ZA200805915B - Thiophenyl and pyrrolyl azepines as serotonin 5-HT2c receptor ligands and uses thereof - Google Patents

Thiophenyl and pyrrolyl azepines as serotonin 5-HT2c receptor ligands and uses thereof

Info

Publication number
ZA200805915B
ZA200805915B ZA200805915A ZA200805915A ZA200805915B ZA 200805915 B ZA200805915 B ZA 200805915B ZA 200805915 A ZA200805915 A ZA 200805915A ZA 200805915 A ZA200805915 A ZA 200805915A ZA 200805915 B ZA200805915 B ZA 200805915B
Authority
ZA
South Africa
Prior art keywords
azepines
thiophenyl
serotonin
pyrrolyl
receptor ligands
Prior art date
Application number
ZA200805915A
Other languages
English (en)
Inventor
Tumey L Nathan
David C Bom
Youssef L Bennani
Michael J Robarge
Original Assignee
Athersys Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Athersys Inc filed Critical Athersys Inc
Publication of ZA200805915B publication Critical patent/ZA200805915B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/06—Peri-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Addiction (AREA)
  • Plant Pathology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Endocrinology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Emergency Medicine (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
ZA200805915A 2006-01-19 2008-07-07 Thiophenyl and pyrrolyl azepines as serotonin 5-HT2c receptor ligands and uses thereof ZA200805915B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US76024006P 2006-01-19 2006-01-19

Publications (1)

Publication Number Publication Date
ZA200805915B true ZA200805915B (en) 2009-04-29

Family

ID=38288237

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200805915A ZA200805915B (en) 2006-01-19 2008-07-07 Thiophenyl and pyrrolyl azepines as serotonin 5-HT2c receptor ligands and uses thereof

Country Status (17)

Country Link
US (3) US7893051B2 (de)
EP (1) EP1981337B1 (de)
JP (1) JP5188986B2 (de)
KR (2) KR20080107375A (de)
CN (1) CN101404882A (de)
AR (1) AR059076A1 (de)
AU (1) AU2007207508B2 (de)
BR (1) BRPI0707183A2 (de)
CA (1) CA2636992C (de)
IL (1) IL192744A0 (de)
MX (1) MX2008009178A (de)
NO (1) NO20083481L (de)
NZ (1) NZ569554A (de)
RU (1) RU2434872C2 (de)
TW (1) TWI402272B (de)
WO (1) WO2007084622A2 (de)
ZA (1) ZA200805915B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100266504A1 (en) 2007-11-15 2010-10-21 Takahiro Matsumoto Condensed pyridine derivative and use thereof
JPWO2011071136A1 (ja) 2009-12-11 2013-04-22 アステラス製薬株式会社 線維筋痛症治療剤
US8217183B2 (en) * 2010-05-18 2012-07-10 Corning Incorporated Methods of making fused thiophenes
WO2012030953A1 (en) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists in the treatment of disorders ameliorated by reduction of norepinephrine level
US8901114B2 (en) 2011-03-08 2014-12-02 Sanofi Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof
WO2012120055A1 (de) 2011-03-08 2012-09-13 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2683700B1 (de) 2011-03-08 2015-02-18 Sanofi Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8828994B2 (en) 2011-03-08 2014-09-09 Sanofi Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
US8828995B2 (en) 2011-03-08 2014-09-09 Sanofi Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
JP6198715B2 (ja) 2012-03-06 2017-09-20 武田薬品工業株式会社 三環性化合物
WO2014159067A1 (en) * 2013-03-13 2014-10-02 Abt Holding Company Thienylindole azepines as serotonin 5-ht2c receptor ligands and uses thereof
WO2015066344A1 (en) 2013-11-01 2015-05-07 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists and compositions and methods of use

