ZA200702541B - Process for preparing 4,5-dihydro-pyrazolo [3,4-c]pyrid-2-ones - Google Patents

Process for preparing 4,5-dihydro-pyrazolo [3,4-c]pyrid-2-ones

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Publication number
ZA200702541B
ZA200702541B ZA200702541A ZA200702541A ZA200702541B ZA 200702541 B ZA200702541 B ZA 200702541B ZA 200702541 A ZA200702541 A ZA 200702541A ZA 200702541 A ZA200702541 A ZA 200702541A ZA 200702541 B ZA200702541 B ZA 200702541B
Authority
ZA
South Africa
Prior art keywords
pyrid
pyrazolo
dihydro
ones
preparing
Prior art date
Application number
ZA200702541A
Other languages
English (en)
Inventor
Shapiro Rafael
Boguslaw M Mudryk
Oberholzer Matthew
Chen Bang-Chi
Lucius T Rossano
Cuniere Nicolas
Zhang Huiping
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of ZA200702541B publication Critical patent/ZA200702541B/xx

Links

ZA200702541A 2004-09-28 2007-03-27 Process for preparing 4,5-dihydro-pyrazolo [3,4-c]pyrid-2-ones ZA200702541B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US61393804P 2004-09-28 2004-09-28

Publications (1)

Publication Number Publication Date
ZA200702541B true ZA200702541B (en) 2008-09-25

Family

ID=38965672

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200702541A ZA200702541B (en) 2004-09-28 2007-03-27 Process for preparing 4,5-dihydro-pyrazolo [3,4-c]pyrid-2-ones

Country Status (2)

Country Link
CN (1) CN101065379B (xx)
ZA (1) ZA200702541B (xx)

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CN101967145B (zh) * 2010-09-09 2012-07-04 华东理工大学 一种抗血栓药物阿匹沙班的制备方法
CN103159670A (zh) * 2011-12-16 2013-06-19 中国科学院兰州化学物理研究所 阿哌沙班中间体1-(4-硝基苯基)-2-哌啶酮的合成方法
CN102675314A (zh) * 2012-06-14 2012-09-19 南京正科制药有限公司 一种阿哌沙班的合成方法
CN104797580A (zh) * 2012-10-10 2015-07-22 广东东阳光药业有限公司 阿哌沙班的晶型或无定形及其制备工艺
CN103539795A (zh) * 2013-03-18 2014-01-29 齐鲁制药有限公司 阿哌沙班的多晶型及其制备方法
CN104109165A (zh) * 2013-04-19 2014-10-22 四川海思科制药有限公司 4,5-二氢-吡唑并[3,4-c]吡啶-2-酮衍生物、其制备方法以及应用
CN104341336B (zh) 2013-08-02 2018-10-16 上海科胜药物研发有限公司 一种合成阿哌沙班重要中间体的新方法
CN104370902A (zh) * 2013-08-12 2015-02-25 药源药物化学（上海）有限公司 一种阿哌沙班新晶型及其制备方法
CN103694237B (zh) * 2014-01-07 2016-03-23 上海现代制药股份有限公司 一种抗凝血药阿哌沙班的制备方法及关键中间体
CN104788448A (zh) * 2014-01-17 2015-07-22 北京蓝丹医药科技有限公司 阿哌沙班晶型及其制备方法
CN103833755A (zh) * 2014-03-24 2014-06-04 重庆东得医药科技有限公司 阿哌沙班晶型b及其制备方法
CN104086544B (zh) * 2014-07-15 2017-09-19 上海右手医药科技开发有限公司 阿哌沙班一水合物及其制备方法和药物组合物
CN104311558B (zh) * 2014-09-19 2016-06-01 广东东阳光药业有限公司 含有环己烷取代基的吡唑并哌啶酮类化合物及其组合物及用途
CN105884763A (zh) * 2014-09-28 2016-08-24 深圳翰宇药业股份有限公司 一种阿哌沙班的纯化方法
EP3009435B1 (en) * 2014-10-15 2016-08-17 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Apixaban glycol esters as key intermediates and impurities of the synthesis of Apixaban
CN106279149A (zh) * 2015-06-02 2017-01-04 天津药物研究院有限公司 一种制备高纯度阿哌沙班的方法
CN104892601B (zh) * 2015-06-09 2017-09-19 江苏中邦制药有限公司 一种抗血栓药物阿哌沙班的制备方法
CN105175415A (zh) * 2015-10-20 2015-12-23 南京美嘉宁逸医药研究开发有限公司 阿哌沙班的含有两个结晶水的h2-2晶型的制备方法
CN106496221A (zh) * 2016-08-31 2017-03-15 成都倍特药业有限公司 一种制备阿哌沙班n‑1 晶型的方法
CN110922403B (zh) 2019-09-26 2021-02-26 浙江天宇药业股份有限公司 阿哌沙班与羧酸形成的共晶及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002350217A1 (en) * 2001-12-04 2003-06-17 Bristol-Myers Squibb Company Glycinamides as factor xa inhibitors
TW200303201A (en) * 2001-12-10 2003-09-01 Bristol Myers Squibb Co Synthesis of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones

Also Published As

Publication number Publication date
CN101065379A (zh) 2007-10-31
CN101065379B (zh) 2011-05-11

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