ZA200806646B - Pyrazoloquinolones are potent parp inhibitors - Google Patents
Pyrazoloquinolones are potent parp inhibitorsInfo
- Publication number
- ZA200806646B ZA200806646B ZA200806646A ZA200806646A ZA200806646B ZA 200806646 B ZA200806646 B ZA 200806646B ZA 200806646 A ZA200806646 A ZA 200806646A ZA 200806646 A ZA200806646 A ZA 200806646A ZA 200806646 B ZA200806646 B ZA 200806646B
- Authority
- ZA
- South Africa
- Prior art keywords
- pyrazoloquinolones
- parp inhibitors
- potent parp
- potent
- inhibitors
- Prior art date
Links
- 239000012661 PARP inhibitor Substances 0.000 title 1
- 229940121906 Poly ADP ribose polymerase inhibitor Drugs 0.000 title 1
- 230000003389 potentiating effect Effects 0.000 title 1
- QKQGPTWJARHPJQ-UHFFFAOYSA-N pyrazolo[3,4-h]quinolin-2-one Chemical class C1=C2N=NC=C2C2=NC(=O)C=CC2=C1 QKQGPTWJARHPJQ-UHFFFAOYSA-N 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Ophthalmology & Optometry (AREA)
- Virology (AREA)
- Psychology (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US77351306P | 2006-02-15 | 2006-02-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200806646B true ZA200806646B (en) | 2010-01-27 |
Family
ID=38229340
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200806646A ZA200806646B (en) | 2006-02-15 | 2008-07-30 | Pyrazoloquinolones are potent parp inhibitors |
Country Status (18)
Country | Link |
---|---|
US (2) | US8546368B2 (xx) |
EP (2) | EP2468748B1 (xx) |
JP (1) | JP5242419B2 (xx) |
KR (1) | KR20080094729A (xx) |
CN (1) | CN101421268B (xx) |
AU (1) | AU2007214411B2 (xx) |
BR (1) | BRPI0707902A2 (xx) |
CA (1) | CA2641776C (xx) |
CR (1) | CR10277A (xx) |
EC (1) | ECSP088676A (xx) |
ES (2) | ES2587827T3 (xx) |
GT (1) | GT200800158A (xx) |
IL (1) | IL193272A0 (xx) |
NO (1) | NO20083923L (xx) |
RU (1) | RU2008136784A (xx) |
TW (1) | TW200811173A (xx) |
WO (1) | WO2007095628A1 (xx) |
ZA (1) | ZA200806646B (xx) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG150534A1 (en) | 2003-11-20 | 2009-03-30 | Janssen Pharmaceutica Nv | 7-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(adp- ribose) polymerase inhibitors |
KR101118582B1 (ko) | 2003-11-20 | 2012-02-27 | 얀센 파마슈티카 엔.브이. | 폴리(adp-리보스)폴리머라제 저해제로서의 6-알케닐 및6-페닐알킬 치환된 2-퀴놀리논 및 2-퀴녹살리논 |
CA2569827C (en) | 2004-06-30 | 2013-04-09 | Janssen Pharmaceutica N.V. | Quinazolinedione derivatives as parp inhibitors |
CA2569826C (en) | 2004-06-30 | 2013-07-16 | Janssen Pharmaceutica N.V. | Substituted 2-alkyl quinazolinone derivatives as parp inhibitors |
ES2563954T3 (es) | 2004-06-30 | 2016-03-16 | Janssen Pharmaceutica Nv | Derivados de ftalazina como inhibidores de PARP |
ES2381446T3 (es) | 2007-03-08 | 2012-05-28 | Janssen Pharmaceutica, N.V. | Derivado de quinolinona como inhibidores de PARP y TANK |
EP2215075B1 (en) | 2007-10-26 | 2013-12-11 | Janssen Pharmaceutica, N.V. | Quinolinone derivatives as parp inhibitors |
CA2716726C (en) * | 2008-03-27 | 2017-01-24 | Janssen Pharmaceutica Nv | Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as parp and tubulin polymerization inhibitors |
WO2009118384A1 (en) | 2008-03-27 | 2009-10-01 | Janssen Pharmaceutica Nv | Quinazolinone derivatives as tubulin polymerization inhibitors |
PT2364983E (pt) * | 2008-11-11 | 2014-01-07 | Jeil Pharmaceutical Co Ltd | Novo derivado tricíclico ou seus sais farmaceuticamente aceitáveis, seu método de preparação, e composição farmacêutica que o contém |
