ZA200709481B - Diaryl-purine, azapurines and -deazapurines as non-nucleoside reverse transcriptase inhibitors for treatment of HIV - Google Patents

Diaryl-purine, azapurines and -deazapurines as non-nucleoside reverse transcriptase inhibitors for treatment of HIV

Info

Publication number
ZA200709481B
ZA200709481B ZA200709481A ZA200709481A ZA200709481B ZA 200709481 B ZA200709481 B ZA 200709481B ZA 200709481 A ZA200709481 A ZA 200709481A ZA 200709481 A ZA200709481 A ZA 200709481A ZA 200709481 B ZA200709481 B ZA 200709481B
Authority
ZA
South Africa
Prior art keywords
azapurines
deazapurines
reverse transcriptase
hiv
transcriptase inhibitors
Prior art date
Application number
ZA200709481A
Other languages
English (en)
Inventor
Girardet Jean Luc
Shaw Stephanie
Koh Yung-Hyo
Kim Hong Woo
Original Assignee
Ardea Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ardea Biosciences Inc filed Critical Ardea Biosciences Inc
Publication of ZA200709481B publication Critical patent/ZA200709481B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA200709481A 2005-05-05 2007-11-02 Diaryl-purine, azapurines and -deazapurines as non-nucleoside reverse transcriptase inhibitors for treatment of HIV ZA200709481B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US67866705P 2005-05-05 2005-05-05

Publications (1)

Publication Number Publication Date
ZA200709481B true ZA200709481B (en) 2008-11-26

Family

ID=37397195

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200709481A ZA200709481B (en) 2005-05-05 2007-11-02 Diaryl-purine, azapurines and -deazapurines as non-nucleoside reverse transcriptase inhibitors for treatment of HIV

Country Status (12)

Country Link
US (2) US8227601B2 (https=)
EP (1) EP1877411B9 (https=)
JP (2) JP5138585B2 (https=)
CN (1) CN101233135B (https=)
AT (1) ATE541848T1 (https=)
AU (1) AU2006244195B2 (https=)
BR (1) BRPI0611455A2 (https=)
CA (1) CA2607021C (https=)
ES (1) ES2380951T3 (https=)
MX (1) MX2007013715A (https=)
WO (1) WO2006122003A2 (https=)
ZA (1) ZA200709481B (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100475815C (zh) * 2003-09-25 2009-04-08 詹森药业有限公司 抑制hiv复制的嘌呤衍生物
AU2006244195B2 (en) 2005-05-05 2012-03-15 Ardea Biosciences, Inc. Diaryl-purine, azapurines and -deazapurines as non-nucleoside reverse transcriptase inhibitors for treatment of HIV
CA2673965A1 (en) * 2006-12-28 2008-07-10 Taisho Pharmaceutical Co., Ltd. Pyrazolopyrimidine compound
ES2389752T3 (es) 2007-12-14 2012-10-31 Ardea Biosciences, Inc. Inhibidores de la transcriptasa inversa
PE20091485A1 (es) 2008-02-06 2009-10-26 Novartis Ag DERIVADOS DE PIRROLO-[2,3-d]-PIRIMIDINA COMO INHIBIDORES DE CINASAS
WO2010111406A2 (en) * 2009-03-24 2010-09-30 Myriad Pharmaceuticals, Inc. Compounds and therapeutic uses thereof
PT3030563T (pt) * 2013-06-27 2017-11-15 Janssen Sciences Ireland Uc Derivados de pirrolo[3,2-d]pirimidina para o tratamento de infeções virais e outras doenças
WO2015162515A1 (en) 2014-04-25 2015-10-29 Pfizer Inc. Heteroaromatic compounds and their use as dopamine d1 ligands
CN107801397B (zh) 2015-02-13 2021-07-30 达纳－法伯癌症研究所公司 Lrrk2抑制剂及其制备和使用方法
CN106188060A (zh) * 2015-04-29 2016-12-07 厦门大学 嘧啶并吡咯类化合物、其制备方法、药用组合物及其应用
US10562902B2 (en) 2015-08-13 2020-02-18 Beijing Hanmi Pharmaceutical Co., Ltd. IRAK4 inhibitor and use thereof
CN106117242B (zh) * 2016-06-27 2018-08-03 山东大学 四氢噻喃并嘧啶类衍生物及其制备方法与应用
CN107793417B (zh) * 2016-09-05 2020-06-09 复旦大学 吡咯并[2,3-d]嘧啶类化合物及其盐，及制备方法和药用用途
CN106749266B (zh) * 2016-11-14 2019-01-22 山东大学 吡咯并[2,3-d]嘧啶类化合物的高效制备方法
TW201945003A (zh) 2018-03-01 2019-12-01 愛爾蘭商健生科學愛爾蘭無限公司 ２，４－二胺基喹唑啉衍生物及其醫學用途
CN111499639B (zh) * 2019-01-31 2022-03-04 四川大学华西医院 嘧啶酮衍生物及其在制药中的应用
US20230279006A1 (en) * 2020-07-08 2023-09-07 Klotho Therapeutics, Inc. Novel compounds and methods for increasing klotho gene expression
EP4251613A4 (en) * 2020-11-27 2024-11-20 Allorion Therapeutics Inc. AMINOHETEROARYL KINASE INHIBITORS
CN121002017A (zh) * 2023-05-04 2025-11-21 株式会社大熊制药 新颖的杂环胺衍生物以及包含其的药物组合物
US20250333424A1 (en) * 2024-03-01 2025-10-30 Gilead Sciences, Inc. Antiviral compounds

