ZA200609635B - Mitochondrially targeted antioxidants in the treatment of liver diseases and epithelial cancers - Google Patents

Mitochondrially targeted antioxidants in the treatment of liver diseases and epithelial cancers

Info

Publication number
ZA200609635B
ZA200609635B ZA200609635A ZA200609635A ZA200609635B ZA 200609635 B ZA200609635 B ZA 200609635B ZA 200609635 A ZA200609635 A ZA 200609635A ZA 200609635 A ZA200609635 A ZA 200609635A ZA 200609635 B ZA200609635 B ZA 200609635B
Authority
ZA
South Africa
Prior art keywords
treatment
liver diseases
epithelial cancers
mitochondrially targeted
targeted antioxidants
Prior art date
Application number
ZA200609635A
Other languages
English (en)
Inventor
Froehlich Eleonore
Kvietikova Ivica
Zatloukal Kurt
Schatz Gottfried
Denk Helmut
Stumptner Cornelia
Buck Charles
Original Assignee
Oridis Biomed Forschungs Und E
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oridis Biomed Forschungs Und E filed Critical Oridis Biomed Forschungs Und E
Publication of ZA200609635B publication Critical patent/ZA200609635B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
ZA200609635A 2004-07-13 2006-11-20 Mitochondrially targeted antioxidants in the treatment of liver diseases and epithelial cancers ZA200609635B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04103318 2004-07-13

Publications (1)

Publication Number Publication Date
ZA200609635B true ZA200609635B (en) 2008-08-27

Family

ID=34929318

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200609635A ZA200609635B (en) 2004-07-13 2006-11-20 Mitochondrially targeted antioxidants in the treatment of liver diseases and epithelial cancers

Country Status (11)

