ZA200801511B - Novel diazaspiroalkanes and their use for treatment of CCR8 medicated diseases - Google Patents

Novel diazaspiroalkanes and their use for treatment of CCR8 medicated diseases

Info

Publication number
ZA200801511B
ZA200801511B ZA200801511A ZA200801511A ZA200801511B ZA 200801511 B ZA200801511 B ZA 200801511B ZA 200801511 A ZA200801511 A ZA 200801511A ZA 200801511 A ZA200801511 A ZA 200801511A ZA 200801511 B ZA200801511 B ZA 200801511B
Authority
ZA
South Africa
Prior art keywords
ccr8
treatment
diazaspiroalkanes
novel
medicated diseases
Prior art date
Application number
ZA200801511A
Other languages
English (en)
Inventor
Boerjesson Lena
Johansson Henrik
Linnanen Tero
Skrinjar Marco
Connolly Stephen
Kristoffersson Anna
Shamovsky Igor
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of ZA200801511B publication Critical patent/ZA200801511B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ZA200801511A 2005-09-06 2008-02-14 Novel diazaspiroalkanes and their use for treatment of CCR8 medicated diseases ZA200801511B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0501967 2005-09-06

Publications (1)

Publication Number Publication Date
ZA200801511B true ZA200801511B (en) 2008-11-26

Family

ID=37836107

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200801511A ZA200801511B (en) 2005-09-06 2008-02-14 Novel diazaspiroalkanes and their use for treatment of CCR8 medicated diseases

Country Status (17)

Country Link
US (1) US20090156575A1 (fr)
EP (1) EP1926730A4 (fr)
JP (1) JP2009507070A (fr)
KR (1) KR20080043396A (fr)
CN (1) CN101305005A (fr)
AR (1) AR055630A1 (fr)
AU (1) AU2006287976A1 (fr)
BR (1) BRPI0615634A2 (fr)
CA (1) CA2621187A1 (fr)
EC (1) ECSP088329A (fr)
IL (1) IL189528A0 (fr)
NO (1) NO20081729L (fr)
RU (1) RU2008110915A (fr)
TW (1) TW200800999A (fr)
UY (1) UY29781A1 (fr)
WO (1) WO2007030061A1 (fr)
ZA (1) ZA200801511B (fr)

