ZA201000354B - Dual modulators of 5-HT2A and D3 receptors - Google Patents
Dual modulators of 5-HT2A and D3 receptorsInfo
- Publication number
- ZA201000354B ZA201000354B ZA201000354A ZA201000354A ZA201000354B ZA 201000354 B ZA201000354 B ZA 201000354B ZA 201000354 A ZA201000354 A ZA 201000354A ZA 201000354 A ZA201000354 A ZA 201000354A ZA 201000354 B ZA201000354 B ZA 201000354B
- Authority
- ZA
- South Africa
- Prior art keywords
- ht2a
- receptors
- dual modulators
- modulators
- dual
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07113252 | 2007-07-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA201000354B true ZA201000354B (en) | 2010-10-27 |
Family
ID=40281888
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA201000354A ZA201000354B (en) | 2007-07-26 | 2010-01-18 | Dual modulators of 5-HT2A and D3 receptors |
Country Status (16)
Country | Link |
---|---|
US (4) | US20090029977A1 (xx) |
EP (1) | EP2183245B1 (xx) |
JP (1) | JP5502733B2 (xx) |
KR (1) | KR101169518B1 (xx) |
CN (1) | CN101778844B (xx) |
AR (1) | AR067662A1 (xx) |
AU (1) | AU2008280187B2 (xx) |
BR (1) | BRPI0815092A2 (xx) |
CA (1) | CA2694009A1 (xx) |
CL (1) | CL2008002162A1 (xx) |
ES (1) | ES2498673T3 (xx) |
PE (1) | PE20090892A1 (xx) |
RU (1) | RU2480466C2 (xx) |
TW (1) | TWI363623B (xx) |
WO (1) | WO2009013212A2 (xx) |
ZA (1) | ZA201000354B (xx) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4855485B2 (ja) * | 2006-02-17 | 2012-01-18 | エフ.ホフマン−ラ ロシュ アーゲー | 5ht2/d3モジュレーターとしてのベンゾイル−ピペリジン誘導体 |
KR101329548B1 (ko) * | 2008-09-22 | 2013-11-18 | 에프. 호프만-라 로슈 아게 | 피페라진 d3 및 5-ht2a 수용체 조절제 |
EP2337783A1 (en) * | 2008-09-23 | 2011-06-29 | F. Hoffmann-La Roche AG | Isoxazolo[4,5]pyridin-3-yl-piperazin derivatives useful as modulatorsof dopamine d3 receptors |
US8470828B2 (en) * | 2010-07-06 | 2013-06-25 | Hoffmann-La Roche Inc. | Anellated pyridine compounds |
US8877778B2 (en) * | 2010-12-15 | 2014-11-04 | Hoffmann-La Roche Inc. | Benzofurane compounds |
US8722683B2 (en) * | 2011-02-17 | 2014-05-13 | Hoffmann La-Roche Inc. | Benzodioxole piperazine compounds |
US8598357B2 (en) * | 2011-03-03 | 2013-12-03 | Hoffmann-La Roche Inc. | Benzodioxole piperidine compounds |
US8921397B2 (en) * | 2011-05-04 | 2014-12-30 | Hoffmann-La Roche Inc. | Benzofurane-piperidine compounds |
CN105367565B (zh) * | 2014-08-20 | 2018-10-02 | 上海医药工业研究院 | 哌嗪(啶)环己基衍生物及其治疗精神神经疾病的应用 |
WO2017045599A1 (zh) * | 2015-09-15 | 2017-03-23 | 浙江京新药业股份有限公司 | 环己烷衍生物或其立体异构体或盐及其制备与应用 |
CN106518841B (zh) * | 2015-09-15 | 2019-03-05 | 浙江京新药业股份有限公司 | 环己烷衍生物或其立体异构体或盐及其制备与应用 |
WO2018021447A1 (ja) | 2016-07-28 | 2018-02-01 | 塩野義製薬株式会社 | ドーパミンd3受容体拮抗作用を有する含窒素縮環化合物 |
BR112020014875A2 (pt) | 2018-01-26 | 2020-12-08 | Shionogi & Co., Ltd. | Composto cíclico condensado tendo antagonismo de receptor de dopamina d3 |
