ZA202106815B - Crystalline pyrimidinyl-3,8-diazabicyclo[3.2.1]octanylmethanone compound and use thereof - Google Patents
Crystalline pyrimidinyl-3,8-diazabicyclo[3.2.1]octanylmethanone compound and use thereofInfo
- Publication number
- ZA202106815B ZA202106815B ZA2021/06815A ZA202106815A ZA202106815B ZA 202106815 B ZA202106815 B ZA 202106815B ZA 2021/06815 A ZA2021/06815 A ZA 2021/06815A ZA 202106815 A ZA202106815 A ZA 202106815A ZA 202106815 B ZA202106815 B ZA 202106815B
- Authority
- ZA
- South Africa
- Prior art keywords
- diazabicyclo
- octanylmethanone
- pyrimidinyl
- crystalline
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962806180P | 2019-02-15 | 2019-02-15 | |
| PCT/IB2020/051128 WO2020165788A1 (en) | 2019-02-15 | 2020-02-12 | Crystalline pyrimidinyl-3,8-diazabicyclo[3.2.1]octanylmethanone compound and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA202106815B true ZA202106815B (en) | 2026-03-25 |
Family
ID=69726639
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2021/06815A ZA202106815B (en) | 2019-02-15 | 2021-09-14 | Crystalline pyrimidinyl-3,8-diazabicyclo[3.2.1]octanylmethanone compound and use thereof |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US12312358B2 (https=) |
| EP (1) | EP3924355B1 (https=) |
| JP (1) | JP7561497B2 (https=) |
| KR (2) | KR20210114470A (https=) |
| CN (1) | CN113646310A (https=) |
| AR (1) | AR118099A1 (https=) |
| AU (1) | AU2020222083B2 (https=) |
| BR (1) | BR112021015951A2 (https=) |
| CA (1) | CA3130034C (https=) |
| MX (1) | MX2021009761A (https=) |
| SG (1) | SG11202108863WA (https=) |
| TW (1) | TWI820301B (https=) |
| WO (1) | WO2020165788A1 (https=) |
| ZA (1) | ZA202106815B (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12312358B2 (en) * | 2019-02-15 | 2025-05-27 | Pfizer Inc. | Crystalline pyrimidinyl-3,8-diazabicyclo[3.2.1]octanylmethanone compound and use thereof |
| WO2021249367A1 (zh) * | 2020-06-09 | 2021-12-16 | 苏州晶云药物科技股份有限公司 | 二氮杂双环类化合物的对甲苯磺酸盐新晶型及其制备方法 |
| CN114835717A (zh) * | 2021-02-01 | 2022-08-02 | 杭州领业医药科技有限公司 | Brepocitinib甲苯磺酸盐的晶型及其制备方法和用途 |
| CN113461687B (zh) * | 2021-08-10 | 2022-04-19 | 四川大学华西医院 | 2,8-氮杂-[4,5]十螺环酮衍生物及其制备方法和用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5023556A (en) | 1990-02-02 | 1991-06-11 | Conax Florida Corporation | Sensor circuit response to different fluid conductivities and having time delay feature |
| GEP201606600B (en) | 2013-02-22 | 2017-01-10 | Pfizer | Pyrrolo [2, 3 -d]pyrimidine derivatives as inhibitors of janus- related kinases (jak) |
| NO2721710T3 (https=) | 2014-08-21 | 2018-03-31 | ||
| SMT202400306T1 (it) * | 2018-03-30 | 2024-09-16 | Incyte Corp | Trattamento dell'idrosadenite suppurativa utilizzando inibitori di jak. |
| US12312358B2 (en) * | 2019-02-15 | 2025-05-27 | Pfizer Inc. | Crystalline pyrimidinyl-3,8-diazabicyclo[3.2.1]octanylmethanone compound and use thereof |
-
2020
- 2020-02-12 US US17/430,373 patent/US12312358B2/en active Active
- 2020-02-12 MX MX2021009761A patent/MX2021009761A/es unknown
- 2020-02-12 AU AU2020222083A patent/AU2020222083B2/en active Active
- 2020-02-12 CA CA3130034A patent/CA3130034C/en active Active
- 2020-02-12 SG SG11202108863WA patent/SG11202108863WA/en unknown
- 2020-02-12 JP JP2020021119A patent/JP7561497B2/ja active Active
- 2020-02-12 TW TW109104358A patent/TWI820301B/zh active
- 2020-02-12 KR KR1020217025620A patent/KR20210114470A/ko not_active Abandoned
- 2020-02-12 WO PCT/IB2020/051128 patent/WO2020165788A1/en not_active Ceased
- 2020-02-12 CN CN202080028910.4A patent/CN113646310A/zh active Pending
