ZA200801034B - Bicyclic piperazines as metabotropic glutamate receptor antagonists - Google Patents

Bicyclic piperazines as metabotropic glutamate receptor antagonists

Info

Publication number
ZA200801034B
ZA200801034B ZA200801034A ZA200801034A ZA200801034B ZA 200801034 B ZA200801034 B ZA 200801034B ZA 200801034 A ZA200801034 A ZA 200801034A ZA 200801034 A ZA200801034 A ZA 200801034A ZA 200801034 B ZA200801034 B ZA 200801034B
Authority
ZA
South Africa
Prior art keywords
receptor antagonists
glutamate receptor
metabotropic glutamate
piperazines
bicyclic
Prior art date
Application number
ZA200801034A
Other languages
English (en)
Inventor
Edwards Louise
Isaac Methvin
Slassi Abdelmalik
Sun Guang-Ri
Xin Tao
Minidis Alexander
Dove Peter
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of ZA200801034B publication Critical patent/ZA200801034B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA200801034A 2005-08-15 2008-01-31 Bicyclic piperazines as metabotropic glutamate receptor antagonists ZA200801034B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70794505P 2005-08-15 2005-08-15

Publications (1)

Publication Number Publication Date
ZA200801034B true ZA200801034B (en) 2008-12-31

Family

ID=37451264

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200801034A ZA200801034B (en) 2005-08-15 2008-01-31 Bicyclic piperazines as metabotropic glutamate receptor antagonists

Country Status (16)

Country Link
US (2) US20080312240A1 (ko)
EP (1) EP1919911A1 (ko)
JP (1) JP2009504735A (ko)
KR (1) KR20080050392A (ko)
CN (1) CN101248071A (ko)
AR (1) AR055367A1 (ko)
AU (1) AU2006280232A1 (ko)
BR (1) BRPI0614480A2 (ko)
CA (1) CA2616308A1 (ko)
IL (1) IL188808A0 (ko)
MX (1) MX2008001607A (ko)
NO (1) NO20080671L (ko)
TW (1) TW200800204A (ko)
UY (1) UY29734A1 (ko)
WO (1) WO2007021574A1 (ko)
ZA (1) ZA200801034B (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010114971A1 (en) * 2009-04-03 2010-10-07 Sepracor Inc. Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof
FR2974365B1 (fr) 2011-04-20 2017-08-25 Centre Nat De La Rech Scient (C N R S) 1,2,3-triazoles 1,4-disubstituees, leurs procedes de preparation et leurs utilisations diagnostiques et therapeutiques
AU2013334707B2 (en) 2012-10-22 2018-02-22 City Of Hope ETP derivatives
PE20190629A1 (es) 2016-08-10 2019-04-26 Bayer Cropscience Ag 2-heterociclilimidazolilcarboxamidas sustituidas como pesticidas
CN109952104B (zh) 2016-09-15 2023-03-28 希望之城 二硫etp衍生物
CN114907258B (zh) * 2021-02-09 2023-04-11 中国科学院化学研究所 一种钯与氮杂环卡宾协同催化制备炔丙基酮类化合物的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006506340A (ja) * 2002-08-09 2006-02-23 アストラゼネカ アクチボラグ 代謝調節型グルタミン酸受容体５のモジュレーターとしてのオキサジアゾール
CA2527170A1 (en) * 2003-04-15 2004-10-28 Astrazeneca Ab Therapeutic compounds
WO2005077373A2 (en) * 2004-02-03 2005-08-25 Astrazeneca Ab Treatment of gastro-esophageal reflux disease (gerd)

Also Published As

Publication number Publication date
US20080312240A1 (en) 2008-12-18
JP2009504735A (ja) 2009-02-05
TW200800204A (en) 2008-01-01
MX2008001607A (es) 2008-04-14
US20070037816A1 (en) 2007-02-15
CA2616308A1 (en) 2007-02-22
NO20080671L (no) 2008-03-04
UY29734A1 (es) 2007-02-28
BRPI0614480A2 (pt) 2017-06-06
AU2006280232A1 (en) 2007-02-22
CN101248071A (zh) 2008-08-20
KR20080050392A (ko) 2008-06-05
AR055367A1 (es) 2007-08-22
WO2007021574A1 (en) 2007-02-22
IL188808A0 (en) 2008-08-07
EP1919911A1 (en) 2008-05-14

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