ZA200703383B - 6-(pyridinyl)-4-pyrimidone derivates as tau protein kinase 1 inhibitors - Google Patents
6-(pyridinyl)-4-pyrimidone derivates as tau protein kinase 1 inhibitorsInfo
- Publication number
- ZA200703383B ZA200703383B ZA200703383A ZA200703383A ZA200703383B ZA 200703383 B ZA200703383 B ZA 200703383B ZA 200703383 A ZA200703383 A ZA 200703383A ZA 200703383 A ZA200703383 A ZA 200703383A ZA 200703383 B ZA200703383 B ZA 200703383B
- Authority
- ZA
- South Africa
- Prior art keywords
- pyrimidone
- derivates
- pyridinyl
- inhibitors
- protein kinase
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2004313115 | 2004-09-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200703383B true ZA200703383B (en) | 2009-05-27 |
Family
ID=35848411
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200703383A ZA200703383B (en) | 2004-09-29 | 2005-09-29 | 6-(pyridinyl)-4-pyrimidone derivates as tau protein kinase 1 inhibitors |
Country Status (25)
Country | Link |
---|---|
US (1) | US8129377B2 (fr) |
EP (3) | EP1805164B9 (fr) |
JP (1) | JP5186213B2 (fr) |
KR (1) | KR20070057931A (fr) |
CN (1) | CN101048397A (fr) |
AR (1) | AR051823A1 (fr) |
AT (1) | ATE499356T1 (fr) |
AU (1) | AU2005288045B2 (fr) |
BR (1) | BRPI0515851A (fr) |
CA (1) | CA2581179A1 (fr) |
CY (1) | CY1112326T1 (fr) |
DE (1) | DE602005026546D1 (fr) |
DK (1) | DK1805164T3 (fr) |
EA (1) | EA013004B1 (fr) |
ES (1) | ES2359071T3 (fr) |
IL (1) | IL182223A0 (fr) |
MX (1) | MX2007003722A (fr) |
NO (1) | NO20072214L (fr) |
NZ (1) | NZ554722A (fr) |
PL (1) | PL1805164T3 (fr) |
PT (1) | PT1805164E (fr) |
SI (1) | SI1805164T1 (fr) |
TW (1) | TWI354669B (fr) |
WO (1) | WO2006036015A2 (fr) |
ZA (1) | ZA200703383B (fr) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200621760A (en) * | 2004-09-09 | 2006-07-01 | Mitsubishi Pharma Corp | 2-morpholino-4-pyrimidone compound |
GB0510141D0 (en) | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B3 |
GB0510142D0 (en) * | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds A1 |
TW200740779A (en) | 2005-07-22 | 2007-11-01 | Mitsubishi Pharma Corp | Intermediate compound for synthesizing pharmaceutical agent and production method thereof |
TW200813015A (en) * | 2006-03-15 | 2008-03-16 | Mitsubishi Pharma Corp | 2-(cyclic amino)-pyrimidone derivatives |
ATE530540T1 (de) * | 2006-08-23 | 2011-11-15 | Pfizer Prod Inc | Pyrimidonverbindungen als gsk-3-inhibitoren |
WO2008026046A1 (fr) * | 2006-08-30 | 2008-03-06 | Pfizer Products Inc. | Antagonistes à base de morpholine de la dopamine d3 |
AR064660A1 (es) | 2006-12-26 | 2009-04-15 | Mitsubishi Tanabe Pharma Corp | Derivados de pirimidinona 6-heterociclica 2-sustituida, medicamentos que los contienen y usos para prevenir y/o tratar enfermedades neurodegenerativas entre otras |
TWI432422B (zh) | 2007-08-22 | 2014-04-01 | Astrazeneca Ab | 環丙基醯胺衍生物 |
EA201070367A1 (ru) * | 2007-09-14 | 2010-08-30 | Мицубиси Танабе Фарма Корпорейшн | Производное 6-пиримидинилпиримид-4-она |
TW201039825A (en) | 2009-02-20 | 2010-11-16 | Astrazeneca Ab | Cyclopropyl amide derivatives 983 |
WO2011019090A1 (fr) * | 2009-08-13 | 2011-02-17 | Mitsubishi Tanabe Pharma Corporation | Dérivés de pyrimidone utilisés en tant qu'inhibiteurs de la protéine kinase tau 1 |
US20130005710A1 (en) | 2009-11-18 | 2013-01-03 | Tetsuya Tsukamoto | Aminopyridine derivative |
US9452980B2 (en) * | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
