ZA201906887B - Bruton's tyrosine kinase inhibitors - Google Patents
Bruton's tyrosine kinase inhibitorsInfo
- Publication number
- ZA201906887B ZA201906887B ZA2019/06887A ZA201906887A ZA201906887B ZA 201906887 B ZA201906887 B ZA 201906887B ZA 2019/06887 A ZA2019/06887 A ZA 2019/06887A ZA 201906887 A ZA201906887 A ZA 201906887A ZA 201906887 B ZA201906887 B ZA 201906887B
- Authority
- ZA
- South Africa
- Prior art keywords
- bruton
- tyrosine kinase
- kinase inhibitors
- inhibitors
- tyrosine
- Prior art date
Links
- 102000001714 Agammaglobulinaemia Tyrosine Kinase Human genes 0.000 title 1
- 108010029445 Agammaglobulinaemia Tyrosine Kinase Proteins 0.000 title 1
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 title 1
- 239000005483 tyrosine kinase inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762474686P | 2017-03-22 | 2017-03-22 | |
| PCT/US2018/023455 WO2018175512A1 (en) | 2017-03-22 | 2018-03-21 | Bruton's tyrosine kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA201906887B true ZA201906887B (en) | 2022-03-30 |
Family
ID=63585694
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2019/06887A ZA201906887B (en) | 2017-03-22 | 2019-10-18 | Bruton's tyrosine kinase inhibitors |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US11554118B2 (ro) |
| EP (1) | EP3601264A4 (ro) |
| JP (1) | JP7219902B2 (ro) |
| KR (1) | KR102627756B1 (ro) |
| CN (1) | CN110494433B (ro) |
| AU (1) | AU2018237123B2 (ro) |
| BR (1) | BR112019019588A2 (ro) |
| CA (1) | CA3055602A1 (ro) |
| EA (1) | EA201992147A1 (ro) |
| IL (1) | IL269152B2 (ro) |
| MX (1) | MX2019011116A (ro) |
| WO (1) | WO2018175512A1 (ro) |
| ZA (1) | ZA201906887B (ro) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2019011116A (es) * | 2017-03-22 | 2020-02-05 | Liao Xibin | Inhibidores de la tirosina quinasa de bruton. |
| JP2022517280A (ja) * | 2019-01-18 | 2022-03-07 | シービン リィアォ | ブルトン型チロシンキナーゼ阻害剤 |
| CA3129665A1 (en) | 2019-03-21 | 2020-09-24 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| EP3966204A4 (en) * | 2019-05-10 | 2023-07-19 | Henan Zhiwei Biomedicine Co., Ltd. | SUBSTITUTED 1-AMINO-1H-IMIDAZOLE-5-CARBOXAMIDE AS BRUTON TYROSINE KINASE INHIBITORS |
| CN114761006A (zh) | 2019-11-08 | 2022-07-15 | Inserm(法国国家健康医学研究院) | 对激酶抑制剂产生耐药性的癌症的治疗方法 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| CN111471048B (zh) * | 2020-04-30 | 2021-06-15 | 成都海博为药业有限公司 | 一种具有含氮桥环、螺环或并环结构的化合物及其用途 |
| CN115073468B (zh) * | 2021-03-15 | 2023-12-22 | 药雅科技(上海)有限公司 | 咪唑并吡嗪类btk抑制剂的制备及用途 |
| WO2022228302A1 (en) * | 2021-04-25 | 2022-11-03 | Bionova Pharmaceuticals (Shanghai) Limited | Heteroaromatic carboxamide compounds and its use |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004058755A2 (en) * | 2002-12-24 | 2004-07-15 | Biofocus Plc | Compound libraries of imidazo[1,5-a]pyridin-3-yl derivatives and related heterobicycles for targetting compounds capable of binding to g-protein coupled receptors |
