ZA200902384B - Heteroaryl compounds, compositions thereof, and use thereof as protein kinase inhibitors - Google Patents

Heteroaryl compounds, compositions thereof, and use thereof as protein kinase inhibitors

Info

Publication number
ZA200902384B
ZA200902384B ZA200902384A ZA200902384A ZA200902384B ZA 200902384 B ZA200902384 B ZA 200902384B ZA 200902384 A ZA200902384 A ZA 200902384A ZA 200902384 A ZA200902384 A ZA 200902384A ZA 200902384 B ZA200902384 B ZA 200902384B
Authority
ZA
South Africa
Prior art keywords
compositions
protein kinase
kinase inhibitors
heteroaryl compounds
conditions
Prior art date
Application number
ZA200902384A
Other languages
English (en)
Inventor
Deborah Sue Mortensen
Maria Mercedes Delgado Mederos
John Joseph Sapienza
Ronald J Albers
Branden G Lee
Dehua Huang
Kimberly Lyn Schwarz
Jason Simon Riggs Jennifer R Parnes
Patrick William Papa
Original Assignee
Signal Pharm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Signal Pharm Llc filed Critical Signal Pharm Llc
Publication of ZA200902384B publication Critical patent/ZA200902384B/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4

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  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Diabetes (AREA)
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  • Endocrinology (AREA)
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  • Pregnancy & Childbirth (AREA)
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ZA200902384A 2006-10-19 2007-10-18 Heteroaryl compounds, compositions thereof, and use thereof as protein kinase inhibitors ZA200902384B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US85313506P 2006-10-19 2006-10-19

Publications (1)

Publication Number Publication Date
ZA200902384B true ZA200902384B (en) 2010-07-28

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Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200902384A ZA200902384B (en) 2006-10-19 2007-10-18 Heteroaryl compounds, compositions thereof, and use thereof as protein kinase inhibitors

Country Status (17)

Country Link
US (2) US7968556B2 (ja)
EP (1) EP2078018B1 (ja)
JP (1) JP5513119B2 (ja)
KR (1) KR101451290B1 (ja)
CN (1) CN101679432B (ja)
AT (1) ATE549336T1 (ja)
AU (1) AU2007309468B2 (ja)
BR (1) BRPI0717773A2 (ja)
CA (1) CA2666624C (ja)
ES (1) ES2383370T3 (ja)
HK (1) HK1131146A1 (ja)
IL (1) IL198116A (ja)
MX (1) MX2009004019A (ja)
NZ (1) NZ576279A (ja)
RU (1) RU2474582C2 (ja)
WO (1) WO2008051494A1 (ja)
ZA (1) ZA200902384B (ja)

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