MA43162A - Inhibiteurs de type imidazopyrazine de tyrosine kinase de bruton - Google Patents

Inhibiteurs de type imidazopyrazine de tyrosine kinase de bruton

Info

Publication number
MA43162A
MA43162A MA043162A MA43162A MA43162A MA 43162 A MA43162 A MA 43162A MA 043162 A MA043162 A MA 043162A MA 43162 A MA43162 A MA 43162A MA 43162 A MA43162 A MA 43162A
Authority
MA
Morocco
Prior art keywords
imidazopyrazine
inhibitors
tyrosine kinase
bruton tyrosine
bruton
Prior art date
Application number
MA043162A
Other languages
English (en)
Inventor
Tjeerd Barf
Zwart Edwin De
Dennis Demont
Niels Hoogenboom
Saskia Verkaik
Original Assignee
Acerta Pharma Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acerta Pharma Bv filed Critical Acerta Pharma Bv
Publication of MA43162A publication Critical patent/MA43162A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
MA043162A 2015-11-06 2016-11-04 Inhibiteurs de type imidazopyrazine de tyrosine kinase de bruton MA43162A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562252420P 2015-11-06 2015-11-06
US201562261228P 2015-11-30 2015-11-30

Publications (1)

Publication Number Publication Date
MA43162A true MA43162A (fr) 2018-09-12

Family

ID=57286764

Family Applications (1)

Application Number Title Priority Date Filing Date
MA043162A MA43162A (fr) 2015-11-06 2016-11-04 Inhibiteurs de type imidazopyrazine de tyrosine kinase de bruton

Country Status (6)

Country Link
US (2) US10736893B2 (fr)
EP (2) EP3865485A1 (fr)
JP (1) JP6890602B2 (fr)
CN (1) CN108602827B (fr)
MA (1) MA43162A (fr)
WO (1) WO2017077507A1 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108602827B (zh) * 2015-11-06 2021-08-20 安塞塔制药公司 Bruton酪氨酸激酶的咪唑并吡嗪抑制剂
JP6715357B2 (ja) * 2016-06-30 2020-07-01 杭州三因泰医薬科技有限公司Ｈａｎｇｚｈｏｕ Ｓａｎｙｉｎｔａｉ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏ．， Ｌｔｄ． イミダゾピリジンアミンフェニル誘導体およびその使用
CN108101905A (zh) * 2016-11-24 2018-06-01 中国科学院上海药物研究所 嘧啶并[5,4-b]吲嗪或嘧啶并[5,4-b]吡呤化合物、其制备方法及用途
WO2018175512A1 (fr) 2017-03-22 2018-09-27 Suzhou Baijibugong Pharmaceutical Technology Co. Ltd. Inhibiteurs de tyrosine kinase de bruton
WO2018191815A1 (fr) * 2017-04-20 2018-10-25 Apotex Inc. Procédés de préparation d'acalabrutinib, et ses intermédiaires
WO2019013562A1 (fr) * 2017-07-12 2019-01-17 주식회사 대웅제약 Nouveau dérivé de 1h-pyrazolopyridine et composition pharmaceutique le contenant
KR102384924B1 (ko) 2017-07-12 2022-04-08 주식회사 대웅제약 신규한 1h-피라졸로피리딘 유도체 및 이를 포함하는 약학 조성물
CN109836416B (zh) * 2017-11-27 2023-02-03 苏州鹏旭医药科技有限公司 一种化合物的制备方法
EP3706740A4 (fr) * 2017-11-06 2021-07-28 Suzhou Pengxu Pharmatech Co., Ltd. Processus de production de l'acalabrutinib
CN108129483B (zh) * 2018-01-26 2019-06-04 成都施贝康生物医药科技有限公司 一种btk抑制剂及其应用
CN108250186B (zh) * 2018-02-07 2020-01-14 杭州科巢生物科技有限公司 Acalabrutinib及其中间体的合成方法
KR102106821B1 (ko) * 2018-04-27 2020-05-06 재단법인대구경북과학기술원 이브루티닙을 유효성분으로 포함하는 퇴행성 뇌질환의 예방 또는 치료용 약학적 조성물
CN109053780B (zh) * 2018-07-05 2020-09-29 浙江合聚生物医药有限公司 一种抗肿瘤药物Acalabrutinib关键中间体的制备方法
BR112021003480A2 (pt) * 2018-08-29 2021-05-18 Acerta Pharma B.V. processos para a preparação de 4-{8-amino-3-[(2s)-1-(but-2-inoil)-pirrolidin-2-il]imidazo[1,5-a]-pirazin-1-il}-n-(piridin-2-il)-benzamida
CN116284057A (zh) * 2018-09-14 2023-06-23 正大天晴药业集团股份有限公司 含有呋喃并[3,4-b]吡咯的化合物
CN114364798A (zh) 2019-03-21 2022-04-15 欧恩科斯欧公司 用于治疗癌症的Dbait分子与激酶抑制剂的组合
WO2020225831A1 (fr) * 2019-05-09 2020-11-12 Msn Laboratories Private Limited, R&D Center Procédé amélioré pour la préparation de 4-{8-amino-3-[(2s)-1-(but-2-ynoyl)pyrrolidin-2-yl] imidazo[1,5-a]pyrazin-1-yl)}-n-(pyridine-2-yl)benzamide
WO2021008441A1 (fr) * 2019-07-12 2021-01-21 正大天晴药业集团股份有限公司 Inhibiteur de btk contenant du 5-azaspiroheptane
WO2021089791A1 (fr) 2019-11-08 2021-05-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes pour le traitement de cancers qui ont acquis une résistance aux inhibiteurs de kinase
WO2021148581A1 (fr) 2020-01-22 2021-07-29 Onxeo Nouvelle molécule dbait et son utilisation
US20240100172A1 (en) 2020-12-21 2024-03-28 Hangzhou Jijing Pharmaceutical Technology Limited Methods and compounds for targeted autophagy