TWI461410B (zh) | 2008-12-30 | 2014-11-21 | Arqule Inc | 經取代之5,6-二氫-6-苯基苯並〔f〕異喹啉-2-胺化合物類 |
EP2379551A1 (en) | 2008-12-30 | 2011-10-26 | ArQule, Inc. | Substituted pyrazolo [3, 4-b]pyridine compounds |
KR101787116B1 (ko) | 2009-01-28 | 2017-10-18 | 케러 테라퓨틱스, 인코포레이티드 | 바이시클릭 피라졸로-헤테로사이클 |
US7741350B1 (en) | 2009-01-28 | 2010-06-22 | Cara Therapeutics, Inc. | Bicyclic pyrazolo-heterocycles |
AR079234A1 (es) * | 2009-12-01 | 2012-01-04 | Abbott Lab | Derivados heterociclicos condensados nitrogenados, composiciones farmaceuticas que los contienen y uso de los mismos para tratar afecciones oncologicas, del sistema nervioso y/o del sistema inmune. |
JP5892620B2 (ja) * | 2010-05-24 | 2016-03-23 | ハンデ ファーマ リミテッドHande Pharma Limited | ピラゾール誘導体 |
EP3265560B1 (en) | 2015-03-02 | 2021-12-08 | Sinai Health System | Homologous recombination factors |
CN112010850A (zh) * | 2019-05-31 | 2020-12-01 | 江苏天士力帝益药业有限公司 | 一种parp抑制剂的中间体tsl-1502m及其制备方法 |
CN114053276B (zh) * | 2020-07-30 | 2024-05-07 | 江苏天士力帝益药业有限公司 | 一种parp抑制剂tsl-1502中间体tsl-1502m的用途 |
CN114053271B (zh) * | 2020-07-30 | 2024-05-07 | 江苏天士力帝益药业有限公司 | 一种含有tsl-1502m的药物组合物及其应用 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
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US4601580A (en) | 1982-08-18 | 1986-07-22 | University Of Southampton | Measurement of oscillatory and vibrational motion |
IT1154024B (it) | 1982-09-22 | 1987-01-21 | Lepetit Spa | Derivati pridinici e procedimento per la loro produzione |
US5212310A (en) * | 1991-12-19 | 1993-05-18 | Neurogen Corporation | Certain aryl fused imidazopyrimidines; a new class of GABA brain receptor ligands |
US5677309A (en) * | 1996-03-22 | 1997-10-14 | Neurogen Corporation | 1,2,4-triazolo 4,3-c! quinazolin-3-ones and 1,2,4-triazolo 4,3-c!quinazolin-3-thiones; a new class of GABA brain receptor ligands |
GB2321130B (en) * | 1997-12-23 | 1998-12-23 | Bookham Technology Ltd | An integrated optical transceiver |
JP2000319278A (ja) | 1999-05-11 | 2000-11-21 | Ono Pharmaceut Co Ltd | 縮合ピラジン化合物およびその化合物を有効成分とする薬剤 |
IL139197A0 (en) * | 1999-10-29 | 2001-11-25 | Pfizer Prod Inc | Use of corticotropin releasing factor antagonists and related compositions |
TWI271406B (en) | 1999-12-13 | 2007-01-21 | Eisai Co Ltd | Tricyclic condensed heterocyclic compounds, preparation method of the same and pharmaceuticals comprising the same |
GB9929685D0 (en) * | 1999-12-15 | 2000-02-09 | Merck Sharp & Dohme | Therapeutic agents |
US7005430B2 (en) * | 1999-12-24 | 2006-02-28 | Kyowa Hakko Kogyo Co., Ltd. | Fused purine derivatives |
US6949648B2 (en) * | 2000-03-27 | 2005-09-27 | Takeda Pharmaceutical Company Limited | Condensed pyrazole derivatives, process for producing the same and use thereof |
AUPS019702A0 (en) * | 2002-01-29 | 2002-02-21 | Fujisawa Pharmaceutical Co., Ltd. | Condensed heterocyclic compounds |
AUPS137402A0 (en) * | 2002-03-26 | 2002-05-09 | Fujisawa Pharmaceutical Co., Ltd. | Novel tricyclic compounds |
US7222827B2 (en) * | 2002-04-19 | 2007-05-29 | Crain Enterprises, Inc. | Telescoping leg lock with thumb actuator |
EP1566380B1 (en) | 2002-11-22 | 2012-01-11 | Mitsubishi Tanabe Pharma Corporation | Isoquinoline compounds and medicinal use thereof |
