ZA200810741B - Methodes for the preparation of biologically active compounds in nanoparticulate form - Google Patents
Methodes for the preparation of biologically active compounds in nanoparticulate formInfo
- Publication number
- ZA200810741B ZA200810741B ZA200810741A ZA200810741A ZA200810741B ZA 200810741 B ZA200810741 B ZA 200810741B ZA 200810741 A ZA200810741 A ZA 200810741A ZA 200810741 A ZA200810741 A ZA 200810741A ZA 200810741 B ZA200810741 B ZA 200810741B
- Authority
- ZA
- South Africa
- Prior art keywords
- methodes
- preparation
- biologically active
- active compounds
- nanoparticulate form
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2006903527A AU2006903527A0 (en) | 2006-06-30 | Methods For The Preparation Of Pharmaceutically Active Compounds in Nanoparticulate Form |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200810741B true ZA200810741B (en) | 2010-05-26 |
Family
ID=41284114
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200810741A ZA200810741B (en) | 2006-06-30 | 2007-06-29 | Methodes for the preparation of biologically active compounds in nanoparticulate form |
Country Status (6)
Country | Link |
---|---|
US (1) | US8808751B2 (xx) |
CN (3) | CN101568330A (xx) |
BR (1) | BRPI0713053A2 (xx) |
NZ (4) | NZ573823A (xx) |
TW (2) | TWI564033B (xx) |
ZA (1) | ZA200810741B (xx) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5508003B2 (ja) | 2006-06-30 | 2014-05-28 | アイスイティカ ピーティーワイ リミテッド | ナノ粒子状の形態における生物学的に活性な化合物の調製のための方法 |
BRPI1014276B8 (pt) * | 2009-04-24 | 2021-05-25 | Iceutica Pty Ltd | produção de nanopartículas encapsuladas em escala comercial |
KR101679522B1 (ko) * | 2009-04-24 | 2016-11-24 | 아이슈티카 피티와이 리미티드 | 생물학적 활성 물질의 용해 프로파일 개선방법 |
BRPI1014275B8 (pt) | 2009-04-24 | 2021-05-25 | Iceutica Pty Ltd | composição que compreende partículas de indometacina dispersas em pelo menos dois materiais de moagem parcialmente moídos |
CN102438610A (zh) | 2009-04-24 | 2012-05-02 | 伊休蒂卡有限公司 | 双氯芬酸的新剂型 |
EP2421509B1 (en) * | 2009-04-24 | 2017-11-22 | Iceutica Pty Ltd. | Production of encapsulated nanoparticles at high volume fractions |
FR2953217B1 (fr) * | 2009-11-27 | 2012-10-05 | Ifremer | Procede de depolymerisation de polysaccharides par broyage mecanique |
US8740114B2 (en) | 2010-01-07 | 2014-06-03 | Metronic Xomed, Inc. | System and method of bone processing |
US8465582B2 (en) * | 2010-03-16 | 2013-06-18 | Taipei Medical University | Process for producing inorganic interconnected 3D open cell bone substitutes |
WO2012158380A1 (en) | 2011-05-16 | 2012-11-22 | Drexel University | Disaggregation of aggregated nanodiamond clusters |
TWI580442B (zh) * | 2011-10-19 | 2017-05-01 | 傑特大學 | 醫藥毫微懸浮物 |
PL2969227T3 (pl) * | 2013-03-15 | 2019-12-31 | Sun Pharma Global Fze | Formulacja octanu abirateronu |
US20150246060A1 (en) | 2013-03-15 | 2015-09-03 | Iceutica Inc. | Abiraterone Acetate Formulation and Methods of Use |
US20150157646A1 (en) | 2013-09-27 | 2015-06-11 | Iceutica Inc. | Abiraterone Steroid Formulation |
KR101742152B1 (ko) * | 2014-02-27 | 2017-06-01 | 바로돈에스에프주식회사 | 비특이성 면역증강제 조성물 및 그 제조방법, 그리고 그 용도 |
US9526734B2 (en) | 2014-06-09 | 2016-12-27 | Iceutica Pty Ltd. | Formulation of meloxicam |
CN108697700B (zh) | 2016-02-04 | 2021-08-17 | 辛多美制药有限公司 | 氘代多潘立酮组合物和用于治疗病症的方法 |
EP3606506A4 (en) * | 2017-04-07 | 2021-01-06 | MAA Laboratories, Inc. | PROCESS FOR IMPROVING THE SOLUBILITY AND BIOAVAILABILITY OF THERAPEUTICS |
US11364226B2 (en) | 2017-06-30 | 2022-06-21 | Cinrx Pharma, Llc | Deuterated domperidone compositions, methods, and preparation |
CN107281163B (zh) * | 2017-07-05 | 2020-08-14 | 郑州大学 | 羧基化合物在促进载药纳米粒微球口服吸收方面的应用 |
CN109646423A (zh) * | 2018-12-03 | 2019-04-19 | 泓博元生命科技(深圳)有限公司 | 含nadh的生物高分子纳米球及其制备方法与应用 |
