ZA200706338B - 1-H-pyrrole-2-carboxamides and imidazole-5-carboxamides and use thereof as FAK, KDR and TIE2 Kinase modulators for the treatment of cancer - Google Patents
1-H-pyrrole-2-carboxamides and imidazole-5-carboxamides and use thereof as FAK, KDR and TIE2 Kinase modulators for the treatment of cancerInfo
- Publication number
- ZA200706338B ZA200706338B ZA200706338A ZA200706338A ZA200706338B ZA 200706338 B ZA200706338 B ZA 200706338B ZA 200706338 A ZA200706338 A ZA 200706338A ZA 200706338 A ZA200706338 A ZA 200706338A ZA 200706338 B ZA200706338 B ZA 200706338B
- Authority
- ZA
- South Africa
- Prior art keywords
- carboxamides
- fak
- kdr
- pyrrole
- imidazole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0501092A FR2881426B1 (fr) | 2005-02-03 | 2005-02-03 | Pyrolles et imidazoles substitues, compositions les contenant, procede de frabrication et utilisation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200706338B true ZA200706338B (en) | 2008-11-26 |
Family
ID=34954950
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200706338A ZA200706338B (en) | 2005-02-03 | 2006-02-01 | 1-H-pyrrole-2-carboxamides and imidazole-5-carboxamides and use thereof as FAK, KDR and TIE2 Kinase modulators for the treatment of cancer |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7560571B2 (de) |
| EP (1) | EP1856043B1 (de) |
| JP (1) | JP2008528661A (de) |
| KR (1) | KR20070103420A (de) |
| CN (1) | CN101133023A (de) |
| AR (1) | AR053540A1 (de) |
| AT (1) | ATE512133T1 (de) |
| AU (1) | AU2006210343A1 (de) |
| BR (1) | BRPI0606761A2 (de) |
| CA (1) | CA2595987A1 (de) |
| EA (1) | EA012267B1 (de) |
| FR (1) | FR2881426B1 (de) |
| IL (1) | IL184710A0 (de) |
| MA (1) | MA29264B1 (de) |
| MX (1) | MX2007009442A (de) |
| NO (1) | NO20074414L (de) |
| TW (1) | TW200640857A (de) |
| UY (1) | UY29361A1 (de) |
| WO (1) | WO2006082309A1 (de) |
| ZA (1) | ZA200706338B (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2881742B1 (fr) | 2005-02-10 | 2007-09-07 | Aventis Pharma Sa | Pyrroles substitues, compositions les contenant, procede de fabrication et utilisation |
| CA2648923A1 (en) * | 2006-04-11 | 2007-10-18 | Vertex Pharmaceuticals Incorporated | Thiazoles, imidazoles, and pyrazoles useful as inhibitors of protein kinases |
| AU2009262199B2 (en) | 2008-06-27 | 2012-08-09 | Amgen Inc. | Ang-2 inhibition to treat multiple sclerosis |
| US8642628B2 (en) * | 2008-08-15 | 2014-02-04 | N30 Pharmaceuticals, Inc. | Pyrrole inhibitors of S-nitrosoglutathione reductase |
| DK2315591T3 (en) | 2008-08-15 | 2016-06-06 | Nivalis Therapeutics Inc | NOVEL PYRROLE INHIBITORS OF S-nitrosoglutathione-reductase as therapeutic agents |
| EP2318007B1 (de) | 2008-08-15 | 2013-01-23 | N30 Pharmaceuticals, Inc. | Neuartige pyrrolhemmer der s-nitrosoglutathion-reduktase als therapeutische mittel |
| CN102775354A (zh) * | 2011-05-10 | 2012-11-14 | 无锡立诺康医药科技有限公司 | 一种合成4-芳基-5-羧酸咪唑及其酯的工艺方法 |
| AU2013299557B2 (en) | 2012-08-10 | 2017-06-22 | Boehringer Ingelheim International Gmbh | Heteroaromatic compounds as Bruton's tyrosine kinase (BTK) inhibitors |
| EP3099674B1 (de) | 2014-01-29 | 2018-10-24 | Boehringer Ingelheim International Gmbh | Pyrazolverbindungen als btk-hemmer |
| CA3005268C (en) | 2015-12-16 | 2024-04-30 | Boehringer Ingelheim International Gmbh | Heteroaromatic compounds as btk inhibitors |
