PT1799649E - 3-(2-hidroxifenil)-pirazóis e a sua utilização como moduladores da hsp90 - Google Patents

3-(2-hidroxifenil)-pirazóis e a sua utilização como moduladores da hsp90 Download PDF

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Publication number
PT1799649E
PT1799649E PT57874513T PT05787451T PT1799649E PT 1799649 E PT1799649 E PT 1799649E PT 57874513 T PT57874513 T PT 57874513T PT 05787451 T PT05787451 T PT 05787451T PT 1799649 E PT1799649 E PT 1799649E
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PT
Portugal
Prior art keywords
pyrazoles
hydroxyphenyl
hsp90 modulators
hsp90
modulators
Prior art date
Application number
PT57874513T
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English (en)
Inventor
Wolf Dr Michael
Hans-Michael Eggenweiler
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Merck Patent Gmbh
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Publication of PT1799649E publication Critical patent/PT1799649E/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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    • A61P31/22—Antivirals for DNA viruses for herpes viruses
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    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
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    • A61P35/04—Antineoplastic agents specific for metastasis
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
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  • Virology (AREA)
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  • Communicable Diseases (AREA)
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  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biotechnology (AREA)
  • Vascular Medicine (AREA)
  • Psychology (AREA)
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PT57874513T 2004-10-08 2005-09-14 3-(2-hidroxifenil)-pirazóis e a sua utilização como moduladores da hsp90 PT1799649E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102004049078A DE102004049078A1 (de) 2004-10-08 2004-10-08 Phenylpyrazole

Publications (1)

Publication Number Publication Date
PT1799649E true PT1799649E (pt) 2014-10-01

Family

ID=35427769

Family Applications (1)

Application Number Title Priority Date Filing Date
PT57874513T PT1799649E (pt) 2004-10-08 2005-09-14 3-(2-hidroxifenil)-pirazóis e a sua utilização como moduladores da hsp90

Country Status (17)

Country Link
US (1) US20080090880A1 (pt)
EP (1) EP1799649B1 (pt)
JP (1) JP2008515823A (pt)
KR (1) KR20070098782A (pt)
CN (1) CN101035766A (pt)
AR (1) AR051135A1 (pt)
AU (1) AU2005293937A1 (pt)
BR (1) BRPI0515582A (pt)
CA (1) CA2583292A1 (pt)
DE (1) DE102004049078A1 (pt)
DK (1) DK1799649T3 (pt)
ES (1) ES2494920T3 (pt)
MX (1) MX2007004041A (pt)
PT (1) PT1799649E (pt)
RU (1) RU2007116868A (pt)
WO (1) WO2006039977A1 (pt)
ZA (1) ZA200703677B (pt)

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JP4954083B2 (ja) 2004-11-18 2012-06-13 シンタ ファーマスーティカルズ コーポレイション Ｈｓｐ９０活性を調節するトリアゾール化合物
WO2006109085A1 (en) * 2005-04-13 2006-10-19 Astex Therapeutics Limited Hydroxybenzamide derivatives and their use as inhibitors of hsp90
US7754725B2 (en) 2006-03-01 2010-07-13 Astex Therapeutics Ltd. Dihydroxyphenyl isoindolymethanones
DE102006023336A1 (de) * 2006-05-18 2007-11-22 Merck Patent Gmbh 1,5-Diphenyl-pyrazole II
WO2008044054A2 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Hydroxy-substituted benzoic acid amide compounds for use in therapy
WO2008044045A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
US8779132B2 (en) 2006-10-12 2014-07-15 Astex Therapeutics Limited Pharmaceutical compounds
JP5721949B2 (ja) 2006-10-12 2015-05-20 アステックス、セラピューティックス、リミテッドＡｓｔｅｘ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ 複合薬剤
JP5528806B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
GB0620259D0 (en) 2006-10-12 2006-11-22 Astex Therapeutics Ltd Pharmaceutical compounds
GB0806527D0 (en) 2008-04-11 2008-05-14 Astex Therapeutics Ltd Pharmaceutical compounds
US20110124634A1 (en) * 2008-05-13 2011-05-26 Poniard Pharmaceuticals, Inc. Bioactive compounds for treatment of cancer and neurodegenerative diseases
EP2299824B1 (en) * 2008-06-11 2013-06-19 Merck Sharp & Dohme Corp. Pyrazole derivatives useful as inhibitors of faah
EP2560640A1 (en) 2010-04-19 2013-02-27 Synta Pharmaceuticals Corp. Cancer therapy using a combination of a hsp90 inhibitory compounds and a egfr inhibitor
CA2853799A1 (en) 2011-11-02 2013-05-10 Synta Pharmaceuticals Corp. Cancer therapy using a combination of hsp90 inhibitors with topoisomerase i inhibitors
CA2853806C (en) 2011-11-02 2020-07-14 Synta Pharmaceuticals Corp. Combination therapy of hsp90 inhibitors with platinum-containing agents
CA2854188A1 (en) 2011-11-14 2013-05-23 Synta Pharmaceuticals Corp. Combination therapy of hsp90 inhibitors with braf inhibitors
WO2015089800A1 (en) * 2013-12-19 2015-06-25 Eli Lilly And Company Fluorophenyl pyrazol compounds
CN106795120B (zh) * 2014-10-31 2020-09-01 豪夫迈·罗氏有限公司 新的吡啶基氧基-和苯基氧基-吡唑基化合物
US11142504B2 (en) 2016-03-07 2021-10-12 Northwestern University Substituted heterocycles as c-MYC targeting agents
EP3426636B1 (en) 2016-03-07 2021-12-29 Northwestern University Specific 2-(4-(phenoxy)-1h-pyrazol-3-yl)phenol derivatives as inhibitors of c-myc/dna binding activity for treating cancer
WO2020046382A1 (en) 2018-08-31 2020-03-05 Northwestern University Substituted heterocycles as c-myc targeting agents
WO2020257261A1 (en) 2019-06-17 2020-12-24 Northwestern University SUBSTITUTED HETEROCYCLES AS c-MYC TARGETING AGENTS

