ES2380951T3 - Diaril-purinas, -azapurinasy - desazapurinas como inhibidores no nucleósidos de la transcriptasa inversa para el tratamiento del VIH - Google Patents

Diaril-purinas, -azapurinasy - desazapurinas como inhibidores no nucleósidos de la transcriptasa inversa para el tratamiento del VIH Download PDF

Info

Publication number
ES2380951T3
ES2380951T3 ES06759292T ES06759292T ES2380951T3 ES 2380951 T3 ES2380951 T3 ES 2380951T3 ES 06759292 T ES06759292 T ES 06759292T ES 06759292 T ES06759292 T ES 06759292T ES 2380951 T3 ES2380951 T3 ES 2380951T3
Authority
ES
Spain
Prior art keywords
purines
reverse transcriptase
transcriptase inhibitors
azapurinasy
desazapurines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES06759292T
Other languages
English (en)
Spanish (es)
Other versions
ES2380951T9 (es
Inventor
Jean Luc Girardet
Yung-Hyo Koh
Stephanie Shaw
Hong Woo Kim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ardea Biociences Inc
Original Assignee
Ardea Biociences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ardea Biociences Inc filed Critical Ardea Biociences Inc
Application granted granted Critical
Publication of ES2380951T3 publication Critical patent/ES2380951T3/es
Publication of ES2380951T9 publication Critical patent/ES2380951T9/es
Anticipated expiration legal-status Critical
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ES06759292T 2005-05-05 2006-05-05 Diaril-purinas, -azapurinasy - desazapurinas como inhibidores no nucleósidos de la transcriptasa inversa para el tratamiento del VIH Active ES2380951T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67866705P 2005-05-05 2005-05-05
US678667P 2005-05-05
PCT/US2006/017677 WO2006122003A2 (en) 2005-05-05 2006-05-05 Diaryl-purine, azapurines and -deazapurines as non-nucleoside reverse transcriptase inhibitors for treatment of hiv

Publications (2)

Publication Number Publication Date
ES2380951T3 true ES2380951T3 (es) 2012-05-21
ES2380951T9 ES2380951T9 (es) 2012-12-21

Family

ID=37397195

Family Applications (1)

Application Number Title Priority Date Filing Date
ES06759292T Active ES2380951T3 (es) 2005-05-05 2006-05-05 Diaril-purinas, -azapurinasy - desazapurinas como inhibidores no nucleósidos de la transcriptasa inversa para el tratamiento del VIH

Country Status (12)