| WO2017123695A1 (en) | 2016-01-13 | 2017-07-20 | Boehringer Ingelheim International Gmbh | Isoquinolones as btk inhibitors |
| US11034669B2 (en) | 2018-11-30 | 2021-06-15 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020173507A1 (en) * | 2000-08-15 | 2002-11-21 | Vincent Santora | Urea compounds and methods of uses |
| GB0107901D0 (en) | 2001-03-29 | 2001-05-23 | Cyclacel Ltd | Anti-cancer compounds |
| JP2006515828A (ja) * | 2001-09-27 | 2006-06-08 | スミスクライン・ビーチャム・コーポレイション | 化学化合物 |
| US20040138269A1 (en) * | 2002-10-11 | 2004-07-15 | Sugen, Inc. | Substituted pyrroles as kinase inhibitors |
| MXPA05011702A (es) * | 2003-04-30 | 2006-01-23 | Pfizer Prod Inc | Agentes antidiabeticos. |
| DE10354060A1 (de) | 2003-11-19 | 2005-06-02 | Merck Patent Gmbh | Pyrrolderivate |
| US7183285B2 (en) | 2004-04-29 | 2007-02-27 | Pharmix Corp. | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase |
| FR2881742B1 (fr) | 2005-02-10 | 2007-09-07 | Aventis Pharma Sa | Pyrroles substitues, compositions les contenant, procede de fabrication et utilisation |
-
2005
- 2005-02-03 FR FR0501092A patent/FR2881426B1/fr not_active Expired - Fee Related
-
2006
- 2006-01-26 TW TW095102965A patent/TW200640857A/zh unknown
- 2006-02-01 AR ARP060100362A patent/AR053540A1/es unknown
- 2006-02-01 WO PCT/FR2006/000220 patent/WO2006082309A1/fr active Application Filing
- 2006-02-01 BR BRPI0606761-1A patent/BRPI0606761A2/pt not_active IP Right Cessation
- 2006-02-01 AT AT06709213T patent/ATE512133T1/de not_active IP Right Cessation
- 2006-02-01 CA CA002595987A patent/CA2595987A1/fr not_active Abandoned
- 2006-02-01 EP EP06709213A patent/EP1856043B1/de active Active
- 2006-02-01 MX MX2007009442A patent/MX2007009442A/es not_active Application Discontinuation
- 2006-02-01 ZA ZA200706338A patent/ZA200706338B/xx unknown
- 2006-02-01 EA EA200701648A patent/EA012267B1/ru not_active IP Right Cessation
- 2006-02-01 AU AU2006210343A patent/AU2006210343A1/en not_active Withdrawn
- 2006-02-01 CN CNA2006800069922A patent/CN101133023A/zh active Pending
- 2006-02-01 JP JP2007553647A patent/JP2008528661A/ja active Pending
- 2006-02-01 KR KR1020077017902A patent/KR20070103420A/ko not_active Application Discontinuation
- 2006-02-03 UY UY29361A patent/UY29361A1/es unknown
-
2007
- 2007-07-18 IL IL184710A patent/IL184710A0/en unknown
- 2007-08-01 US US11/832,206 patent/US7560571B2/en not_active Expired - Fee Related
- 2007-08-23 MA MA30160A patent/MA29264B1/fr unknown
- 2007-08-29 NO NO20074414A patent/NO20074414L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EA200701648A1 (ru) | 2008-02-28 |
| FR2881426A1 (fr) | 2006-08-04 |
| MA29264B1 (fr) | 2008-02-01 |
| UY29361A1 (es) | 2006-08-31 |
| ATE512133T1 (de) | 2011-06-15 |
| JP2008528661A (ja) | 2008-07-31 |
| KR20070103420A (ko) | 2007-10-23 |
| EP1856043B1 (de) | 2011-06-08 |
| FR2881426B1 (fr) | 2007-03-30 |
| NO20074414L (no) | 2007-11-05 |
| US7560571B2 (en) | 2009-07-14 |
| EP1856043A1 (de) | 2007-11-21 |
| TW200640857A (en) | 2006-12-01 |
| WO2006082309A1 (fr) | 2006-08-10 |
| EA012267B1 (ru) | 2009-08-28 |
| CA2595987A1 (fr) | 2006-08-10 |
| BRPI0606761A2 (pt) | 2009-07-14 |
| US20080045542A1 (en) | 2008-02-21 |
| AU2006210343A1 (en) | 2006-08-10 |
| CN101133023A (zh) | 2008-02-27 |
| MX2007009442A (es) | 2008-03-10 |
| IL184710A0 (en) | 2007-12-03 |
| AR053540A1 (es) | 2007-05-09 |
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