ZA724880B - 6-substituted 4h-imidazo(112-a)(1,4)benzodiazepine and processes for their production - Google Patents

6-substituted 4h-imidazo(112-a)(1,4)benzodiazepine and processes for their production

Info

Publication number
ZA724880B
ZA724880B ZA724880A ZA724880A ZA724880B ZA 724880 B ZA724880 B ZA 724880B ZA 724880 A ZA724880 A ZA 724880A ZA 724880 A ZA724880 A ZA 724880A ZA 724880 B ZA724880 B ZA 724880B
Authority
ZA
South Africa
Prior art keywords
benzodiazepine
imidazo
substituted
processes
production
Prior art date
Application number
ZA724880A
Other languages
English (en)
Inventor
J Hester
A R Hanze
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of ZA724880B publication Critical patent/ZA724880B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/116—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Polymers & Plastics (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Food Science & Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA724880A 1971-08-04 1972-07-14 6-substituted 4h-imidazo(112-a)(1,4)benzodiazepine and processes for their production ZA724880B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16909171A 1971-08-04 1971-08-04

Publications (1)

Publication Number Publication Date
ZA724880B true ZA724880B (en) 1973-06-27

Family

ID=22614230

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA724880A ZA724880B (en) 1971-08-04 1972-07-14 6-substituted 4h-imidazo(112-a)(1,4)benzodiazepine and processes for their production

Country Status (8)

Country Link
JP (3) JPS5714351B1 (ja)
AU (1) AU461139B2 (ja)
BE (1) BE787251A (ja)
CH (3) CH584206A5 (ja)
DE (1) DE2237592C2 (ja)
FR (1) FR2150732B1 (ja)
GB (4) GB1389437A (ja)
ZA (1) ZA724880B (ja)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3917627A (en) * 1971-08-04 1975-11-04 Upjohn Co 6-Substituted 4H-imidazo{8 1,2-a{9 {8 1,4{9 benzodiazepines and process for their production
FR2183716A1 (en) * 1972-05-05 1973-12-21 Centre Etd Ind Pharma Substd-6-phenyl-4h-imidazo (1,2-a)-1,4-benzo diazepines - - tranquillisers anxiolytics,sedatives and muscle-relaxants
ZA755418B (en) * 1974-09-11 1977-06-29 Hoffmann La Roche Diazepine derivatives
US3910946A (en) * 1974-09-12 1975-10-07 Upjohn Co 4H-Imidazo{8 1,2-a{9 {8 1,4{9 benzodiazepines
JPS6015633B2 (ja) * 1974-11-06 1985-04-20 パーク・デービス・アンド・コンパニー 新規なジアゼピン化合物の製法
AU509371B2 (en) * 1975-08-07 1980-05-08 F. Hoffmann-La Roche Ag Diazepine Derivatives
US4118386A (en) * 1977-04-04 1978-10-03 Hoffmann-La Roche Inc. Synthesis of imidazo[1,5-a]diazepine-3-carboxylates
EP0698015A1 (en) * 1993-05-14 1996-02-28 Genentech, Inc. Preparation of n-cyanodithioimino-carbonates and 3-mercapto-5-amino-1h-1,2,4-triazole
WO1996023790A1 (de) * 1995-02-02 1996-08-08 F. Hoffmann-La Roche Ag Acetylimidazobenzodiazepine
US10266534B2 (en) 2014-06-26 2019-04-23 The Johns Hopkins University Peripherally restricted GABA positive allosteric modulators for the treatment of irritable bowel syndrome and other ailments of the peripheral nervous system
EP3535253A1 (en) * 2016-11-01 2019-09-11 H. Hoffnabb-La Roche Ag 1,3-dihydro-1,4-benzodiazepine-2-thiones for the treatment of cns related diseases
CN113717176B (zh) * 2021-10-09 2022-07-05 上海再启生物技术有限公司 一种制备瑞马唑仑的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3987052A (en) * 1969-03-17 1976-10-19 The Upjohn Company 6-Phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines

Also Published As

Publication number Publication date
GB1389437A (en) 1975-04-03
JPS5547686A (en) 1980-04-04
DE2237592A1 (de) 1973-02-15
DE2237592C2 (de) 1985-08-14
AU4467372A (en) 1974-01-24
GB1389435A (en) 1975-04-03
BE787251A (fr) 1973-02-05
CH584206A5 (ja) 1977-01-31
GB1389434A (en) 1975-04-03
CH574444A5 (ja) 1976-04-15
GB1389436A (en) 1975-04-03
JPS5726667A (en) 1982-02-12
CH591488A5 (ja) 1977-09-30
JPS5732066B2 (ja) 1982-07-08
FR2150732B1 (ja) 1976-04-16
FR2150732A1 (ja) 1973-04-13
JPS5714351B1 (ja) 1982-03-24
AU461139B2 (en) 1975-05-15
JPS5734277B2 (ja) 1982-07-22

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