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US8796297B2 (en) 2009-06-30 2014-08-05 Abbvie Inc. 4-substituted-2-amino-pyrimidine derivatives
KR101509809B1 (ko) * 2009-12-01 2015-04-08 현대자동차주식회사 차량의 커튼에어백용 램프브라켓
CN102933579B (zh) 2009-12-17 2015-07-15 贝林格尔.英格海姆国际有限公司 新的ccr2受体拮抗剂及其用途
WO2011115813A1 (fr) 2010-03-18 2011-09-22 Abbott Laboratories Acétamides de lactame en tant que bloqueurs des canaux calciques
WO2011151251A1 (fr) 2010-06-01 2011-12-08 Boehringer Ingelheim International Gmbh Nouveaux antagonistes du ccr2
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US8299117B2 (en) 2010-06-16 2012-10-30 Metabolex Inc. GPR120 receptor agonists and uses thereof
CN102796100B (zh) * 2011-05-27 2015-05-06 中国医学科学院医药生物技术研究所 一种取代苯基-(二氮杂螺环-n)-甲酮类衍生物
EP2641903B1 (fr) 2012-03-19 2014-10-22 Symrise AG Dérivés de dihydrobenzofuranes en tant que parfums et/ou arômes
AU2013276617B9 (en) * 2012-06-13 2018-03-29 F. Hoffmann-La Roche Ag New diazaspirocycloalkane and azaspirocycloalkane
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CN102942570A (zh) * 2012-12-05 2013-02-27 武汉药明康德新药开发有限公司 1-三氟甲基-2,8-二氮杂-螺[4.5]癸烷衍生物及其制备方法
AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
MY187449A (en) 2013-11-26 2021-09-22 Hoffmann La Roche New octahydro-cyclobuta [1,2-c;3,4-c']dipyrrol-2-yl
PE20161223A1 (es) 2014-03-26 2016-11-12 Hoffmann La Roche Compuestos condensados de [1,4]diazepina como inhibidores de la produccion de autotaxina (atx) y acido lisofosfatidico (lpa)
DK3122750T3 (da) 2014-03-26 2019-11-04 Hoffmann La Roche Bicykliske forbindelser som autotaxin (ATX)- og lysofosfatidsyre (LPA)-produktionshæmmere
SI3169666T1 (en) 2014-07-15 2018-08-31 Gruenenthal Gmbh SUBSTITUTED DERIVATIVES AZASPIRO (4.5) DECAN
TW201607923A (zh) 2014-07-15 2016-03-01 歌林達有限公司 被取代之氮螺環（４．５）癸烷衍生物
JP6601707B2 (ja) * 2015-02-15 2019-11-06 国立大学法人金沢大学 線維化判定方法
MA41898A (fr) 2015-04-10 2018-02-13 Hoffmann La Roche Dérivés de quinazolinone bicyclique
ES2811098T3 (es) 2015-07-02 2021-03-10 Centrexion Therapeutics Corp Citrato de (4-((3r,4r)-3-metoxitetrahidro-pirano-4-ilamino)piperidin-1-il)(5-metil-6-(((2r, 6s)-6-(p-tolil)tetrahidro-2hpirano-2-il) metilamino)pirimidin-4il) metanona
JP6886967B2 (ja) 2015-09-04 2021-06-16 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ フェノキシメチル誘導体
BR112018006024A2 (pt) 2015-09-24 2020-05-12 F. Hoffmann-La Roche Ag Compostos bicíclicos como inibidores de atx
CN107614505B (zh) 2015-09-24 2021-05-07 豪夫迈·罗氏有限公司 作为双重atx/ca抑制剂的新型二环化合物
MA42923A (fr) 2015-09-24 2021-04-28 Hoffmann La Roche Composés bicycliques comme inhibiteurs mixtes de atx/ca
JP6876685B2 (ja) 2015-09-24 2021-05-26 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ａｔｘ阻害剤としての二環式化合物
CN106908559B (zh) * 2015-12-23 2020-08-11 重庆华邦胜凯制药有限公司 卡泊三醇中间体l及相关杂质的分离与测定方法
EA038164B1 (ru) * 2016-11-08 2021-07-16 Бристол-Маерс Сквибб Компани 3-замещенные пропановые кислоты в качестве ингибиторов интегрина v
CN108456208B (zh) * 2017-02-22 2021-04-16 广州市恒诺康医药科技有限公司 氮杂螺环类化合物及其制备方法和应用
CN106928092B (zh) * 2017-02-28 2019-02-15 上海微巨实业有限公司 一种间氰甲基苯甲酸甲酯的制备方法
WO2018167113A1 (fr) 2017-03-16 2018-09-20 F. Hoffmann-La Roche Ag Nouveaux composés bicycliques utilisés en tant qu'inhibiteurs d'atx
WO2018166855A1 (fr) 2017-03-16 2018-09-20 Basf Se Dihydroisoxazoles à substitution hétérobicyclique
RU2019132254A (ru) 2017-03-16 2021-04-16 Ф. Хоффманн-Ля Рош Аг Гетероциклические соединения, пригодные в качестве дуальных ингибиторов atx/ca
WO2019084075A1 (fr) * 2017-10-24 2019-05-02 The Trustees Of The University Of Pennsylvania Antagonistes sélectifs du récepteur de la dopamine et leurs procédés d'utilisation
JP2021516229A (ja) 2018-02-28 2021-07-01 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 低親和性ポリ（ａｄ−リボース）ポリメラーゼ１依存性細胞毒性剤
WO2020048828A1 (fr) 2018-09-03 2020-03-12 Bayer Pharma Aktiengesellschaft Composés du 5-hétéroaryl-3,9-diazaspiro[5.5]undécane
WO2020048827A1 (fr) 2018-09-03 2020-03-12 Bayer Aktiengesellschaft Composés de la 1,3,9-triazaspiro[5.5]undécan-2-one
WO2020048829A1 (fr) 2018-09-03 2020-03-12 Bayer Aktiengesellschaft Composés de 3,9-diazaspiro[5.5]undécane
CN110963955A (zh) * 2018-09-30 2020-04-07 南京富润凯德生物医药有限公司 一种单氟代螺环化合物的合成方法及其中间体
CN111087336A (zh) * 2018-10-24 2020-05-01 南京富润凯德生物医药有限公司 一种双氟代螺环化合物的合成方法及其中间体
US20230064809A1 (en) 2019-11-28 2023-03-02 Bayer Aktiengesellschaft Substituted aminoquinolones as dgkalpha inhibitors for immune activation
JP2023504249A (ja) 2019-11-28 2023-02-02 バイエル・アクチエンゲゼルシヤフト 免疫活性化のためのｄｇｋアルファ阻害剤としての置換アミノキノロン類
KR20230035602A (ko) * 2020-07-03 2023-03-14 난징 이뮤노파지 바이오테크 코., 엘티디. CCR8 억제제로 Tregs를 표적화하는 방법 및 조성물
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Also Published As

Publication number Publication date
JP2009507070A (ja) 2009-02-19
CA2621187A1 (fr) 2007-03-15
US20090156575A1 (en) 2009-06-18
TW200800999A (en) 2008-01-01
RU2008110915A (ru) 2009-10-20
NO20081729L (no) 2008-05-16
AU2006287976A1 (en) 2007-03-15
AR055630A1 (es) 2007-08-29
EP1926730A1 (fr) 2008-06-04
WO2007030061A1 (fr) 2007-03-15
BRPI0615634A2 (pt) 2011-05-24
EP1926730A4 (fr) 2011-02-16
IL189528A0 (en) 2008-08-07
CN101305005A (zh) 2008-11-12
ECSP088329A (es) 2008-04-28
UY29781A1 (es) 2007-04-30
KR20080043396A (ko) 2008-05-16

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