ZA200709087B - Novel thiophene derivatives as sphingosine-1-phosphate-1 receptor agonists - Google Patents
Novel thiophene derivatives as sphingosine-1-phosphate-1 receptor agonistsInfo
- Publication number
- ZA200709087B ZA200709087B ZA200709087A ZA200709087A ZA200709087B ZA 200709087 B ZA200709087 B ZA 200709087B ZA 200709087 A ZA200709087 A ZA 200709087A ZA 200709087 A ZA200709087 A ZA 200709087A ZA 200709087 B ZA200709087 B ZA 200709087B
- Authority
- ZA
- South Africa
- Prior art keywords
- sphingosine
- phosphate
- receptor agonists
- thiophene derivatives
- novel thiophene
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Otolaryngology (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP2005003070 | 2005-03-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200709087B true ZA200709087B (en) | 2008-09-25 |
Family
ID=36699202
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200709087A ZA200709087B (en) | 2005-03-23 | 2007-10-22 | Novel thiophene derivatives as sphingosine-1-phosphate-1 receptor agonists |
Country Status (25)
Country | Link |
---|---|
US (1) | US7605269B2 (ko) |
EP (1) | EP1863474B1 (ko) |
JP (1) | JP5072825B2 (ko) |
KR (1) | KR20070116645A (ko) |
CN (1) | CN101146529B (ko) |
AR (1) | AR055751A1 (ko) |
AT (1) | ATE413874T1 (ko) |
AU (1) | AU2006226020A1 (ko) |
BR (1) | BRPI0609668A2 (ko) |
CA (1) | CA2602475C (ko) |
CY (1) | CY1108750T1 (ko) |
DE (1) | DE602006003642D1 (ko) |
DK (1) | DK1863474T3 (ko) |
ES (1) | ES2316062T3 (ko) |
IL (1) | IL186150A0 (ko) |
MX (1) | MX2007011672A (ko) |
NO (1) | NO20075298L (ko) |
NZ (1) | NZ562561A (ko) |
PL (1) | PL1863474T3 (ko) |
PT (1) | PT1863474E (ko) |
RU (1) | RU2404178C2 (ko) |
SI (1) | SI1863474T1 (ko) |
TW (1) | TW200700406A (ko) |
WO (1) | WO2006100633A1 (ko) |
ZA (1) | ZA200709087B (ko) |
Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4678139B2 (ja) * | 2004-05-10 | 2011-04-27 | トヨタ自動車株式会社 | 自動車の暖房制御システム |
WO2006010379A1 (en) * | 2004-07-29 | 2006-02-02 | Actelion Pharmaceuticals Ltd. | Novel thiophene derivatives as immunosuppressive agents |
US7605269B2 (en) | 2005-03-23 | 2009-10-20 | Actelion Pharmaceuticals Ltd. | Thiophene derivatives as Sphingosine-1-phosphate-1 receptor agonists |
WO2006100635A2 (en) * | 2005-03-23 | 2006-09-28 | Actelion Pharmaceuticals Ltd | Novel thiophene derivatives as sphingosine-1-phosphate-1 receptor agonists |
PT1863787E (pt) * | 2005-03-23 | 2011-07-29 | Actelion Pharmaceuticals Ltd | Derivados de benzo(c)tiofenos hidrogenados como imunomoduladores |
CA2612661A1 (en) * | 2005-06-24 | 2006-12-28 | Actelion Pharmaceuticals Ltd. | Novel thiophene derivatives |
AR057894A1 (es) * | 2005-11-23 | 2007-12-26 | Actelion Pharmaceuticals Ltd | Derivados de tiofeno |
TWI404706B (zh) * | 2006-01-11 | 2013-08-11 | Actelion Pharmaceuticals Ltd | 新穎噻吩衍生物 |
JP5063615B2 (ja) * | 2006-01-24 | 2012-10-31 | アクテリオン ファーマシューティカルズ リミテッド | 新規ピリジン誘導体 |
ES2453372T3 (es) * | 2006-04-03 | 2014-04-07 | Astellas Pharma Inc. | Derivados de oxadiazol como agonistas de S1P1 |
ES2400533T3 (es) | 2006-09-07 | 2013-04-10 | Actelion Pharmaceuticals Ltd. | Derivados de piridin 4-ilo como agentes inmunomoduladores |
AR061841A1 (es) | 2006-09-07 | 2008-09-24 | Actelion Pharmaceuticals Ltd | Derivados de tiofen-oxadiazoles, agonistas del receptor s1p1/edg1, composiciones farmaceuticas que los contienen y usos como agentes inmunomoduladores. |
