ZA200608569B - Polymorphic forms of methyl (+)-(S)-alpha- (2-chlorophenyl)-6, 7-dinydrothieno[3,2-C] pyridine-5(4H) acetate hydrobromide, clopidrogel hydrobromide - Google Patents

Polymorphic forms of methyl (+)-(S)-alpha- (2-chlorophenyl)-6, 7-dinydrothieno[3,2-C] pyridine-5(4H) acetate hydrobromide, clopidrogel hydrobromide

Info

Publication number
ZA200608569B
ZA200608569B ZA200608569A ZA200608569A ZA200608569B ZA 200608569 B ZA200608569 B ZA 200608569B ZA 200608569 A ZA200608569 A ZA 200608569A ZA 200608569 A ZA200608569 A ZA 200608569A ZA 200608569 B ZA200608569 B ZA 200608569B
Authority
ZA
South Africa
Prior art keywords
hydrobromide
dinydrothieno
chlorophenyl
pyridine
alpha
Prior art date
Application number
ZA200608569A
Other languages
English (en)
Inventor
Keith Richard Lorimer
Alicia Tee Fuay Ng
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of ZA200608569B publication Critical patent/ZA200608569B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
ZA200608569A 2004-04-20 2005-04-18 Polymorphic forms of methyl (+)-(S)-alpha- (2-chlorophenyl)-6, 7-dinydrothieno[3,2-C] pyridine-5(4H) acetate hydrobromide, clopidrogel hydrobromide ZA200608569B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US56379604P 2004-04-20 2004-04-20

Publications (1)

Publication Number Publication Date
ZA200608569B true ZA200608569B (en) 2007-12-27

Family

ID=34966201

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200608569A ZA200608569B (en) 2004-04-20 2005-04-18 Polymorphic forms of methyl (+)-(S)-alpha- (2-chlorophenyl)-6, 7-dinydrothieno[3,2-C] pyridine-5(4H) acetate hydrobromide, clopidrogel hydrobromide

Country Status (20)

Country Link
US (1) US20070088049A1 (no)
EP (1) EP1756116A1 (no)
JP (1) JP2007533744A (no)
KR (1) KR20070012675A (no)
CN (1) CN1997648A (no)
AU (1) AU2005236034A1 (no)
BR (1) BRPI0509997A (no)
CA (1) CA2562507A1 (no)
CR (1) CR8678A (no)
EA (1) EA010831B1 (no)
EC (1) ECSP066932A (no)
IL (1) IL178680A0 (no)
MA (1) MA28588B1 (no)
MX (1) MXPA06012205A (no)
NO (1) NO20065233L (no)
NZ (1) NZ551371A (no)
TN (1) TNSN06331A1 (no)
UA (1) UA83919C2 (no)
WO (1) WO2005103058A1 (no)
ZA (1) ZA200608569B (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0321256D0 (en) 2003-09-11 2003-10-08 Generics Uk Ltd Novel crystalline compounds
US20060154957A1 (en) * 2004-09-21 2006-07-13 Nina Finkelstein Crystalline clopidogrel hydrobromide and processes for preparation thereof
SI22492A (sl) * 2007-03-08 2008-10-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Polimorfne oblike klopidogrel hidrobromida
UY31531A1 (es) * 2007-12-17 2009-08-03 Sales derivadas de 8-oxoadenina composiciones farmacéuticas que las contienen y su uso en terapia como moduladores de receptor tipo toll (tlr)
ES2376057T3 (es) * 2008-02-26 2012-03-08 Laboratorios Lesvi, S.L. Formulaciones farmacéuticas que contienen clopidogrel.
HUP1400294A2 (hu) 2014-06-13 2015-12-28 Skillpharm Kft Clopidogrel új alkalmazása

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2623810B2 (fr) * 1987-02-17 1992-01-24 Sanofi Sa Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant
FR2779726B1 (fr) * 1998-06-15 2001-05-18 Sanofi Sa Forme polymorphe de l'hydrogenosulfate de clopidogrel
JP2003524634A (ja) * 1999-12-06 2003-08-19 ユーロ−セルティーク，エス．エイ． ノシセプチン受容体親和性を有するベンズイミダゾール化合物
HUP0402485A3 (en) * 2001-12-18 2008-10-28 Teva Pharma Polymorphs of clopidogrel hydrogensulfate
US7074928B2 (en) * 2002-01-11 2006-07-11 Teva Pharmaceutical Industries, Ltd. Polymorphs of clopidogrel hydrogensulfate
HUP0200438A3 (en) * 2002-02-06 2003-10-28 Egis Gyogyszergyar Nyilvanosan Novel clopidogrel hydrochloride polymorphs, process for the preparation thereof, their use and pharmaceutical compositions containing them
CZ297472B6 (cs) * 2002-08-27 2006-12-13 Zentiva, A.S. Zpusob výroby clopidogrelu hydrogensulfátu krystalické formy I
DE10305984A1 (de) * 2003-02-13 2004-09-02 Helm Ag Salze organischer Säuren mit Clopidogrel und deren Verwendung zur Herstellung phamazeutischer Formulierungen
GB0321256D0 (en) * 2003-09-11 2003-10-08 Generics Uk Ltd Novel crystalline compounds
GB0325603D0 (en) * 2003-11-03 2003-12-10 Sandoz Ag Organic compounds
EA008972B1 (ru) * 2004-01-13 2007-10-26 Зентива А.С. Новые кристаллические формы гидробромида клопидогреля и способы их получения
AU2005214469A1 (en) * 2004-02-24 2005-09-01 Siegfried Generics International Ag Pharmacologically acceptable salts of clopidogrel

