ZA200700651B - 3-substituted-5-and 6-aminoalkyl indole-2-carboxylic acid amides and related analogs as inhibitors of casein kinase - Google Patents

3-substituted-5-and 6-aminoalkyl indole-2-carboxylic acid amides and related analogs as inhibitors of casein kinase

Info

Publication number
ZA200700651B
ZA200700651B ZA200700651A ZA200700651A ZA200700651B ZA 200700651 B ZA200700651 B ZA 200700651B ZA 200700651 A ZA200700651 A ZA 200700651A ZA 200700651 A ZA200700651 A ZA 200700651A ZA 200700651 B ZA200700651 B ZA 200700651B
Authority
ZA
South Africa
Prior art keywords
inhibitors
substituted
carboxylic acid
acid amides
casein kinase
Prior art date
Application number
ZA200700651A
Other languages
English (en)
Inventor
William Arthur Metz Jr
Ding Fa-Xiang
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of ZA200700651B publication Critical patent/ZA200700651B/xx

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
ZA200700651A 2004-08-19 2007-01-22 3-substituted-5-and 6-aminoalkyl indole-2-carboxylic acid amides and related analogs as inhibitors of casein kinase ZA200700651B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US60338004P 2004-08-19 2004-08-19

Publications (1)

Publication Number Publication Date
ZA200700651B true ZA200700651B (en) 2008-09-25

Family

ID=35311279

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200700651A ZA200700651B (en) 2004-08-19 2007-01-22 3-substituted-5-and 6-aminoalkyl indole-2-carboxylic acid amides and related analogs as inhibitors of casein kinase

Country Status (27)

Country Link
US (2) US7629376B2 (fr)
EP (1) EP1794122B1 (fr)
JP (1) JP4843608B2 (fr)
KR (2) KR20070043012A (fr)
CN (1) CN101006055B (fr)
AR (1) AR050919A1 (fr)
AT (1) ATE508112T1 (fr)
AU (1) AU2005277523B2 (fr)
BR (1) BRPI0514380A (fr)
CA (1) CA2577667C (fr)
DE (1) DE602005027858D1 (fr)
GT (1) GT200500214A (fr)
HK (1) HK1105196A1 (fr)
IL (1) IL181156A (fr)
JO (1) JO2724B1 (fr)
MA (1) MA28863B1 (fr)
MX (1) MX2007001382A (fr)
NO (1) NO20071466L (fr)
NZ (1) NZ552800A (fr)
PA (1) PA8642901A1 (fr)
PE (1) PE20060498A1 (fr)
RU (1) RU2369599C2 (fr)
SV (1) SV2006002192A (fr)
TW (1) TWI357897B (fr)
UY (1) UY29078A1 (fr)
WO (1) WO2006023467A1 (fr)
ZA (1) ZA200700651B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010092660A1 (fr) * 2009-02-12 2010-08-19 株式会社ファルマデザイン Inhibiteur de la caséine kinase 1δ et de la caséine kinase 1ε
SG175210A1 (en) * 2009-04-17 2011-11-28 Cylene Pharmaceuticals Inc Method of treating disorders associated with protein kinase ck2 activity
BR112014032581A8 (pt) 2012-06-27 2018-08-14 4Sc Discovery Gmbh inibidores de bifluorodioxalano-amino-benzimidazol quinase para o tratamento de câncer, distúrbios do snc e inflamação autoimune
EP3746438A1 (fr) 2018-01-29 2020-12-09 Cadila Healthcare Limited Composés hétérocycliques utiles en tant qu'agents antibactériens
WO2022006377A2 (fr) * 2020-07-02 2022-01-06 Mbq Pharma Inhibiteurs hétérocycliques de gtpases rho pour le traitement d'une maladie

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5296471A (en) 1992-12-22 1994-03-22 Glycomed Incorporated Method for controlling o-desulfation of heparin and compositions produced thereby
WO2000075669A1 (fr) 1999-06-08 2000-12-14 Aventis Pharmaceuticals Inc. Methodes de criblage visant la modification des proteines du rythme circadien
EP1534695B1 (fr) * 2002-08-09 2010-09-29 Merck Sharp & Dohme Corp. Inhibiteurs de tyrosine kinases
US7402672B2 (en) * 2003-12-11 2008-07-22 Aventis Pharmaceuticals Inc. Substituted 1H-pyrrolo[3,2-b, 3,2-c, and 2,3-c]pyridine-2-carboxamides and related analogs as inhibitors of casein kinase lepsilon

Also Published As

Publication number Publication date
US7629376B2 (en) 2009-12-08
KR20070043012A (ko) 2007-04-24
MX2007001382A (es) 2007-04-19
PA8642901A1 (es) 2006-05-16
PE20060498A1 (es) 2006-07-10
RU2007109783A (ru) 2008-09-27
US7923466B2 (en) 2011-04-12
CA2577667C (fr) 2011-01-04
AU2005277523B2 (en) 2011-09-29
AU2005277523A1 (en) 2006-03-02
BRPI0514380A (pt) 2008-06-10
CN101006055A (zh) 2007-07-25
NZ552800A (en) 2010-11-26
JP2008510017A (ja) 2008-04-03
IL181156A0 (en) 2007-07-04
US20080027124A1 (en) 2008-01-31
EP1794122A1 (fr) 2007-06-13
EP1794122B1 (fr) 2011-05-04
NO20071466L (no) 2007-04-19
JO2724B1 (en) 2013-09-15
KR20130038409A (ko) 2013-04-17
IL181156A (en) 2011-09-27
UY29078A1 (es) 2006-03-31
AR050919A1 (es) 2006-12-06
TW200621711A (en) 2006-07-01
TWI357897B (en) 2012-02-11
US20090082340A1 (en) 2009-03-26
WO2006023467A1 (fr) 2006-03-02
MA28863B1 (fr) 2007-09-03
DE602005027858D1 (de) 2011-06-16
GT200500214A (es) 2006-03-27
CA2577667A1 (fr) 2006-03-02
RU2369599C2 (ru) 2009-10-10
SV2006002192A (es) 2006-06-28
HK1105196A1 (en) 2008-02-06
CN101006055B (zh) 2011-06-22
ATE508112T1 (de) 2011-05-15
JP4843608B2 (ja) 2011-12-21

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