JP7250405B2 (ja) * | 2018-01-26 | 2023-04-03 | 塩野義製薬株式会社 | ドーパミンd3受容体拮抗作用を有する環式化合物 |
KR20220119597A (ko) | 2019-10-29 | 2022-08-30 | 상하이 한서 바이오메디컬 컴퍼니 리미티드 | 4원 고리 유도체의 개질제, 및 이의 제조 방법 및 용도 |
WO2021088920A1 (zh) | 2019-11-05 | 2021-05-14 | 上海翰森生物医药科技有限公司 | 苯并噻吩类衍生物调节剂、其制备方法和应用 |
EP4144725A4 (en) * | 2020-04-26 | 2023-10-25 | Jiangsu NHWA Pharmaceutical Co., Ltd | 1,5-DIHYDRO-2,4-BENZODIAZEPINE-3-ONE DERIVATIVE AND ITS USE |
EP4332093A1 (en) | 2021-04-28 | 2024-03-06 | Shanghai Hansoh Biomedical Co., Ltd. | Salt containing piperazine polycyclic derivative, crystal form thereof, preparation method therefor, and use thereof |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5776963A (en) * | 1989-05-19 | 1998-07-07 | Hoechst Marion Roussel, Inc. | 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility |
US5364866A (en) * | 1989-05-19 | 1994-11-15 | Hoechst-Roussel Pharmaceuticals, Inc. | Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics |
DK60693D0 (da) * | 1993-05-26 | 1993-05-26 | Novo Nordisk As | Kemiske forbindelser, deres fremstilling og anvendelse |
HUP0001308A3 (en) | 1997-02-07 | 2001-07-30 | Aventis Pharmaceuticals Inc Br | (4-piperidinyl)-1h-2-benzopyran derivatives useful as antipsychotic agents, process for their preparation and pharmaceutical compositions containing the same |
PT1054885E (pt) * | 1998-02-09 | 2007-10-03 | Duphar Int Res | Derivativos de benzisoxazole tendo uma actividade d4-antagonista |
DE10010612A1 (de) * | 2000-03-03 | 2001-09-27 | Merck Patent Gmbh | Verwendung von PDE V-Inhibitoren |
WO2002066446A1 (en) | 2001-02-16 | 2002-08-29 | Aventis Pharmaceuticals Inc. | Heterocyclic substituted carbonyl derivatives and their use as dopamine d3 receptor ligands |
GB0117577D0 (en) * | 2001-02-16 | 2001-09-12 | Aventis Pharm Prod Inc | Novel heterocyclic substituted carbonyl derivatives and their use as dopamine D receptor ligands |
GB0117950D0 (en) | 2001-02-16 | 2001-09-19 | Aventis Pharma Inc | Novel heterocyclic urea derivatives andd their use as dopamine D3 receptor ligands |
IL157412A0 (en) | 2001-02-16 | 2004-03-28 | Aventis Pharmaceuticals Inc Av | Novel heterocyclic amide derivatives and their use as dopamine d3 receptor ligands |
JP4855485B2 (ja) * | 2006-02-17 | 2012-01-18 | エフ.ホフマン−ラ ロシュ アーゲー | 5ht2/d3モジュレーターとしてのベンゾイル−ピペリジン誘導体 |
AU2007316249B2 (en) * | 2006-10-31 | 2013-01-24 | F. Hoffmann-La Roche Ag | Ether derivatives dual modulators of the 5-HT2A and D3 receptors |
MX2010001195A (es) * | 2007-08-09 | 2010-03-01 | Hoffmann La Roche | Derivados de benzoil-peperidina como moduladores dobles de los receptores 5-ht2a y d3. |
KR101329548B1 (ko) * | 2008-09-22 | 2013-11-18 | 에프. 호프만-라 로슈 아게 | 피페라진 d3 및 5-ht2a 수용체 조절제 |