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3652588A (en) * 1969-10-23 1972-03-28 Upjohn Co 6-alkyl-1 2 3 4 5 6-hexahydroazepino(4 5-b)indoles
ZA821020B (en) * 1981-02-18 1983-10-26 Thomae Gmbh Dr K Azepine derivatives, process for their preparation and pharmaceutical compositions thereof
CH649553A5 (de) * 1982-05-06 1985-05-31 Sandoz Ag Azepinoindole und verfahren zu deren herstellung.
DE3230696A1 (de) 1982-08-18 1984-02-23 Dr. Karl Thomae Gmbh, 7950 Biberach Neue thieno-thiazol-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
GB8800891D0 (en) * 1988-01-15 1988-02-17 Lilly Industries Ltd Pharmaceutical compounds
GB9025890D0 (en) 1990-11-28 1991-01-09 Lilly Industries Ltd Pharmaceutical compounds
CA2104371A1 (en) 1991-12-26 1993-06-27 Tohru Nakao Condensed thiophene compound and pharmaceutical use thereof
US5532240A (en) 1991-12-26 1996-07-02 Yoshitomi Pharmaceutical Industries, Ltd. Condensed thiophene compound and pharmaceutical use thereof
EP0785939A1 (de) 1994-10-11 1997-07-30 Takeda Chemical Industries, Ltd. Substituierte heterobicyclische alkylamine und ihre verwendung als squalenoxidcyclase-inhibitoren
US6407092B1 (en) * 1999-04-23 2002-06-18 Pharmacia & Upjohn Company Tetracyclic azepinoindole compounds
PE20010052A1 (es) * 1999-04-23 2001-01-27 Upjohn Co Compuestos de azepinindol tetraciclico como agonistas o antagonistas del receptor de 5-ht
BR0012086A (pt) * 1999-06-15 2002-04-02 Bristol Myers Squibb Pharma Co Compostos derivados de gama-carbolinas fundidas com heterociclos substituìdos, composição farmacêutica e usos dos compostos
JP2004509894A (ja) * 2000-09-20 2004-04-02 ファルマシア・アンド・アップジョン・カンパニー 置換アゼピノ［４，５−ｂ］インドリン誘導体
ATE297734T1 (de) * 2000-12-22 2005-07-15 Hoffmann La Roche Tetrahydro-(benzo- oder thieno-)azepin-pyrazin und triazinderivative als mglur 1 antagonisten
DE60325985D1 (de) 2002-09-12 2009-03-12 Merck & Co Inc Substituierte bizyklische thiophen-derivate, diese verbindungen enthaltende zusammensetzungen und anwendungsverfahren
CN1805938B (zh) 2003-06-17 2010-06-16 艾尼纳制药公司 用于治疗5ht2c受体相关疾病的苯并氮杂卓衍生物
ES2571220T3 (es) 2003-06-17 2016-05-24 Arena Pharm Inc Clorhidrato de 8-cloro-1-metil-2,3,4,5-tetrahidro-1H-3-benzazepina
AU2004283196B2 (en) 2003-09-17 2011-08-25 Janssen Pharmaceutica, N.V. Fused heterocyclic compounds
US20070275949A1 (en) 2003-10-22 2007-11-29 Arena Pharmaceuticals, Inc. Benzazepine Derivatives and Methods of Prophylaxis or Treatment of 5Ht2C Receptor Associated Diseases
WO2005042491A1 (en) 2003-10-22 2005-05-12 Arena Pharmaceuticals, Inc. Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases
RU2485125C2 (ru) * 2004-06-30 2013-06-20 Эсерсис, Инк. ЗАМЕЩЕННЫЕ ПРОИЗВОДНЫЕ АЗЕПИНА, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЙ, РАССТРОЙСТВ И/ИЛИ ПАТОЛОГИЧЕСКИХ СОСТОЯНИЙ, ПРИ КОТОРЫХ ЖЕЛАТЕЛЬНО МОДУЛИРОВАНИЕ ФУНКЦИИ 5HT2c-РЕЦЕПТОРОВ

Also Published As

Publication number Publication date
EP1981337A2 (de) 2008-10-22
WO2007084622A2 (en) 2007-07-26
US20070191342A1 (en) 2007-08-16
MX2008009178A (es) 2008-12-05
US7893051B2 (en) 2011-02-22
KR20080107375A (ko) 2008-12-10
RU2008133980A (ru) 2010-02-27
EP1981337B1 (de) 2015-09-02
AU2007207508B2 (en) 2011-08-18
KR101503681B1 (ko) 2015-03-19
TW200738732A (en) 2007-10-16
BRPI0707183A2 (pt) 2011-04-26
CA2636992A1 (en) 2007-07-26
US8716276B2 (en) 2014-05-06
NZ569554A (en) 2011-10-28
JP5188986B2 (ja) 2013-04-24
TWI402272B (zh) 2013-07-21
NO20083481L (no) 2008-08-12
AR059076A1 (es) 2008-03-12
EP1981337A4 (de) 2010-08-11
CN101404882A (zh) 2009-04-08
IL192744A0 (en) 2009-02-11
KR20140062185A (ko) 2014-05-22
AU2007207508A1 (en) 2007-07-26
RU2434872C2 (ru) 2011-11-27
JP2009523809A (ja) 2009-06-25
WO2007084622A3 (en) 2007-12-21
US20110112072A1 (en) 2011-05-12
US20140206672A1 (en) 2014-07-24
CA2636992C (en) 2015-10-06

Similar Documents

Publication Publication Date Title
ZA200805915B (en) Thiophenyl and pyrrolyl azepines as serotonin 5-HT2c receptor ligands and uses thereof
HK1205960A1 (en) Sustained-release drug carrier composition
IL202826A0 (en) New compounds and their uses 708
TWI372079B (en) Microspheres
IL190587A0 (en) Substituted benzofused derivatives and their use as vanilliod receptor ligands
TWI347842B (en) Tricyclic compounds, compositions, and methods
PL2026902T3 (pl) Mikrosfery
ZA200807758B (en) Microspheres
GB0711952D0 (en) Microspheres
EP2222165A4 (de) Neue verbindungen als cannabinoidrezeptorliganden und ihre verwendungen
EP2128647A4 (de) Emblem
TWI368617B (en) Thiophene compounds and thrombopoietin receptor activators
IL208754A (en) Benzothiophene compounds and their uses
SI2234976T1 (sl) Novi s pirazolom substituirani arilamidi
PT2752439T (pt) Polímeros de redução de arrasto não polialfaolefínicos dispersos
EP2094695A4 (de) Tetrahydro-5h-pyrido[2,3-d]azepine als 5-ht2c-liganden
ZA200807960B (en) Catalyst composition
EP2127745A4 (de) Katalysatorzusammensetzung
IL201015A0 (en) New compounds and their uses 707
HK1081060A2 (en) Soap bar composition
GB2436937B (en) Garment hanger with wall-mountable carrier
GB0714093D0 (en) Stationary item
GB0624987D0 (en) Novel aminoguanidines as melanocortin receptor ligands
GB2437738B (en) Coat hook
GB0615157D0 (en) Cylinder carrier