EA201890614A1 - Комбинированная антибактериальная композиция и короткий курс антибактериальной терапии - Google Patents

Комбинированная антибактериальная композиция и короткий курс антибактериальной терапии

Info

Publication number
EA201890614A1
EA201890614A1 EA201890614A EA201890614A EA201890614A1 EA 201890614 A1 EA201890614 A1 EA 201890614A1 EA 201890614 A EA201890614 A EA 201890614A EA 201890614 A EA201890614 A EA 201890614A EA 201890614 A1 EA201890614 A1 EA 201890614A1
Authority
EA
Eurasian Patent Office
Prior art keywords
antibacterial
combined
short course
therapy
composition
Prior art date
Application number
EA201890614A
Other languages
English (en)
Inventor
Кхисимузи Джр. Мдлули
Кэри М. Мэндел
Эрик Нюрмбергер
Original Assignee
Зе Глобал Эллайенс Фо Тб Драг Девелопмент, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=58518568&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201890614(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Зе Глобал Эллайенс Фо Тб Драг Девелопмент, Инк. filed Critical Зе Глобал Эллайенс Фо Тб Драг Девелопмент, Инк.
Publication of EA201890614A1 publication Critical patent/EA201890614A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Настоящее изобретение относится к лекарственным комбинациям антибактериальных средств линезолида, бедаквилина и претоманида и, возможно, с пиразинамидом для перорального приёма в коротком режиме при лечении туберкулёза.
EA201890614A 2015-10-14 2016-10-05 Комбинированная антибактериальная композиция и короткий курс антибактериальной терапии EA201890614A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562241280P 2015-10-14 2015-10-14
PCT/US2016/055414 WO2017066053A1 (en) 2015-10-14 2016-10-05 Combination antibacterial composition and short-course antibacterial regimen

Publications (1)

Publication Number Publication Date
EA201890614A1 true EA201890614A1 (ru) 2019-02-28

Family

ID=58518568

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201890614A EA201890614A1 (ru) 2015-10-14 2016-10-05 Комбинированная антибактериальная композиция и короткий курс антибактериальной терапии

Country Status (13)

Country Link
US (3) US20180280401A1 (ru)
EP (2) EP4324824A3 (ru)
JP (4) JP6845233B2 (ru)
KR (1) KR20180063318A (ru)
CN (2) CN108495631A (ru)
AU (3) AU2016338637A1 (ru)
BR (1) BR112018007625A2 (ru)
CA (1) CA3001309C (ru)
EA (1) EA201890614A1 (ru)
HK (1) HK1254620A1 (ru)
HR (1) HRP20240309T1 (ru)
WO (1) WO2017066053A1 (ru)
ZA (1) ZA201802236B (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180280401A1 (en) * 2015-10-14 2018-10-04 The Global Alliance For Tb Drug Development, Inc. Combination antibacterial composition and short-course antibacterial regimen
CN109387594B (zh) * 2017-08-08 2021-01-19 武汉武药科技有限公司 一种分离和分析贝达喹啉光学异构体的方法
MX2022000816A (es) * 2019-07-19 2022-05-13 The Global Alliance For Tb Drug Dev Inc Composiciones de pretomanida.
EP4164626A1 (en) * 2020-06-15 2023-04-19 Mylan Laboratories Ltd. Combination antibacterial composition and method for antibacterial therapy
GB202009684D0 (en) * 2020-06-26 2020-08-12 Viiv Healthcare Co Formulations

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7889101B2 (en) * 2008-04-14 2011-02-15 Alpine Electronics, Inc Method and apparatus for generating location based reminder message for navigation system
US20110190199A1 (en) * 2008-09-03 2011-08-04 Pfizer Inc. Combination Therapy for Tuberculosis
WO2011139832A2 (en) * 2010-04-28 2011-11-10 Rib-X Pharmaceuticals, Inc. Method for treating mycobacterial infections
US20180280401A1 (en) * 2015-10-14 2018-10-04 The Global Alliance For Tb Drug Development, Inc. Combination antibacterial composition and short-course antibacterial regimen

Also Published As

Publication number Publication date
AU2024203012A1 (en) 2024-05-23
US20230414625A1 (en) 2023-12-28
US20200237770A1 (en) 2020-07-30
EP3362068C0 (en) 2023-12-20
EP3362068B1 (en) 2023-12-20
US20180280401A1 (en) 2018-10-04
EP4324824A3 (en) 2024-05-08
BR112018007625A2 (pt) 2018-10-30
JP2022082753A (ja) 2022-06-02
ZA201802236B (en) 2022-07-27
AU2016338637A1 (en) 2018-04-26
HRP20240309T1 (hr) 2024-05-10
HK1254620A1 (zh) 2019-07-26
CA3001309A1 (en) 2017-04-20
EP3362068A1 (en) 2018-08-22
CN108495631A (zh) 2018-09-04
CA3001309C (en) 2023-12-19
JP2024053045A (ja) 2024-04-12
AU2021258039A1 (en) 2021-11-25
JP2018530578A (ja) 2018-10-18
JP2021038257A (ja) 2021-03-11
EP4324824A2 (en) 2024-02-21
KR20180063318A (ko) 2018-06-11
CN114796231A (zh) 2022-07-29
AU2021258039B2 (en) 2024-02-08
EP3362068A4 (en) 2019-06-19
JP7221922B2 (ja) 2023-02-14
JP6845233B2 (ja) 2021-03-17
WO2017066053A1 (en) 2017-04-20

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