- 2020-02-12 BR BR112021015951-7A patent/BR112021015951A2/pt unknown
- 2020-02-12 EP EP20708183.7A patent/EP3924355B1/en active Active
- 2020-02-12 KR KR1020247024393A patent/KR102820235B1/ko active Active
- 2020-02-14 AR ARP200100415A patent/AR118099A1/es unknown
-
2021
- 2021-09-14 ZA ZA2021/06815A patent/ZA202106815B/en unknown
-
2025
- 2025-04-25 US US19/189,349 patent/US20250282789A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR102820235B1 (ko) | 2025-06-16 |
| TW202045511A (zh) | 2020-12-16 |
| JP2020138960A (ja) | 2020-09-03 |
| JP7561497B2 (ja) | 2024-10-04 |
| EP3924355A1 (en) | 2021-12-22 |
| MX2021009761A (es) | 2021-12-15 |
| CN113646310A (zh) | 2021-11-12 |
| AR118099A1 (es) | 2021-09-15 |
| AU2020222083A1 (en) | 2021-09-02 |
| BR112021015951A2 (pt) | 2021-10-05 |
| AU2020222083B2 (en) | 2022-11-17 |
| US20220144846A1 (en) | 2022-05-12 |
| WO2020165788A1 (en) | 2020-08-20 |
| EP3924355C0 (en) | 2025-12-31 |
| SG11202108863WA (en) | 2021-09-29 |
| KR20240116855A (ko) | 2024-07-30 |
| CA3130034A1 (en) | 2020-08-20 |
| EP3924355B1 (en) | 2025-12-31 |
| TWI820301B (zh) | 2023-11-01 |
| US20250282789A1 (en) | 2025-09-11 |
| KR20210114470A (ko) | 2021-09-23 |
| CA3130034C (en) | 2023-12-19 |
| US12312358B2 (en) | 2025-05-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA202106815B (en) | Crystalline pyrimidinyl-3,8-diazabicyclo[3.2.1]octanylmethanone compound and use thereof | |
| ZA202007671B (en) | Pharmaceutical combination, composition, and combination formulation containing glucokinase activator and biguanide hypoglycemic drug as well as preparation method and use thereof | |
| ZA202206923B (en) | New methylquinazolinone derivatives | |
| GEP201606555B (en) | Compounds and compositions for modulating egfr activity | |
| EP4467549A3 (en) | Intermediates of n-(3-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)benzamide derivatives | |
| DE602004021472D1 (en) | Pyrimiidinverbindungen | |
| TW200801003A (en) | Novel compounds | |
| PH12020551891A1 (en) | New quinoline derivatives | |
| WO2020113213A3 (en) | Cyclic pantetheine derivatives and uses thereof | |
| AU2003228770A8 (en) | Substituted pyrazolopyrimidines | |
| JOP20220006A1 (ar) | مشتقات 3، 6-داي أمينو-بيريدازين-3-يل، تركيبات صيدلية تحتوي عليها واستخدامها في صورة عوامل مساعدة على تلاشي الخلايا | |
| MY200061A (en) | Irak inhibitor and preparation method therefor and use thereof | |
| WO2020127819A3 (en) | Pharmaceutical composition comprising apixaban | |
| GEP20257772B (en) | Pyrrole compounds | |
| CR20210181A (es) | Inhibidores de o-glicoproteína-2-acetamido-2-desoxi-3-d-glucopiranosidasa | |
| PH12020551342A1 (en) | Saturated-ring-fused dihydropyrimidinone or dihydrotriazinone compounds and pharmaceutical use thereof | |
| WO2020235974A3 (ko) | 단일염기 치환 단백질 및 이를 포함하는 조성물 | |
| EP4643954A3 (en) | Novel heterocyclic amine derivative and pharmaceutical composition comprising same | |
| MY198008A (en) | Crystal of benzofuran derivative free base and preparation method | |
| EP4295916A3 (en) | Salts of 4-amino-n-(1-((3-chloro-2-fluorophenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide, and crystalline forms thereof | |
| TW200639156A (en) | New compounds | |
| GEP20084306B (en) | Antibacterial indolone oxazolidinones, intermediates for their preparation and pharmaceutical compositions containing them | |
| JOP20200327A1 (ar) | مركبات سيانوتريازول واستخداماتها | |
| HUE072069T2 (hu) | 2-((1R,4R)-4-((3-(3-(trifluormetil)fenil)imidazo[1,2- b]piridazin-6-il)amino)ciklohexil)propán-2-ol sósavas sójának kristályos formája | |
| WO2004087652A3 (en) | Imidazotriazine compounds |