ZA200804607B - Substituted aminophenylsulfonamide compounds as HIV protease inhibitor - Google Patents

Substituted aminophenylsulfonamide compounds as HIV protease inhibitor

Info

Publication number
ZA200804607B
ZA200804607B ZA200804607A ZA200804607A ZA200804607B ZA 200804607 B ZA200804607 B ZA 200804607B ZA 200804607 A ZA200804607 A ZA 200804607A ZA 200804607 A ZA200804607 A ZA 200804607A ZA 200804607 B ZA200804607 B ZA 200804607B
Authority
ZA
South Africa
Prior art keywords
protease inhibitor
hiv protease
compounds
substituted
substituted aminophenylsulfonamide
Prior art date
Application number
ZA200804607A
Other languages
English (en)
Inventor
De Kock Herman Augustinus
Jonckers Tim Hugo Maria
Last Stefaan Julien
Boonants Paul Jozef Gabriel Maria
Surleraux Dominique Louis Nestor Ghislain
Wigerinck Piet Tom Bert Paul
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36217947&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA200804607(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Publication of ZA200804607B publication Critical patent/ZA200804607B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
ZA200804607A 2005-11-28 2008-05-27 Substituted aminophenylsulfonamide compounds as HIV protease inhibitor ZA200804607B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05111394 2005-11-28

Publications (1)

Publication Number Publication Date
ZA200804607B true ZA200804607B (en) 2009-10-28

Family

ID=36217947

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200804607A ZA200804607B (en) 2005-11-28 2008-05-27 Substituted aminophenylsulfonamide compounds as HIV protease inhibitor

Country Status (12)

Country Link
US (1) US8084494B2 (de)
EP (1) EP1960404B1 (de)
JP (1) JP5279503B2 (de)
CN (1) CN101316850A (de)
AR (1) AR057182A1 (de)
AU (1) AU2006316403B2 (de)
BR (1) BRPI0619011A2 (de)
CA (1) CA2628542A1 (de)
EA (1) EA017138B1 (de)
TW (1) TWI385173B (de)
WO (1) WO2007060253A1 (de)
ZA (1) ZA200804607B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI482775B (zh) 2008-09-01 2015-05-01 Tibotec Pharm Ltd 用於製備（３ｒ，３ａｓ，６ａｒ）－六氫呋喃并〔２，３－ｂ〕呋喃－３－基（１ｓ，２ｒ）－３－〔〔（４－胺基苯基）磺醯基〕（異丁基）胺基〕－１－苯甲基－２－羥基丙基胺基甲酸酯之方法
US8921415B2 (en) 2009-01-29 2014-12-30 Mapi Pharma Ltd. Polymorphs of darunavir
CN102686594A (zh) 2009-12-16 2012-09-19 熙德隆研究基金会 地瑞那韦的多晶型物
ES2516916T3 (es) 2010-01-28 2014-10-31 Mapi Pharma Limited Procedimiento para la preparación de darunavir e intermedios de darunavir
EP2571355B1 (de) 2010-05-20 2016-09-07 Hetero Research Foundation Kristallines hydrochloridsalz von darunavir
CN102617586B (zh) * 2011-01-26 2016-04-06 浙江九洲药业股份有限公司 地瑞那韦中间体的制备方法
WO2018091559A1 (en) 2016-11-17 2018-05-24 Janssen Sciences Ireland Uc A simplified procedure for the preparation of darunavir

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5723490A (en) * 1992-09-08 1998-03-03 Vertex Pharmaceuticals Incorporated THF-containing sulfonamide inhibitors of aspartyl protease
US5831117A (en) 1995-01-20 1998-11-03 G. D. Searle & Co. Method of preparing retroviral protease inhibitor intermediates
US6436989B1 (en) 1997-12-24 2002-08-20 Vertex Pharmaceuticals, Incorporated Prodrugs of aspartyl protease inhibitors
AU2012199A (en) 1997-12-24 1999-07-19 Vertex Pharmaceuticals Incorporated Prodrugs of aspartyl protease inhibitors
CA2316218A1 (en) 1997-12-24 1999-07-08 Vertex Pharmaceuticals Incorporated Prodrugs of aspartyl protease inhibitors
WO1999033792A2 (en) 1997-12-24 1999-07-08 Vertex Pharmaceuticals Incorporated Prodrugs os aspartyl protease inhibitors
BR9912169A (pt) * 1998-06-19 2001-04-10 Vertex Pharma Inibidores de sulfonamida de protease de aspartil
WO1999067254A2 (en) * 1998-06-23 1999-12-29 The United States Of America Represented By The Secretary, Department Of Health And Human Services Multi-drug resistant retroviral protease inhibitors and use thereof
TWI286476B (en) * 2001-12-12 2007-09-11 Tibotec Pharm Ltd Combination of cytochrome P450 dependent protease inhibitors
US7157489B2 (en) * 2002-03-12 2007-01-02 The Board Of Trustees Of The University Of Illinois HIV protease inhibitors
US7462608B2 (en) 2002-04-26 2008-12-09 Gilead Sciences, Inc. Non nucleoside reverse transcriptase inhibitors

Also Published As

Publication number Publication date
JP5279503B2 (ja) 2013-09-04
US20080269322A1 (en) 2008-10-30
AR057182A1 (es) 2007-11-21
JP2009517371A (ja) 2009-04-30
AU2006316403B2 (en) 2012-09-06
EP1960404A1 (de) 2008-08-27
AU2006316403A1 (en) 2007-05-31
EP1960404B1 (de) 2015-06-17
BRPI0619011A2 (pt) 2013-04-02
US8084494B2 (en) 2011-12-27
CN101316850A (zh) 2008-12-03
CA2628542A1 (en) 2007-05-31
EA017138B1 (ru) 2012-10-30
EA200801476A1 (ru) 2009-02-27
TWI385173B (zh) 2013-02-11
WO2007060253A1 (en) 2007-05-31
TW200801015A (en) 2008-01-01

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