ZA201209298B - Hydroxyalkyl benzyl pyrazoles,and use thereof for the treatment of hyperproliferative and angiogenic diseases - Google Patents

Hydroxyalkyl benzyl pyrazoles,and use thereof for the treatment of hyperproliferative and angiogenic diseases

Info

Publication number
ZA201209298B
ZA201209298B ZA2012/09298A ZA201209298A ZA201209298B ZA 201209298 B ZA201209298 B ZA 201209298B ZA 2012/09298 A ZA2012/09298 A ZA 2012/09298A ZA 201209298 A ZA201209298 A ZA 201209298A ZA 201209298 B ZA201209298 B ZA 201209298B
Authority
ZA
South Africa
Prior art keywords
hyperproliferative
treatment
angiogenic diseases
hydroxyalkyl
pyrazoles
Prior art date
Application number
ZA2012/09298A
Other languages
English (en)
Inventor
Michael Harter
Frank Submeier
Peter Ellinghaus
Karl-Heinz Thierauch
Hartmut Beck
Susanne Greschat-Schade
Kerstin Berhorster
Joachim Schuhmacher
Original Assignee
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh
Publication of ZA201209298B publication Critical patent/ZA201209298B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA2012/09298A 2010-05-08 2012-12-07 Hydroxyalkyl benzyl pyrazoles,and use thereof for the treatment of hyperproliferative and angiogenic diseases ZA201209298B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10004854 2010-05-08
PCT/EP2011/057019 WO2011141325A1 (fr) 2010-05-08 2011-05-03 Hydroxyalkylbenzyle-pyrazoles et leur utilisation pour le traitement de maladies hyperprolifératives et angiogéniques

Publications (1)

Publication Number Publication Date
ZA201209298B true ZA201209298B (en) 2014-05-28

Family

ID=44243203

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA2012/09298A ZA201209298B (en) 2010-05-08 2012-12-07 Hydroxyalkyl benzyl pyrazoles,and use thereof for the treatment of hyperproliferative and angiogenic diseases

Country Status (12)

Country Link
EP (1) EP2569309A1 (fr)
JP (1) JP2013530139A (fr)
KR (1) KR20130108998A (fr)
CN (1) CN103003266A (fr)
AU (1) AU2011252222A1 (fr)
BR (1) BR112012028652A2 (fr)
CA (1) CA2798374A1 (fr)
IL (1) IL222850A0 (fr)
MX (1) MX2012012905A (fr)
RU (1) RU2012152800A (fr)
WO (1) WO2011141325A1 (fr)
ZA (1) ZA201209298B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2888256A4 (fr) * 2012-08-24 2016-02-17 Univ Texas Modulateurs hétérocycliques de l'activité du facteur hif utilisés pour le traitement de maladies
NZ704799A (en) 2012-08-24 2018-06-29 Univ Texas Heterocyclic modulators of hif activity for treatment of disease
EP2888253A4 (fr) 2012-08-24 2016-01-06 Univ Texas Modulateurs hétérocycliques de l'activité du facteur hif utilisés pour le traitement de maladies
ES2726648T3 (es) 2014-02-25 2019-10-08 Univ Texas Sales de moduladores heterocíclicos de la actividad del HIF para el tratamiento de enfermedades
CN107235873B (zh) * 2017-07-04 2018-11-06 中节能万润股份有限公司 一种美司钠的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004228057A1 (en) 2003-04-03 2004-10-21 Merck & Co., Inc. Di-aryl substituted pyrazole modulators of metabotropic glutamate receptor-5
WO2005030121A2 (fr) 2003-06-30 2005-04-07 Hif Bio, Inc. Composes, compositions et procedes
WO2007065010A2 (fr) 2005-12-02 2007-06-07 Hif Bio, Inc. Composes anti-angiogenese
WO2008141731A2 (fr) 2007-05-18 2008-11-27 Bayer Healthcare Ag Dérivés pyrazoles à substitution hétéroaryle utiles pour le traitement de troubles hyperprolifératifs et de maladies associées à l'angiogenèse
EP2356113B1 (fr) * 2008-11-14 2015-01-07 Bayer Intellectual Property GmbH Composés aryles substitués par hétérocycle comme inhibiteurs de hif
DE102008057344A1 (de) * 2008-11-14 2010-05-20 Bayer Schering Pharma Aktiengesellschaft Aminoalkyl-substituierte Aryl-Verbindungen und ihre Verwendung
EP2202232A1 (fr) 2008-12-26 2010-06-30 Laboratorios Almirall, S.A. Dérivés du 1,2,4-oxadiazole et leur application thérapeutique
US8389509B2 (en) 2009-01-23 2013-03-05 Bristol-Myers Squibb Company Substituted pyrazole compounds

Also Published As

Publication number Publication date
AU2011252222A1 (en) 2012-12-06
CN103003266A (zh) 2013-03-27
BR112012028652A2 (pt) 2016-08-09
KR20130108998A (ko) 2013-10-07
RU2012152800A (ru) 2014-06-20
IL222850A0 (en) 2012-12-31
CA2798374A1 (fr) 2011-11-17
MX2012012905A (es) 2012-12-17
JP2013530139A (ja) 2013-07-25
EP2569309A1 (fr) 2013-03-20
WO2011141325A1 (fr) 2011-11-17

Similar Documents

Publication Publication Date Title
HK1169573A1 (en) Applicator device for cosmetic and or medical use
EP2445568A4 (fr) Dispositifs médicaux d'administration orientables et procédés d'utilisation
ZA201202596B (en) Compounds for the treatment of dyslipidemia and related diseases
IL216967B (en) The history of 17-hydroxy-17-pentafluoroethyl-astra-9,4 (10)-diene-11-aryl and their use for the treatment of diseases
HK1215787A1 (zh) 用於治療疼痛的藥物組合
ZA201201287B (en) Therapeutic aryl-amido-aryl compounds and their use
IL219888A0 (en) Pyridine-pyridinone derivatives, preparation and therapeutic use thereof
IL220318A (en) Aqueous solutions containing 3-quinoclidinones for the treatment of diseases of overgrowth, autoimmunity and heart disease
GB0920258D0 (en) New medical agents and use thereof
HK1186412A1 (zh) 鎳紋蛋白用於治療異常性疼痛、痛覺過敏、自發性疼痛和幻痛的用途
ZA201209298B (en) Hydroxyalkyl benzyl pyrazoles,and use thereof for the treatment of hyperproliferative and angiogenic diseases
GB201011411D0 (en) Therapeutic compounds and their use
IL225755B (en) amido derivatives - 6 of epoxymorphinans - a5, 4 for the treatment of pain
HRP20151393T8 (hr) UPORABA BENZIDAMINA U LIJEČENJU BOLESTI KOJE SU p40-OVISNE
EP2568805A4 (fr) Fluide médical, procédé de traitement et utilisation du fluide
PL2555790T3 (pl) ZASTOSOWANIE LECZNICZE ß2-MIKROGLOBULINY
HK1214771A1 (zh) 用於治療皮膚病的製劑
SI2421864T1 (sl) 1-pirazolo(4,3-c)izokinolinski derivati, njihova priprava in njihova terapevtska uporaba
HK1188565A1 (en) Diarylpyridazinone derivatives, preparation thereof, and use thereof for the treatment of humans
ZA201005770B (en) The treatment of damaged skin
GB0913300D0 (en) Therapeutic compounds and their use
GB0913955D0 (en) Lactams and their therapeutic use