Country Link
US (2) US8227601B2 (https=)
EP (1) EP1877411B9 (https=)
JP (2) JP5138585B2 (https=)
CN (1) CN101233135B (https=)
AT (1) ATE541848T1 (https=)
AU (1) AU2006244195B2 (https=)
BR (1) BRPI0611455A2 (https=)
CA (1) CA2607021C (https=)
ES (1) ES2380951T3 (https=)
MX (1) MX2007013715A (https=)
WO (1) WO2006122003A2 (https=)
ZA (1) ZA200709481B (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602004031641D1 (de) * 2003-09-25 2011-04-14 Janssen Pharmaceutica Nv Die replikation von hiv hemmende purinderivate
WO2006122003A2 (en) 2005-05-05 2006-11-16 Ardea Biosciences, Inc. Diaryl-purine, azapurines and -deazapurines as non-nucleoside reverse transcriptase inhibitors for treatment of hiv
US20100298557A1 (en) * 2006-12-28 2010-11-25 Taisho Pharmaceutical Co., Ltd Pyrazolopyrimidine compound
ES2389752T3 (es) 2007-12-14 2012-10-31 Ardea Biosciences, Inc. Inhibidores de la transcriptasa inversa
UY31631A1 (es) 2008-02-06 2009-09-30 Nuevos derivados de 7-fenil-7h-pirrolo-[2,3d]-pirimidin-2-il-amino, sales de los mismos, procesos para su preparacion, composiciones farmacéuticas que los comprenden y aplicaciones
WO2010111406A2 (en) * 2009-03-24 2010-09-30 Myriad Pharmaceuticals, Inc. Compounds and therapeutic uses thereof
BR112015032546B1 (pt) * 2013-06-27 2022-05-17 Janssen Sciences Ireland Uc Derivados de pirrolo[3,2-d]pirimidina e composição farmacêutica que os compreende para o tratamento de infecções virais e outras doenças
EA201691831A1 (ru) 2014-04-25 2017-02-28 Пфайзер Инк. Гетероароматические соединения и их применение в качестве допаминовых d1 лигандов
AU2016219102B2 (en) 2015-02-13 2020-10-15 Dana-Farber Cancer Institute, Inc. LRRK2 inhibitors and methods of making and using the same
CN106188060A (zh) * 2015-04-29 2016-12-07 厦门大学 嘧啶并吡咯类化合物、其制备方法、药用组合物及其应用
KR102048719B1 (ko) * 2015-08-13 2019-11-26 베이징 한미 파마슈티컬 컴퍼니 리미티드 Irak4억제제 및 이의 용도
CN106117242B (zh) * 2016-06-27 2018-08-03 山东大学 四氢噻喃并嘧啶类衍生物及其制备方法与应用
CN107793417B (zh) * 2016-09-05 2020-06-09 复旦大学 吡咯并[2,3-d]嘧啶类化合物及其盐，及制备方法和药用用途
CN106749266B (zh) * 2016-11-14 2019-01-22 山东大学 吡咯并[2,3-d]嘧啶类化合物的高效制备方法
WO2022011171A1 (en) * 2020-07-08 2022-01-13 Klotho Therapeutics, Inc. Novel compounds and methods for increasing klotho gene expression
TW202415645A (zh) 2018-03-01 2024-04-16 愛爾蘭商健生科學愛爾蘭無限公司 ２，４－二胺基喹唑啉衍生物及其醫學用途
CN111499639B (zh) * 2019-01-31 2022-03-04 四川大学华西医院 嘧啶酮衍生物及其在制药中的应用
KR20230127228A (ko) * 2020-11-27 2023-08-31 올오리온 테라퓨틱스 인크. 아미노헤테로아릴 키나아제 억제제
AU2024266528A1 (en) * 2023-05-04 2025-10-16 Daewoong Pharmaceutical Co., Ltd. Novel heterocyclic amine derivatives and pharmaceutical composition comprising same
WO2025184609A1 (en) * 2024-03-01 2025-09-04 Gilead Sciences, Inc. Antiviral compounds

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ229453A (en) * 1988-06-10 1991-08-27 Univ Minnesota & Southern Rese A pharmaceutical composition containing purine derivatives with nucleosides such as azt, as antiviral agents
EP1129096B1 (en) 1998-11-12 2003-05-21 Neurocrine Biosciences, Inc. Crf receptor antagonists and methods relating thereto
WO2000037471A1 (en) * 1998-12-23 2000-06-29 Neurogen Corporation 2-amino-9-alkylpurines: gaba brain receptor ligands
CZ27399A3 (cs) 1999-01-26 2000-08-16 Ústav Experimentální Botaniky Av Čr Substituované dusíkaté heterocyklické deriváty, způsob jejich přípravy, tyto deriváty pro použití jako léčiva, farmaceutická kompozice a kombinovaný farmaceutický přípravek tyto deriváty obsahující a použití těchto derivátů pro výrobu léčiv
YU25500A (sh) * 1999-05-11 2003-08-29 Pfizer Products Inc. Postupak za sintezu analoga nukleozida
JO3429B1 (ar) 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز
BRPI0407329A (pt) 2003-02-07 2006-01-10 Janssen Pharmaceutica Nv Derivados de pirimidina para a prevenção de infecção de hiv
DE602004031641D1 (de) * 2003-09-25 2011-04-14 Janssen Pharmaceutica Nv Die replikation von hiv hemmende purinderivate
AU2005298637B8 (en) 2004-10-29 2012-12-06 Janssen Sciences Ireland Uc HIV inhibiting bicyclic pyrimidine derivatives
WO2006122003A2 (en) * 2005-05-05 2006-11-16 Ardea Biosciences, Inc. Diaryl-purine, azapurines and -deazapurines as non-nucleoside reverse transcriptase inhibitors for treatment of hiv

