ZA200705752B - 7- {4-[2-(2,6-Dichloro-4-methylphenoxy)-ethoxy] phenyl}-3,9-diazabicyclo [3.3.1] non-6-ene-6-carboxylic acid cyclopropyl- (2,3-dimethylbenzyl) amides as inhibitors of renin for the treatment of hypertension - Google Patents
7- {4-[2-(2,6-Dichloro-4-methylphenoxy)-ethoxy] phenyl}-3,9-diazabicyclo [3.3.1] non-6-ene-6-carboxylic acid cyclopropyl- (2,3-dimethylbenzyl) amides as inhibitors of renin for the treatment of hypertensionInfo
- Publication number
- ZA200705752B ZA200705752B ZA200705752A ZA200705752A ZA200705752B ZA 200705752 B ZA200705752 B ZA 200705752B ZA 200705752 A ZA200705752 A ZA 200705752A ZA 200705752 A ZA200705752 A ZA 200705752A ZA 200705752 B ZA200705752 B ZA 200705752B
- Authority
- ZA
- South Africa
- Prior art keywords
- methylphenoxy
- renin
- dimethylbenzyl
- diazabicyclo
- ene
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/504—Pyridazines; Hydrogenated pyridazines forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP2005000842 | 2005-01-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200705752B true ZA200705752B (en) | 2009-02-25 |
Family
ID=36263952
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200705752A ZA200705752B (en) | 2005-01-28 | 2007-07-12 | 7- {4-[2-(2,6-Dichloro-4-methylphenoxy)-ethoxy] phenyl}-3,9-diazabicyclo [3.3.1] non-6-ene-6-carboxylic acid cyclopropyl- (2,3-dimethylbenzyl) amides as inhibitors of renin for the treatment of hypertension |
Country Status (20)
Country | Link |
---|---|
US (1) | US7915259B2 (xx) |
EP (1) | EP1846407B1 (xx) |
JP (1) | JP4111533B1 (xx) |
KR (1) | KR100938364B1 (xx) |
CN (1) | CN101107248A (xx) |
AR (1) | AR052894A1 (xx) |
AT (1) | ATE514697T1 (xx) |
AU (1) | AU2006208992A1 (xx) |
CA (1) | CA2595986A1 (xx) |
CR (1) | CR9268A (xx) |
ES (1) | ES2367267T3 (xx) |
IL (1) | IL184885A0 (xx) |
MA (1) | MA29267B1 (xx) |
MX (1) | MX2007009004A (xx) |
NI (1) | NI200700189A (xx) |
NO (1) | NO20074303L (xx) |
RU (1) | RU2007132438A (xx) |
TW (1) | TW200637861A (xx) |
WO (1) | WO2006079988A1 (xx) |
ZA (1) | ZA200705752B (xx) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE462703T1 (de) * | 2004-08-25 | 2010-04-15 | Actelion Pharmaceuticals Ltd | Bicyclononen-derivate als renin-inhibitoren |
JP4297972B2 (ja) * | 2005-05-27 | 2009-07-15 | アクテリオン ファーマシューティカルズ リミテッド | 新規なピペリジンカルボン酸アミド誘導体 |
EP1981847A1 (en) * | 2006-02-02 | 2008-10-22 | Actelion Pharmaceuticals Ltd. | Secondary amines as renin inhibitors |
JP2009529033A (ja) * | 2006-03-08 | 2009-08-13 | アクテリオン ファーマシューティカルズ リミテッド | 新規アミン |
CL2007002689A1 (es) * | 2006-09-18 | 2008-04-18 | Vitae Pharmaceuticals Inc | Compuestos derivados de piperidin-1-carboxamida, inhibidores de la renina; compuestos intermediarios; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como hipertension, insuficiencia cardiaca, fibrosis cardiaca, entre otras. |
WO2008088690A2 (en) * | 2007-01-12 | 2008-07-24 | Merck & Co., Inc. | A process for preparing diazabicyclo[3.3.1] nonane compounds |
US8129538B1 (en) | 2007-03-28 | 2012-03-06 | Takeda Pharmaceutical Company Limited | Renin inhibitors |
AU2008253519A1 (en) | 2007-05-24 | 2008-11-27 | Merck Frosst Canada Ltd | Novel case of renin inhibitors |
WO2009023964A1 (en) | 2007-08-20 | 2009-02-26 | Merck Frosst Canada Ltd. | Renin inhibitors |
ES2548134T3 (es) | 2008-05-05 | 2015-10-14 | Actelion Pharmaceuticals Ltd. | Derivados de piperidina 3,4-sustituida como inhibidores de renina |