NZ576059A (en) | 2006-09-08 | 2012-03-30 | Actelion Pharmaceuticals Ltd | Pyridin-3-yl derivatives as immunomodulating agents |
JO2701B1 (en) | 2006-12-21 | 2013-03-03 | جلاكسو جروب ليميتد | Vehicles |
SI2125797T1 (sl) * | 2007-03-16 | 2014-03-31 | Actelion Pharmaceuticals Ltd. | Derivati amino-piridina kot agonisti receptorja s1p1/edg1 |
JO2686B1 (en) | 2007-04-19 | 2013-03-03 | جلاكسو جروب ليمتد | Vehicles |
MX2010005889A (es) * | 2007-12-10 | 2010-06-22 | Actelion Pharmaceuticals Ltd | Derivados de tiofeno como agonistas de s1p1/edg1. |
PE20091339A1 (es) | 2007-12-21 | 2009-09-26 | Glaxo Group Ltd | Derivados de oxadiazol con actividad sobre receptores s1p1 |
GB0725101D0 (en) | 2007-12-21 | 2008-01-30 | Glaxo Group Ltd | Compounds |
EP2262799B1 (en) * | 2008-03-06 | 2012-07-04 | Actelion Pharmaceuticals Ltd. | Pyridine compounds |
WO2009109872A1 (en) * | 2008-03-07 | 2009-09-11 | Actelion Pharmaceuticals Ltd | Pyridin-2-yl derivatives as immunomodulating agents |
AR070842A1 (es) | 2008-03-17 | 2010-05-05 | Actelion Pharmaceuticals Ltd | Regimen de dosificacion para un agonista de receptor selectivo de s1p1 |
GB0807910D0 (en) * | 2008-04-30 | 2008-06-04 | Glaxo Group Ltd | Compounds |
EP2297139A1 (en) * | 2008-06-20 | 2011-03-23 | Glaxo Group Limited | Compounds |
HUE030424T2 (en) | 2008-07-23 | 2017-05-29 | Arena Pharm Inc | Substituted 1,2,3,4-tetrahydrocyclopenta [b] indol-3-ylacetic acid derivatives useful in the treatment of autoimmune and inflammatory disorders |
ES2583630T3 (es) | 2008-08-27 | 2016-09-21 | Arena Pharmaceuticals, Inc. | Derivados de ácido tricíclico sustituido como agonistas del receptor S1P1 útiles en el tratamiento de trastornos autoinmunes e inflamatorios |
EP2389377B1 (en) | 2009-01-23 | 2014-07-16 | Bristol-Myers Squibb Company | Substituted oxadiazole derivatives as s1p agonists in the treatment of autoimmune and inflammatory diseases |
JP2012515789A (ja) | 2009-01-23 | 2012-07-12 | ブリストル−マイヤーズ スクイブ カンパニー | スフィンゴシン−1−リン酸アゴニストとしてのピラゾール−1,2,4−オキサジアゾール誘導体 |
WO2010085581A1 (en) | 2009-01-23 | 2010-07-29 | Bristol-Myers Squibb Company | Substituted oxadiazole derivatives as s1p agonists in the treatment of autoimmune and inflammatory diseases |
WO2010117662A1 (en) * | 2009-03-30 | 2010-10-14 | Exelixis, Inc. | Modulators of s1p and methods of making and using |
DE102009002514A1 (de) | 2009-04-21 | 2010-10-28 | Evonik Degussa Gmbh | Verfahren zur Herstellung von substituierten 1,4-Chinonmethiden |
GB0910674D0 (en) | 2009-06-19 | 2009-08-05 | Glaxo Group Ltd | Novel compounds |
RU2547098C2 (ru) | 2009-07-16 | 2015-04-10 | Актелион Фармасьютиклз Лтд | Производные пиридин-4-ила |
US8399451B2 (en) | 2009-08-07 | 2013-03-19 | Bristol-Myers Squibb Company | Heterocyclic compounds |
US9216972B2 (en) | 2009-10-29 | 2015-12-22 | Bristol-Myers Squibb Company | Tricyclic heterocyclic compounds |
CN103221391B (zh) | 2010-01-27 | 2018-07-06 | 艾尼纳制药公司 | (R)-2-(7-(4-环戊基-3-(三氟甲基)苄基氧基)-1,2,3,4-四氢环戊二烯并[b]吲哚-3-基)乙酸及其盐的制备方法 |
JP2013521301A (ja) | 2010-03-03 | 2013-06-10 | アリーナ ファーマシューティカルズ, インコーポレイテッド | S1p1受容体修飾物質およびその結晶形の調製のためのプロセス |
EP2560969B1 (en) | 2010-04-23 | 2015-08-12 | Bristol-Myers Squibb Company | 4-(5-isoxazolyl or 5-pyrrazolyl-1,2,4-oxadiazol-3-yl)-mandelic acid amides as sphingosin-1-phosphate 1 receptor agonists |
