ZA201200276B - Improved anti-serum albumin binding variable domains - Google Patents
Improved anti-serum albumin binding variable domainsInfo
- Publication number
- ZA201200276B ZA201200276B ZA2012/00276A ZA201200276A ZA201200276B ZA 201200276 B ZA201200276 B ZA 201200276B ZA 2012/00276 A ZA2012/00276 A ZA 2012/00276A ZA 201200276 A ZA201200276 A ZA 201200276A ZA 201200276 B ZA201200276 B ZA 201200276B
- Authority
- ZA
- South Africa
- Prior art keywords
- serum albumin
- variable domains
- albumin binding
- improved anti
- binding variable
- Prior art date
Links
- 102000009027 Albumins Human genes 0.000 title 1
- 108010088751 Albumins Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Mycology (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Plant Pathology (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22602809P | 2009-07-16 | 2009-07-16 | |
| US30755410P | 2010-02-24 | 2010-02-24 | |
| PCT/EP2010/060112 WO2011006915A2 (en) | 2009-07-16 | 2010-07-14 | Improved anti-serum albumin binding single variable domains |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA201200276B true ZA201200276B (en) | 2012-09-26 |
Family
ID=42829253
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2012/00276A ZA201200276B (en) | 2009-07-16 | 2012-01-13 | Improved anti-serum albumin binding variable domains |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US8679496B2 (show.php) |
| EP (1) | EP2454285A2 (show.php) |
| JP (1) | JP2012532620A (show.php) |
| KR (1) | KR20120038494A (show.php) |
| CN (1) | CN102574914A (show.php) |
| AU (1) | AU2010272590B2 (show.php) |
| BR (1) | BR112012001681A2 (show.php) |
| CA (1) | CA2768462A1 (show.php) |
| EA (1) | EA201270174A1 (show.php) |
| IL (1) | IL217520A0 (show.php) |
| IN (1) | IN2012DN00640A (show.php) |
| MX (1) | MX2012000765A (show.php) |
| SG (1) | SG177601A1 (show.php) |
| WO (1) | WO2011006915A2 (show.php) |
| ZA (1) | ZA201200276B (show.php) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20110119806A (ko) * | 2009-02-19 | 2011-11-02 | 글락소 그룹 리미티드 | 개선된 항ｔｎｆｒ1 폴리펩티드，항체 가변 도메인 및 길항제 |
| CN102574914A (zh) * | 2009-07-16 | 2012-07-11 | 葛兰素集团有限公司 | 改进的抗血清清蛋白结合性单可变区 |
| WO2012020143A1 (en) * | 2010-08-13 | 2012-02-16 | Glaxo Group Limited | Improved anti-serum albumin binding variants |
| JP2014501515A (ja) * | 2010-12-01 | 2014-01-23 | グラクソ グループ リミテッド | 改良された抗血清アルブミン結合単一可変ドメイン |
| CA2856216C (en) | 2011-11-11 | 2021-01-12 | Ucb Pharma S.A. | Albumin binding antibodies and binding fragments thereof |
| GB201200563D0 (en) * | 2012-01-13 | 2012-02-29 | Imp Innovations Ltd | Binding molecule |
| WO2017041114A2 (en) * | 2015-09-03 | 2017-03-09 | The Children's Mercy Hospital | Anti-nicotinamide phosphoribosyltransferase antibody genes and methods of use thereof |
| NO2768984T3 (show.php) | 2015-11-12 | 2018-06-09 | ||
| SI3374392T1 (sl) * | 2015-11-13 | 2022-04-29 | Ablynx Nv | Izboljšane variabilne domene imunoglobulina, ki vežejo serumski albumin |
| MX2018006246A (es) | 2015-11-18 | 2018-08-01 | Merck Sharp & Dohme | Aglutinantes ctla4p. |
| US10544222B2 (en) | 2015-11-18 | 2020-01-28 | Merck Sharp & Dohme Corp. | PD1/CTLA4 binders |
| AU2016357460B2 (en) | 2015-11-18 | 2023-07-27 | Ablynx Nv | Improved serum albumin binders |
| CA3004748C (en) | 2015-11-18 | 2021-11-16 | Merck Sharp & Dohme Corp. | Pd1 and/or lag3 binders |
| KR20230074598A (ko) | 2016-05-18 | 2023-05-30 | 모더나티엑스, 인크. | 릴랙신을 인코딩하는 폴리뉴클레오타이드 |
