BR112021015951A2 - Composto de pirimidinil-3,8-diazabiciclo[3.2.1]octanilmetanona cristalina e uso do mesmo - Google Patents
Composto de pirimidinil-3,8-diazabiciclo[3.2.1]octanilmetanona cristalina e uso do mesmo Download PDFInfo
- Publication number
- BR112021015951A2 BR112021015951A2 BR112021015951-7A BR112021015951A BR112021015951A2 BR 112021015951 A2 BR112021015951 A2 BR 112021015951A2 BR 112021015951 A BR112021015951 A BR 112021015951A BR 112021015951 A2 BR112021015951 A2 BR 112021015951A2
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- BR
- Brazil
- Prior art keywords
- crystalline form
- diazabicyclo
- difluorocyclopropyl
- methanone
- octan
- Prior art date
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- 150000001875 compounds Chemical class 0.000 title description 58
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 23
- -1 pyrimidinyl-3,8-diazabicyclo[3.2.1]octanylmethanone compound Chemical class 0.000 claims abstract description 20
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
Applications Claiming Priority (3)
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|---|---|---|---|
| US201962806180P | 2019-02-15 | 2019-02-15 | |
| US62/806,180 | 2019-02-15 | ||
| PCT/IB2020/051128 WO2020165788A1 (en) | 2019-02-15 | 2020-02-12 | Crystalline pyrimidinyl-3,8-diazabicyclo[3.2.1]octanylmethanone compound and use thereof |
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| BR112021015951A2 true BR112021015951A2 (pt) | 2021-10-05 |
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| BR112021015951-7A BR112021015951A2 (pt) | 2019-02-15 | 2020-02-12 | Composto de pirimidinil-3,8-diazabiciclo[3.2.1]octanilmetanona cristalina e uso do mesmo |
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| US (2) | US12312358B2 (https=) |
| EP (1) | EP3924355B1 (https=) |
| JP (1) | JP7561497B2 (https=) |
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| CN (1) | CN113646310A (https=) |
| AR (1) | AR118099A1 (https=) |
| AU (1) | AU2020222083B2 (https=) |
| BR (1) | BR112021015951A2 (https=) |
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| WO (1) | WO2020165788A1 (https=) |
| ZA (1) | ZA202106815B (https=) |
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| US12312358B2 (en) * | 2019-02-15 | 2025-05-27 | Pfizer Inc. | Crystalline pyrimidinyl-3,8-diazabicyclo[3.2.1]octanylmethanone compound and use thereof |
| WO2021249367A1 (zh) * | 2020-06-09 | 2021-12-16 | 苏州晶云药物科技股份有限公司 | 二氮杂双环类化合物的对甲苯磺酸盐新晶型及其制备方法 |
| CN114835717A (zh) * | 2021-02-01 | 2022-08-02 | 杭州领业医药科技有限公司 | Brepocitinib甲苯磺酸盐的晶型及其制备方法和用途 |
| CN113461687B (zh) * | 2021-08-10 | 2022-04-19 | 四川大学华西医院 | 2,8-氮杂-[4,5]十螺环酮衍生物及其制备方法和用途 |
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| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5023556A (en) | 1990-02-02 | 1991-06-11 | Conax Florida Corporation | Sensor circuit response to different fluid conductivities and having time delay feature |
| GEP201606600B (en) | 2013-02-22 | 2017-01-10 | Pfizer | Pyrrolo [2, 3 -d]pyrimidine derivatives as inhibitors of janus- related kinases (jak) |
| NO2721710T3 (https=) | 2014-08-21 | 2018-03-31 | ||
| SMT202400306T1 (it) * | 2018-03-30 | 2024-09-16 | Incyte Corp | Trattamento dell'idrosadenite suppurativa utilizzando inibitori di jak. |
| US12312358B2 (en) * | 2019-02-15 | 2025-05-27 | Pfizer Inc. | Crystalline pyrimidinyl-3,8-diazabicyclo[3.2.1]octanylmethanone compound and use thereof |
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2020
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Also Published As
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| KR102820235B1 (ko) | 2025-06-16 |
| TW202045511A (zh) | 2020-12-16 |
| JP2020138960A (ja) | 2020-09-03 |
| JP7561497B2 (ja) | 2024-10-04 |
| EP3924355A1 (en) | 2021-12-22 |
| MX2021009761A (es) | 2021-12-15 |
| CN113646310A (zh) | 2021-11-12 |
| AR118099A1 (es) | 2021-09-15 |
| AU2020222083A1 (en) | 2021-09-02 |
| AU2020222083B2 (en) | 2022-11-17 |
| US20220144846A1 (en) | 2022-05-12 |
| ZA202106815B (en) | 2026-03-25 |
| WO2020165788A1 (en) | 2020-08-20 |
| EP3924355C0 (en) | 2025-12-31 |
| SG11202108863WA (en) | 2021-09-29 |
| KR20240116855A (ko) | 2024-07-30 |
| CA3130034A1 (en) | 2020-08-20 |
| EP3924355B1 (en) | 2025-12-31 |
| TWI820301B (zh) | 2023-11-01 |
| US20250282789A1 (en) | 2025-09-11 |
| KR20210114470A (ko) | 2021-09-23 |
| CA3130034C (en) | 2023-12-19 |
| US12312358B2 (en) | 2025-05-27 |
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