US8822510B2 (en) | 2010-07-20 | 2014-09-02 | Bristol-Myers Squibb Company | Substituted 3-phenyl-1,2,4-Oxadiazole compounds |
US9187437B2 (en) | 2010-09-24 | 2015-11-17 | Bristol-Myers Squibb Company | Substituted oxadiazole compounds |
EP2635573B1 (en) | 2010-11-03 | 2014-10-01 | Bristol-Myers Squibb Company | Heterocyclic compounds as s1p1 agonists for the treatment of autoimmune and vascular diseases |
WO2012098505A1 (en) | 2011-01-19 | 2012-07-26 | Actelion Pharmaceuticals Ltd | 2-methoxy-pyridin-4-yl derivatives |
EP2885266B1 (en) | 2012-08-17 | 2020-03-18 | Actelion Pharmaceuticals Ltd | Process for the preparation of (2z,5z)-5-(3-chloro-4-((r)-2,3-dihydroxypropoxy)benzylidene)-2-(propylimino)-3-(o-tolyl)thiazolidin-4-one and intermediate used in said process |
TWI613182B (zh) | 2013-02-21 | 2018-02-01 | 必治妥美雅史谷比公司 | 雙環化合物 |
MA40082B1 (fr) | 2014-08-20 | 2019-09-30 | Bristol Myers Squibb Co | Nouveau compose de substitution sphingosine phosphate utile traitement maladie rhumatisme |
CN107405332A (zh) | 2015-01-06 | 2017-11-28 | 艾尼纳制药公司 | 治疗与s1p1受体有关的病症的方法 |
US10385069B2 (en) | 2015-02-03 | 2019-08-20 | Active Biotech Ab | Imidazo[2,1-B]thiazole and 5,6-dihydroimidazo[2,1-B]thiazole derivatives useful as S100-inhibitors |
SG11201708794PA (en) | 2015-05-20 | 2017-12-28 | Idorsia Pharmaceuticals Ltd | Crystalline form of the compound (s)-3-{4-[5-(2-cyclopentyl-6-methoxy-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenoxy}-propane-1,2-diol |
US10111841B2 (en) | 2015-06-19 | 2018-10-30 | University Of South Florida | Stabilization of alcohol intoxication-induced cardiovascular instability |
US10301262B2 (en) | 2015-06-22 | 2019-05-28 | Arena Pharmaceuticals, Inc. | Crystalline L-arginine salt of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta [b]indol-3-yl)acetic acid(Compund1) for use in SIPI receptor-associated disorders |
WO2017004608A1 (en) * | 2015-07-02 | 2017-01-05 | Exelixis, Inc. | Oxadiazole modulators of s1p methods of making and using |
JP7029445B2 (ja) | 2016-09-02 | 2022-03-03 | ブリストル-マイヤーズ スクイブ カンパニー | 置換された三環式ヘテロ環化合物 |
EP3582772A1 (en) | 2017-02-16 | 2019-12-25 | Arena Pharmaceuticals, Inc. | Compounds and methods for treatment of primary biliary cholangitis |
MA47503A (fr) | 2017-02-16 | 2021-04-21 | Arena Pharm Inc | Composés et méthodes pour le traitement de maladies inflammatoires chroniques de l'intestin avec manifestations extra-intestinales |
US11046646B2 (en) | 2017-08-09 | 2021-06-29 | Bristol-Myers Squibb Company | Alkylphenyl compounds |
WO2019032631A1 (en) | 2017-08-09 | 2019-02-14 | Bristol-Myers Squibb Company | OXIME ETHER COMPOUNDS |
EP3847158A1 (en) | 2018-09-06 | 2021-07-14 | Arena Pharmaceuticals, Inc. | Compounds useful in the treatment of autoimmune and inflammatory disorders |
US11014940B1 (en) | 2018-10-16 | 2021-05-25 | Celgene Corporation | Thiazolidinone and oxazolidinone compounds and formulations |
US11014897B1 (en) | 2018-10-16 | 2021-05-25 | Celgene Corporation | Solid forms comprising a thiazolidinone compound, compositions and methods of use thereof |
US11186556B1 (en) | 2018-10-16 | 2021-11-30 | Celgene Corporation | Salts of a thiazolidinone compound, solid forms, compositions and methods of use thereof |
