ZA200806407B - Novel spiro [imidazolidine-4, 3'-indole] 2,2', 5(1' H)-triones for treatment of conditions associated with vanillid receptor 1 - Google Patents
Novel spiro [imidazolidine-4, 3'-indole] 2,2', 5(1' H)-triones for treatment of conditions associated with vanillid receptor 1Info
- Publication number
- ZA200806407B ZA200806407B ZA200806407A ZA200806407A ZA200806407B ZA 200806407 B ZA200806407 B ZA 200806407B ZA 200806407 A ZA200806407 A ZA 200806407A ZA 200806407 A ZA200806407 A ZA 200806407A ZA 200806407 B ZA200806407 B ZA 200806407B
- Authority
- ZA
- South Africa
- Prior art keywords
- vanillid
- triones
- imidazolidine
- indole
- receptor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US77111906P | 2006-02-07 | 2006-02-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200806407B true ZA200806407B (en) | 2009-04-29 |
Family
ID=38345567
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200806407A ZA200806407B (en) | 2006-02-07 | 2008-07-23 | Novel spiro [imidazolidine-4, 3'-indole] 2,2', 5(1' H)-triones for treatment of conditions associated with vanillid receptor 1 |
Country Status (21)
Country | Link |
---|---|
US (2) | US20070185179A1 (ko) |
EP (1) | EP2013215A4 (ko) |
JP (1) | JP2009526043A (ko) |
KR (1) | KR20080094906A (ko) |
CN (1) | CN101415711A (ko) |
AR (1) | AR059265A1 (ko) |
AU (1) | AU2007212786B2 (ko) |
BR (1) | BRPI0707423A2 (ko) |
CA (1) | CA2641632A1 (ko) |
CL (1) | CL2009000523A1 (ko) |
IL (1) | IL192890A0 (ko) |
NO (1) | NO20083547L (ko) |
NZ (1) | NZ571070A (ko) |
RU (1) | RU2421457C2 (ko) |
SA (1) | SA07280027B1 (ko) |
SG (1) | SG169387A1 (ko) |
TW (1) | TW200801011A (ko) |
UA (1) | UA93226C2 (ko) |
UY (1) | UY30132A1 (ko) |
WO (1) | WO2007091947A2 (ko) |
ZA (1) | ZA200806407B (ko) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6050238B2 (ja) * | 2011-10-19 | 2016-12-21 | 興和株式会社 | 新規なスピロインドリン化合物、及びそれを含有する医薬 |
TWI586668B (zh) * | 2012-09-06 | 2017-06-11 | 第一三共股份有限公司 | 二螺吡咯啶衍生物之結晶 |
CN108409746B (zh) * | 2018-05-15 | 2021-08-24 | 中山大学 | 一种含吡咯或吲哚并氮杂环烷结构的手性氧代螺环吲哚类化合物及其消旋体和制备方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA806623B (en) * | 1979-11-13 | 1981-12-30 | Ici Ltd | Substituted indoline-2-one derivatives |
AU532110B2 (en) * | 1979-11-13 | 1983-09-15 | Ici Ltd. | Spiro(imidazolidine-4,3:-indoline)-2,2:5-trione derivatives |
IE52879B1 (en) * | 1981-05-12 | 1988-03-30 | Ici Plc | Pharmaceutical spiro-hydantoin derivatives |
GB8331194D0 (en) | 1982-12-20 | 1983-12-29 | Ici Plc | Chemical process |
US4611062A (en) * | 1984-03-26 | 1986-09-09 | Imperial Chemical Industries Plc | Process for resolving certain spiro compounds |
WO1992007830A2 (en) | 1990-10-29 | 1992-05-14 | Pfizer Inc. | Oxindole peptide antagonists |
CA2378202A1 (en) * | 1999-07-21 | 2001-01-25 | Odd-Geir Berge | New compounds |
US7248802B2 (en) | 2002-11-27 | 2007-07-24 | Nokia Corporation | Distribution of a synchronization signal in an optical communication system |
TW200508197A (en) | 2003-03-31 | 2005-03-01 | Ucb Sa | Indolone-acetamide derivatives, processes for preparing them and their uses |
SE0301446D0 (sv) * | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | New Compounds |