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US5968921A (en) 1997-10-24 1999-10-19 Orgegon Health Sciences University Compositions and methods for promoting nerve regeneration
AU3378599A (en) 1998-04-03 1999-10-25 University Of Pittsburgh Benzoquinoid ansamycins for the treatment of cardiac arrest and stroke
WO2000053169A2 (en) 1999-03-12 2000-09-14 The United States Of America, Represented By The Secretary Department Of Health And Human Services Method of inhibiting a chaperone protein
JP2003528886A (ja) 2000-03-24 2003-09-30 デューク・ユニバーシティ Ｃｒｐ９４−リガンド相互作用の特徴付けおよびそれに関連する精製、スクリーニングおよび治療法
US6887853B2 (en) 2000-06-29 2005-05-03 The Trustees Of Boston University Use of geldanamycin and related compounds for treatment of fibrogenic disorders
EP1322325A4 (en) 2000-07-20 2004-09-15 Merck & Co Inc INHIBITION OF PROCESSING AND REPLICATION OF HEPATITIS C VIRUS
JP2004505044A (ja) 2000-07-28 2004-02-19 スローン−ケッタリング・インスティテュート・フォー・キャンサー・リサーチ 細胞増殖性障害およびウイルス感染の治療方法
US7439359B2 (en) 2000-11-02 2008-10-21 Sloan-Kettering Institute For Cancer Research Small molecule compositions for binding to hsp90
WO2003041643A2 (en) 2001-11-09 2003-05-22 Conforma Therapeutics Corporation Hsp90-inhibiting zearalanol compounds and methods of producing and using same
WO2003055860A1 (en) 2001-12-21 2003-07-10 Vernalis (Cambridge) Limited 3,4-diarylpyrazoles and their use in the therapy of cancer
GB0228417D0 (en) * 2002-12-05 2003-01-08 Cancer Rec Tech Ltd Pyrazole compounds
GB0229618D0 (en) 2002-12-19 2003-01-22 Cancer Rec Tech Ltd Pyrazole compounds
JP2005225787A (ja) * 2004-02-12 2005-08-25 Nippon Kayaku Co Ltd Ｈｓｐ９０阻害剤

Also Published As

Publication number Publication date
RU2007116868A (ru) 2008-11-20
ZA200703677B (en) 2008-08-27
DK1799649T3 (da) 2014-08-11
WO2006039977A1 (de) 2006-04-20
JP2008515823A (ja) 2008-05-15
KR20070098782A (ko) 2007-10-05
DE102004049078A1 (de) 2006-04-13
ES2494920T3 (es) 2014-09-16
MX2007004041A (es) 2007-05-24
EP1799649B1 (de) 2014-06-25
CN101035766A (zh) 2007-09-12
AR051135A1 (es) 2006-12-20
AU2005293937A1 (en) 2006-04-20
BRPI0515582A (pt) 2008-07-29
CA2583292A1 (en) 2006-04-20
EP1799649A1 (de) 2007-06-27
US20080090880A1 (en) 2008-04-17

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