Also Published As

Publication number Publication date
EP1877411B9 (en) 2012-08-29
JP2008540454A (ja) 2008-11-20
EP1877411A2 (en) 2008-01-16
CA2607021A1 (en) 2006-11-16
US8227601B2 (en) 2012-07-24
JP2012188454A (ja) 2012-10-04
WO2006122003A3 (en) 2007-01-04
AU2006244195A1 (en) 2006-11-16
US20120226037A1 (en) 2012-09-06
CN101233135B (zh) 2012-10-03
JP5138585B2 (ja) 2013-02-06
MX2007013715A (es) 2008-01-28
EP1877411A4 (en) 2008-10-22
CN101233135A (zh) 2008-07-30
US20090124802A1 (en) 2009-05-14
ZA200709481B (en) 2008-11-26
ES2380951T9 (es) 2012-12-21
AU2006244195B2 (en) 2012-03-15
US8354532B2 (en) 2013-01-15
CA2607021C (en) 2013-10-29
WO2006122003A2 (en) 2006-11-16
BRPI0611455A2 (pt) 2010-09-08
ATE541848T1 (de) 2012-02-15
EP1877411B1 (en) 2012-01-18

Similar Documents

Publication Publication Date Title
ES2380951T3 (es) Diaril-purinas, -azapurinasy - desazapurinas como inhibidores no nucleósidos de la transcriptasa inversa para el tratamiento del VIH
CL2020002082A1 (es) Inhibidores pd-1/pd-l1.
CL2021000084A1 (es) Inhibidores de pd-1/pd-l1
CO2019011543A2 (es) Inhibidores de pd-1/pd-l1
MX394380B (es) Compuestos dinucleótidos cíclicos para eltratamiento de cáncer
CL2022001406A1 (es) Aminoquinolonas sustituidas como inhibidores de dgk alfa para la activación inmune.
CL2019002368A1 (es) Composiciones y métodos para el tratamiento de cáncer.
CO2019004003A2 (es) Composiciones y anticuerpos anti-lag-3
CO2018008846A2 (es) Derivados de carboxamida útiles como inhibidores de rsk
CL2017003404A1 (es) Compuestos antibacterianos
CL2008000862A1 (es) Compuestos derivados de triazolonas, inhibidores no nucleosidos de transcriptasa inversa; composicion farmaceutica que contiene a dichos compuestos; y uso del compuesto para tratar la infeccion del vih-1.
CL2015000880A1 (es) Compuestos heterociclicos derivados de 4-pirimidinona, inhibidores de la transcriptasa inversa del vih; composicion farmaceutica; uso en la profilaxis o el tratamiento de infeccion por vih o para la profilaxis, tratamiento o retraso de la aparicion del sida en un sujeto.
NI201000044A (es) Bromhidrato de bupropión y aplicaciones terapéuticas
CL2008001631A1 (es) Compuestos derivados de heterociclos sustituidos, con la presencia de un grupo fenoxi, inhibidores de transcriptasa inversa; composicion farmaceutica; y uso en el tratamiento de infecciones virales por vih.
UY34201A (es) Compuestos de azaindol y métodos para el tratamiento de vih.
CL2011000691A1 (es) Compuestos derivados de nicotinamida sustituida; composicion farmaceutica que los comprende; uso para el tratamiento y/o prevencion de cancer, infecciones, enfermedades inflamatorias y autoinmunitarias.
EA201692091A1 (ru) Хиноксалиновые соединения и их применение
CL2008000202A1 (es) Compuestos derivados de n-aril-acetamida, antagonista trpv1;composicion farmaceutica que los comprende, utiles en el tratamiento del dolor.
NI201000015A (es) Bromhidrato de bupropión y aplicaciones terapéuticas
CO2022000481A2 (es) Inhibidores de enzimas
CR20110184A (es) Inhibidores de la integrasa del vih
UY38352A (es) Inhibidores de integrina alfavbeta6
CO2021014747A2 (es) Métodos para el tratamiento de βeta-talasemia
CL2008001537A1 (es) Compuestos heterociclo derivados de 1h-pirimidin-2,4-diona, dihidro-pirimidin-2,4-diona e imidazol-2,4-diona, inhibidores no nucleosidos de la transcriptasa inversa (nnrti) del vih-1; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar enfermedades mediadas por vih, sida o arc.
DK3934653T3 (da) Azelastin som antiviral behandling