CN105658642B (zh) | 2013-10-25 | 2019-05-03 | 蓝图药品公司 | 纤维母细胞生长因子受体抑制剂 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1256326C (zh) | 1995-09-07 | 2006-05-17 | 弗·哈夫曼-拉罗切有限公司 | 治疗心脏和肾功能不全的新型4-(氧烷氧基苯基)-3-氧哌啶化合物 |
US7427613B2 (en) | 2002-04-29 | 2008-09-23 | Actelion Pharmaceuticals Ltd. | 7-aryl-3,9-diazabicyclo(3.3.1)non-6-ene derivatives and their use as renin inhibitors in the treatment of hypertension, cardiovascular or renal diseases |
WO2004096804A1 (en) * | 2003-04-28 | 2004-11-11 | Actelion Pharmaceuticals Ltd | Diazabicyclononene and tetrahydropyridine derivatives as renin inhibitors |
US20060223795A1 (en) | 2003-05-02 | 2006-10-05 | Oliver Bezencon | Novel diazabicyclononene derivatives |
CA2521898A1 (en) | 2003-05-02 | 2004-11-11 | Actelion Pharmaceuticals Ltd | Diazabicyclononene derivatives |
WO2004105762A1 (en) * | 2003-05-30 | 2004-12-09 | Actelion Pharmaceuticals Ltd | Medical use of diazabicyclononene derivatives as inhibitors of parasite aspartic proteases |
-
2006
- 2006-01-26 US US11/795,850 patent/US7915259B2/en not_active Expired - Fee Related
- 2006-01-26 EP EP06710758A patent/EP1846407B1/en active Active
- 2006-01-26 JP JP2007551803A patent/JP4111533B1/ja not_active Expired - Fee Related
- 2006-01-26 KR KR1020077019567A patent/KR100938364B1/ko not_active IP Right Cessation
- 2006-01-26 AT AT06710758T patent/ATE514697T1/de not_active IP Right Cessation
- 2006-01-26 MX MX2007009004A patent/MX2007009004A/es not_active Application Discontinuation
- 2006-01-26 CN CNA2006800027614A patent/CN101107248A/zh active Pending
- 2006-01-26 ES ES06710758T patent/ES2367267T3/es active Active
- 2006-01-26 WO PCT/IB2006/050285 patent/WO2006079988A1/en active Application Filing
- 2006-01-26 AU AU2006208992A patent/AU2006208992A1/en not_active Abandoned
- 2006-01-26 CA CA002595986A patent/CA2595986A1/en not_active Abandoned
- 2006-01-26 RU RU2007132438/04A patent/RU2007132438A/ru not_active Application Discontinuation
- 2006-01-27 AR ARP060100313A patent/AR052894A1/es not_active Application Discontinuation
- 2006-01-27 TW TW095103557A patent/TW200637861A/zh unknown
-
2007
- 2007-07-12 ZA ZA200705752A patent/ZA200705752B/xx unknown
- 2007-07-20 CR CR9268A patent/CR9268A/es not_active Application Discontinuation
- 2007-07-26 IL IL184885A patent/IL184885A0/en unknown
- 2007-07-27 NI NI200700189A patent/NI200700189A/es unknown
- 2007-08-22 NO NO20074303A patent/NO20074303L/no not_active Application Discontinuation
- 2007-08-24 MA MA30163A patent/MA29267B1/fr unknown
Also Published As
Publication number | Publication date |
---|---|
EP1846407B1 (en) | 2011-06-29 |
TW200637861A (en) | 2006-11-01 |
JP4111533B1 (ja) | 2008-07-02 |
NI200700189A (es) | 2008-04-24 |
US20080161313A1 (en) | 2008-07-03 |
MX2007009004A (es) | 2007-09-14 |
CA2595986A1 (en) | 2006-08-03 |
CR9268A (es) | 2007-10-23 |
JP2008528478A (ja) | 2008-07-31 |
EP1846407A1 (en) | 2007-10-24 |
AU2006208992A1 (en) | 2006-08-03 |
US7915259B2 (en) | 2011-03-29 |
RU2007132438A (ru) | 2009-03-10 |
ES2367267T3 (es) | 2011-10-31 |
MA29267B1 (fr) | 2008-02-01 |
KR100938364B1 (ko) | 2010-01-22 |
WO2006079988A1 (en) | 2006-08-03 |
AR052894A1 (es) | 2007-04-11 |
NO20074303L (no) | 2007-08-22 |
ATE514697T1 (de) | 2011-07-15 |
CN101107248A (zh) | 2008-01-16 |
KR20080001707A (ko) | 2008-01-03 |
IL184885A0 (en) | 2007-12-03 |
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