ZA200801875B - Isoquinolines as IGF-IR inhibitors - Google Patents
Isoquinolines as IGF-IR inhibitorsInfo
- Publication number
- ZA200801875B ZA200801875B ZA200801875A ZA200801875A ZA200801875B ZA 200801875 B ZA200801875 B ZA 200801875B ZA 200801875 A ZA200801875 A ZA 200801875A ZA 200801875 A ZA200801875 A ZA 200801875A ZA 200801875 B ZA200801875 B ZA 200801875B
- Authority
- ZA
- South Africa
- Prior art keywords
- igf
- isoquinolines
- inhibitors
- receptor
- inhibit
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
- C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2005002701 | 2005-09-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200801875B true ZA200801875B (en) | 2009-08-26 |
Family
ID=36350070
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200801875A ZA200801875B (en) | 2005-09-09 | 2008-02-28 | Isoquinolines as IGF-IR inhibitors |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8044067B2 (ru) |
| EP (1) | EP1931636B1 (ru) |
| JP (1) | JP2009507819A (ru) |
| KR (1) | KR20080042897A (ru) |
| CN (1) | CN101258130B (ru) |
| AT (1) | ATE505457T1 (ru) |
| AU (1) | AU2006288846B2 (ru) |
| BR (1) | BRPI0616732A2 (ru) |
| CA (1) | CA2621836C (ru) |
| DE (1) | DE602006021327D1 (ru) |
| DK (1) | DK1931636T3 (ru) |
| EA (1) | EA200800785A1 (ru) |
| ES (1) | ES2364673T3 (ru) |
| HK (1) | HK1115500A1 (ru) |
| IL (1) | IL189883A (ru) |
| NO (1) | NO20081207L (ru) |
| NZ (1) | NZ566524A (ru) |
| WO (1) | WO2007029106A1 (ru) |
| ZA (1) | ZA200801875B (ru) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011112666A1 (en) | 2010-03-09 | 2011-09-15 | OSI Pharmaceuticals, LLC | Combination anti-cancer therapy |
| AU2012212075A1 (en) | 2011-02-02 | 2013-07-18 | Amgen Inc. | Methods and compositons relating to inhibition of IGF-1R |
| US20140045847A1 (en) * | 2011-04-21 | 2014-02-13 | Piramal Enterprises Limited | Crystalline form of a salt of a morpholino sulfonyl indole derivative and a process for its preparation |
| AU2012335541B2 (en) | 2011-11-11 | 2017-07-06 | Duke University | Combination drug therapy for the treatment of solid tumors |
| US8980259B2 (en) | 2012-07-20 | 2015-03-17 | Novartis Ag | Combination therapy |
| CN104672136B (zh) * | 2013-11-30 | 2017-01-25 | 沈阳药科大学 | 1‑取代菲基‑n‑烷基(酰基)‑6,7‑二甲氧基‑1,2,3,4‑四氢异喹啉衍生物及其制备方法和用途 |
| WO2017129763A1 (en) | 2016-01-28 | 2017-08-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of signet ring cell gastric cancer |
| WO2020191151A1 (en) * | 2019-03-19 | 2020-09-24 | Oncovalent Therapeutics Inc. | Sumo inhibitor compounds and uses thereof |
| CN114456184B (zh) * | 2022-02-21 | 2023-08-22 | 南华大学附属第一医院 | 一种3-芳基异喹啉衍生物及其制备与应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20080065707A (ko) * | 1999-11-03 | 2008-07-14 | 에이엠알 테크놀로지, 인크. | 4-페닐-치환 테트라히드로이소퀴놀린, 및 노르에피네프린과도파민과 세로토닌의 재흡수를 차단하기 위한 이의 용도 |
| SE0203746D0 (sv) * | 2002-12-18 | 2002-12-18 | Karolinska Innovations Ab | New compounds |
| ATE384700T1 (de) * | 2004-03-12 | 2008-02-15 | Analytecon Sa | Tetrahydroisochinolin- und tetrahydrobenzazepin derivative als igf-1r inhibitoren |
-
2006
- 2006-09-08 DE DE602006021327T patent/DE602006021327D1/de active Active
- 2006-09-08 EA EA200800785A patent/EA200800785A1/ru unknown
- 2006-09-08 US US11/991,431 patent/US8044067B2/en not_active Expired - Fee Related
- 2006-09-08 NZ NZ566524A patent/NZ566524A/en not_active IP Right Cessation
- 2006-09-08 KR KR1020087006671A patent/KR20080042897A/ko not_active Application Discontinuation
- 2006-09-08 CN CN2006800329830A patent/CN101258130B/zh not_active Expired - Fee Related
- 2006-09-08 DK DK06795448.7T patent/DK1931636T3/da active
- 2006-09-08 AT AT06795448T patent/ATE505457T1/de not_active IP Right Cessation
- 2006-09-08 ES ES06795448T patent/ES2364673T3/es active Active
- 2006-09-08 EP EP06795448A patent/EP1931636B1/en active Active
- 2006-09-08 WO PCT/IB2006/002473 patent/WO2007029106A1/en active Application Filing
- 2006-09-08 CA CA2621836A patent/CA2621836C/en not_active Expired - Fee Related
- 2006-09-08 BR BRPI0616732-2A patent/BRPI0616732A2/pt active Search and Examination
- 2006-09-08 AU AU2006288846A patent/AU2006288846B2/en not_active Ceased
- 2006-09-08 JP JP2008529710A patent/JP2009507819A/ja active Pending
-
2008
- 2008-02-28 ZA ZA200801875A patent/ZA200801875B/xx unknown
- 2008-03-02 IL IL189883A patent/IL189883A/en not_active IP Right Cessation
- 2008-03-07 NO NO20081207A patent/NO20081207L/no not_active Application Discontinuation
- 2008-09-29 HK HK08110849.4A patent/HK1115500A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK1931636T3 (da) | 2011-07-25 |
| EP1931636B1 (en) | 2011-04-13 |
| US20090099229A1 (en) | 2009-04-16 |
| NZ566524A (en) | 2011-01-28 |
| AU2006288846B2 (en) | 2011-08-18 |
| NO20081207L (no) | 2008-05-27 |
| ATE505457T1 (de) | 2011-04-15 |
| WO2007029106A1 (en) | 2007-03-15 |
| DE602006021327D1 (de) | 2011-05-26 |
| KR20080042897A (ko) | 2008-05-15 |
| AU2006288846A1 (en) | 2007-03-15 |
| CN101258130B (zh) | 2012-11-28 |
| CA2621836A1 (en) | 2007-03-15 |
| JP2009507819A (ja) | 2009-02-26 |
| IL189883A0 (en) | 2008-11-03 |
| HK1115500A1 (en) | 2008-11-28 |
| EP1931636A1 (en) | 2008-06-18 |
| BRPI0616732A2 (pt) | 2013-01-01 |
| EA200800785A1 (ru) | 2008-08-29 |
| CN101258130A (zh) | 2008-09-03 |
| US8044067B2 (en) | 2011-10-25 |
| IL189883A (en) | 2012-07-31 |
| ES2364673T3 (es) | 2011-09-12 |
| CA2621836C (en) | 2013-11-12 |
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