US7169926B1 (en) * | 2003-08-13 | 2007-01-30 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
WO2005087775A1 (ja) | 2004-03-15 | 2005-09-22 | Ono Pharmaceutical Co., Ltd. | 三環式複素環化合物およびその化合物を有効成分として含有する医薬組成物 |
US8039464B2 (en) * | 2004-07-16 | 2011-10-18 | Proteosys Ag | Muscarinic antagonists with PARP and SIR modulating activity as agents for inflammatory diseases |
US8138173B2 (en) | 2005-04-01 | 2012-03-20 | 3M Innovative Properties Company | Pyrazolo[3,4-C]quinolines, pyrazolo[3,4-C]naphthyridines, analogs thereof, and methods |
JPWO2006112331A1 (ja) | 2005-04-13 | 2008-12-11 | 大日本住友製薬株式会社 | 新規縮合ピロール誘導体 |
AU2006289838B2 (en) | 2005-09-15 | 2011-08-18 | Aska Pharmaceutical Co., Ltd. | Heterocyclic compound, and production process and use thereof |
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2007
- 2007-02-15 CN CN200780013585.9A patent/CN101421268B/zh not_active Expired - Fee Related
- 2007-02-15 EP EP12160548.9A patent/EP2468748B1/en active Active
- 2007-02-15 AU AU2007214411A patent/AU2007214411B2/en not_active Expired - Fee Related
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- 2007-02-15 US US11/675,570 patent/US8546368B2/en active Active
- 2007-02-15 CA CA2641776A patent/CA2641776C/en not_active Expired - Fee Related
- 2007-02-15 ES ES12160548.9T patent/ES2587827T3/es active Active
- 2007-02-15 WO PCT/US2007/062260 patent/WO2007095628A1/en active Application Filing
- 2007-02-15 RU RU2008136784/04A patent/RU2008136784A/ru not_active Application Discontinuation
- 2007-02-15 JP JP2008555496A patent/JP5242419B2/ja not_active Expired - Fee Related
- 2007-02-15 BR BRPI0707902-8A patent/BRPI0707902A2/pt not_active IP Right Cessation
- 2007-02-15 TW TW096105972A patent/TW200811173A/zh unknown
- 2007-02-15 ES ES07757073.7T patent/ES2473344T3/es active Active
- 2007-02-15 KR KR1020087022538A patent/KR20080094729A/ko not_active Application Discontinuation
-
2008
- 2008-07-30 ZA ZA200806646A patent/ZA200806646B/xx unknown
- 2008-08-05 IL IL193272A patent/IL193272A0/en unknown
- 2008-08-12 EC EC2008008676A patent/ECSP088676A/es unknown
- 2008-08-14 GT GT200800158A patent/GT200800158A/es unknown
- 2008-09-09 CR CR10277A patent/CR10277A/es not_active Application Discontinuation
- 2008-09-15 NO NO20083923A patent/NO20083923L/no not_active Application Discontinuation
-
2013
- 2013-08-27 US US14/011,374 patent/US20140213610A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US8546368B2 (en) | 2013-10-01 |
KR20080094729A (ko) | 2008-10-23 |
GT200800158A (es) | 2009-07-09 |
JP5242419B2 (ja) | 2013-07-24 |
EP1989204B1 (en) | 2014-05-21 |
US20140213610A1 (en) | 2014-07-31 |
JP2009526869A (ja) | 2009-07-23 |
WO2007095628A1 (en) | 2007-08-23 |
EP2468748A1 (en) | 2012-06-27 |
ECSP088676A (es) | 2008-09-29 |
BRPI0707902A2 (pt) | 2011-05-17 |
CN101421268A (zh) | 2009-04-29 |
CR10277A (es) | 2008-10-13 |
ES2587827T3 (es) | 2016-10-27 |
AU2007214411A1 (en) | 2007-08-23 |
IL193272A0 (en) | 2009-02-11 |
ES2473344T3 (es) | 2014-07-04 |
AU2007214411B2 (en) | 2010-07-01 |
CN101421268B (zh) | 2016-01-06 |
EP1989204A1 (en) | 2008-11-12 |
NO20083923L (no) | 2008-11-04 |
TW200811173A (en) | 2008-03-01 |
CA2641776A1 (en) | 2007-08-23 |
US20070249597A1 (en) | 2007-10-25 |
EP2468748B1 (en) | 2016-05-25 |
CA2641776C (en) | 2014-04-08 |
RU2008136784A (ru) | 2010-03-20 |
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