| WO2005021545A1 (en) * | 2003-09-03 | 2005-03-10 | Galapagos Nv | IMIDAZO[1,5-a]PYRIDINE OR IMIDAZO[1,5-a]PIPERIDINE DERIVATIVES AND THEIR USE FOR THE PREPARATION OF MEDICAMENT AGAINST 5-HT2A RECEPTOR-RELATED DISORDERS |
| WO2008022060A2 (en) * | 2006-08-14 | 2008-02-21 | Novartis Ag | Imidazo-pyridine derivatives for modulating protein kinase activity |
| EP2532235A1 (en) * | 2006-09-22 | 2012-12-12 | Pharmacyclics, Inc. | Inhibitors of bruton's tyrosine kinase |
| MX2009010284A (es) * | 2007-03-28 | 2010-01-29 | Pharmacyclics Inc | Inhibidores de la tirosina-cinasa de bruton. |
| WO2009143051A1 (en) | 2008-05-19 | 2009-11-26 | Osi Pharmaceuticals, Inc. | Substituted imidazopyr-and imidazotri-azines |
| RU2560162C2 (ru) * | 2010-02-08 | 2015-08-20 | Мерк Шарп и Доум Б.В. | СОЕДИНЕНИЯ 8-МЕТИЛ-1-ФЕНИЛИМИДАЗО[1, 5-а]ПИРАЗИНА |
| US20140221354A1 (en) * | 2011-03-31 | 2014-08-07 | Emblem Technology Transfer Gmbh | IMIDAZO [1,2-a]PYRIDINE COMPOUNDS FOR USE IN THERAPY |
| GB2513821A (en) * | 2011-06-28 | 2014-11-12 | Andrew Levine | Speech-to-text conversion |
| AU2012285988B2 (en) * | 2011-07-19 | 2017-05-25 | Merck Sharp & Dohme B.V. | 4-imidazopyridazin-1-yl-benzamides and 4-imidazotriazin-1-yl-benzamides Btk-inhibitors |
| EP2548877A1 (en) * | 2011-07-19 | 2013-01-23 | MSD Oss B.V. | 4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors |
| ES2708224T3 (es) * | 2011-07-19 | 2019-04-09 | Merck Sharp & Dohme | 4-Imidazopiridazín-1-il-benzamidas y 4-imidazotriazín-1-il-benzamidas como inhibidores de Btk |
| FR2985185B1 (fr) * | 2012-01-04 | 2013-12-27 | Sanofi Sa | Utilisation en therapeutique de derives d'imidazopyridine |
| WO2013113097A1 (en) * | 2012-01-31 | 2013-08-08 | Beta Pharma Canada Inc. | Cyclic molecules as bruton's tyrosine kinase inhibitors |
| WO2014114185A1 (en) | 2013-01-23 | 2014-07-31 | Merck Sharp & Dohme Corp. | Btk inhibitors |
| WO2014113942A1 (en) | 2013-01-23 | 2014-07-31 | Merck Sharp & Dohme Corp. | Btk inhibitors |
| US20160096850A9 (en) | 2013-08-22 | 2016-04-07 | Genentech, Inc. | Alkynyl alcohols and methods of use |
| WO2015057992A1 (en) | 2013-10-16 | 2015-04-23 | Izumi Raquel | Btk inhibitors for hematopoietic mobilization |
| WO2015157955A1 (en) | 2014-04-17 | 2015-10-22 | Abbvie Inc. | Heterocyclic btk inhibit ors |
| CN105017256A (zh) | 2014-04-29 | 2015-11-04 | 浙江导明医药科技有限公司 | 多氟化合物作为布鲁顿酪氨酸激酶抑制剂 |
| WO2016106652A1 (en) | 2014-12-31 | 2016-07-07 | Merck Sharp & Dohme Corp. | Biarylether imidazopyrazine btk inhibitors |
| WO2016106623A1 (en) | 2014-12-31 | 2016-07-07 | Merck Sharp & Dohme Corp. | Benzamide imidazopyrazine btk inhibitors |
| WO2016106626A1 (en) * | 2014-12-31 | 2016-07-07 | Merck Sharp & Dohme Corp. | Imidazopyrazine analogs with 3-tertiary carbon substitutions as btk inhibitors |
| MA41614A (fr) * | 2015-02-25 | 2018-01-02 | Alios Biopharma Inc | Composés antiviraux |
| MA42242A (fr) * | 2015-06-24 | 2018-05-02 | Principia Biopharma Inc | Inhibiteurs de la tyrosine kinase |
| US20190008859A1 (en) | 2015-08-21 | 2019-01-10 | Acerta Pharma B.V. | Therapeutic Combinations of a MEK Inhibitor and a BTK Inhibitor |