EP2420558B1 (en) * | 2010-08-17 | 2017-08-02 | The Procter & Gamble Company | Stable sustainable hand dish-washing detergents |
US8877778B2 (en) * | 2010-12-15 | 2014-11-04 | Hoffmann-La Roche Inc. | Benzofurane compounds |
-
2008
- 2008-07-17 CN CN2008800255361A patent/CN101778844B/zh not_active Expired - Fee Related
- 2008-07-17 KR KR1020107004201A patent/KR101169518B1/ko not_active IP Right Cessation
- 2008-07-17 BR BRPI0815092-3A2A patent/BRPI0815092A2/pt not_active IP Right Cessation
- 2008-07-17 ES ES08775170.7T patent/ES2498673T3/es active Active
- 2008-07-17 CA CA2694009A patent/CA2694009A1/en not_active Abandoned
- 2008-07-17 RU RU2010104631/04A patent/RU2480466C2/ru not_active IP Right Cessation
- 2008-07-17 AU AU2008280187A patent/AU2008280187B2/en not_active Ceased
- 2008-07-17 EP EP08775170.7A patent/EP2183245B1/en not_active Not-in-force
- 2008-07-17 JP JP2010517368A patent/JP5502733B2/ja not_active Expired - Fee Related
- 2008-07-17 WO PCT/EP2008/059356 patent/WO2009013212A2/en active Application Filing
- 2008-07-18 US US12/175,476 patent/US20090029977A1/en not_active Abandoned
- 2008-07-23 PE PE2008001250A patent/PE20090892A1/es not_active Application Discontinuation
- 2008-07-24 CL CL2008002162A patent/CL2008002162A1/es unknown
- 2008-07-24 AR ARP080103200A patent/AR067662A1/es not_active Application Discontinuation
- 2008-07-25 TW TW097128485A patent/TWI363623B/zh not_active IP Right Cessation
-
2010
- 2010-01-18 ZA ZA201000354A patent/ZA201000354B/xx unknown
-
2011
- 2011-10-25 US US13/280,523 patent/US20120040972A1/en not_active Abandoned
-
2013
- 2013-02-21 US US13/772,390 patent/US8829029B2/en not_active Expired - Fee Related
-
2014
- 2014-07-24 US US14/340,093 patent/US20140350051A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
PE20090892A1 (es) | 2009-07-13 |
WO2009013212A3 (en) | 2009-06-11 |
US20140350051A1 (en) | 2014-11-27 |
CL2008002162A1 (es) | 2009-05-29 |
US20130165432A1 (en) | 2013-06-27 |
US20090029977A1 (en) | 2009-01-29 |
AR067662A1 (es) | 2009-10-21 |
EP2183245A2 (en) | 2010-05-12 |
WO2009013212A2 (en) | 2009-01-29 |
RU2480466C2 (ru) | 2013-04-27 |
CN101778844B (zh) | 2013-01-02 |
EP2183245B1 (en) | 2014-07-09 |
AU2008280187B2 (en) | 2013-05-16 |
KR101169518B1 (ko) | 2012-07-27 |
CA2694009A1 (en) | 2009-01-29 |
RU2010104631A (ru) | 2011-09-10 |
KR20100036384A (ko) | 2010-04-07 |
CN101778844A (zh) | 2010-07-14 |
JP5502733B2 (ja) | 2014-05-28 |
TWI363623B (en) | 2012-05-11 |
TW200911236A (en) | 2009-03-16 |
JP2010534632A (ja) | 2010-11-11 |
ES2498673T3 (es) | 2014-09-25 |
BRPI0815092A2 (pt) | 2015-02-03 |
AU2008280187A1 (en) | 2009-01-29 |
US20120040972A1 (en) | 2012-02-16 |
US8829029B2 (en) | 2014-09-09 |
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