LT2882724T - Junginiai, skirti naudoti susirgimų, kurie yra palengvinami slopinant hdac, gydymui - Google Patents
Junginiai, skirti naudoti susirgimų, kurie yra palengvinami slopinant hdac, gydymuiInfo
- Publication number
- LT2882724T LT2882724T LTEP13745671.1T LT13745671T LT2882724T LT 2882724 T LT2882724 T LT 2882724T LT 13745671 T LT13745671 T LT 13745671T LT 2882724 T LT2882724 T LT 2882724T
- Authority
- LT
- Lithuania
- Prior art keywords
- hdac
- ameliorated
- disorders
- inhibition
- compounds
- Prior art date
Links
- 230000001668 ameliorated effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 208000035475 disorder Diseases 0.000 title 1
- 230000005764 inhibitory process Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000405A ITRM20120405A1 (it) | 2012-08-09 | 2012-08-09 | Compounds for use in the treatment of disorders that are ameliorated by inhibition of hdac |
| PCT/EP2013/066524 WO2014023754A1 (en) | 2012-08-09 | 2013-08-07 | Compounds for use in the treatment of disorders that are ameliorated by inhibition of hdac |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LT2882724T true LT2882724T (lt) | 2018-02-12 |
Family
ID=47046750
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEP13745671.1T LT2882724T (lt) | 2012-08-09 | 2013-08-07 | Junginiai, skirti naudoti susirgimų, kurie yra palengvinami slopinant hdac, gydymui |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9371295B2 (lt) |
| EP (1) | EP2882724B1 (lt) |
| JP (1) | JP6367800B2 (lt) |
| BR (1) | BR112015002646A2 (lt) |
| CA (1) | CA2880121A1 (lt) |
| CY (1) | CY1120654T1 (lt) |
| DK (1) | DK2882724T3 (lt) |
| ES (1) | ES2658194T3 (lt) |
| HR (1) | HRP20180187T1 (lt) |
| HU (1) | HUE036285T2 (lt) |
| IT (1) | ITRM20120405A1 (lt) |
| LT (1) | LT2882724T (lt) |
| NO (1) | NO2882724T3 (lt) |
| PL (1) | PL2882724T3 (lt) |
| PT (1) | PT2882724T (lt) |
| SI (1) | SI2882724T1 (lt) |
| WO (1) | WO2014023754A1 (lt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12331044B2 (en) | 2018-08-01 | 2025-06-17 | Merck Sharp & Dohme Llc | Inhibitors of histone deacetylase useful for the treatment or prevention of HIV infection |
| US20210403479A1 (en) * | 2018-11-08 | 2021-12-30 | Merck Sharp & Dohme Corp. | Inhibitors of histone deacetylase useful for the treatment or prevention of hiv infection |
| EP3901253A4 (en) * | 2018-12-20 | 2022-09-07 | Sumitomo Chemical Company Limited | EMBRYONIC ERYTHROBLAST CONTAINING CELL POPULATION AND METHODS FOR THEIR PRODUCTION, CELL CULTURE COMPOSITION AND COMBINATION TESTING METHODS |
| WO2020150091A1 (en) * | 2019-01-15 | 2020-07-23 | Merck Sharp & Dohme Corp. | Inhibitors of histone deacetylase useful for the treatment or prevention of hiv infection |
| WO2020190827A1 (en) | 2019-03-21 | 2020-09-24 | Merck Sharp & Dohme Corp. | Inhibitors of histone deacetylase useful for the treatment or prevention of hiv infection |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI319387B (en) | 2002-04-05 | 2010-01-11 | Astrazeneca Ab | Benzamide derivatives |
| US20050197336A1 (en) * | 2004-03-08 | 2005-09-08 | Miikana Therapeutics Corporation | Inhibitors of histone deacetylase |
| AR050926A1 (es) * | 2004-09-03 | 2006-12-06 | Astrazeneca Ab | Derivados de benzamida como inhibidores de la histonadesacetilasa(hdac) |
| EP1828171B1 (en) * | 2004-12-10 | 2014-03-12 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Heterocycle derivatives as histone deacetylase (hdac) inhibitors |
| GB0526107D0 (en) * | 2005-12-22 | 2006-02-01 | Angeletti P Ist Richerche Bio | Therapeutic Compounds |
| US8012972B2 (en) * | 2007-03-28 | 2011-09-06 | Santen Pharmaceutical Co., Ltd. | Pyridinecarboxylic acid (2-aminophenyl) amide derivative having urea structure |
| GB2460181B (en) | 2008-05-22 | 2010-08-18 | Karus Therapeutics Ltd | Depsipeptides and their therapeutic use |
| CN102802412A (zh) | 2009-12-08 | 2012-11-28 | 海玛奎斯特医药公司 | 用于治疗红细胞病症的方法及低剂量方案 |
-
2012
- 2012-08-09 IT IT000405A patent/ITRM20120405A1/it unknown
-
2013
- 2013-08-07 ES ES13745671.1T patent/ES2658194T3/es active Active
- 2013-08-07 US US14/419,988 patent/US9371295B2/en not_active Expired - Fee Related
- 2013-08-07 HR HRP20180187TT patent/HRP20180187T1/hr unknown
- 2013-08-07 LT LTEP13745671.1T patent/LT2882724T/lt unknown
- 2013-08-07 NO NO13745671A patent/NO2882724T3/no unknown
- 2013-08-07 EP EP13745671.1A patent/EP2882724B1/en active Active
- 2013-08-07 CA CA2880121A patent/CA2880121A1/en not_active Abandoned
- 2013-08-07 HU HUE13745671A patent/HUE036285T2/hu unknown
- 2013-08-07 JP JP2015525871A patent/JP6367800B2/ja not_active Expired - Fee Related
- 2013-08-07 DK DK13745671.1T patent/DK2882724T3/en active
- 2013-08-07 PL PL13745671T patent/PL2882724T3/pl unknown
- 2013-08-07 PT PT137456711T patent/PT2882724T/pt unknown
- 2013-08-07 SI SI201330940T patent/SI2882724T1/en unknown
- 2013-08-07 WO PCT/EP2013/066524 patent/WO2014023754A1/en not_active Ceased
- 2013-08-07 BR BR112015002646A patent/BR112015002646A2/pt not_active IP Right Cessation
-
2018
- 2018-01-31 CY CY181100114T patent/CY1120654T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2658194T3 (es) | 2018-03-08 |
| BR112015002646A2 (pt) | 2018-02-06 |
| US20150218112A1 (en) | 2015-08-06 |
| PL2882724T3 (pl) | 2018-04-30 |
| CA2880121A1 (en) | 2014-02-13 |
| EP2882724B1 (en) | 2017-11-01 |
| JP6367800B2 (ja) | 2018-08-01 |
| SI2882724T1 (en) | 2018-03-30 |
| ITRM20120405A1 (it) | 2014-02-10 |
| PT2882724T (pt) | 2018-02-05 |
| NO2882724T3 (lt) | 2018-03-31 |
| US9371295B2 (en) | 2016-06-21 |
| EP2882724A1 (en) | 2015-06-17 |
| JP2015524459A (ja) | 2015-08-24 |
| HUE036285T2 (hu) | 2018-06-28 |
| DK2882724T3 (en) | 2018-02-05 |
| HRP20180187T1 (hr) | 2018-03-23 |
| WO2014023754A1 (en) | 2014-02-13 |
| CY1120654T1 (el) | 2019-12-11 |
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