| CN106478633A (zh) | 2015-08-27 | 2017-03-08 | 正大天晴药业集团股份有限公司 | 一类布鲁顿酪氨酸激酶抑制剂 |
| US20170071962A1 (en) | 2015-09-11 | 2017-03-16 | Acerta Pharma B.V. | Therapeutic Combinations of a Proteasome Inhibitor and a BTK Inhibitor |
| US20170035881A1 (en) | 2015-10-19 | 2017-02-09 | Acerta Pharma B.V. | Therapeutic Combinations of an IRAK4 Inhibitor and a BTK Inhibitor |
| MA43162A (fr) * | 2015-11-06 | 2018-09-12 | Acerta Pharma Bv | Inhibiteurs de type imidazopyrazine de tyrosine kinase de bruton |
| WO2017156495A1 (en) | 2016-03-11 | 2017-09-14 | Corvus Pharmaceuticals, Inc. | Compounds and methods for modulating bruton's tyrosine kinase |
| ES2878973T3 (es) | 2016-06-30 | 2021-11-19 | Hangzhou Bangshun Pharmaceutical Co Ltd | Derivado de fenilo de imidazopiridinamina y uso del mismo |
| EP3492471B1 (en) | 2016-08-17 | 2020-12-02 | Shenzhen TargetRx, Inc. | Fused bicyclic compound for inhibiting activity of tyrosine kinase |
| MX2019011116A (es) * | 2017-03-22 | 2020-02-05 | Liao Xibin | Inhibidores de la tirosina quinasa de bruton. |
-
2018
- 2018-03-21 MX MX2019011116A patent/MX2019011116A/es unknown
- 2018-03-21 IL IL269152A patent/IL269152B2/en unknown
- 2018-03-21 EP EP18770944.9A patent/EP3601264A4/en active Pending
- 2018-03-21 CN CN201880020300.2A patent/CN110494433B/zh active Active
- 2018-03-21 EA EA201992147A patent/EA201992147A1/ru unknown
- 2018-03-21 BR BR112019019588A patent/BR112019019588A2/pt unknown
- 2018-03-21 US US16/496,426 patent/US11554118B2/en active Active
- 2018-03-21 JP JP2020501418A patent/JP7219902B2/ja active Active
- 2018-03-21 KR KR1020197031084A patent/KR102627756B1/ko active IP Right Grant
- 2018-03-21 WO PCT/US2018/023455 patent/WO2018175512A1/en unknown
- 2018-03-21 CA CA3055602A patent/CA3055602A1/en active Pending
- 2018-03-21 AU AU2018237123A patent/AU2018237123B2/en active Active
-
2019
- 2019-05-22 US US16/420,148 patent/US10933063B2/en active Active
- 2019-10-18 ZA ZA2019/06887A patent/ZA201906887B/en unknown
-
2021
- 2021-01-01 US US17/140,025 patent/US11974999B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2018237123A1 (en) | 2019-10-10 |
| JP2020511547A (ja) | 2020-04-16 |
| US20210121458A1 (en) | 2021-04-29 |
| CN110494433B (zh) | 2023-03-17 |
| US10933063B2 (en) | 2021-03-02 |
| EP3601264A4 (en) | 2021-03-24 |
| IL269152A (en) | 2019-11-28 |
| IL269152B1 (en) | 2023-07-01 |
| CA3055602A1 (en) | 2018-09-27 |
| WO2018175512A1 (en) | 2018-09-27 |
| KR20190133199A (ko) | 2019-12-02 |
| US11974999B2 (en) | 2024-05-07 |
| CN110494433A (zh) | 2019-11-22 |
| AU2018237123B2 (en) | 2022-08-04 |
| KR102627756B1 (ko) | 2024-01-23 |
| JP7219902B2 (ja) | 2023-02-09 |
| US20190275037A1 (en) | 2019-09-12 |
| MX2019011116A (es) | 2020-02-05 |
| EA201992147A1 (ru) | 2020-02-20 |
| IL269152B2 (en) | 2023-11-01 |
| US11554118B2 (en) | 2023-01-17 |
| BR112019019588A2 (pt) | 2020-04-22 |
| US20210107903A1 (en) | 2021-04-15 |
| EP3601264A1 (en) | 2020-02-05 |
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