ZA201402907B - Disubstituted 3,4-diamino-3-cyclobutene-1,2-dione compounds for use in the treatment of chemokine-mediated pathologies - Google Patents

Disubstituted 3,4-diamino-3-cyclobutene-1,2-dione compounds for use in the treatment of chemokine-mediated pathologies

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Publication number
ZA201402907B
ZA201402907B ZA2014/02907A ZA201402907A ZA201402907B ZA 201402907 B ZA201402907 B ZA 201402907B ZA 2014/02907 A ZA2014/02907 A ZA 2014/02907A ZA 201402907 A ZA201402907 A ZA 201402907A ZA 201402907 B ZA201402907 B ZA 201402907B
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ZA
South Africa
Prior art keywords
cyclobutene
chemokine
disubstituted
diamino
treatment
Prior art date
Application number
ZA2014/02907A
Other languages
English (en)
Inventor
Branislav Musicki
Jean-Guy Boiteau
Patricia Rossio
Jerome Aubert
Laurence Clary
Marlene Schuppli-Nollet
Original Assignee
Galderma Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galderma Res & Dev filed Critical Galderma Res & Dev
Publication of ZA201402907B publication Critical patent/ZA201402907B/en

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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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ZA2014/02907A 2011-10-28 2014-04-22 Disubstituted 3,4-diamino-3-cyclobutene-1,2-dione compounds for use in the treatment of chemokine-mediated pathologies ZA201402907B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161552829P 2011-10-28 2011-10-28
FR1159829A FR2981934B1 (fr) 2011-10-28 2011-10-28 Nouveaux composes di-substitues de la diamino-3,4-cyclobutene-3-dione-1,2 utiles dans le traitement de pathologies mediees par des chimiokines.
PCT/FR2012/052479 WO2013061005A1 (fr) 2011-10-28 2012-10-26 Composés di-substitués de la diamino-3,4-cyclobutène-3-dione-1,2 utiles dans le traitement de pathologies médiées par des chimiokines

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ZA201402907B true ZA201402907B (en) 2015-04-29

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ZA2014/02907A ZA201402907B (en) 2011-10-28 2014-04-22 Disubstituted 3,4-diamino-3-cyclobutene-1,2-dione compounds for use in the treatment of chemokine-mediated pathologies

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Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2981934B1 (fr) * 2011-10-28 2013-12-20 Galderma Res & Dev Nouveaux composes di-substitues de la diamino-3,4-cyclobutene-3-dione-1,2 utiles dans le traitement de pathologies mediees par des chimiokines.
EA029826B1 (ru) 2013-12-02 2018-05-31 Кемосентрикс, Инк. Соединения против ccr6
TWI724056B (zh) * 2015-11-19 2021-04-11 美商卡默森屈有限公司 Ｃｘｃｒ２抑制劑
TWI734715B (zh) * 2015-11-19 2021-08-01 美商卡默森屈有限公司 趨化因子受體調節劑
US10660909B2 (en) 2016-11-17 2020-05-26 Syntrix Biosystems Inc. Method for treating cancer using chemokine antagonists
AU2018318075B2 (en) 2017-08-14 2023-04-13 Allergan, Inc. 3,4-disubstituted 3-cyclobutene-1,2-diones and use thereof
US11207294B2 (en) 2018-01-08 2021-12-28 Chemocentryx, Inc. Methods of treating generalized pustular psoriasis with an antagonist of CCR6 or CXCR2
WO2019165315A1 (en) 2018-02-23 2019-08-29 Syntrix Biosystems Inc. Method for treating cancer using chemokine antagonists alone or in combination
GEP20237476B (en) 2018-09-21 2023-03-27 Pfizer N-substituted-dioxocyclobutenylamino-3-hydroxypicolinamides useful as ccr6 inhibitors
CN111362878B (zh) * 2020-03-18 2023-09-19 湖南复瑞生物医药技术有限责任公司 一种4-氨基-1,3-二氢-苯并咪唑-2-酮的制备方法
EP4143179B1 (en) 2020-04-30 2025-10-22 Idorsia Pharmaceuticals Ltd Azetidin-3-ylmethanol derivatives as ccr6 receptor modulators for the treatment of cancer
WO2023057548A1 (en) 2021-10-07 2023-04-13 Idorsia Pharmaceuticals Ltd Ccr6 receptor modulators
WO2023072924A1 (en) 2021-10-26 2023-05-04 Idorsia Pharmaceuticals Ltd Ccr6 receptor modulators
AU2022374959A1 (en) 2021-10-28 2024-06-06 Idorsia Pharmaceuticals Ltd Ccr6 receptor modulators

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2344123C9 (ru) * 2001-04-16 2009-05-20 Шеринг Корпорейшн 3,4-дизамещенные циклобутен-1,2-дионы как лиганды схс-хемокинового рецептора
EP1485089B1 (en) * 2002-03-18 2013-04-17 Merck Sharp & Dohme Corp. Combination treatments for chemokine-mediated diseases
CN101511809A (zh) * 2006-07-07 2009-08-19 先灵公司 作为cxc-趋化因子受体配体的3,4-二取代的环丁烯-1,2-二酮
US8183281B2 (en) * 2007-06-06 2012-05-22 Novartis Ag CXC-chemokine receptor ligands
UA103198C2 (en) * 2008-08-04 2013-09-25 Новартис Аг Squaramide derivatives as cxcr2 antagonists
KR200444641Y1 (ko) * 2008-12-03 2009-05-27 강민수 헤드작동형 다기능 스패너
WO2010063802A1 (en) * 2008-12-05 2010-06-10 Novartis Ag 3, 4-di-substituted cyclobutene- 1, 2 -diones as cxcr2 receptor antagonists
WO2010131146A1 (en) * 2009-05-12 2010-11-18 Pfizer Limited Cyclobutenedione derivatives
FR2981934B1 (fr) * 2011-10-28 2013-12-20 Galderma Res & Dev Nouveaux composes di-substitues de la diamino-3,4-cyclobutene-3-dione-1,2 utiles dans le traitement de pathologies mediees par des chimiokines.

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CA2849977A1 (fr) 2013-05-02
US9526732B2 (en) 2016-12-27
CN103958505A (zh) 2014-07-30
FR2981934A1 (fr) 2013-05-03
CN103958505B (zh) 2016-08-24
AU2012328199A1 (en) 2014-06-12
ES2550983T3 (es) 2015-11-13
RU2014121394A (ru) 2015-12-10
IN2014CN02364A (OSRAM) 2015-06-19
US20140309208A1 (en) 2014-10-16
FR2981934B1 (fr) 2013-12-20
EP2771334A1 (fr) 2014-09-03
US9090596B2 (en) 2015-07-28
BR112014009950A2 (pt) 2017-05-02
WO2013061005A1 (fr) 2013-05-02
KR20140090166A (ko) 2014-07-16
MX2014004858A (es) 2014-05-27
JP6068487B2 (ja) 2017-01-25
JP2014530895A (ja) 2014-11-20
US20150374708A1 (en) 2015-12-31

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