 2,6-diamino-dihydropyridines,their production,and their medicinal use

Info

Publication number
ZA731501B
ZA731501B ZA731501A ZA731501A ZA731501B ZA 731501 B ZA731501 B ZA 731501B ZA 731501 A ZA731501 A ZA 731501A ZA 731501 A ZA731501 A ZA 731501A ZA 731501 B ZA731501 B ZA 731501B
Authority
ZA
South Africa
Prior art keywords
dihydropyridines
diamino
new
production
medicinal use
Prior art date
Application number
ZA731501A
Other languages
English (en)
Inventor
H Meyer
F Bossert
W Vater
K Stoepel
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of ZA731501B publication Critical patent/ZA731501B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
ZA731501A 1972-03-06 1973-03-05 New 2,6-diamino-dihydropyridines,their production,and their medicinal use ZA731501B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2210687A DE2210687C3 (de) 1972-03-06 1972-03-06 2,6-Diamino-3,5-diäthoxycarbonyldihydropyridine, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel

Publications (1)

Publication Number Publication Date
ZA731501B true ZA731501B (en) 1973-11-28

Family

ID=5838037

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA731501A ZA731501B (en) 1972-03-06 1973-03-05 New 2,6-diamino-dihydropyridines,their production,and their medicinal use

Country Status (24)

Country Link
JP (2) JPS5626659B2 (OSRAM)
KR (1) KR780000119B1 (OSRAM)
AT (3) AT324338B (OSRAM)
BE (1) BE796279A (OSRAM)
BG (2) BG22815A3 (OSRAM)
CA (1) CA988524A (OSRAM)
CH (2) CH577473A5 (OSRAM)
CS (2) CS182781B2 (OSRAM)
DD (1) DD106833A5 (OSRAM)
DE (1) DE2210687C3 (OSRAM)
DK (1) DK136061C (OSRAM)
ES (1) ES412323A1 (OSRAM)
FI (1) FI55996C (OSRAM)
FR (1) FR2181789B1 (OSRAM)
GB (1) GB1379005A (OSRAM)
HU (1) HU167089B (OSRAM)
IE (1) IE37370B1 (OSRAM)
IL (1) IL41664A (OSRAM)
LU (1) LU67147A1 (OSRAM)
NL (1) NL7303137A (OSRAM)
PL (2) PL92078B1 (OSRAM)
RO (2) RO63068A (OSRAM)
SE (1) SE384208B (OSRAM)
ZA (1) ZA731501B (OSRAM)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2210687C3 (de) * 1972-03-06 1981-09-24 Bayer Ag, 5090 Leverkusen 2,6-Diamino-3,5-diäthoxycarbonyldihydropyridine, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel
DE2406198C2 (de) * 1974-02-09 1983-12-15 Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von neuen 2-Amino-6-dialkylamino-dihydropyridinen
JPS5922593U (ja) * 1982-08-03 1984-02-10 日本マランツ株式会社 ヘツドホ−ン用ホ−ン部取付構造
JPS5922594U (ja) * 1982-08-03 1984-02-10 日本マランツ株式会社 耳栓型ヘツドホ−ン
JPS6282898A (ja) * 1985-10-08 1987-04-16 Matsushita Electric Ind Co Ltd ヘツドホン
JPS6293060U (OSRAM) * 1985-11-28 1987-06-13
AU2021387535A1 (en) * 2020-11-30 2023-07-06 George Kanianthara Chandy POTENT AND SELECTIVE INHIBITORS OF THE CALCIUM-ACTIVATED POTASSIUM CHANNEL, KCa3.1, FOR USE AS PLATFORM THERAPEUTICS

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2210687C3 (de) * 1972-03-06 1981-09-24 Bayer Ag, 5090 Leverkusen 2,6-Diamino-3,5-diäthoxycarbonyldihydropyridine, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel
US3855231A (en) * 1972-03-06 1974-12-17 Bayer Ag 2,6-diamino-1,4-dihydropyridine derivatives
DE2406198C2 (de) * 1974-02-09 1983-12-15 Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von neuen 2-Amino-6-dialkylamino-dihydropyridinen

Also Published As

Publication number Publication date
DK136061B (da) 1977-08-08
JPS48103579A (OSRAM) 1973-12-25
FR2181789A1 (OSRAM) 1973-12-07
FI55996B (fi) 1979-07-31
FR2181789B1 (OSRAM) 1976-12-03
AT324338B (de) 1975-08-25
JPS5911584B2 (ja) 1984-03-16
CA988524A (en) 1976-05-04
RO61192A (OSRAM) 1976-09-15
BE796279A (fr) 1973-09-05
CS182792B2 (en) 1978-05-31
JPS5626659B2 (OSRAM) 1981-06-19
LU67147A1 (OSRAM) 1973-05-22
GB1379005A (en) 1975-01-02
DE2210687A1 (de) 1973-09-20
IE37370B1 (en) 1977-07-06
RO63068A (OSRAM) 1978-05-15
DE2210687C3 (de) 1981-09-24
CH580589A5 (OSRAM) 1976-10-15
NL7303137A (OSRAM) 1973-09-10
ES412323A1 (es) 1976-01-01
IL41664A0 (en) 1973-05-31
AT327904B (de) 1976-02-25
DK136061C (da) 1978-01-02
BG20583A3 (bg) 1975-12-05
BG22815A3 (bg) 1977-04-20
IE37370L (en) 1973-09-06
DD106833A5 (OSRAM) 1974-07-05
CH577473A5 (OSRAM) 1976-07-15
JPS5699460A (en) 1981-08-10
KR780000119B1 (en) 1978-04-15
IL41664A (en) 1976-01-30
SE384208B (sv) 1976-04-26
HU167089B (OSRAM) 1975-08-28
ATA925774A (de) 1975-05-15
CS182781B2 (en) 1978-05-31
FI55996C (fi) 1979-11-12
PL89256B1 (OSRAM) 1976-11-30
DE2210687B2 (de) 1980-09-04
PL92078B1 (OSRAM) 1977-03-31

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