AU2004247559B2 (en) | 2003-06-12 | 2009-08-27 | Astellas Pharma Inc. | Benzamide derivative or salt thereof |
GB0326633D0 (en) * | 2003-11-14 | 2003-12-17 | Merck Sharp & Dohme | Therapeutic agents |
US7879866B2 (en) | 2004-07-19 | 2011-02-01 | Dorte Xenia Gram | Inhibition of the activity of the capsaicin receptor in the treatment of obesity or obesity-related diseases and disorders |
US20090076049A1 (en) | 2006-02-07 | 2009-03-19 | Astrazeneca Ab | Novel Spiro [Imidazolidine-4, 3' -Indole] 2, 2', 5' (1H) Triones for Treatment of Conditions Associated with Vanilloid Receptor 1 |
-
2007
- 2007-01-31 AR ARP070100412A patent/AR059265A1/es not_active Application Discontinuation
- 2007-01-31 TW TW096103591A patent/TW200801011A/zh unknown
- 2007-02-05 US US11/671,153 patent/US20070185179A1/en not_active Abandoned
- 2007-02-06 AU AU2007212786A patent/AU2007212786B2/en not_active Ceased
- 2007-02-06 RU RU2008131905/04A patent/RU2421457C2/ru not_active IP Right Cessation
- 2007-02-06 UY UY30132A patent/UY30132A1/es not_active Application Discontinuation
- 2007-02-06 JP JP2008554186A patent/JP2009526043A/ja active Pending
- 2007-02-06 BR BRPI0707423-9A patent/BRPI0707423A2/pt not_active IP Right Cessation
- 2007-02-06 SA SA07280027A patent/SA07280027B1/ar unknown
- 2007-02-06 CN CNA2007800125819A patent/CN101415711A/zh active Pending
- 2007-02-06 EP EP07709323A patent/EP2013215A4/en not_active Withdrawn
- 2007-02-06 CA CA002641632A patent/CA2641632A1/en not_active Abandoned
- 2007-02-06 SG SG201100854-7A patent/SG169387A1/en unknown
- 2007-02-06 NZ NZ571070A patent/NZ571070A/en unknown
- 2007-02-06 WO PCT/SE2007/000107 patent/WO2007091947A2/en active Application Filing
- 2007-02-06 KR KR1020087019272A patent/KR20080094906A/ko not_active Application Discontinuation
- 2007-06-02 UA UAA200809311A patent/UA93226C2/ru unknown
-
2008
- 2008-07-17 IL IL192890A patent/IL192890A0/en unknown
- 2008-07-23 ZA ZA200806407A patent/ZA200806407B/xx unknown
- 2008-08-14 NO NO20083547A patent/NO20083547L/no not_active Application Discontinuation
- 2008-11-20 US US12/274,837 patent/US7868181B2/en not_active Expired - Fee Related
-
2009
- 2009-03-05 CL CL2009000523A patent/CL2009000523A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
NZ571070A (en) | 2011-07-29 |
SA07280027B1 (ar) | 2010-11-22 |
WO2007091947A3 (en) | 2007-10-04 |
TW200801011A (en) | 2008-01-01 |
EP2013215A2 (en) | 2009-01-14 |
NO20083547L (no) | 2008-11-05 |
CA2641632A1 (en) | 2007-08-16 |
BRPI0707423A2 (pt) | 2011-05-03 |
AR059265A1 (es) | 2008-03-19 |
CN101415711A (zh) | 2009-04-22 |
UA93226C2 (en) | 2011-01-25 |
AU2007212786A1 (en) | 2007-08-16 |
JP2009526043A (ja) | 2009-07-16 |
EP2013215A4 (en) | 2010-09-08 |
KR20080094906A (ko) | 2008-10-27 |
AU2007212786B2 (en) | 2011-06-02 |
IL192890A0 (en) | 2009-02-11 |
SG169387A1 (en) | 2011-03-30 |
US20090137650A1 (en) | 2009-05-28 |
RU2421457C2 (ru) | 2011-06-20 |
US7868181B2 (en) | 2011-01-11 |
CL2009000523A1 (es) | 2009-07-17 |
RU2008131905A (ru) | 2010-03-20 |
AU2007212786A8 (en) | 2010-05-06 |
US20070185179A1 (en) | 2007-08-09 |
WO2007091947A8 (en) | 2008-08-07 |
UY30132A1 (es) | 2009-07-17 |
WO2007091947A2 (en) | 2007-08-16 |
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