| KR20230061582A (ko) * | 2016-12-07 | 2023-05-08 | 아블린쓰 엔.브이. | 개선된 혈청 알부민 결합성 면역글로불린 단일 가변 도메인 |
| LT3571225T (lt) * | 2017-01-17 | 2024-11-11 | Ablynx Nv | Patobulintos serumo albumino rišamosios medžiagos |
| RS66173B1 (sr) | 2017-01-17 | 2024-12-31 | Ablynx NV | Poboljšana veziva serumskog albumina |
| JP7200138B2 (ja) | 2017-02-16 | 2023-01-06 | ソネット バイオセラピューティクス，インコーポレイテッド | アルブミン結合ドメイン融合タンパク質 |
| BR112020006999A2 (pt) | 2017-10-10 | 2020-10-06 | Numab Therapeutics AG | anticorpo multiespecífico, composição farmacêutica e método de produção |
| EP3470426A1 (en) | 2017-10-10 | 2019-04-17 | Numab Therapeutics AG | Multispecific antibody |
| US12479909B2 (en) | 2019-02-22 | 2025-11-25 | Anwita Biosciences, Inc. | Albumin binding antibodies and use thereof |
| EP3816185A1 (en) | 2019-11-04 | 2021-05-05 | Numab Therapeutics AG | Multispecific antibody directed against pd-l1 and a tumor-associated antigen |
| GB201919061D0 (en) | 2019-12-20 | 2020-02-05 | Ucb Biopharma Sprl | Multi-specific antibody |
| US20230293647A1 (en) | 2020-04-09 | 2023-09-21 | Autolus Limited | Polypeptide |
| GB202007441D0 (en) | 2020-05-19 | 2020-07-01 | Autolus Ltd | Polypeptide |
| EP3915580A1 (en) | 2020-05-29 | 2021-12-01 | Numab Therapeutics AG | Multispecific antibody |
| IT202000013006A1 (it) * | 2020-06-01 | 2021-12-01 | Bioreweal S R L | Processo per la produzione biologica di idrogeno e/o di metano mediante assorbimento e conversione biologica di anidride carbonica. |
| EP3988568A1 (en) | 2020-10-21 | 2022-04-27 | Numab Therapeutics AG | Combination treatment |
| US20240067758A1 (en) | 2020-12-07 | 2024-02-29 | UCB Biopharma SRL | Multi-specific antibodies and antibody combinations |
| CA3208781A1 (en) | 2021-02-02 | 2022-08-11 | Bithi CHATTERJEE | Multispecific antibodies having specificity for ror1 and cd3 |
| EP4183800A1 (en) | 2021-11-19 | 2023-05-24 | Medizinische Hochschule Hannover | Novel sars-cov-2 neutralizing antibodies |
| WO2024038095A1 (en) | 2022-08-16 | 2024-02-22 | Iome Bio | NOVEL ANTI-RGMb ANTIBODIES |
| TW202448926A (zh) | 2023-02-17 | 2024-12-16 | 比利時商艾伯霖克斯公司 | 結合新生兒fc受體之多肽 |
| AR133903A1 (es) | 2023-09-22 | 2025-11-12 | Ablynx Nv | Agentes de unión de albúmina bi- y multivalentes |
| US12134635B1 (en) | 2023-12-29 | 2024-11-05 | Sonnet BioTherapeutics, Inc. | Interleukin 18 (IL-18) variants and fusion proteins comprising same |
| US12459994B2 (en) | 2024-04-12 | 2025-11-04 | Paragon Therapeutics, Inc. | Albumin binding proteins and methods of use |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL127127A0 (en) | 1998-11-18 | 1999-09-22 | Peptor Ltd | Small functional units of antibody heavy chain variable regions |
| JP2005500034A (ja) * | 2001-06-20 | 2005-01-06 | プロション バイオテク リミテッド | 受容体型タンパク質チロシンキナーゼ活性化を遮断する抗体、そのスクリーニング方法、及びその使用 |
| WO2004003019A2 (en) | 2002-06-28 | 2004-01-08 | Domantis Limited | Immunoglobin single variant antigen-binding domains and dual-specific constructs |
| US20100081792A1 (en) * | 2001-06-28 | 2010-04-01 | Smithkline Beecham Corporation | Ligand |
| US9321832B2 (en) * | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
| EP2172553A1 (en) | 2004-03-24 | 2010-04-07 | Domantis Limited | Gas1 universal leader |
| CA2569240A1 (en) | 2004-06-01 | 2005-12-15 | Domantis Limited | Drug fusion comprising a polypeptide drug and an immunoglobulin heavy chain variable domain specific for serum albumin |
| US7563443B2 (en) * | 2004-09-17 | 2009-07-21 | Domantis Limited | Monovalent anti-CD40L antibody polypeptides and compositions thereof |
