ZA200703677B - 3-(2-hydroxyphenyl)pyrazoles and their use as HSP90 modulators - Google Patents

3-(2-hydroxyphenyl)pyrazoles and their use as HSP90 modulators

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Publication number
ZA200703677B
ZA200703677B ZA200703677A ZA200703677A ZA200703677B ZA 200703677 B ZA200703677 B ZA 200703677B ZA 200703677 A ZA200703677 A ZA 200703677A ZA 200703677 A ZA200703677 A ZA 200703677A ZA 200703677 B ZA200703677 B ZA 200703677B
Authority
ZA
South Africa
Prior art keywords
pyrazoles
hydroxyphenyl
hsp90 modulators
hsp90
modulators
Prior art date
Application number
ZA200703677A
Other languages
English (en)
Inventor
Eggenweiler Hans-Michael
Wolf Michael
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of ZA200703677B publication Critical patent/ZA200703677B/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P35/00—Antineoplastic agents
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    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Virology (AREA)
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  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
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  • Endocrinology (AREA)
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  • AIDS & HIV (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
ZA200703677A 2004-10-08 2007-05-07 3-(2-hydroxyphenyl)pyrazoles and their use as HSP90 modulators ZA200703677B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102004049078A DE102004049078A1 (de) 2004-10-08 2004-10-08 Phenylpyrazole

Publications (1)

Publication Number Publication Date
ZA200703677B true ZA200703677B (en) 2008-08-27

Family

ID=35427769

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200703677A ZA200703677B (en) 2004-10-08 2007-05-07 3-(2-hydroxyphenyl)pyrazoles and their use as HSP90 modulators

Country Status (17)

Country Link
US (1) US20080090880A1 (pt)
EP (1) EP1799649B1 (pt)
JP (1) JP2008515823A (pt)
KR (1) KR20070098782A (pt)
CN (1) CN101035766A (pt)
AR (1) AR051135A1 (pt)
AU (1) AU2005293937A1 (pt)
BR (1) BRPI0515582A (pt)
CA (1) CA2583292A1 (pt)
DE (1) DE102004049078A1 (pt)
DK (1) DK1799649T3 (pt)
ES (1) ES2494920T3 (pt)
MX (1) MX2007004041A (pt)
PT (1) PT1799649E (pt)
RU (1) RU2007116868A (pt)
WO (1) WO2006039977A1 (pt)
ZA (1) ZA200703677B (pt)