US11013723B1 (en) | 2018-10-16 | 2021-05-25 | Celgene Corporation | Solid forms of a thiazolidinone compound, compositions and methods of use thereof |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991015583A1 (en) | 1990-04-05 | 1991-10-17 | The American National Red Cross | A protein family related to immediate-early protein expressed by human endothelial cells during differentiation |
JP2002505868A (ja) | 1998-03-09 | 2002-02-26 | スミスクライン・ビーチャム・コーポレイション | ヒトEDG−1cポリヌクレオチドおよびポリペプチドおよびその使用法 |
GB9808665D0 (en) * | 1998-04-23 | 1998-06-24 | Merck Sharp & Dohme | Therapeutic compounds |
DE60330047D1 (en) | 2002-01-18 | 2009-12-24 | Merck & Co Inc | "n-(benzyl)aminoalkyl carboxylate, phosphinate, phosphonate und tetrazole als edg rezeptoragonisten" |
CA2488117A1 (en) * | 2002-06-17 | 2003-12-24 | Merck & Co., Inc. | 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylates and 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)pyrrolidine-3-carboxylates as edg receptor agonists |
AU2003279915A1 (en) | 2002-10-15 | 2004-05-04 | Merck And Co., Inc. | Process for making azetidine-3-carboxylic acid |
AU2004240586A1 (en) | 2003-05-15 | 2004-12-02 | Merck & Co., Inc. | 3-(2-amino-1-azacyclyl)-5-aryl-1,2,4-oxadiazoles as S1P receptor agonists |
WO2006010379A1 (en) * | 2004-07-29 | 2006-02-02 | Actelion Pharmaceuticals Ltd. | Novel thiophene derivatives as immunosuppressive agents |
US7866319B2 (en) * | 2004-09-27 | 2011-01-11 | Avon Protection Systems, Inc. | Respirator exhalation unit |
US7605269B2 (en) | 2005-03-23 | 2009-10-20 | Actelion Pharmaceuticals Ltd. | Thiophene derivatives as Sphingosine-1-phosphate-1 receptor agonists |
WO2006100635A2 (en) * | 2005-03-23 | 2006-09-28 | Actelion Pharmaceuticals Ltd | Novel thiophene derivatives as sphingosine-1-phosphate-1 receptor agonists |
PT1863787E (pt) * | 2005-03-23 | 2011-07-29 | Actelion Pharmaceuticals Ltd | Derivados de benzo(c)tiofenos hidrogenados como imunomoduladores |
AR057894A1 (es) * | 2005-11-23 | 2007-12-26 | Actelion Pharmaceuticals Ltd | Derivados de tiofeno |
JP5063615B2 (ja) * | 2006-01-24 | 2012-10-31 | アクテリオン ファーマシューティカルズ リミテッド | 新規ピリジン誘導体 |
-
2006
- 2006-03-20 US US11/909,436 patent/US7605269B2/en not_active Expired - Fee Related
- 2006-03-20 DK DK06727683T patent/DK1863474T3/da active
- 2006-03-20 DE DE602006003642T patent/DE602006003642D1/de active Active
- 2006-03-20 NZ NZ562561A patent/NZ562561A/en not_active IP Right Cessation
- 2006-03-20 KR KR1020077024345A patent/KR20070116645A/ko not_active Application Discontinuation
- 2006-03-20 ES ES06727683T patent/ES2316062T3/es active Active
- 2006-03-20 CA CA2602475A patent/CA2602475C/en not_active Expired - Fee Related
- 2006-03-20 AT AT06727683T patent/ATE413874T1/de active
- 2006-03-20 JP JP2008502540A patent/JP5072825B2/ja not_active Expired - Fee Related
- 2006-03-20 MX MX2007011672A patent/MX2007011672A/es active IP Right Grant
- 2006-03-20 BR BRPI0609668-9A patent/BRPI0609668A2/pt not_active IP Right Cessation
- 2006-03-20 PL PL06727683T patent/PL1863474T3/pl unknown
- 2006-03-20 RU RU2007138869/04A patent/RU2404178C2/ru not_active IP Right Cessation
- 2006-03-20 EP EP06727683A patent/EP1863474B1/en active Active
- 2006-03-20 WO PCT/IB2006/050850 patent/WO2006100633A1/en active Application Filing
- 2006-03-20 CN CN2006800092312A patent/CN101146529B/zh not_active Expired - Fee Related
- 2006-03-20 PT PT06727683T patent/PT1863474E/pt unknown
- 2006-03-20 AU AU2006226020A patent/AU2006226020A1/en not_active Abandoned
- 2006-03-20 SI SI200630178T patent/SI1863474T1/sl unknown