CN111481514B (zh) * | 2019-01-25 | 2023-01-10 | 鲁南制药集团股份有限公司 | 一种治疗高血脂的片剂及其制备方法 |
CN113508114B (zh) * | 2019-02-27 | 2024-03-26 | 四川科伦博泰生物医药股份有限公司 | 以氮杂环丁烷衍生物为活性成分的口服药物组合物、其制备方法及用途 |
CN110170489B (zh) * | 2019-05-31 | 2021-06-01 | 国网河南省电力公司新野县供电公司 | 一种高压配电柜带电清洗装置和方法 |
CN111939151A (zh) * | 2020-07-04 | 2020-11-17 | 浙江工业大学 | 一种复合型阿霉素白蛋白纳米粒及其制备方法和应用 |
CN114088624B (zh) * | 2021-11-09 | 2022-08-26 | 北京中检葆泰生物技术有限公司 | 用于谷物颗粒表面规则度检测设备 |
CN114166871B (zh) * | 2022-02-15 | 2022-04-26 | 西南石油大学 | 一种陆相页岩油储层脆性评价方法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2642486B2 (ja) | 1989-08-04 | 1997-08-20 | 田辺製薬株式会社 | 難溶性薬物の超微粒子化法 |
US5145684A (en) * | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
AU660852B2 (en) * | 1992-11-25 | 1995-07-06 | Elan Pharma International Limited | Method of grinding pharmaceutical substances |
US5298262A (en) * | 1992-12-04 | 1994-03-29 | Sterling Winthrop Inc. | Use of ionic cloud point modifiers to prevent particle aggregation during sterilization |
DE19932157A1 (de) * | 1999-07-13 | 2001-01-18 | Pharmasol Gmbh | Verfahren zur schonenden Herstellung von hochfeinen Mikropartikeln und Nanopartikeln |
JP4763957B2 (ja) * | 2000-05-10 | 2011-08-31 | オバン・エナジー・リミテッド | メディアミリング |
ATE424811T1 (de) * | 2000-08-31 | 2009-03-15 | Jagotec Ag | Gemahlene partikel |
DE60222160T2 (de) * | 2001-10-12 | 2008-06-12 | Elan Pharma International Ltd., Athlone | Zusammensetzungen mit einer kombination aus eigenschaften sofortiger freisetzung und kontrollierter freisetzung |
WO2003063838A1 (en) * | 2002-02-01 | 2003-08-07 | Pfizer Products Inc. | Dry granulated formulations of azithromycin |
US20070059356A1 (en) * | 2002-05-31 | 2007-03-15 | Almarsson Oern | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
WO2004058216A2 (en) * | 2002-12-17 | 2004-07-15 | Elan Pharma International Ltd. | Milling microgram quantities of nanoparticulate candidate compounds |
US20090028948A1 (en) * | 2004-12-31 | 2009-01-29 | Iceutica Pty Ltd | Nanoparticle composition and methods of synthesis thereof |
EP1973523A2 (en) | 2005-12-15 | 2008-10-01 | Acusphere, Inc. | Processes for making particle-based pharmaceutical formulations for pulmonary or nasal administration |
-
2007
- 2007-06-29 US US12/306,948 patent/US8808751B2/en active Active
- 2007-06-29 TW TW096123830A patent/TWI564033B/zh active
- 2007-06-29 NZ NZ573823A patent/NZ573823A/en unknown
- 2007-06-29 NZ NZ61499507A patent/NZ614995A/en not_active IP Right Cessation
- 2007-06-29 CN CNA2007800248024A patent/CN101568330A/zh active Pending
- 2007-06-29 TW TW104138047A patent/TWI645862B/zh active
- 2007-06-29 ZA ZA200810741A patent/ZA200810741B/xx unknown
- 2007-06-29 CN CN201410460941.3A patent/CN104288103B/zh not_active Expired - Fee Related
- 2007-06-29 NZ NZ705763A patent/NZ705763A/en not_active IP Right Cessation
- 2007-06-29 CN CN201210401138.3A patent/CN102895194B/zh not_active Expired - Fee Related
- 2007-06-29 NZ NZ599069A patent/NZ599069A/xx not_active IP Right Cessation
- 2007-06-29 BR BRPI0713053-8A patent/BRPI0713053A2/pt not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN102895194B (zh) | 2015-09-09 |
BRPI0713053A2 (pt) | 2012-07-17 |
TWI564033B (zh) | 2017-01-01 |
CN104288103A (zh) | 2015-01-21 |
US20100092563A1 (en) | 2010-04-15 |
CN102895194A (zh) | 2013-01-30 |
NZ573823A (en) | 2012-05-25 |
CN104288103B (zh) | 2019-10-15 |
NZ599069A (en) | 2013-10-25 |
TW200808377A (en) | 2008-02-16 |
US8808751B2 (en) | 2014-08-19 |
CN101568330A (zh) | 2009-10-28 |
TWI645862B (zh) | 2019-01-01 |
TW201609190A (zh) | 2016-03-16 |
NZ705763A (en) | 2016-10-28 |
NZ614995A (en) | 2015-03-27 |
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