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KR101374553B1 (ko) 2004-11-18 2014-03-17 신타 파마슈티칼스 코프. Ｈｓｐ90 활성을 조절하는 트리아졸 화합물
ME02051B (me) 2005-04-13 2015-05-20 Astex Therapeutics Ltd Derivati hidroksibenzamida i njihova primena kao inhibitora hsp90
US7754725B2 (en) 2006-03-01 2010-07-13 Astex Therapeutics Ltd. Dihydroxyphenyl isoindolymethanones
DE102006023336A1 (de) * 2006-05-18 2007-11-22 Merck Patent Gmbh 1,5-Diphenyl-pyrazole II
GB0620259D0 (en) 2006-10-12 2006-11-22 Astex Therapeutics Ltd Pharmaceutical compounds
US8277807B2 (en) 2006-10-12 2012-10-02 Astex Therapeutics Limited Pharmaceutical combinations
JP5528806B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
JP5410285B2 (ja) 2006-10-12 2014-02-05 アステックス、セラピューティックス、リミテッド 医薬化合物
EP2073807A1 (en) 2006-10-12 2009-07-01 Astex Therapeutics Limited Pharmaceutical combinations
US9730912B2 (en) 2006-10-12 2017-08-15 Astex Therapeutics Limited Pharmaceutical compounds
GB0806527D0 (en) 2008-04-11 2008-05-14 Astex Therapeutics Ltd Pharmaceutical compounds
EP2273882A4 (en) * 2008-05-13 2011-07-13 Poniard Pharmaceuticals Inc BIOACTIVE COMPOUNDS FOR THE TREATMENT OF CANCER AND NEURODEEGENERATIVE DISEASES
AU2009257795A1 (en) * 2008-06-11 2009-12-17 Merck Sharp & Dohme Corp. Pyrazole derivatives useful as inhibitors of FAAH
US9205086B2 (en) 2010-04-19 2015-12-08 Synta Pharmaceuticals Corp. Cancer therapy using a combination of a Hsp90 inhibitory compounds and a EGFR inhibitor
CA2853806C (en) 2011-11-02 2020-07-14 Synta Pharmaceuticals Corp. Combination therapy of hsp90 inhibitors with platinum-containing agents
WO2013067162A1 (en) 2011-11-02 2013-05-10 Synta Pharmaceuticals Corp. Cancer therapy using a combination of hsp90 inhibitors with topoisomerase i inhibitors
AU2012339679A1 (en) 2011-11-14 2014-06-12 Synta Pharmaceuticals Corp. Combination therapy of Hsp90 inhibitors with BRAF inhibitors
WO2015089800A1 (en) * 2013-12-19 2015-06-25 Eli Lilly And Company Fluorophenyl pyrazol compounds
CN106795120B (zh) * 2014-10-31 2020-09-01 豪夫迈·罗氏有限公司 新的吡啶基氧基-和苯基氧基-吡唑基化合物
EP3426636B1 (en) 2016-03-07 2021-12-29 Northwestern University Specific 2-(4-(phenoxy)-1h-pyrazol-3-yl)phenol derivatives as inhibitors of c-myc/dna binding activity for treating cancer
US11142504B2 (en) 2016-03-07 2021-10-12 Northwestern University Substituted heterocycles as c-MYC targeting agents
WO2020046382A1 (en) 2018-08-31 2020-03-05 Northwestern University Substituted heterocycles as c-myc targeting agents
WO2020257261A1 (en) 2019-06-17 2020-12-24 Northwestern University SUBSTITUTED HETEROCYCLES AS c-MYC TARGETING AGENTS

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AU3378599A (en) 1998-04-03 1999-10-25 University Of Pittsburgh Benzoquinoid ansamycins for the treatment of cardiac arrest and stroke
AU776652B2 (en) 1999-03-12 2004-09-16 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The Method of inhibiting a chaperone protein
WO2001072779A1 (en) 2000-03-24 2001-10-04 Duke University Characterization of grp94-ligand interactions and purification, screening, and therapeutic methods relating thereto
WO2002002123A1 (en) 2000-06-29 2002-01-10 Trustees Of Boston University Use of geldanamycin and related compounds for prophylaxis or treatment of fibrogenic disorders
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EP1450784A4 (en) 2001-11-09 2005-02-09 Conforma Therapeutics Corp HSP90-INHIBITABLE ZEARALANOL COMPOUNDS AND METHOD FOR THEIR PREPARATION AND USE
EP1456180B1 (en) * 2001-12-21 2007-10-03 Vernalis (Cambridge) Limited 3-(2,4)dihydroxyphenyl-4-phenylpyrazoles and their medical use
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JP2005225787A (ja) * 2004-02-12 2005-08-25 Nippon Kayaku Co Ltd Ｈｓｐ９０阻害剤

Also Published As

Publication number Publication date
BRPI0515582A (pt) 2008-07-29
MX2007004041A (es) 2007-05-24
JP2008515823A (ja) 2008-05-15
ES2494920T3 (es) 2014-09-16
DE102004049078A1 (de) 2006-04-13
DK1799649T3 (da) 2014-08-11
RU2007116868A (ru) 2008-11-20
AU2005293937A1 (en) 2006-04-20
PT1799649E (pt) 2014-10-01
AR051135A1 (es) 2006-12-20
KR20070098782A (ko) 2007-10-05
CA2583292A1 (en) 2006-04-20
WO2006039977A1 (de) 2006-04-20
EP1799649B1 (de) 2014-06-25
EP1799649A1 (de) 2007-06-27
CN101035766A (zh) 2007-09-12
US20080090880A1 (en) 2008-04-17

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