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JPH0565233A (ja) 1991-03-08 1993-03-19 Mitsui Toatsu Chem Inc モノクローナル抗体含有凍結乾燥製剤
US6267958B1 (en) 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
US20030113316A1 (en) 2001-07-25 2003-06-19 Kaisheva Elizabet A. Stable lyophilized pharmaceutical formulation of IgG antibodies
KR20090021298A (ko) 2006-06-14 2009-03-02 임클론 시스템즈 인코포레이티드 항-ｅｇｆｒ 항체의 동결건조 제제
US7894450B2 (en) 2007-12-31 2011-02-22 Nortel Network, Ltd. Implementation of VPNs over a link state protocol controlled ethernet network
US8703777B2 (en) 2008-01-04 2014-04-22 Intellikine Llc Certain chemical entities, compositions and methods
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
US9290504B2 (en) * 2011-07-19 2016-03-22 Merck Sharp & Dohme B.V. 4-imidazopyridazin-1-yl-benzamides and 4-imidazotriazin-1-yl-benzamides as Btk inhibitors
EP2548877A1 (fr) * 2011-07-19 2013-01-23 MSD Oss B.V. Dérivés de 4-(pyridine condensée à 5 chaînons)benzamide comme inhibiteurs de BTK
WO2015057992A1 (fr) * 2013-10-16 2015-04-23 Izumi Raquel Inhibiteurs btk pour la mobilisation hématopoïétique
WO2015110923A2 (fr) * 2014-01-21 2015-07-30 Acerta Pharma B.V. Méthodes de traitement de la leucémie lymphoïde chronique et du lymphome à petits lymphocytes en utilisant un inhibiteur de btk
TW201618774A (zh) 2014-08-11 2016-06-01 艾森塔製藥公司 使用ｂｔｋ抑制劑透過調變腫瘤微環境來治療實體腫瘤及其他疾病之方法
CN108602827B (zh) * 2015-11-06 2021-08-20 安塞塔制药公司 Bruton酪氨酸激酶的咪唑并吡嗪抑制剂

Also Published As

Publication number Publication date
JP2018536705A (ja) 2018-12-13
WO2017077507A1 (fr) 2017-05-11
CN108602827A (zh) 2018-09-28
US20200330461A1 (en) 2020-10-22
EP3865485A1 (fr) 2021-08-18
JP6890602B2 (ja) 2021-06-18
US10736893B2 (en) 2020-08-11
US20180318297A1 (en) 2018-11-08
EP3371189A1 (fr) 2018-09-12
US11110088B2 (en) 2021-09-07
CN108602827B (zh) 2021-08-20

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