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ229453A (en) * 1988-06-10 1991-08-27 Univ Minnesota & Southern Rese A pharmaceutical composition containing purine derivatives with nucleosides such as azt, as antiviral agents
PT1129096E (pt) 1998-11-12 2003-09-30 Neurocrine Biosciences Inc Antagonistas de receptor de crf e metodos de tratamento relacionados com os mesmos
WO2000037471A1 (en) * 1998-12-23 2000-06-29 Neurogen Corporation 2-amino-9-alkylpurines: gaba brain receptor ligands
CZ27399A3 (cs) 1999-01-26 2000-08-16 Ústav Experimentální Botaniky Av Čr Substituované dusíkaté heterocyklické deriváty, způsob jejich přípravy, tyto deriváty pro použití jako léčiva, farmaceutická kompozice a kombinovaný farmaceutický přípravek tyto deriváty obsahující a použití těchto derivátů pro výrobu léčiv
YU25500A (sh) * 1999-05-11 2003-08-29 Pfizer Products Inc. Postupak za sintezu analoga nukleozida
JO3429B1 (ar) 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز
BRPI0407329A (pt) 2003-02-07 2006-01-10 Janssen Pharmaceutica Nv Derivados de pirimidina para a prevenção de infecção de hiv
CN100475815C (zh) * 2003-09-25 2009-04-08 詹森药业有限公司 抑制hiv复制的嘌呤衍生物
JP5118972B2 (ja) 2004-10-29 2013-01-16 テイボテク・フアーマシユーチカルズ Ｈｉｖ阻害性二環式ピリミジン誘導体
AU2006244195B2 (en) * 2005-05-05 2012-03-15 Ardea Biosciences, Inc. Diaryl-purine, azapurines and -deazapurines as non-nucleoside reverse transcriptase inhibitors for treatment of HIV

Also Published As

Publication number Publication date
EP1877411A4 (en) 2008-10-22
AU2006244195A1 (en) 2006-11-16
EP1877411B1 (en) 2012-01-18
JP5138585B2 (ja) 2013-02-06
US20090124802A1 (en) 2009-05-14
ATE541848T1 (de) 2012-02-15
CA2607021C (en) 2013-10-29
BRPI0611455A2 (pt) 2010-09-08
WO2006122003A2 (en) 2006-11-16
CN101233135A (zh) 2008-07-30
WO2006122003A3 (en) 2007-01-04
CN101233135B (zh) 2012-10-03
US8227601B2 (en) 2012-07-24
EP1877411A2 (en) 2008-01-16
ES2380951T9 (es) 2012-12-21
JP2008540454A (ja) 2008-11-20
JP2012188454A (ja) 2012-10-04
AU2006244195B2 (en) 2012-03-15
ES2380951T3 (es) 2012-05-21
US20120226037A1 (en) 2012-09-06
US8354532B2 (en) 2013-01-15
CA2607021A1 (en) 2006-11-16
MX2007013715A (es) 2008-01-28
EP1877411B9 (en) 2012-08-29

Similar Documents

Publication Publication Date Title
ZA200709481B (en) Diaryl-purine, azapurines and -deazapurines as non-nucleoside reverse transcriptase inhibitors for treatment of HIV
MX2009013349A (es) Compuestos quimicos.
MX2009009292A (es) Compuestos activos en ppar.
EA201000777A1 (ru) Ингибиторы репликации вируса иммунодефицита человека
PH12023500023A1 (en) Cdk2 degraders and uses thereof
MX2009005009A (es) Compuestos heterociclicos biciclicos 4-cianofenilamino sustituidos como inhibidores del virus de inmunodeficiencia humana.
MX2009009290A (es) Compuestos activos en ppar.
TW201713640A (en) Bruton's tyrosine kinase inhibitors
EA201390609A1 (ru) ПРОИЗВОДНЫЕ ГИДАНТОИНА, ПОЛЕЗНЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ Kv3-КАНАЛОВ
TW200626068A (en) Active compounds for seed treatment
ATE518010T1 (de) Aktive oberflächengekoppelte polymerasen
MX2009005881A (es) Derivados de 2-(piperidin-4-il)-4-fenoxi o fenilamino-pirimidina como inhibidores de la transcriptasa inversa no nucleosida.
MY163477A (en) Pyrimidinyl-pyridazinone derivatives
MX2010006738A (es) Inhibidores de proteasa del virus de la hepatitis c (hcv) y usos de los mismos.
MX2009008347A (es) Oxabicicloheptanos y oxabicicloheptenos, su preparacion y uso.
IL190730A0 (en) Potassium channel inhibitors
TNSN08400A1 (en) Organic compounds and their uses
NO20055130L (no) Aminocykloheksyleter-forbindelser og deres anvendelse
EA200971068A1 (ru) Триазолиламинопиримидиновые соединения
TW200603783A (en) Non-nucleoside reverse transcriptase inhibitors
PH12022550130A1 (en) Enzyme inhibitors
SG148179A1 (en) Benzyltriazolone compounds as non-nucleoside reverse transcriptase inhibitors
ATE549024T1 (de) Chinazolin-kaliumkanalhemmer
TW200716088A (en) Formulations and methods for treating amyloidosis
TW200738700A (en) HIV integrase inhibitors