- 2006-03-22 AR ARP060101135A patent/AR055751A1/es not_active Application Discontinuation
- 2006-03-22 TW TW095109955A patent/TW200700406A/zh unknown
-
2007
- 2007-09-20 IL IL186150A patent/IL186150A0/en unknown
- 2007-10-17 NO NO20075298A patent/NO20075298L/no not_active Application Discontinuation
- 2007-10-22 ZA ZA200709087A patent/ZA200709087B/xx unknown
-
2009
- 2009-02-05 CY CY20091100133T patent/CY1108750T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
US7605269B2 (en) | 2009-10-20 |
EP1863474A1 (en) | 2007-12-12 |
RU2007138869A (ru) | 2009-04-27 |
EP1863474B1 (en) | 2008-11-12 |
ATE413874T1 (de) | 2008-11-15 |
CN101146529A (zh) | 2008-03-19 |
KR20070116645A (ko) | 2007-12-10 |
DE602006003642D1 (en) | 2008-12-24 |
CN101146529B (zh) | 2012-08-29 |
NO20075298L (no) | 2007-12-20 |
CY1108750T1 (el) | 2014-04-09 |
PL1863474T3 (pl) | 2009-04-30 |
AR055751A1 (es) | 2007-09-05 |
CA2602475C (en) | 2014-11-04 |
WO2006100633A1 (en) | 2006-09-28 |
JP2008534491A (ja) | 2008-08-28 |
MX2007011672A (es) | 2007-11-15 |
ES2316062T3 (es) | 2009-04-01 |
DK1863474T3 (da) | 2009-02-09 |
JP5072825B2 (ja) | 2012-11-14 |
PT1863474E (pt) | 2009-01-20 |
BRPI0609668A2 (pt) | 2011-10-18 |
IL186150A0 (en) | 2008-01-20 |
RU2404178C2 (ru) | 2010-11-20 |
US20080318955A1 (en) | 2008-12-25 |
AU2006226020A1 (en) | 2006-09-28 |
CA2602475A1 (en) | 2006-09-28 |
SI1863474T1 (sl) | 2009-04-30 |
NZ562561A (en) | 2010-11-26 |
TW200700406A (en) | 2007-01-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZA200709087B (en) | Novel thiophene derivatives as sphingosine-1-phosphate-1 receptor agonists | |
ZA200709086B (en) | Novel thiophene derivatives as sphingosine-1-phosphate-1 receptor agonists | |
ZA200711147B (en) | Novel thiophene derivatives | |
ZA200805407B (en) | Novel thiophene derivatives | |
EP1874295A4 (en) | benzothiophene | |
IL198931A0 (en) | Benzamide derivatives as ep4 receptor agonists | |
IL180962A0 (en) | Novel thiophene derivatives | |
IL192657A0 (en) | Novel thiophene derivatives as s1p1/edg1 receptor agonists | |
HK1099019A1 (en) | Quinolinone-carboxamide compounds as 5-ht4 receptor agonists | |
HK1130255A1 (en) | Indole derivatives as s1p1 receptor agonists | |
IL177059A0 (en) | Indazole-carboxamide compounds as 5-ht4 receptor agonists | |
ZA200800405B (en) | Pyrisazinone derivatives as thyroid hormone receptor agonists | |
ZA200800320B (en) | Indol-3-carbonyl-spiro-piperidine derivatives as Via receptor antagonists | |
IL177799A0 (en) | Substituted thiophene derivatives as anti-cancer agents | |
AP2008004441A0 (en) | Piperdin-4-ylpyrazin-2-ylamine derivatives as fastdissociating dopamine 2 receptor antagonists | |
IL185692A0 (en) | Acetylenyl-pyrazolo-pyrimidine derivatives as mglur2 antagonists | |
HK1135966A1 (en) | Oxyindole derivatives as 5ht4 receptor agonists | |
IL189897A0 (en) | Benzimidazole thiophene compounds | |
IL190094A0 (en) | Amino-alkyl-amide derivatives as ccr3 receptor liquids | |
IL186883A0 (en) | Benzimidazole-carboxamide compounds as 5-ht4 receptor agonists | |
GB0622472D0 (en) | Novel heterocyclic derivatives | |
ZA200903829B (en) | Indole derivatives as S1P1 receptor agonists | |
GB0614154D0 (en) | Novel Pyriazine Derivatives | |
ZA200709829B (en) | Benzimidazole-carboxamide compounds as 5-HT4 receptor agonists | |
GB0516439D0 (en) | EP2 receptor agonists |