Also Published As

Publication number Publication date
EA010831B1 (ru) 2008-12-30
MXPA06012205A (es) 2007-01-31
MA28588B1 (fr) 2007-05-02
KR20070012675A (ko) 2007-01-26
CR8678A (es) 2007-08-28
CA2562507A1 (en) 2005-11-03
EP1756116A1 (en) 2007-02-28
US20070088049A1 (en) 2007-04-19
AU2005236034A1 (en) 2005-11-03
ECSP066932A (es) 2006-12-20
CN1997648A (zh) 2007-07-11
WO2005103058A1 (en) 2005-11-03
IL178680A0 (en) 2007-02-11
NO20065233L (no) 2006-11-14
EA200601921A1 (ru) 2007-02-27
UA83919C2 (en) 2008-08-26
BRPI0509997A (pt) 2007-10-16
JP2007533744A (ja) 2007-11-22
NZ551371A (en) 2010-07-30
TNSN06331A1 (en) 2008-02-22

Similar Documents

Publication Publication Date Title
ZA200504238B (en) Thieno[3,2-b]pyridine-6-carbonitriles and thienoo[2,3-b]pyridine-5-carbonitriles as protein kinase inhibitors
HK1098480A1 (en) Method of preparing thieno [3,2-c]pyridine derivatives and intermediates used therein
IL181514A0 (en) 6H-[1] BENZOPYRANO[4,3-b]QUINOLINES AND THEIR USE AS ESTROGENIC AGENTS
IL208249A0 (en) Spirocyclic heterocyclic derivatives and methods of their use
ZA200608569B (en) Polymorphic forms of methyl (+)-(S)-alpha- (2-chlorophenyl)-6, 7-dinydrothieno[3,2-C] pyridine-5(4H) acetate hydrobromide, clopidrogel hydrobromide
IL185510A0 (en) Fused thieno [2,3-b] pyridine and thiazolo [5,4-b] pyridine compounds for inhibiting ksp kinesin activity
AU2003251247A1 (en) Methods for preparation of olanzapine polymorphic form i
ZA200802690B (en) Thieno[2,3-b]pyridine-5-carbonitriles as protein kinase inhibitors
DK1635839T3 (da) Benzo[4,5]thieno[2,3-D]pyrimidin-4-oner og deres terapeutiske anvendelse
IL189667A0 (en) 4-amino-thieno[3,2-c]pyridine-7-carboxylic acid derivatives
IL178019A0 (en) METHODS FOR THE PREPARATION OF (3R,3aS,6aR)HEXAHYDRO-FURO[2,3-b]FURAN-3OL
AU2003211047A8 (en) Method of preparation of 21-amino epothilone derivatives
UA84335C2 (ru) Клопидогрель и его полиморфные формы
EP1628664A4 (en) POLYMORPHIC FORMS OF NALTREXONE
ZA201000627B (en) 2-(2-oxoindoline-3-ylidene)methyl-5-(2-hydroxy-3-morpholin-4-yl-propyl)-6,7-dihydro-1h-pyrrol[3,2-c]pyridine-4(5h)-one compounds and use as protein kinase inhibitors
PL357928A1 (en) Method of obtaining pharmaceutically pure polymorphic form of i olanzapine
HU0600194D0 (en) Process for producing (s)-(+)-methyl-alpha-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4h)-acetate hidrogen sulfate polimorph i
SG113595A1 (en) New benzo[b]chromeno-naphthyridin-7-one and pyrano[2',3':7,8] quino[2,3-b]quinoxalin-7-one compounds, process for their preparation and pharmaceutical compositions containing them
ZA200605930B (en) Crystalline forms of 5,11-dihydro-11-ethyl-5-methyl-8-{2-{(1-oxido-4-quinolinyl)oxyl}ethyl}-6H-dipyrido[3,2-B:2',3'-e][1,4]diazepin-6-one
WO2008108742A3 (en) Polymorphic forms of clopidogrel hydrobromide
HU0700809D0 (en) Racemisation process for producing methyl (r,s)-(+)-alpha-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridin-5(4h)-acetate hydrogene sulfate intermediate
PL380849A1 (pl) Krystaliczna postać racemicznego -(2-chlorofenylo)-6,7-dihydrotieno[3,2-c]pirydylo-5(4H)-octanu metylu, sposób jej wytwarzania i zastosowanie
PL376058A1 (pl) Nowe pochodne 8-chloro-5,5-dioksoimidazo[1,2-b][1,4,2]benzoditiazyny i sposób ich otrzymywania
DK1392698T3 (da) Fremgangsmåde til fremstilling af 6-aryl-4H-s-triazolo-[3,4-c]thieno[2,3-e]-1,4-diazepiner
IL178688A0 (en) THIENO [3,2-b] PYRIDINE-6-CARBONITRILES AS PROTEIN KINASE INHIBITORS