| GB0521621D0 (en) * | 2005-10-24 | 2005-11-30 | Domantis Ltd | Tumor necrosis factor receptor 1 antagonists for treating respiratory diseases |
| WO2006059106A2 (en) | 2004-12-02 | 2006-06-08 | Domantis Limited | Bispecific domain antibodies targeting serum albumin and glp-1 or pyy |
| JP2009519011A (ja) * | 2005-12-01 | 2009-05-14 | ドマンティス リミテッド | インターロイキン１受容体１型に結合する非競合ドメイン抗体フォーマット |
| US20080311111A1 (en) * | 2005-12-01 | 2008-12-18 | Drew Philip D | Competitive Domain Antibody Formats That Bind Interleukin 1 Receptor Type 1 |
| US20100056439A1 (en) * | 2005-12-06 | 2010-03-04 | Domantis Limited | Ligands that have binding specificity for egfr and/or vegf and methods of use therefor |
| TW200804593A (en) * | 2006-01-24 | 2008-01-16 | Domantis Ltd | Fusion proteins that contain natural junctions |
| EP1976991A1 (en) | 2006-01-24 | 2008-10-08 | Domantis Limited | Fusion proteins that contain natural junctions |
| CA2688433A1 (en) | 2007-06-06 | 2008-12-11 | Domantis Limited | Methods for selecting protease resistant polypeptides |
| WO2009149143A1 (en) * | 2008-06-03 | 2009-12-10 | E. I. Du Pont De Nemours And Company | Adhesion of polyamides to epoxy resins |
| US8906035B2 (en) * | 2008-06-04 | 2014-12-09 | Ethicon Endo-Surgery, Inc. | Endoscopic drop off bag |
| US10198891B2 (en) * | 2008-06-06 | 2019-02-05 | Epona Llc | System and method for regulating fuel transactions |
| CN104130993B (zh) * | 2008-06-06 | 2018-10-23 | 丹尼斯科美国公司 | 包括微生物蛋白酶变体的组合物和方法 |
| CN102574914A (zh) * | 2009-07-16 | 2012-07-11 | 葛兰素集团有限公司 | 改进的抗血清清蛋白结合性单可变区 |
-
2010
- 2010-07-14 CN CN2010800414331A patent/CN102574914A/zh active Pending
- 2010-07-14 SG SG2012001855A patent/SG177601A1/en unknown
- 2010-07-14 BR BR112012001681A patent/BR112012001681A2/pt not_active IP Right Cessation
- 2010-07-14 KR KR1020127003939A patent/KR20120038494A/ko not_active Withdrawn
- 2010-07-14 US US13/384,316 patent/US8679496B2/en not_active Expired - Fee Related
- 2010-07-14 CA CA2768462A patent/CA2768462A1/en not_active Abandoned
- 2010-07-14 JP JP2012520016A patent/JP2012532620A/ja active Pending
- 2010-07-14 IN IN640DEN2012 patent/IN2012DN00640A/en unknown
- 2010-07-14 EA EA201270174A patent/EA201270174A1/ru unknown
- 2010-07-14 EP EP10734965A patent/EP2454285A2/en not_active Withdrawn
- 2010-07-14 AU AU2010272590A patent/AU2010272590B2/en not_active Ceased
- 2010-07-14 WO PCT/EP2010/060112 patent/WO2011006915A2/en not_active Ceased
- 2010-07-14 MX MX2012000765A patent/MX2012000765A/es not_active Application Discontinuation
-
2012
- 2012-01-12 IL IL217520A patent/IL217520A0/en unknown
- 2012-01-13 ZA ZA2012/00276A patent/ZA201200276B/en unknown
-
2014
- 2014-01-30 US US14/168,168 patent/US20140140996A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN102574914A (zh) | 2012-07-11 |
| AU2010272590B2 (en) | 2013-10-10 |
| US8679496B2 (en) | 2014-03-25 |
| JP2012532620A (ja) | 2012-12-20 |
| US20140140996A1 (en) | 2014-05-22 |
| MX2012000765A (es) | 2012-02-13 |
| SG177601A1 (en) | 2012-02-28 |
| WO2011006915A2 (en) | 2011-01-20 |
| EP2454285A2 (en) | 2012-05-23 |
| BR112012001681A2 (pt) | 2019-09-24 |
| AU2010272590A1 (en) | 2012-02-02 |
| IL217520A0 (en) | 2012-02-29 |
| WO2011006915A3 (en) | 2011-03-03 |
| CA2768462A1 (en) | 2011-01-20 |
| EA201270174A1 (ru) | 2012-07-30 |
| KR20120038494A (ko) | 2012-04-23 |
| IN2012DN00640A (show.php) | 2015-08-21 |
| US20120114647A1 (en) | 2012-05-10 |
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