SG183274A1 (en) | 2010-02-18 | 2012-09-27 | Astrazeneca Ab | Processes for making cyclopropyl amide derivatives and intermediates associated therewith |
US9365539B2 (en) | 2010-05-11 | 2016-06-14 | Merck Sharp & Dohme Corp. | Prolylcarboxypeptidase inhibitors |
EP2928473B1 (fr) * | 2012-12-07 | 2017-06-28 | Merck Sharp & Dohme Corp. | Arylation n-2 régiosélective d'indazoles |
SG11201909807TA (en) | 2017-04-24 | 2019-11-28 | Tesaro Inc | Methods of manufacturing of niraparib |
CN111138412B (zh) * | 2018-11-06 | 2023-09-15 | 上海奕拓医药科技有限责任公司 | 一种螺芳环化合物及其应用 |
CN111704611B (zh) * | 2019-07-25 | 2022-01-14 | 上海凌达生物医药有限公司 | 一类芳基螺环类shp2抑制剂化合物、制备方法和用途 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR023052A1 (es) | 1998-09-25 | 2002-09-04 | Mitsuharu Yoshimura Milton | Derivados de pirimidona |
EP1136482A1 (fr) * | 2000-03-23 | 2001-09-26 | Sanofi-Synthelabo | Dérivés de 2-amino-3-(alkyl)-pyrimidone comme inhibiteurs de GSK3bêta |
EP1136483A1 (fr) * | 2000-03-23 | 2001-09-26 | Sanofi-Synthelabo | Dérivés de 2-[pipérazinyl]pyrimidinone |
CA2460121C (fr) | 2001-09-21 | 2010-11-02 | Mitsubishi Pharma Corporation | Derives de 3-substitue-4-pyrimidone |
KR100754596B1 (ko) | 2001-09-21 | 2007-09-05 | 미쯔비시 웰 파마 가부시키가이샤 | 3-치환-4-피리미돈 유도체 |
EP1454908B1 (fr) * | 2003-03-07 | 2008-02-27 | Sanofi-Aventis | Dérivés de pyridinyl-2-(diaza-bicyclo-alkyl)-pyrimidinone substitués |
TWI357408B (en) * | 2003-03-26 | 2012-02-01 | Mitsubishi Tanabe Pharma Corp | 3-substituted-4-pyrimidone derivatives |
-
2005
- 2005-09-29 EP EP05790292A patent/EP1805164B9/fr not_active Not-in-force
- 2005-09-29 JP JP2007533116A patent/JP5186213B2/ja not_active Expired - Fee Related
- 2005-09-29 WO PCT/JP2005/018497 patent/WO2006036015A2/fr active Application Filing
- 2005-09-29 CA CA002581179A patent/CA2581179A1/fr not_active Abandoned
- 2005-09-29 MX MX2007003722A patent/MX2007003722A/es active IP Right Grant
- 2005-09-29 KR KR1020077008236A patent/KR20070057931A/ko not_active Application Discontinuation
- 2005-09-29 EP EP10010448A patent/EP2261224A3/fr not_active Withdrawn
- 2005-09-29 ZA ZA200703383A patent/ZA200703383B/xx unknown
- 2005-09-29 DE DE602005026546T patent/DE602005026546D1/de active Active
- 2005-09-29 PT PT05790292T patent/PT1805164E/pt unknown
- 2005-09-29 EA EA200700756A patent/EA013004B1/ru not_active IP Right Cessation
- 2005-09-29 DK DK05790292.6T patent/DK1805164T3/da active
- 2005-09-29 CN CNA2005800330250A patent/CN101048397A/zh active Pending
- 2005-09-29 AU AU2005288045A patent/AU2005288045B2/en not_active Ceased
- 2005-09-29 US US11/576,062 patent/US8129377B2/en not_active Expired - Fee Related
- 2005-09-29 BR BRPI0515851-6A patent/BRPI0515851A/pt not_active IP Right Cessation
- 2005-09-29 ES ES05790292T patent/ES2359071T3/es active Active
- 2005-09-29 PL PL05790292T patent/PL1805164T3/pl unknown
- 2005-09-29 AR ARP050104099A patent/AR051823A1/es not_active Application Discontinuation
- 2005-09-29 SI SI200531256T patent/SI1805164T1/sl unknown
- 2005-09-29 TW TW094134059A patent/TWI354669B/zh not_active IP Right Cessation
- 2005-09-29 AT AT05790292T patent/ATE499356T1/de active
- 2005-09-29 EP EP10010450A patent/EP2266969A3/fr not_active Withdrawn
- 2005-09-29 NZ NZ554722A patent/NZ554722A/en not_active IP Right Cessation
-
2007
- 2007-03-27 IL IL182223A patent/IL182223A0/en unknown
- 2007-04-27 NO NO20072214A patent/NO20072214L/no not_active Application Discontinuation
-
2011
- 2011-05-04 CY CY20111100427T patent/CY1112326T1/el unknown
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