Country Link
US (1) US20070225255A1 (ja)
EP (1) EP1765413A2 (ja)
JP (1) JP2008506667A (ja)
CN (1) CN1997403A (ja)
AU (1) AU2005261654A1 (ja)
CA (1) CA2573456A1 (ja)
IL (1) IL179738A0 (ja)
RU (1) RU2007105138A (ja)
SG (1) SG156613A1 (ja)
WO (1) WO2006005759A2 (ja)
ZA (1) ZA200609635B (ja)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA06008293A (es) 2004-01-22 2007-06-11 Univ Miami Formulaciones topicas de coenzima q10 y metodos de uso.
US20080032940A1 (en) * 2006-08-07 2008-02-07 Balaraman Kalyanaraman Methods for reducing anthracycline-induced toxicity
EP2119436A4 (en) 2006-10-20 2010-03-03 Ltd Liability Company Mitotech PHARMACEUTICAL COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF EYE DISEASES
EA200900583A1 (ru) 2006-10-20 2009-08-28 Общество С Ограниченной Ответственностью "Митотехнология" Композиция для регенерации, стимуляции роста и адаптации растений к различным стрессовым факторам
US9427444B2 (en) 2007-01-29 2016-08-30 Mitotech Sa Pharmaceutical and cosmetic compositions for accelerated healing of wounds and other surface damages
US8349902B2 (en) * 2007-01-29 2013-01-08 Mitotech Sa Pharmaceutical compositions useful for preventing and treating oncological diseases
US9439916B2 (en) 2007-04-11 2016-09-13 Mitotech Sa Composition for decelerating the aging in the organism and for extending the life time thereof and the use of said composition
US8518915B2 (en) 2007-06-29 2013-08-27 Mitotech Sa Use of mitochondrially-addressed compounds for preventing and treating cardiovascular diseases
WO2009033130A1 (en) * 2007-09-07 2009-03-12 Gencia Corporation Mitochondrial compositions and uses thereof
US8388936B2 (en) * 2008-02-22 2013-03-05 Mcw Research Foundation, Inc. In vivo mitochondrial labeling using positively-charged nitroxide enhanced and gadolinium chelate enhanced magnetic resonance imaging
US8388931B2 (en) * 2008-02-29 2013-03-05 Marcos Lopez 99m Tc-labeled triphenylphosphonium derivative contrasting agents and molecular probes for early detection and imaging of breast tumors
CA2721071C (en) 2008-04-11 2017-10-17 Cytotech Labs, Llc Methods and use of inducing apoptosis in cancer cells
WO2010056145A1 (ru) 2008-11-12 2010-05-20 Общество С Ограниченной Ответственностью "Митотехнология" Способ умеренного повышения протонной проводимости биологических мембран при помощи митохондриально- адресованных делокализованных катионов
AU2010236203A1 (en) * 2009-04-17 2011-10-13 Colby Pharmaceutical Company Pharmaceutically active compositions comprising oxidative stress modulators (OSM), new chemical entities, compositions and uses
JP6081195B2 (ja) 2009-05-11 2017-02-15 バーグ エルエルシー エピメタボリックシフター、多次元細胞内分子、または環境影響因子を使用する腫瘍性障害の診断のための方法
EP2441453B1 (en) 2009-06-10 2014-11-26 Mitotech SA Pharmaceutical composition for use in medical and veterinary ophthalmology
BR112012011197A2 (pt) 2009-11-13 2020-10-20 Obschestvo S Ogranichennoi Otvetsvennostyu "Mitotekh" subtâncias farmacêuticas com base em antioxidantes direcionados à mitocôndria
CN103608323B (zh) 2011-04-04 2016-08-17 博格有限责任公司 治疗中枢神经系统肿瘤的方法
EA031399B1 (ru) 2011-06-03 2018-12-28 Общество С Ограниченной Ответственностью "Митотех" Изготовление и использование пероральных фармацевтических композиций на основе митохондриально-адресованных антиоксидантов
AU2012312654B2 (en) 2011-09-19 2017-04-13 Gencia Corporation Modified creatine compounds
US10933032B2 (en) 2013-04-08 2021-03-02 Berg Llc Methods for the treatment of cancer using coenzyme Q10 combination therapies
SI2989110T1 (sl) * 2013-04-24 2019-01-31 Smart Brain s.r.o. Derivati tamoksifena za zdravljenje neoplastičnih bolezni, predvsem z višjo stopnjo proteina HER2
IL276423B2 (en) 2013-09-04 2024-05-01 Berg Llc Pharmaceutical preparations containing coenzyme Q10 for use in cancer treatment
US10058542B1 (en) 2014-09-12 2018-08-28 Thioredoxin Systems Ab Composition comprising selenazol or thiazolone derivatives and silver and method of treatment therewith
KR101773404B1 (ko) 2015-08-25 2017-08-31 (주) 씨유스킨 자외선에 의한 피부 손상의 예방 또는 개선을 위한 화장료 조성물
CN107510848A (zh) * 2016-06-15 2017-12-26 常州莱道斯生物医药科技有限公司 线粒体靶向制剂MitoPBN在防治糖尿病中的应用
CN108201543A (zh) * 2016-12-19 2018-06-26 北京福纳康生物技术有限公司 水溶性富勒烯结构在制备治疗脂肪肝的药物中的应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9722361D0 (en) * 1997-10-24 1997-12-17 Pharma Nord Uk Ltd Pharmaceutical formulation for treating liver disorders
US6331532B1 (en) * 1998-11-25 2001-12-18 University Of Otago Mitochondrially targeted antioxidants
WO2005019232A1 (en) * 2003-08-22 2005-03-03 Antipodean Pharmaceuticals, Inc. Mitoquinone derivatives used as mitochondrially targeted antioxidants
CA2354743A1 (en) * 2001-08-07 2003-02-07 University Of Otago Mitochondrially targeted antioxidants
NZ513547A (en) * 2001-08-13 2002-09-27 Antipodean Biotechnology Ltd Synthesis of triphenylphosphonium quinols (e.g. mitoquinol) and/or quinones (e.g. mitoquinone)

Also Published As

Publication number Publication date
IL179738A0 (en) 2007-05-15
EP1765413A2 (en) 2007-03-28
SG156613A1 (en) 2009-11-26
CN1997403A (zh) 2007-07-11
AU2005261654A1 (en) 2006-01-19
WO2006005759A2 (en) 2006-01-19
RU2007105138A (ru) 2008-08-20
US20070225255A1 (en) 2007-09-27
WO2006005759A3 (en) 2006-05-11
CA2573456A1 (en) 2006-01-19
JP2008506667A (ja) 2008-03-06

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