ZA201802236B - Combination antibacterial composition and short-course antibacterial regimen - Google Patents

Combination antibacterial composition and short-course antibacterial regimen

Info

Publication number
ZA201802236B
ZA201802236B ZA2018/02236A ZA201802236A ZA201802236B ZA 201802236 B ZA201802236 B ZA 201802236B ZA 2018/02236 A ZA2018/02236 A ZA 2018/02236A ZA 201802236 A ZA201802236 A ZA 201802236A ZA 201802236 B ZA201802236 B ZA 201802236B
Authority
ZA
South Africa
Prior art keywords
antibacterial
course
short
regimen
combination
Prior art date
Application number
ZA2018/02236A
Other languages
English (en)
Inventor
E Mdluli Khisimuzi
M Mendel Carl
Nuermberger Eric
Original Assignee
Global Alliance For Tb Drug Development Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=58518568&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA201802236(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Global Alliance For Tb Drug Development Inc filed Critical Global Alliance For Tb Drug Development Inc
Publication of ZA201802236B publication Critical patent/ZA201802236B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA2018/02236A 2015-10-14 2018-04-05 Combination antibacterial composition and short-course antibacterial regimen ZA201802236B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562241280P 2015-10-14 2015-10-14
PCT/US2016/055414 WO2017066053A1 (en) 2015-10-14 2016-10-05 Combination antibacterial composition and short-course antibacterial regimen

Publications (1)

Publication Number Publication Date
ZA201802236B true ZA201802236B (en) 2022-07-27

Family

ID=58518568

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA2018/02236A ZA201802236B (en) 2015-10-14 2018-04-05 Combination antibacterial composition and short-course antibacterial regimen

Country Status (15)

Country Link
US (3) US20180280401A1 (enExample)
EP (2) EP4324824A3 (enExample)
JP (5) JP6845233B2 (enExample)
KR (2) KR102706436B1 (enExample)
CN (2) CN114796231A (enExample)
AU (3) AU2016338637A1 (enExample)
BR (1) BR112018007625A2 (enExample)
CA (1) CA3001309C (enExample)
EA (1) EA201890614A1 (enExample)
ES (1) ES2972618T3 (enExample)
HK (1) HK1254620A1 (enExample)
HR (1) HRP20240309T1 (enExample)
PL (1) PL3362068T3 (enExample)
WO (1) WO2017066053A1 (enExample)
ZA (1) ZA201802236B (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2016338637A1 (en) * 2015-10-14 2018-04-26 The Global Alliance For Tb Drug Development, Inc. Combination antibacterial composition and short-course antibacterial regimen
AU2018298855B2 (en) 2017-07-14 2024-07-18 Janssen Pharmaceutica Nv Long-acting formulations
CN109387594B (zh) * 2017-08-08 2021-01-19 武汉武药科技有限公司 一种分离和分析贝达喹啉光学异构体的方法
AU2020316989B2 (en) * 2019-07-19 2024-02-15 The Global Alliance For Tb Drug Development, Inc. Pretomanid compositions
EP4164626A4 (en) * 2020-06-15 2024-07-03 Mylan Laboratories Ltd. Combination antibacterial composition and method for antibacterial therapy
EP4164645A4 (en) * 2020-06-15 2024-07-10 The Global Alliance for TB Drug Development, Inc. COMBINED ANTIBACTERIAL COMPOSITION AND ANTIBACTERIAL THERAPY METHOD
GB202009684D0 (en) * 2020-06-26 2020-08-12 Viiv Healthcare Co Formulations
CA3206024A1 (en) * 2021-02-01 2022-08-04 The Global Alliance For Tb Drug Development, Inc. Pretomanid amorphous form
JP2026525955A (ja) 2023-07-18 2026-08-04 ヤンセン ファーマシューティカ エヌ.ベー. ベダキリン、プレトマニド又はデラマニド、及びシトクロムbc1阻害剤を含む、少なくとも三種の抗生物質の組み合わせ製品、並びにマイコバクテリア感染症の治療におけるそれらの使用
CN117137918A (zh) * 2023-09-28 2023-12-01 深圳国家感染性疾病临床医学研究中心 一种药物组合物及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7889101B2 (en) * 2008-04-14 2011-02-15 Alpine Electronics, Inc Method and apparatus for generating location based reminder message for navigation system
NZ591169A (en) * 2008-09-03 2012-12-21 Pfizer Combination therapy for tuberculosis
WO2011139832A2 (en) * 2010-04-28 2011-11-10 Rib-X Pharmaceuticals, Inc. Method for treating mycobacterial infections
AU2016338637A1 (en) 2015-10-14 2018-04-26 The Global Alliance For Tb Drug Development, Inc. Combination antibacterial composition and short-course antibacterial regimen

Also Published As

Publication number Publication date
EP3362068C0 (en) 2023-12-20
JP2018530578A (ja) 2018-10-18
BR112018007625A2 (pt) 2018-10-30
KR102706436B1 (ko) 2024-09-12
EP4324824A3 (en) 2024-05-08
US20200237770A1 (en) 2020-07-30
JP2024053045A (ja) 2024-04-12
EP4324824A2 (en) 2024-02-21
HRP20240309T1 (hr) 2024-05-10
KR20240137128A (ko) 2024-09-19
EP3362068A1 (en) 2018-08-22
AU2024203012A1 (en) 2024-05-23
ES2972618T3 (es) 2024-06-13
EP3362068B1 (en) 2023-12-20
JP6845233B2 (ja) 2021-03-17
JP2024167369A (ja) 2024-12-03
JP2021038257A (ja) 2021-03-11
PL3362068T3 (pl) 2024-06-24
AU2016338637A1 (en) 2018-04-26
AU2024203012B2 (en) 2025-07-10
CA3001309A1 (en) 2017-04-20
US20230414625A1 (en) 2023-12-28
AU2021258039A1 (en) 2021-11-25
JP7221922B2 (ja) 2023-02-14
WO2017066053A1 (en) 2017-04-20
JP2022082753A (ja) 2022-06-02
EP3362068A4 (en) 2019-06-19
AU2021258039B2 (en) 2024-02-08
CA3001309C (en) 2023-12-19
CN114796231A (zh) 2022-07-29
HK1254620A1 (zh) 2019-07-26
CN108495631A (zh) 2018-09-04
EA201890614A1 (ru) 2019-02-28
KR20180063318A (ko) 2018-06-11
US20180280401A1 (en) 2018-10-04

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